| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Sarissa Capital Management LP | 1,673,500 | 430,969 | 17,923,185 | 9.841 | 8.1369 | 03/25/2025 |
| 2 | Kynam Capital Management LP | 620,731 | 0 | 6,648,029.01 | 0.5517 | 3.0181 | 12/31/2024 |
| 3 | Morgan Stanley & Co. LLC | 203,462 | 92,473 | 2,179,078.02 | 0.0009 | 0.9893 | 12/31/2024 |
| 4 | Waterfront Wealth, Inc. | 125,731 | 81,640 | 1,346,579.01 | 0.3283 | 0.6113 | 03/31/2025 |
| 5 | SCP Investment LP | 125,000 | 0 | 1,338,750 | 1.2598 | 0.6078 | 12/31/2024 |
| 6 | Two Sigma Investments LP | 108,687 | -10,314 | 1,164,037.77 | 0.0028 | 0.5285 | 12/31/2024 |
| 7 | PSM Vermogensverwaltung GmbH Langen v.d.Goltz, Dr. Prinz | 91,005 | -24,036 | 974,663.55 | 6.0801 | 0.4425 | 02/28/2025 |
| 8 | Acadian Asset Management LLC | 89,290 | 76,139 | 956,295.9 | 0.0023 | 0.4341 | 12/31/2024 |
| 9 | Two Sigma Advisers LP | 86,965 | -11,835 | 931,395.15 | 0.0022 | 0.4228 | 12/31/2024 |
| 10 | Longitude Investment SA | 81,000 | -37,500 | 867,510 | 1.0725 | 0.3938 | 12/31/2024 |
| 11 | Eversept Partners LP | 75,830 | -89,635 | 812,139.3 | 0.0912 | 0.3687 | 12/31/2024 |
| 12 | BNP Paribas Financial Markets | 67,046 | 1,973 | 718,062.66 | 0.0006 | 0.326 | 12/31/2024 |
| 13 | Quinn Opportunity Partners LLC | 55,327 | 25,449 | 592,552.17 | 0.0428 | 0.269 | 12/31/2024 |
| 14 | GSA Capital Partners LLP | 54,852 | 54,852 | 587,464.92 | 0.0464 | 0.2667 | 12/31/2024 |
| 15 | Hayek Kallen Investment Management LLC | 51,216 | 0 | 548,523.36 | 0.2032 | 0.249 | 12/31/2024 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | PSM Value Strategy UI | 47,005 | -3,000 | 503,423.55 | 3.9402 | 0.2285 | 02/28/2025 |
| 2 | PSM Macro Strategy | 41,500 | 0 | 444,465 | 3.7261 | 0.2018 | 12/31/2023 |
| 3 | Old Westbury Small & Mid Cap Strategies Fund | 17,645 | 17,645 | 188,977.95 | 0.0021 | 0.0858 | 01/31/2025 |
| 4 | SPDR Portfolio Developed World ex-US ETF | 14,056 | 1,681 | 150,539.76 | 0.0006 | 0.0683 | 04/30/2025 |
| 5 | iShares IV Plc - NASDAQ US Biotechnology UCITS ETF | 10,213 | -1,618 | 109,381.23 | 0.0264 | 0.0497 | 04/30/2025 |
| 6 | Macquarie Healthcare Fund | 9,500 | 0 | 101,745 | 0.0153 | 0.0462 | 03/31/2025 |
| 7 | Fidelity Nasdaq Composite Index Fund | 7,909 | 558 | 84,705.39 | 0.0005 | 0.0385 | 03/31/2025 |
| 8 | Voya Multi Manager International Small Cap Fund | 7,058 | 7,058 | 75,591.18 | 0.0237 | 0.0343 | 03/31/2025 |
| 9 | LUNIS Biotech Growth Opportunities Fund | 6,900 | 0 | 73,899 | 6.0428 | 0.0335 | 09/30/2024 |
| 10 | SPDR S&P International Small Cap ETF | 6,492 | -203 | 69,529.32 | 0.0106 | 0.0316 | 04/30/2025 |
| 11 | Invesco Markets Plc - NASDAQ Biotech UCITS ETF | 5,684 | -1,020 | 60,875.64 | 0.0246 | 0.0276 | 04/30/2025 |
| 12 | Optimum International Fund | 4,811 | 4,811 | 51,525.81 | 0.0053 | 0.0234 | 03/31/2025 |
| 13 | SEI Institutional Intl. Trust-International Equity | 4,275 | 4,275 | 45,785.25 | 0.0014 | 0.0208 | 04/30/2025 |
| 14 | China Universal Nasdaq Biotechnology Index ETF | 4,243 | 1,895 | 45,442.53 | 0.023 | 0.0206 | 12/31/2024 |
| 15 | Hector SICAV - Fide Growth | 3,250 | 0 | 34,807.5 | 0.0709 | 0.0158 | 12/31/2024 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Sarissa Capital Management LP | 1,673,500 | 430,969 | 17,923,185 | 9.841 | 8.1369 | 03/25/2025 |
| 2 | Morgan Stanley & Co. LLC | 203,462 | 92,473 | 2,179,078.02 | 0.0009 | 0.9893 | 12/31/2024 |
| 3 | Waterfront Wealth, Inc. | 125,731 | 81,640 | 1,346,579.01 | 0.3283 | 0.6113 | 03/31/2025 |
| 4 | Acadian Asset Management LLC | 89,290 | 76,139 | 956,295.9 | 0.0023 | 0.4341 | 12/31/2024 |
| 5 | GSA Capital Partners LLP | 54,852 | 54,852 | 587,464.92 | 0.0464 | 0.2667 | 12/31/2024 |
| 6 | AXA Investment Managers UK Ltd. | 49,468 | 49,468 | 529,802.28 | 0.0019 | 0.2405 | 12/31/2024 |
| 7 | Quinn Opportunity Partners LLC | 55,327 | 25,449 | 592,552.17 | 0.0428 | 0.269 | 12/31/2024 |
| 8 | Mercer Global Advisors, Inc. | 17,600 | 17,600 | 188,496 | 0.0005 | 0.0856 | 12/31/2024 |
| 9 | Jane Street Capital LLC | 13,411 | 13,411 | 143,631.81 | 0.0002 | 0.0652 | 12/31/2024 |
| 10 | SEI Investments Management Corp. | 11,925 | 11,925 | 127,716.75 | 0.0002 | 0.058 | 12/31/2024 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Eversept Partners LP | 75,830 | -89,635 | 812,139.3 | 0.0912 | 0.3687 | 12/31/2024 |
| 2 | Longitude Investment SA | 81,000 | -37,500 | 867,510 | 1.0725 | 0.3938 | 12/31/2024 |
| 3 | PSM Vermogensverwaltung GmbH Langen v.d.Goltz, Dr. Prinz | 91,005 | -24,036 | 974,663.55 | 6.0801 | 0.4425 | 02/28/2025 |
| 4 | UBS Financial Services, Inc. | 4,559 | -16,875 | 48,826.89 | 0 | 0.0222 | 12/31/2024 |
| 5 | Two Sigma Advisers LP | 86,965 | -11,835 | 931,395.15 | 0.0022 | 0.4228 | 12/31/2024 |
| 6 | Two Sigma Investments LP | 108,687 | -10,314 | 1,164,037.77 | 0.0028 | 0.5285 | 12/31/2024 |
| 7 | OneDigital Investment Advisors LLC | 32,835 | -7,400 | 351,662.85 | 0.0041 | 0.1596 | 03/31/2025 |
| 8 | American Financial Advisors LLC | 0 | -5,819 | 0 | 0 | 0 | |
| 9 | Checchi Capital Advisers LLC | 0 | -5,239 | 0 | 0 | 0 | |
| 10 | Invesco Capital Management LLC | 838 | -3,439 | 8,974.98 | 0 | 0.0041 | 12/31/2024 |
Data provided by FactSet Research Systems Inc.