# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Deep Track Capital LP 3,480,144 -99,065 284,118,956.16 6.856 5.4906 06/30/2025
2 Adar1 Capital Management LLC 3,071,340 1,557,947 250,744,197.6 27.8469 4.8457 06/30/2025
3 Cormorant Asset Management LP 2,130,000 0 173,893,200 9.3966 3.3605 06/30/2025
4 Caligan Partners LP 1,674,400 922,233 136,698,016 17.2437 2.6417 06/30/2025
5 Nantahala Capital Management LLC 1,482,994 46,947 121,071,630.16 7.1103 2.3397 06/30/2025
6 Franklin Advisers, Inc. 1,371,050 -95,012 111,932,522 0.0508 2.1631 06/30/2025
7 Great Point Partners LLC 1,291,617 -356,906 105,447,611.88 33.3293 2.0378 06/30/2025
8 Octagon Capital Advisors LP 1,267,000 1,267,000 103,437,880 15.5722 1.9989 06/30/2025
9 Millennium Management LLC 1,251,765 320,586 102,194,094.6 0.0869 1.9749 06/30/2025
10 Citadel Advisors LLC 1,247,667 473,857 101,859,533.88 0.115 1.9684 06/30/2025
11 Boothbay Fund Management LLC 870,438 463,535 71,062,558.32 2.0646 1.3733 06/30/2025
12 abrdn, Inc. 710,516 286,335 58,006,526.24 0.5834 1.121 06/30/2025
13 Saturn V Capital Management LP 622,479 -30,592 50,819,185.56 12.6583 0.9821 06/30/2025
14 Ensign Peak Advisors, Inc. 455,684 455,684 37,202,041.76 0.0598 0.7189 06/30/2025
15 Morgan Stanley & Co. International Plc 434,503 -18,046 35,472,824.92 0.38 0.6855 06/30/2025
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 abrdn World Healthcare Fund 751,516 327,335 61,353,766.24 11.5886 1.1857 07/31/2025
2 FTIF SICAV - Biotechnology Discovery Fund 423,100 -450,195 34,541,884 1.6369 0.6675 07/31/2025
3 Franklin Biotechnology Discovery Fund 225,965 -271,727 18,447,782.6 0.8637 0.3565 07/31/2025
4 abrdn Healthcare Opportunities Fund 109,000 109,000 8,898,760 1.1025 0.172 07/31/2025
5 Biotech Growth Trust Plc (The) 84,100 84,100 6,865,924 2.0944 0.1327 07/31/2025
6 ODDO BHF Avenir Europe 81,099 81,099 6,620,922.36 0.5139 0.128 07/31/2025
7 Oddo BHF Avenir EUR 20,698 20,698 1,689,784.72 0.563 0.0327 07/31/2025
8 Fidelity Nasdaq Composite Index Fund 16,749 0 1,367,388.36 0.0065 0.0264 06/30/2025
9 MissionSquare Growth Fund 10,640 10,640 868,649.6 0.0277 0.0168 07/31/2025
10 Steward International Enhanced Index Fund 7,858 0 641,527.12 0.251 0.0124 07/31/2025
11 Wilshire Large Company Growth Portfolio 6,769 6,769 552,621.16 0.2054 0.0107 07/31/2025
12 SEI Institutional Invt. Trust - Large Cap Fund 5,681 5,681 463,796.84 0.0689 0.009 07/31/2025
13 AMG TimesSquare Small Cap Growth Fund 3,000 3,000 244,920 0.2091 0.0047 07/31/2025
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Adar1 Capital Management LLC 3,071,340 1,557,947 250,744,197.6 27.8469 4.8457 06/30/2025
2 Octagon Capital Advisors LP 1,267,000 1,267,000 103,437,880 15.5722 1.9989 06/30/2025
3 Caligan Partners LP 1,674,400 922,233 136,698,016 17.2437 2.6417 06/30/2025
4 Citadel Advisors LLC 1,247,667 473,857 101,859,533.88 0.115 1.9684 06/30/2025
5 Boothbay Fund Management LLC 870,438 463,535 71,062,558.32 2.0646 1.3733 06/30/2025
6 Ensign Peak Advisors, Inc. 455,684 455,684 37,202,041.76 0.0598 0.7189 06/30/2025
7 Millennium Management LLC 1,251,765 320,586 102,194,094.6 0.0869 1.9749 06/30/2025
8 abrdn, Inc. 710,516 286,335 58,006,526.24 0.5834 1.121 06/30/2025
9 Citigroup Global Markets, Inc. (Investment Management) 170,733 170,733 13,938,642.12 0.0112 0.2694 06/30/2025
10 Woodline Partners LP 183,800 135,664 15,005,432 0.0755 0.29 06/30/2025
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Commodore Capital LP 0 -1,284,110 0 0 0
2 VHCP Management LLC 0 -998,570 0 0 0
3 Blackstone Alternative Asset Management LP 0 -936,607 0 0 0
4 JPMorgan Securities LLC (Investment Management) 0 -728,919 0 0 0
5 Allostery Investments LP 167,350 -423,903 13,662,454 64.1541 0.264 06/30/2025
6 Great Point Partners LLC 1,291,617 -356,906 105,447,611.88 33.3293 2.0378 06/30/2025
7 Walleye Capital LLC 0 -302,642 0 0 0
8 SilverArc Capital Management LLC 0 -285,120 0 0 0
9 Springhill Fund Asset Management (HK) Co. Ltd. 0 -207,600 0 0 0
10 Atika Capital Management LLC 0 -103,929 0 0 0

Data provided by FactSet Research Systems Inc.