| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Fidelity Management & Research Co. LLC | 5,302,686 | 787,532 | 3,338,093,863.86 | 0.2235 | 8.7271 | 12/31/2024 |
| 2 | T. Rowe Price Associates, Inc. (IM) | 4,703,181 | -292,112 | 2,960,699,471.31 | 0.3901 | 7.7405 | 12/31/2024 |
| 3 | Artisan Partners LP | 3,069,995 | -443,247 | 1,932,592,552.45 | 1.6943 | 5.0526 | 12/31/2024 |
| 4 | Janus Henderson Investors US LLC | 2,310,686 | -166,959 | 1,454,599,943.86 | 0.8249 | 3.8029 | 12/31/2024 |
| 5 | Capital Research & Management Co. (World Investors) | 1,786,936 | 86,687 | 1,124,894,081.36 | 0.1327 | 2.9409 | 12/31/2024 |
| 6 | Avoro Capital Advisor LLC | 1,238,467 | 0 | 779,627,361.17 | 11.6503 | 2.0383 | 12/31/2024 |
| 7 | T. Rowe Price International Ltd. | 813,713 | -11,541 | 512,240,470.63 | 0.3656 | 1.3392 | 12/31/2024 |
| 8 | RTW Investments LP | 673,497 | 19,067 | 423,973,096.47 | 6.482 | 1.1084 | 12/31/2024 |
| 9 | ClearBridge Investments LLC | 629,828 | 40,330 | 396,483,024.28 | 0.3175 | 1.0366 | 12/31/2024 |
| 10 | Bellevue Asset Management AG | 593,184 | -39,645 | 373,415,259.84 | 5.8487 | 0.9763 | 12/31/2024 |
| 11 | Morgan Stanley & Co. LLC | 566,696 | 8,019 | 356,740,798.96 | 0.1436 | 0.9327 | 12/31/2024 |
| 12 | Citadel Advisors LLC | 506,675 | -97,219 | 318,956,979.25 | 0.4231 | 0.8339 | 12/31/2024 |
| 13 | T. Rowe Price Investment Management, Inc. | 487,853 | -283,719 | 307,108,342.03 | 0.204 | 0.8029 | 12/31/2024 |
| 14 | Paradigm BioCapital Advisors LP | 481,305 | 931 | 302,986,310.55 | 12.2164 | 0.7921 | 12/31/2024 |
| 15 | Invesco Advisers, Inc. | 387,080 | -28,186 | 243,670,730.8 | 0.1036 | 0.6371 | 12/31/2024 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | American Funds EuroPacific Growth Fund | 1,164,588 | 45,097 | 733,119,791.88 | 0.602 | 1.9167 | 03/31/2025 |
| 2 | Fidelity Growth Company Commingled Pool | 875,886 | 32,158 | 551,378,995.86 | 0.6699 | 1.4415 | 02/28/2025 |
| 3 | T Rowe Price New Horizons Fund | 779,726 | -89,021 | 490,845,314.26 | 3.0584 | 1.2833 | 03/31/2025 |
| 4 | T Rowe Price Health Sciences Fund | 736,981 | -67,575 | 463,936,909.31 | 3.81 | 1.2129 | 03/31/2025 |
| 5 | T Rowe Price Growth Stock Fund | 653,403 | -116,414 | 411,323,722.53 | 0.9015 | 1.0754 | 03/31/2025 |
| 6 | Fidelity Growth Company Fund | 625,502 | 5,849 | 393,759,764.02 | 0.6595 | 1.0294 | 02/28/2025 |
| 7 | Janus Henderson Forty Fund | 611,281 | -9,810 | 384,807,502.31 | 1.8946 | 1.006 | 12/31/2024 |
| 8 | Fidelity Contrafund | 390,980 | 217,340 | 246,125,819.8 | 0.1669 | 0.6435 | 02/28/2025 |
| 9 | American Funds New Economy Fund | 368,017 | 52,897 | 231,670,381.67 | 0.7191 | 0.6057 | 03/31/2025 |
| 10 | Fidelity OTC Portfolio | 320,526 | 48,402 | 201,774,322.26 | 0.7074 | 0.5275 | 02/28/2025 |
| 11 | Artisan Mid Cap Fund | 311,658 | -58,689 | 196,191,827.58 | 5.4734 | 0.5129 | 03/31/2025 |
| 12 | Janus Henderson Enterprise Fund | 305,977 | -42,400 | 192,615,581.27 | 0.9058 | 0.5036 | 12/31/2024 |
| 13 | Fidelity Global Innovators Investment Trust | 303,214 | 167,300 | 190,876,245.14 | 1.1559 | 0.499 | 02/28/2025 |
| 14 | Invesco Developing Markets Fund | 281,108 | -68,093 | 176,960,297.08 | 1.1533 | 0.4626 | 02/28/2025 |
| 15 | Fidelity Select Port. - Health Care Portfolio | 280,000 | -5,000 | 176,262,800 | 2.7603 | 0.4608 | 02/28/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Fidelity Management & Research Co. LLC | 5,302,686 | 787,532 | 3,338,093,863.86 | 0.2235 | 8.7271 | 12/31/2024 |
| 2 | D. E. Shaw & Co. LP | 288,299 | 186,697 | 181,487,103.49 | 0.2117 | 0.4745 | 12/31/2024 |
| 3 | Allspring Global Investments LLC | 162,382 | 162,382 | 102,221,092.82 | 0.1445 | 0.2672 | 03/31/2025 |
| 4 | Point72 Asset Management LP | 157,546 | 157,546 | 99,176,782.46 | 0.2526 | 0.2593 | 12/31/2024 |
| 5 | Marshall Wace LLP | 191,553 | 124,271 | 120,584,529.03 | 0.1567 | 0.3153 | 12/31/2024 |
| 6 | The Public Sector Pension Investment Board | 105,972 | 105,972 | 66,710,433.72 | 0.2712 | 0.1744 | 12/31/2024 |
| 7 | Capital Research & Management Co. (World Investors) | 1,786,936 | 86,687 | 1,124,894,081.36 | 0.1327 | 2.9409 | 12/31/2024 |
| 8 | Assenagon Asset Management SA (Germany) | 110,390 | 81,596 | 69,491,608.9 | 0.1133 | 0.1817 | 03/31/2025 |
| 9 | Lazard Asset Management LLC | 70,637 | 64,684 | 44,466,697.87 | 0.0423 | 0.1163 | 12/31/2024 |
| 10 | Jennison Associates LLC | 302,149 | 64,183 | 190,205,816.99 | 0.1154 | 0.4973 | 12/31/2024 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Artisan Partners LP | 3,069,995 | -443,247 | 1,932,592,552.45 | 1.6943 | 5.0526 | 12/31/2024 |
| 2 | Deep Track Capital LP | 0 | -365,000 | 0 | 0 | 0 | |
| 3 | T. Rowe Price Associates, Inc. (IM) | 4,703,181 | -292,112 | 2,960,699,471.31 | 0.3901 | 7.7405 | 12/31/2024 |
| 4 | T. Rowe Price Investment Management, Inc. | 487,853 | -283,719 | 307,108,342.03 | 0.204 | 0.8029 | 12/31/2024 |
| 5 | Alkeon Capital Management LLC | 75,000 | -270,000 | 47,213,250 | 0.2744 | 0.1234 | 12/31/2024 |
| 6 | Holocene Advisors, LP | 10,570 | -184,534 | 6,653,920.7 | 0.0229 | 0.0174 | 12/31/2024 |
| 7 | Janus Henderson Investors US LLC | 2,310,686 | -166,959 | 1,454,599,943.86 | 0.8249 | 3.8029 | 12/31/2024 |
| 8 | Silverbay Capital Management LLC | 36,850 | -132,988 | 23,197,443.5 | 0.258 | 0.0606 | 12/31/2024 |
| 9 | Citadel Advisors LLC | 506,675 | -97,219 | 318,956,979.25 | 0.4231 | 0.8339 | 12/31/2024 |
| 10 | Bank of America, NA (Private Banking) | 4,329 | -86,840 | 2,725,148.79 | 0.0014 | 0.0071 | 12/31/2024 |
Data provided by FactSet Research Systems Inc.