| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | EcoR1 Capital, LLC | 27,404,070 | 0 | 6,933,229.71 | 0.3465 | 10.7096 | 03/31/2025 |
| 2 | Long Focus Capital Management LLC | 23,756,687 | 3,262,294 | 6,010,441.81 | 0.3751 | 9.2842 | 03/31/2025 |
| 3 | Two Seas Capital LP | 20,529,685 | 5,694,539 | 5,194,010.3 | 0.5901 | 8.0231 | 03/31/2025 |
| 4 | Morgan Stanley & Co. LLC | 2,628,112 | 1,615,329 | 664,912.34 | 0.0002 | 1.0271 | 03/31/2025 |
| 5 | Rock Springs Capital Management LP | 2,483,468 | 0 | 628,317.4 | 0.0339 | 0.9705 | 03/31/2025 |
| 6 | Acadian Asset Management LLC | 2,218,215 | 1,707,999 | 561,208.4 | 0.0012 | 0.8669 | 03/31/2025 |
| 7 | Renaissance Technologies LLC | 1,813,860 | -712,664 | 458,906.58 | 0.0006 | 0.7089 | 03/31/2025 |
| 8 | Bank of America, NA (Private Banking) | 1,147,012 | -1,715,317 | 290,194.04 | 0.0001 | 0.4483 | 03/31/2025 |
| 9 | UBS Securities LLC | 1,010,940 | 870,996 | 255,767.82 | 0.0001 | 0.3951 | 03/31/2025 |
| 10 | JPMorgan Asset Management (UK) Ltd. | 881,690 | -34,610 | 223,067.57 | 0.0002 | 0.3446 | 03/31/2025 |
| 11 | Mercer Global Investments Europe Ltd. | 538,309 | 0 | 136,192.18 | 0.0004 | 0.2104 | 12/31/2024 |
| 12 | Rathbones Investment Management Ltd. | 432,818 | 0 | 109,502.95 | 0.0002 | 0.1691 | 03/31/2025 |
| 13 | SSgA Funds Management, Inc. | 421,292 | 21,213 | 106,586.88 | 0 | 0.1646 | 03/31/2025 |
| 14 | Clear Harbor Asset Management LLC | 240,725 | 222,200 | 60,903.42 | 0.0045 | 0.0941 | 03/31/2025 |
| 15 | Two Sigma Advisers LP | 206,732 | 135,997 | 52,303.2 | 0.0001 | 0.0808 | 03/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | JPMorgan Funds - Thematics - Genetic Therapies | 916,300 | 0 | 231,823.9 | 0.0565 | 0.3581 | 12/31/2024 |
| 2 | Galileo - Biotech Innovation Fund | 752,458 | 0 | 190,371.87 | 0.6762 | 0.2941 | 12/31/2024 |
| 3 | MGI Funds Plc - Mercer Global Small Cap Equity Fund | 538,309 | 0 | 136,192.18 | 0.0122 | 0.2104 | 12/31/2024 |
| 4 | SPDR Portfolio Developed World ex-US ETF | 284,405 | 33,325 | 71,954.46 | 0.0003 | 0.1111 | 06/30/2025 |
| 5 | SEI Institutional Intl. Trust-International Equity | 167,248 | -79,496 | 42,313.74 | 0.0012 | 0.0654 | 06/30/2025 |
| 6 | SPDR S&P International Small Cap ETF | 140,209 | -6,690 | 35,472.88 | 0.005 | 0.0548 | 06/30/2025 |
| 7 | Fidelity Enhanced Small Cap ETF | 123,869 | -61,854 | 31,338.86 | 0.0016 | 0.0484 | 06/30/2025 |
| 8 | Top Class HealthCare, FI | 74,972 | 0 | 18,967.92 | 0.1459 | 0.0293 | 12/31/2024 |
| 9 | Fidelity Nasdaq Composite Index Fund | 67,032 | -72,769 | 16,959.1 | 0.0001 | 0.0262 | 05/31/2025 |
| 10 | Northern Small Cap Core Fund | 16,891 | 0 | 4,273.42 | 0.0011 | 0.0066 | 03/31/2025 |
| 11 | Diversified Equity Master Portfolio | 8,118 | 0 | 2,053.85 | 0.0001 | 0.0032 | 12/31/2024 |
| 12 | KES Strategic Investment Fund | 6,547 | 0 | 1,656.39 | 0.0003 | 0.0026 | 05/30/2025 |
| 13 | Blackstone Alternative Multi Strategy Fund | 3,721 | 3,000 | 941.41 | 0 | 0.0015 | 03/31/2025 |
| 14 | Guggenheim Active Allocation Fund | 273 | 0 | 69.07 | 0 | 0.0001 | 02/28/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Two Seas Capital LP | 20,529,685 | 5,694,539 | 5,194,010.3 | 0.5901 | 8.0231 | 03/31/2025 |
| 2 | Long Focus Capital Management LLC | 23,756,687 | 3,262,294 | 6,010,441.81 | 0.3751 | 9.2842 | 03/31/2025 |
| 3 | Acadian Asset Management LLC | 2,218,215 | 1,707,999 | 561,208.4 | 0.0012 | 0.8669 | 03/31/2025 |
| 4 | Morgan Stanley & Co. LLC | 2,628,112 | 1,615,329 | 664,912.34 | 0.0002 | 1.0271 | 03/31/2025 |
| 5 | UBS Securities LLC | 1,010,940 | 870,996 | 255,767.82 | 0.0001 | 0.3951 | 03/31/2025 |
| 6 | Clear Harbor Asset Management LLC | 240,725 | 222,200 | 60,903.42 | 0.0045 | 0.0941 | 03/31/2025 |
| 7 | Two Sigma Advisers LP | 206,732 | 135,997 | 52,303.2 | 0.0001 | 0.0808 | 03/31/2025 |
| 8 | Tennessee Consolidated Retirement System | 73,376 | 73,376 | 18,564.13 | 0.0001 | 0.0287 | 03/31/2025 |
| 9 | Millennium Management LLC | 94,283 | 64,724 | 23,853.6 | 0 | 0.0368 | 03/31/2025 |
| 10 | Two Sigma Investments LP | 135,947 | 59,600 | 34,394.59 | 0.0001 | 0.0531 | 03/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Matrix Capital Management Co. LP | 0 | -22,500,000 | 0 | 0 | 0 | |
| 2 | Baillie Gifford & Co. | 0 | -11,819,095 | 0 | 0 | 0 | |
| 3 | PFM Health Sciences LP | 0 | -4,871,969 | 0 | 0 | 0 | |
| 4 | Bank of America, NA (Private Banking) | 1,147,012 | -1,715,317 | 290,194.04 | 0.0001 | 0.4483 | 03/31/2025 |
| 5 | Redmile Group LLC | 0 | -715,607 | 0 | 0 | 0 | |
| 6 | Renaissance Technologies LLC | 1,813,860 | -712,664 | 458,906.58 | 0.0006 | 0.7089 | 03/31/2025 |
| 7 | Marshall Wace LLP | 0 | -529,123 | 0 | 0 | 0 | |
| 8 | Jane Street Capital LLC | 0 | -326,937 | 0 | 0 | 0 | |
| 9 | Morgan Stanley Smith Barney LLC (Investment Management) | 87,550 | -224,246 | 22,150.15 | 0 | 0.0342 | 03/31/2025 |
| 10 | LPL Financial LLC | 0 | -183,479 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.