| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Sarissa Capital Management LP | 1,242,531 | 0 | 18,600,689.07 | 11.633 | 6.0005 | 03/31/2025 |
| 2 | Kynam Capital Management LP | 620,731 | 0 | 9,292,343.07 | 0.7355 | 2.9977 | 03/31/2025 |
| 3 | Acadian Asset Management LLC | 189,576 | 100,286 | 2,837,952.72 | 0.006 | 0.9155 | 03/31/2025 |
| 4 | Eversept Partners LP | 169,960 | 94,130 | 2,544,301.2 | 0.2846 | 0.8208 | 03/31/2025 |
| 5 | Waterfront Wealth, Inc. | 125,731 | 1,643 | 1,882,193.07 | 0.4246 | 0.6072 | 03/31/2025 |
| 6 | SCP Investment LP | 125,000 | 0 | 1,871,250 | 1.3884 | 0.6037 | 03/31/2025 |
| 7 | Morgan Stanley & Co. LLC | 116,045 | -87,417 | 1,737,193.65 | 0.0006 | 0.5604 | 03/31/2025 |
| 8 | Two Sigma Investments LP | 92,797 | -15,890 | 1,389,171.09 | 0.0027 | 0.4481 | 03/31/2025 |
| 9 | Longitude Investment SA | 81,000 | 0 | 1,212,570 | 1.0929 | 0.3912 | 12/31/2024 |
| 10 | BNP Paribas Financial Markets | 71,593 | 4,547 | 1,071,747.21 | 0.0007 | 0.3457 | 03/31/2025 |
| 11 | Two Sigma Advisers LP | 64,660 | -22,305 | 967,960.2 | 0.0019 | 0.3123 | 03/31/2025 |
| 12 | PSM Vermogensverwaltung GmbH Langen v.d.Goltz, Dr. Prinz | 64,505 | -29,500 | 965,639.85 | 6.0398 | 0.3115 | 04/30/2025 |
| 13 | Quinn Opportunity Partners LLC | 58,462 | 3,135 | 875,176.14 | 0.054 | 0.2823 | 03/31/2025 |
| 14 | Hayek Kallen Investment Management LLC | 51,216 | 0 | 766,703.52 | 0.2619 | 0.2473 | 03/31/2025 |
| 15 | LCM Capital Management, Inc. | 42,911 | 998 | 642,377.67 | 0.3214 | 0.2072 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | PSM Macro Strategy | 41,500 | 0 | 621,255 | 4.9783 | 0.2004 | 12/31/2023 |
| 2 | PSM Value Strategy UI | 20,505 | -29,500 | 306,959.85 | 2.6163 | 0.099 | 04/30/2025 |
| 3 | Old Westbury Small & Mid Cap Strategies Fund | 18,397 | 18,397 | 275,403.09 | 0.003 | 0.0888 | 04/30/2025 |
| 4 | SPDR Portfolio Developed World ex-US ETF | 14,260 | 1,646 | 213,472.2 | 0.0008 | 0.0689 | 06/30/2025 |
| 5 | iShares IV Plc - NASDAQ US Biotechnology UCITS ETF | 10,213 | -826 | 152,888.61 | 0.032 | 0.0493 | 06/30/2025 |
| 6 | Macquarie Healthcare Fund | 9,500 | 0 | 142,215 | 0.0214 | 0.0459 | 05/30/2025 |
| 7 | Fidelity Nasdaq Composite Index Fund | 7,732 | -177 | 115,748.04 | 0.0006 | 0.0373 | 05/31/2025 |
| 8 | Voya Multi Manager International Small Cap Fund | 7,057 | -1 | 105,643.29 | 0.0269 | 0.0341 | 06/30/2025 |
| 9 | LUNIS Biotech Growth Opportunities Fund | 6,900 | 0 | 103,293 | 7.1113 | 0.0333 | 09/30/2024 |
| 10 | SPDR S&P International Small Cap ETF | 6,390 | -305 | 95,658.3 | 0.0134 | 0.0309 | 06/30/2025 |
| 11 | Invesco Markets Plc - NASDAQ Biotech UCITS ETF | 5,847 | 92 | 87,529.59 | 0.0314 | 0.0282 | 06/30/2025 |
| 12 | China Universal Nasdaq Biotechnology Index ETF | 4,243 | 0 | 63,517.71 | 0.029 | 0.0205 | 12/31/2024 |
| 13 | Hector SICAV - Fide Growth | 3,250 | 0 | 48,652.5 | 0.0934 | 0.0157 | 03/31/2025 |
| 14 | PSM Dynamik | 2,500 | 0 | 37,425 | 2.5228 | 0.0121 | 12/31/2024 |
| 15 | State Board of Administration of Florida Retirement System | 2,213 | 2,213 | 33,128.61 | 0 | 0.0107 | 03/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Acadian Asset Management LLC | 189,576 | 100,286 | 2,837,952.72 | 0.006 | 0.9155 | 03/31/2025 |
| 2 | Eversept Partners LP | 169,960 | 94,130 | 2,544,301.2 | 0.2846 | 0.8208 | 03/31/2025 |
| 3 | Stonepine Capital Management LLC | 32,581 | 26,868 | 487,737.57 | 0.245 | 0.1573 | 03/31/2025 |
| 4 | SEI Investments Management Corp. | 27,914 | 15,989 | 417,872.58 | 0.0004 | 0.1348 | 03/31/2025 |
| 5 | Susquehanna Financial Group LLLP | 10,291 | 7,987 | 154,056.27 | 0.0002 | 0.0497 | 03/31/2025 |
| 6 | Steward Partners Investment Advisory LLC | 6,024 | 5,238 | 90,179.28 | 0.0007 | 0.0291 | 03/31/2025 |
| 7 | Two Sigma Securities LLC | 5,390 | 4,876 | 80,688.3 | 0.0114 | 0.026 | 03/31/2025 |
| 8 | BNP Paribas Financial Markets | 71,593 | 4,547 | 1,071,747.21 | 0.0007 | 0.3457 | 03/31/2025 |
| 9 | Quinn Opportunity Partners LLC | 58,462 | 3,135 | 875,176.14 | 0.054 | 0.2823 | 03/31/2025 |
| 10 | XTX Markets LLC | 2,714 | 2,714 | 40,628.58 | 0.0019 | 0.0131 | 03/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Morgan Stanley & Co. LLC | 116,045 | -87,417 | 1,737,193.65 | 0.0006 | 0.5604 | 03/31/2025 |
| 2 | GSA Capital Partners LLP | 0 | -54,852 | 0 | 0 | 0 | |
| 3 | AXA Investment Managers UK Ltd. | 3,097 | -46,371 | 46,362.09 | 0.0002 | 0.015 | 03/31/2025 |
| 4 | PSM Vermogensverwaltung GmbH Langen v.d.Goltz, Dr. Prinz | 64,505 | -29,500 | 965,639.85 | 6.0398 | 0.3115 | 04/30/2025 |
| 5 | Two Sigma Advisers LP | 64,660 | -22,305 | 967,960.2 | 0.0019 | 0.3123 | 03/31/2025 |
| 6 | Two Sigma Investments LP | 92,797 | -15,890 | 1,389,171.09 | 0.0027 | 0.4481 | 03/31/2025 |
| 7 | Jane Street Capital LLC | 0 | -13,411 | 0 | 0 | 0 | |
| 8 | Group One Trading LLC | 1,460 | -12,321 | 21,856.2 | 0.0007 | 0.0071 | 03/31/2025 |
| 9 | G1 Execution Services LLC | 3,345 | -11,279 | 50,074.65 | 0.0025 | 0.0162 | 03/31/2025 |
| 10 | Citadel Securities LLC | 0 | -8,940 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.