| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Sarissa Capital Management LP | 1,242,527 | -4 | 18,550,928.11 | 10.6131 | 6.0005 | 06/30/2025 |
| 2 | Kynam Capital Management LP | 576,111 | -44,620 | 8,601,337.23 | 0.755 | 2.7822 | 06/30/2025 |
| 3 | Acadian Asset Management LLC | 241,048 | 151,758 | 3,598,846.64 | 0.006 | 1.1641 | 06/30/2025 |
| 4 | Eversept Partners LP | 167,276 | 91,446 | 2,497,430.68 | 0.2302 | 0.8078 | 06/30/2025 |
| 5 | Morgan Stanley & Co. LLC | 147,270 | -56,192 | 2,198,741.1 | 0.0008 | 0.7112 | 06/30/2025 |
| 6 | SCP Investment LP | 125,000 | 0 | 1,866,250 | 1.4764 | 0.6037 | 06/30/2025 |
| 7 | Waterfront Wealth, Inc. | 94,729 | -29,359 | 1,414,303.97 | 0.2975 | 0.4575 | 06/30/2025 |
| 8 | Longitude Investment SA | 81,000 | 0 | 1,209,330 | 0.9988 | 0.3912 | 12/31/2024 |
| 9 | BNP Paribas Financial Markets | 75,941 | 8,895 | 1,133,799.13 | 0.0008 | 0.3667 | 06/30/2025 |
| 10 | Two Sigma Investments LP | 59,024 | -49,663 | 881,228.32 | 0.0015 | 0.285 | 06/30/2025 |
| 11 | Quinn Opportunity Partners LLC | 58,461 | 3,134 | 872,822.73 | 0.0677 | 0.2823 | 06/30/2025 |
| 12 | PSM Vermogensverwaltung GmbH Langen v.d.Goltz, Dr. Prinz | 53,508 | 0 | 798,874.44 | 9.6567 | 0.2584 | 12/31/2024 |
| 13 | Hayek Kallen Investment Management LLC | 51,211 | -5 | 764,580.23 | 0.2443 | 0.2473 | 06/30/2025 |
| 14 | Millennium Management LLC | 45,244 | 43,853 | 675,492.92 | 0.0006 | 0.2185 | 06/30/2025 |
| 15 | Raymond James Financial Services Advisors, Inc. | 43,825 | 10,173 | 654,307.25 | 0.0008 | 0.2116 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | PSM Macro Strategy | 51,008 | 0 | 761,549.44 | 6.754 | 0.2463 | 12/31/2024 |
| 2 | PSM Value Strategy UI | 50,000 | 2,995 | 746,500 | 6.4103 | 0.2415 | 06/30/2025 |
| 3 | Old Westbury Small & Mid Cap Strategies Fund | 18,397 | 752 | 274,667.21 | 0.003 | 0.0888 | 04/30/2025 |
| 4 | Fidelity Nasdaq Composite Index Fund | 17,322 | 9,413 | 258,617.46 | 0.0012 | 0.0837 | 07/31/2025 |
| 5 | SPDR Portfolio Developed World ex-US ETF | 14,816 | 1,131 | 221,202.88 | 0.0007 | 0.0716 | 08/29/2025 |
| 6 | iShares IV Plc - NASDAQ US Biotechnology UCITS ETF | 11,934 | 481 | 178,174.62 | 0.0304 | 0.0576 | 08/29/2025 |
| 7 | SEI Institutional Intl. Trust-International Equity | 11,488 | 7,213 | 171,515.84 | 0.0047 | 0.0555 | 08/31/2025 |
| 8 | Macquarie Healthcare Fund | 9,500 | 0 | 141,835 | 0.0211 | 0.0459 | 07/31/2025 |
| 9 | Voya Multi Manager International Small Cap Fund | 7,057 | -1 | 105,361.01 | 0.0254 | 0.0341 | 06/30/2025 |
| 10 | LUNIS Biotech Growth Opportunities Fund | 6,900 | 0 | 103,017 | 6.2769 | 0.0333 | 09/30/2024 |
| 11 | Invesco Markets Plc - NASDAQ Biotech UCITS ETF | 6,810 | 1,272 | 101,673.3 | 0.0301 | 0.0329 | 08/29/2025 |
| 12 | SPDR S&P International Small Cap ETF | 6,560 | -68 | 97,940.8 | 0.0124 | 0.0317 | 08/29/2025 |
| 13 | China Universal Nasdaq Biotechnology Index ETF | 4,243 | 0 | 63,347.99 | 0.028 | 0.0205 | 12/31/2024 |
| 14 | Hector SICAV - Fide Growth | 3,250 | 0 | 48,522.5 | 0.0901 | 0.0157 | 06/30/2025 |
| 15 | PSM Dynamik | 2,500 | 0 | 37,325 | 3.065 | 0.0121 | 12/31/2024 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Acadian Asset Management LLC | 241,048 | 151,758 | 3,598,846.64 | 0.006 | 1.1641 | 06/30/2025 |
| 2 | Eversept Partners LP | 167,276 | 91,446 | 2,497,430.68 | 0.2302 | 0.8078 | 06/30/2025 |
| 3 | Millennium Management LLC | 45,244 | 43,853 | 675,492.92 | 0.0006 | 0.2185 | 06/30/2025 |
| 4 | George Kaiser Family Foundation | 38,197 | 38,197 | 570,281.21 | 0.0815 | 0.1845 | 06/30/2025 |
| 5 | Leap Investments LP | 38,063 | 38,063 | 568,280.59 | 0.0087 | 0.1838 | 06/30/2025 |
| 6 | Trexquant Investment LP | 32,686 | 32,686 | 488,001.98 | 0.0052 | 0.1578 | 06/30/2025 |
| 7 | Citadel Securities LLC | 38,064 | 29,124 | 568,295.52 | 0.0018 | 0.1838 | 06/30/2025 |
| 8 | Mercer Global Advisors, Inc. | 35,027 | 17,427 | 522,953.11 | 0.0011 | 0.1692 | 06/30/2025 |
| 9 | SEI Investments Management Corp. | 27,913 | 15,988 | 416,741.09 | 0.0004 | 0.1348 | 06/30/2025 |
| 10 | Bank of America, NA (Private Banking) | 15,577 | 15,156 | 232,564.61 | 0.0001 | 0.0752 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Two Sigma Advisers LP | 17,370 | -69,595 | 259,334.1 | 0.0005 | 0.0839 | 06/30/2025 |
| 2 | Morgan Stanley & Co. LLC | 147,270 | -56,192 | 2,198,741.1 | 0.0008 | 0.7112 | 06/30/2025 |
| 3 | GSA Capital Partners LLP | 0 | -54,852 | 0 | 0 | 0 | |
| 4 | Two Sigma Investments LP | 59,024 | -49,663 | 881,228.32 | 0.0015 | 0.285 | 06/30/2025 |
| 5 | AXA Investment Managers UK Ltd. | 0 | -49,468 | 0 | 0 | 0 | |
| 6 | Kynam Capital Management LP | 576,111 | -44,620 | 8,601,337.23 | 0.755 | 2.7822 | 06/30/2025 |
| 7 | Waterfront Wealth, Inc. | 94,729 | -29,359 | 1,414,303.97 | 0.2975 | 0.4575 | 06/30/2025 |
| 8 | Group One Trading LLC | 274 | -13,507 | 4,090.82 | 0.0001 | 0.0013 | 06/30/2025 |
| 9 | Cutter & Co. Brokerage, Inc. (Investment Management) | 0 | -12,001 | 0 | 0 | 0 | |
| 10 | Macquarie Investment Management Business Trust | 0 | -11,633 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.