| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Syncona Investment Management Ltd. | 11,086,909 | 0 | 16,408,625.32 | 42.2692 | 26.0347 | 12/31/2024 |
| 2 | BML Capital Management LLC | 4,100,002 | 0 | 6,068,002.96 | 3.9611 | 9.6278 | 12/31/2024 |
| 3 | Redmile Group LLC | 1,608,089 | 0 | 2,379,971.72 | 0.1774 | 3.7762 | 12/31/2024 |
| 4 | Vestal Point Capital LP | 1,500,000 | 0 | 2,220,000 | 0.1416 | 3.5224 | 12/31/2024 |
| 5 | Ikarian Capital LLC | 1,441,141 | -2,040 | 2,132,888.68 | 0.7641 | 3.3841 | 12/31/2024 |
| 6 | Renaissance Technologies LLC | 547,233 | -90,900 | 809,904.84 | 0.0012 | 1.285 | 12/31/2024 |
| 7 | Boothbay Fund Management LLC | 418,441 | -2,040 | 619,292.68 | 0.0209 | 0.9826 | 12/31/2024 |
| 8 | Acadian Asset Management LLC | 191,829 | -58,996 | 283,906.92 | 0.0007 | 0.4505 | 12/31/2024 |
| 9 | Two Sigma Investments LP | 61,637 | 40,388 | 91,222.76 | 0.0002 | 0.1447 | 12/31/2024 |
| 10 | BNP Paribas Financial Markets | 50,189 | 50,189 | 74,279.72 | 0.0001 | 0.1179 | 12/31/2024 |
| 11 | Two Sigma Advisers LP | 34,200 | 11,800 | 50,616 | 0.0001 | 0.0803 | 12/31/2024 |
| 12 | Morgan Stanley & Co. LLC | 33,731 | 17,300 | 49,921.88 | 0 | 0.0792 | 12/31/2024 |
| 13 | XTX Markets LLC | 26,824 | 26,824 | 39,699.52 | 0.0035 | 0.063 | 12/31/2024 |
| 14 | Geode Capital Management LLC | 21,590 | 0 | 31,953.2 | 0 | 0.0507 | 12/31/2024 |
| 15 | Citadel Securities LLC | 15,799 | 15,799 | 23,382.52 | 0.0001 | 0.0371 | 12/31/2024 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Fidelity Nasdaq Composite Index Fund | 21,590 | 0 | 31,953.2 | 0.0002 | 0.0507 | 02/28/2025 |
| 2 | Blackstone Alternative Multi Strategy Fund | 100 | 0 | 148 | 0 | 0.0002 | 12/31/2024 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | BNP Paribas Financial Markets | 50,189 | 50,189 | 74,279.72 | 0.0001 | 0.1179 | 12/31/2024 |
| 2 | Two Sigma Investments LP | 61,637 | 40,388 | 91,222.76 | 0.0002 | 0.1447 | 12/31/2024 |
| 3 | XTX Markets LLC | 26,824 | 26,824 | 39,699.52 | 0.0035 | 0.063 | 12/31/2024 |
| 4 | Morgan Stanley & Co. LLC | 33,731 | 17,300 | 49,921.88 | 0 | 0.0792 | 12/31/2024 |
| 5 | Citadel Securities LLC | 15,799 | 15,799 | 23,382.52 | 0.0001 | 0.0371 | 12/31/2024 |
| 6 | Two Sigma Advisers LP | 34,200 | 11,800 | 50,616 | 0.0001 | 0.0803 | 12/31/2024 |
| 7 | GAMMA Investing LLC | 806 | 806 | 1,192.88 | 0.0001 | 0.0019 | 03/31/2025 |
| 8 | SBI Securities Co., Ltd. | 322 | 322 | 476.56 | 0 | 0.0008 | 12/31/2024 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Renaissance Technologies LLC | 547,233 | -90,900 | 809,904.84 | 0.0012 | 1.285 | 12/31/2024 |
| 2 | Acadian Asset Management LLC | 191,829 | -58,996 | 283,906.92 | 0.0007 | 0.4505 | 12/31/2024 |
| 3 | Corsair Capital Management LP | 0 | -20,000 | 0 | 0 | 0 | |
| 4 | Baader Bank AG (Investment Management) | 0 | -14,184 | 0 | 0 | 0 | |
| 5 | G1 Execution Services LLC | 0 | -12,434 | 0 | 0 | 0 | |
| 6 | Arcadia Investment Management Corp. | 0 | -3,000 | 0 | 0 | 0 | |
| 7 | Boothbay Fund Management LLC | 418,441 | -2,040 | 619,292.68 | 0.0209 | 0.9826 | 12/31/2024 |
| 8 | Ikarian Capital LLC | 1,441,141 | -2,040 | 2,132,888.68 | 0.7641 | 3.3841 | 12/31/2024 |
| 9 | Merrill Lynch, Pierce, Fenner & Smith, Inc. (Invt Mgmt) | 0 | -15 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.