| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Deep Track Capital LP | 3,579,209 | 0 | 24,982,878.82 | 0.7986 | 5.6469 | 03/31/2025 |
| 2 | Adar1 Capital Management LLC | 2,210,019 | 1,688,407 | 15,425,932.62 | 2.5703 | 3.4868 | 03/31/2025 |
| 3 | Cormorant Asset Management LP | 2,130,000 | 0 | 14,867,400 | 1.0616 | 3.3605 | 03/31/2025 |
| 4 | Great Point Partners LLC | 1,638,111 | -490,662 | 11,434,014.78 | 4.923 | 2.5845 | 03/31/2025 |
| 5 | Nantahala Capital Management LLC | 1,482,994 | 497,360 | 10,351,298.12 | 0.7708 | 2.3397 | 03/31/2025 |
| 6 | Franklin Advisers, Inc. | 1,371,050 | 46,698 | 9,569,929 | 0.0047 | 2.1631 | 03/31/2025 |
| 7 | Citadel Advisors LLC | 1,329,610 | 928,727 | 9,280,677.8 | 0.0122 | 2.0977 | 03/31/2025 |
| 8 | Caligan Partners LP | 1,269,119 | 1,269,119 | 8,858,450.62 | 1.6824 | 2.0023 | 03/31/2025 |
| 9 | Octagon Capital Advisors LP | 1,230,000 | 1,230,000 | 8,585,400 | 1.5421 | 1.9406 | 03/31/2025 |
| 10 | Allostery Investments LP | 1,099,654 | 1,099,654 | 7,675,584.92 | 11.2275 | 1.7349 | 03/31/2025 |
| 11 | VHCP Management LLC | 998,570 | 0 | 6,970,018.6 | 28.5253 | 1.5754 | 12/31/2023 |
| 12 | Millennium Management LLC | 987,414 | 341,777 | 6,892,149.72 | 0.0064 | 1.5578 | 03/31/2025 |
| 13 | JPMorgan Securities LLC (Investment Management) | 907,679 | 907,679 | 6,335,599.42 | 0.0034 | 1.432 | 03/31/2025 |
| 14 | abrdn, Inc. | 710,516 | 394,085 | 4,959,401.68 | 0.049 | 1.121 | 03/31/2025 |
| 15 | Boothbay Fund Management LLC | 570,668 | 570,668 | 3,983,262.64 | 0.1314 | 0.9003 | 03/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | FTIF SICAV - Biotechnology Discovery Fund | 873,295 | 29,295 | 6,095,599.1 | 0.3139 | 1.3778 | 04/30/2025 |
| 2 | abrdn World Healthcare Fund | 710,516 | 394,085 | 4,959,401.68 | 1.0316 | 1.121 | 04/30/2025 |
| 3 | Franklin Biotechnology Discovery Fund | 497,692 | 17,392 | 3,473,890.16 | 0.1736 | 0.7852 | 04/30/2025 |
| 4 | AZ Equity - Biotechnology | 38,350 | 4,030 | 267,683 | 0.8013 | 0.0605 | 05/30/2025 |
| 5 | Fidelity Nasdaq Composite Index Fund | 16,749 | 1,177 | 116,908.02 | 0.0006 | 0.0264 | 04/30/2025 |
| 6 | Steward International Enhanced Index Fund | 7,858 | 0 | 54,848.84 | 0.0247 | 0.0124 | 04/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Adar1 Capital Management LLC | 2,210,019 | 1,688,407 | 15,425,932.62 | 2.5703 | 3.4868 | 03/31/2025 |
| 2 | Caligan Partners LP | 1,269,119 | 1,269,119 | 8,858,450.62 | 1.6824 | 2.0023 | 03/31/2025 |
| 3 | Octagon Capital Advisors LP | 1,230,000 | 1,230,000 | 8,585,400 | 1.5421 | 1.9406 | 03/31/2025 |
| 4 | Allostery Investments LP | 1,099,654 | 1,099,654 | 7,675,584.92 | 11.2275 | 1.7349 | 03/31/2025 |
| 5 | Citadel Advisors LLC | 1,329,610 | 928,727 | 9,280,677.8 | 0.0122 | 2.0977 | 03/31/2025 |
| 6 | JPMorgan Securities LLC (Investment Management) | 907,679 | 907,679 | 6,335,599.42 | 0.0034 | 1.432 | 03/31/2025 |
| 7 | Boothbay Fund Management LLC | 570,668 | 570,668 | 3,983,262.64 | 0.1314 | 0.9003 | 03/31/2025 |
| 8 | Nantahala Capital Management LLC | 1,482,994 | 497,360 | 10,351,298.12 | 0.7708 | 2.3397 | 03/31/2025 |
| 9 | Ensign Peak Advisors, Inc. | 455,684 | 455,684 | 3,180,674.32 | 0.0057 | 0.7189 | 03/31/2025 |
| 10 | abrdn, Inc. | 710,516 | 394,085 | 4,959,401.68 | 0.049 | 1.121 | 03/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Blackstone Alternative Asset Management LP | 0 | -1,522,434 | 0 | 0 | 0 | |
| 2 | Commodore Capital LP | 0 | -1,284,110 | 0 | 0 | 0 | |
| 3 | Adage Capital Management LP | 0 | -530,861 | 0 | 0 | 0 | |
| 4 | Point72 Asset Management LP | 29,418 | -513,482 | 205,337.64 | 0.0005 | 0.0464 | 03/31/2025 |
| 5 | Great Point Partners LLC | 1,638,111 | -490,662 | 11,434,014.78 | 4.923 | 2.5845 | 03/31/2025 |
| 6 | Janus Henderson Investors US LLC | 0 | -410,710 | 0 | 0 | 0 | |
| 7 | SilverArc Capital Management LLC | 210,901 | -250,759 | 1,472,088.98 | 0.267 | 0.3327 | 03/31/2025 |
| 8 | Rosalind Advisors, Inc. | 0 | -139,983 | 0 | 0 | 0 | |
| 9 | Atika Capital Management LLC | 0 | -113,631 | 0 | 0 | 0 | |
| 10 | Saturn V Capital Management LP | 552,926 | -95,093 | 3,859,423.48 | 1.7737 | 0.8724 | 03/31/2025 |
Data provided by FactSet Research Systems Inc.