| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Fidelity Management & Research Co. LLC | 5,360,840 | 845,686 | 3,097,975,827.6 | 0.1925 | 8.8228 | 03/31/2025 |
| 2 | T. Rowe Price Associates, Inc. (IM) | 4,590,184 | -405,109 | 2,652,621,431.76 | 0.3332 | 7.5545 | 03/31/2025 |
| 3 | Artisan Partners LP | 2,785,890 | -727,352 | 1,609,937,972.1 | 1.329 | 4.585 | 03/31/2025 |
| 4 | Janus Henderson Investors US LLC | 2,141,936 | -335,709 | 1,237,803,395.04 | 0.6518 | 3.5252 | 03/31/2025 |
| 5 | Capital Research & Management Co. (World Investors) | 1,937,992 | 237,743 | 1,119,946,196.88 | 0.1238 | 3.1895 | 03/31/2025 |
| 6 | Avoro Capital Advisor LLC | 1,235,177 | -3,290 | 713,796,436.53 | 11.0795 | 2.0328 | 03/31/2025 |
| 7 | T. Rowe Price International Ltd. | 794,402 | -30,852 | 459,076,971.78 | 0.3057 | 1.3074 | 03/31/2025 |
| 8 | RTW Investments LP | 673,497 | 19,067 | 389,207,181.33 | 5.5752 | 1.1084 | 03/31/2025 |
| 9 | ClearBridge Investments LLC | 664,368 | 74,870 | 383,931,623.52 | 0.2961 | 1.0934 | 03/31/2025 |
| 10 | Bellevue Asset Management AG | 578,874 | -53,955 | 334,525,495.86 | 5.9429 | 0.9527 | 03/31/2025 |
| 11 | Citadel Advisors LLC | 541,943 | -61,951 | 313,183,440.27 | 0.4117 | 0.8919 | 03/31/2025 |
| 12 | Morgan Stanley & Co. LLC | 498,552 | -60,125 | 288,108,215.28 | 0.1054 | 0.8205 | 03/31/2025 |
| 13 | Invesco Advisers, Inc. | 365,323 | -49,943 | 211,116,508.47 | 0.0857 | 0.6012 | 03/31/2025 |
| 14 | SEI Investments Management Corp. | 361,000 | -19,695 | 208,618,290 | 0.234 | 0.5941 | 03/31/2025 |
| 15 | Wellington Management Co. LLP | 343,563 | -63,209 | 198,541,622.07 | 0.0342 | 0.5654 | 03/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | American Funds EuroPacific Growth Fund | 1,164,588 | 45,097 | 673,003,759.32 | 0.514 | 1.9167 | 03/31/2025 |
| 2 | Fidelity Growth Company Commingled Pool | 875,886 | -985 | 506,165,760.54 | 0.5701 | 1.4415 | 04/30/2025 |
| 3 | T Rowe Price New Horizons Fund | 779,726 | -89,021 | 450,595,858.14 | 2.6729 | 1.2833 | 03/31/2025 |
| 4 | T Rowe Price Health Sciences Fund | 736,981 | -67,575 | 425,893,950.09 | 3.5231 | 1.2129 | 03/31/2025 |
| 5 | T Rowe Price Growth Stock Fund | 653,403 | -116,414 | 377,595,059.67 | 0.757 | 1.0754 | 03/31/2025 |
| 6 | Fidelity Growth Company Fund | 625,502 | -18,215 | 361,471,350.78 | 0.5499 | 1.0294 | 04/30/2025 |
| 7 | Janus Henderson Forty Fund | 534,577 | -86,514 | 308,926,702.53 | 1.3854 | 0.8798 | 03/31/2025 |
| 8 | Fidelity OTC Portfolio | 417,726 | 97,116 | 241,399,678.14 | 0.8002 | 0.6875 | 04/30/2025 |
| 9 | Fidelity Contrafund | 390,980 | 88,412 | 225,943,432.2 | 0.1419 | 0.6435 | 04/30/2025 |
| 10 | American Funds New Economy Fund | 368,017 | 52,897 | 212,673,344.13 | 0.5932 | 0.6057 | 03/31/2025 |
| 11 | Artisan Mid Cap Fund | 311,658 | -58,689 | 180,104,041.62 | 4.6037 | 0.5129 | 03/31/2025 |
| 12 | Janus Henderson Enterprise Fund | 284,627 | -63,750 | 164,483,097.03 | 0.7399 | 0.4684 | 03/31/2025 |
| 13 | Invesco Developing Markets Fund | 281,108 | -68,093 | 162,449,502.12 | 1.0748 | 0.4626 | 04/30/2025 |
| 14 | Fidelity Select Port. - Health Care Portfolio | 280,000 | -20,000 | 161,809,200 | 2.6815 | 0.4608 | 04/30/2025 |
| 15 | BlackRock Global Funds - World Healthscience Fund | 271,971 | 21,105 | 157,169,321.19 | 1.2065 | 0.4476 | 04/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Fidelity Management & Research Co. LLC | 5,360,840 | 845,686 | 3,097,975,827.6 | 0.1925 | 8.8228 | 03/31/2025 |
| 2 | Capital Research & Management Co. (World Investors) | 1,937,992 | 237,743 | 1,119,946,196.88 | 0.1238 | 3.1895 | 03/31/2025 |
| 3 | Allspring Global Investments LLC | 162,382 | 162,382 | 93,838,933.98 | 0.1243 | 0.2672 | 03/31/2025 |
| 4 | Millennium Management LLC | 268,604 | 158,844 | 155,223,565.56 | 0.1435 | 0.4421 | 03/31/2025 |
| 5 | D. E. Shaw & Co. LP | 260,325 | 158,723 | 150,439,214.25 | 0.166 | 0.4284 | 03/31/2025 |
| 6 | BNP Paribas Financial Markets | 133,359 | 129,067 | 77,066,832.51 | 0.0553 | 0.2195 | 03/31/2025 |
| 7 | Lord, Abbett & Co. LLC | 274,700 | 111,737 | 158,746,383 | 0.4829 | 0.4521 | 03/31/2025 |
| 8 | UBS Securities LLC | 101,032 | 99,786 | 58,385,382.48 | 0.0253 | 0.1663 | 03/31/2025 |
| 9 | The Public Sector Pension Investment Board | 82,082 | 82,082 | 47,434,366.98 | 0.1725 | 0.1351 | 03/31/2025 |
| 10 | Assenagon Asset Management SA (Germany) | 110,390 | 81,596 | 63,793,277.1 | 0.0963 | 0.1817 | 03/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Artisan Partners LP | 2,785,890 | -727,352 | 1,609,937,972.1 | 1.329 | 4.585 | 03/31/2025 |
| 2 | T. Rowe Price Investment Management, Inc. | 80,647 | -690,925 | 46,605,094.83 | 0.0299 | 0.1327 | 03/31/2025 |
| 3 | Paradigm BioCapital Advisors LP | 59,679 | -420,695 | 34,487,897.31 | 1.5144 | 0.0982 | 03/31/2025 |
| 4 | T. Rowe Price Associates, Inc. (IM) | 4,590,184 | -405,109 | 2,652,621,431.76 | 0.3332 | 7.5545 | 03/31/2025 |
| 5 | Deep Track Capital LP | 0 | -365,000 | 0 | 0 | 0 | |
| 6 | Janus Henderson Investors US LLC | 2,141,936 | -335,709 | 1,237,803,395.04 | 0.6518 | 3.5252 | 03/31/2025 |
| 7 | Alkeon Capital Management LLC | 75,000 | -270,000 | 43,341,750 | 0.2145 | 0.1234 | 03/31/2025 |
| 8 | Holocene Advisors, LP | 6,866 | -188,238 | 3,967,792.74 | 0.011 | 0.0113 | 03/31/2025 |
| 9 | Silverbay Capital Management LLC | 36,850 | -132,988 | 21,295,246.5 | 0.2019 | 0.0606 | 03/31/2025 |
| 10 | Pictet Asset Management SA | 229,441 | -122,162 | 132,591,659.49 | 0.0946 | 0.3776 | 03/31/2025 |
Data provided by FactSet Research Systems Inc.