| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Long Focus Capital Management LLC | 23,756,687 | 3,262,294 | 1,425,401.22 | 0.0838 | 8.963 | 06/30/2025 |
| 2 | Two Seas Capital LP | 22,580,701 | 7,745,555 | 1,354,842.06 | 0.1056 | 8.5194 | 06/30/2025 |
| 3 | EcoR1 Capital, LLC | 11,000,000 | -16,404,070 | 660,000 | 0.0288 | 4.1501 | 08/15/2025 |
| 4 | Morgan Stanley & Co. LLC | 4,217,865 | 3,205,082 | 253,071.9 | 0.0001 | 1.5913 | 06/30/2025 |
| 5 | Rock Springs Capital Management LP | 2,483,468 | 0 | 149,008.08 | 0.0084 | 0.937 | 06/30/2025 |
| 6 | Acadian Asset Management LLC | 1,964,141 | 1,453,925 | 117,848.46 | 0.0002 | 0.741 | 06/30/2025 |
| 7 | Renaissance Technologies LLC | 1,882,860 | -643,664 | 112,971.6 | 0.0001 | 0.7104 | 06/30/2025 |
| 8 | Bank of America, NA (Private Banking) | 1,141,712 | -1,720,617 | 68,502.72 | 0 | 0.4308 | 06/30/2025 |
| 9 | Empirical Finance LLC | 800,000 | 800,000 | 48,000 | 0.0024 | 0.3018 | 06/30/2025 |
| 10 | Mercer Global Investments Europe Ltd. | 538,309 | 0 | 32,298.54 | 0.0001 | 0.2031 | 12/31/2024 |
| 11 | Rathbones Investment Management Ltd. | 432,818 | 0 | 25,969.08 | 0.0001 | 0.1633 | 06/30/2025 |
| 12 | SSgA Funds Management, Inc. | 426,714 | 26,635 | 25,602.84 | 0 | 0.161 | 06/30/2025 |
| 13 | Key Client Fiduciary Advisors LLC | 175,555 | -79,804 | 10,533.3 | 0.0041 | 0.0662 | 06/30/2025 |
| 14 | Clear Harbor Asset Management LLC | 145,400 | 126,875 | 8,724 | 0.0006 | 0.0549 | 06/30/2025 |
| 15 | Fidelity Management & Research Co. LLC | 123,869 | -61,854 | 7,432.14 | 0 | 0.0467 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | JPMorgan Funds - Thematics - Genetic Therapies | 916,300 | 0 | 54,978 | 0.0128 | 0.3457 | 12/31/2024 |
| 2 | Galileo - Biotech Innovation Fund | 752,458 | 0 | 45,147.48 | 0.1524 | 0.2839 | 12/31/2024 |
| 3 | MGI Funds Plc - Mercer Global Small Cap Equity Fund | 538,309 | 0 | 32,298.54 | 0.0028 | 0.2031 | 12/31/2024 |
| 4 | SPDR Portfolio Developed World ex-US ETF | 285,179 | 19,092 | 17,110.74 | 0.0001 | 0.1076 | 07/31/2025 |
| 5 | SEI Institutional Intl. Trust-International Equity | 166,848 | -79,896 | 10,010.88 | 0.0003 | 0.0629 | 07/31/2025 |
| 6 | SPDR S&P International Small Cap ETF | 141,693 | -5,206 | 8,501.58 | 0.0011 | 0.0535 | 07/31/2025 |
| 7 | Fidelity Nasdaq Composite Index Fund | 67,032 | -72,769 | 4,021.92 | 0 | 0.0253 | 06/30/2025 |
| 8 | Northern Small Cap Core Fund | 16,891 | 0 | 1,013.46 | 0.0003 | 0.0064 | 06/30/2025 |
| 9 | Diversified Equity Master Portfolio | 8,118 | 0 | 487.08 | 0 | 0.0031 | 12/31/2024 |
| 10 | KES Strategic Investment Fund | 6,547 | 0 | 392.82 | 0.0001 | 0.0025 | 05/30/2025 |
| 11 | Blackstone Alternative Multi Strategy Fund | 3,021 | 2,300 | 181.26 | 0 | 0.0011 | 06/30/2025 |
| 12 | Guggenheim Active Allocation Fund | 273 | 0 | 16.38 | 0 | 0.0001 | 05/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Two Seas Capital LP | 22,580,701 | 7,745,555 | 1,354,842.06 | 0.1056 | 8.5194 | 06/30/2025 |
| 2 | Long Focus Capital Management LLC | 23,756,687 | 3,262,294 | 1,425,401.22 | 0.0838 | 8.963 | 06/30/2025 |
| 3 | Morgan Stanley & Co. LLC | 4,217,865 | 3,205,082 | 253,071.9 | 0.0001 | 1.5913 | 06/30/2025 |
| 4 | Acadian Asset Management LLC | 1,964,141 | 1,453,925 | 117,848.46 | 0.0002 | 0.741 | 06/30/2025 |
| 5 | Empirical Finance LLC | 800,000 | 800,000 | 48,000 | 0.0024 | 0.3018 | 06/30/2025 |
| 6 | Clear Harbor Asset Management LLC | 145,400 | 126,875 | 8,724 | 0.0006 | 0.0549 | 06/30/2025 |
| 7 | Almitas Capital LLC | 109,054 | 109,054 | 6,543.24 | 0.0009 | 0.0411 | 06/30/2025 |
| 8 | XTX Markets LLC | 80,022 | 80,022 | 4,801.32 | 0.0002 | 0.0302 | 06/30/2025 |
| 9 | Tennessee Consolidated Retirement System | 73,376 | 73,376 | 4,402.56 | 0 | 0.0277 | 06/30/2025 |
| 10 | SEI Investments Management Corp. | 54,824 | 54,824 | 3,289.44 | 0 | 0.0207 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Matrix Capital Management Co. LP | 0 | -22,500,000 | 0 | 0 | 0 | |
| 2 | EcoR1 Capital, LLC | 11,000,000 | -16,404,070 | 660,000 | 0.0288 | 4.1501 | 08/15/2025 |
| 3 | Baillie Gifford & Co. | 0 | -11,819,095 | 0 | 0 | 0 | |
| 4 | PFM Health Sciences LP | 0 | -4,871,969 | 0 | 0 | 0 | |
| 5 | Bank of America, NA (Private Banking) | 1,141,712 | -1,720,617 | 68,502.72 | 0 | 0.4308 | 06/30/2025 |
| 6 | JPMorgan Asset Management (UK) Ltd. | 0 | -916,300 | 0 | 0 | 0 | |
| 7 | Redmile Group LLC | 0 | -715,607 | 0 | 0 | 0 | |
| 8 | Renaissance Technologies LLC | 1,882,860 | -643,664 | 112,971.6 | 0.0001 | 0.7104 | 06/30/2025 |
| 9 | Marshall Wace LLP | 0 | -529,123 | 0 | 0 | 0 | |
| 10 | Jane Street Capital LLC | 0 | -326,937 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.