| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | EcoR1 Capital, LLC | 27,404,070 | 0 | 8,221,221 | 0.4605 | 10.7096 | 12/31/2024 |
| 2 | Long Focus Capital Management LLC | 20,494,393 | 7,194,503 | 6,148,317.9 | 0.4924 | 8.0093 | 12/31/2024 |
| 3 | Two Seas Capital LP | 14,835,146 | 14,835,146 | 4,450,543.8 | 0.594 | 5.7976 | 12/31/2024 |
| 4 | PFM Health Sciences LP | 4,871,969 | -5,128,818 | 1,461,590.7 | 0.1143 | 1.904 | 12/31/2024 |
| 5 | Bank of America, NA (Private Banking) | 2,862,329 | -1,789,995 | 858,698.7 | 0.0004 | 1.1186 | 12/31/2024 |
| 6 | Renaissance Technologies LLC | 2,526,524 | 869,949 | 757,957.2 | 0.0011 | 0.9874 | 12/31/2024 |
| 7 | Rock Springs Capital Management LP | 2,483,468 | 58,000 | 745,040.4 | 0.0306 | 0.9705 | 12/31/2024 |
| 8 | Morgan Stanley & Co. LLC | 1,012,783 | -265,018 | 303,834.9 | 0.0001 | 0.3958 | 12/31/2024 |
| 9 | JPMorgan Asset Management (UK) Ltd. | 916,300 | -69,751 | 274,890 | 0.0002 | 0.3581 | 12/31/2024 |
| 10 | Redmile Group LLC | 715,607 | 0 | 214,682.1 | 0.018 | 0.2797 | 12/31/2024 |
| 11 | Mercer Global Investments Europe Ltd. | 538,309 | 247,436 | 161,492.7 | 0.0005 | 0.2104 | 12/31/2024 |
| 12 | Marshall Wace LLP | 529,123 | 6,515 | 158,736.9 | 0.0002 | 0.2068 | 12/31/2024 |
| 13 | Acadian Asset Management LLC | 510,216 | 510,216 | 153,064.8 | 0.0004 | 0.1994 | 12/31/2024 |
| 14 | Rathbones Investment Management Ltd. | 432,818 | 0 | 129,845.4 | 0.0003 | 0.1691 | 12/31/2024 |
| 15 | SSgA Funds Management, Inc. | 400,079 | 3,287 | 120,023.7 | 0 | 0.1564 | 12/31/2024 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Edinburgh Worldwide Investment Trust Plc | 5,282,202 | 0 | 1,584,660.6 | 0.1718 | 2.0643 | 02/28/2025 |
| 2 | JPMorgan Funds - Thematics - Genetic Therapies | 916,300 | 146,714 | 274,890 | 0.0726 | 0.3581 | 12/31/2024 |
| 3 | Galileo - Biotech Innovation Fund | 752,458 | 0 | 225,737.4 | 0.9717 | 0.2941 | 06/30/2024 |
| 4 | MGI Funds Plc - Mercer Global Small Cap Equity Fund | 538,309 | 247,436 | 161,492.7 | 0.0158 | 0.2104 | 12/31/2024 |
| 5 | SPDR Portfolio Developed World ex-US ETF | 280,019 | 33,712 | 84,005.7 | 0.0003 | 0.1094 | 04/30/2025 |
| 6 | SEI Institutional Intl. Trust-International Equity | 246,744 | 246,744 | 74,023.2 | 0.0023 | 0.0964 | 04/30/2025 |
| 7 | SPDR S&P International Small Cap ETF | 142,441 | -4,458 | 42,732.3 | 0.0065 | 0.0557 | 04/30/2025 |
| 8 | Fidelity Nasdaq Composite Index Fund | 139,801 | 0 | 41,940.3 | 0.0002 | 0.0546 | 03/31/2025 |
| 9 | Fidelity Enhanced Small Cap ETF | 120,333 | -41,212 | 36,099.9 | 0.0021 | 0.047 | 04/30/2025 |
| 10 | Invesco NASDAQ Future Gen 200 ETF | 78,031 | 43,222 | 23,409.3 | 0.304 | 0.0305 | 04/30/2025 |
| 11 | Top Class HealthCare, FI | 74,972 | 14,953 | 22,491.6 | 0.178 | 0.0293 | 12/31/2024 |
| 12 | Northern Small Cap Core Fund | 16,891 | 0 | 5,067.3 | 0.0014 | 0.0066 | 12/31/2024 |
| 13 | Diversified Equity Master Portfolio | 8,118 | 0 | 2,435.4 | 0.0001 | 0.0032 | 12/31/2024 |
| 14 | KES Strategic Investment Fund | 6,547 | 0 | 1,964.1 | 0.0004 | 0.0026 | 02/28/2025 |
| 15 | Blackstone Alternative Multi Strategy Fund | 721 | 721 | 216.3 | 0 | 0.0003 | 12/31/2024 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Two Seas Capital LP | 14,835,146 | 14,835,146 | 4,450,543.8 | 0.594 | 5.7976 | 12/31/2024 |
| 2 | Long Focus Capital Management LLC | 20,494,393 | 7,194,503 | 6,148,317.9 | 0.4924 | 8.0093 | 12/31/2024 |
| 3 | Renaissance Technologies LLC | 2,526,524 | 869,949 | 757,957.2 | 0.0011 | 0.9874 | 12/31/2024 |
| 4 | Acadian Asset Management LLC | 510,216 | 510,216 | 153,064.8 | 0.0004 | 0.1994 | 12/31/2024 |
| 5 | Mercer Global Investments Europe Ltd. | 538,309 | 247,436 | 161,492.7 | 0.0005 | 0.2104 | 12/31/2024 |
| 6 | Citadel Securities LLC | 175,052 | 175,052 | 52,515.6 | 0.0002 | 0.0684 | 12/31/2024 |
| 7 | Jane Street Capital LLC | 326,937 | 152,780 | 98,081.1 | 0.0002 | 0.1278 | 12/31/2024 |
| 8 | UBS Securities LLC | 139,944 | 139,927 | 41,983.2 | 0 | 0.0547 | 12/31/2024 |
| 9 | HRT Financial LP (US) | 83,199 | 83,199 | 24,959.7 | 0.0002 | 0.0325 | 12/31/2024 |
| 10 | Two Sigma Advisers LP | 70,735 | 58,787 | 21,220.5 | 0 | 0.0276 | 12/31/2024 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Matrix Capital Management Co. LP | 0 | -37,681,515 | 0 | 0 | 0 | |
| 2 | Baillie Gifford & Co. | 0 | -16,775,860 | 0 | 0 | 0 | |
| 3 | PFM Health Sciences LP | 4,871,969 | -5,128,818 | 1,461,590.7 | 0.1143 | 1.904 | 12/31/2024 |
| 4 | Bank of America, NA (Private Banking) | 2,862,329 | -1,789,995 | 858,698.7 | 0.0004 | 1.1186 | 12/31/2024 |
| 5 | Millennium Management LLC | 29,559 | -685,791 | 8,867.7 | 0 | 0.0116 | 12/31/2024 |
| 6 | DAFNA Capital Management LLC | 0 | -341,064 | 0 | 0 | 0 | |
| 7 | Morgan Stanley & Co. LLC | 1,012,783 | -265,018 | 303,834.9 | 0.0001 | 0.3958 | 12/31/2024 |
| 8 | Susquehanna Financial Group LLLP | 29,150 | -141,901 | 8,745 | 0 | 0.0114 | 12/31/2024 |
| 9 | Morgan Stanley Smith Barney LLC (Investment Management) | 311,796 | -109,143 | 93,538.8 | 0 | 0.1219 | 12/31/2024 |
| 10 | Key Client Fiduciary Advisors LLC | 150,150 | -105,209 | 45,045 | 0.0206 | 0.0587 | 03/31/2025 |
Data provided by FactSet Research Systems Inc.