| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | RA Capital Management LP | 10,112,744 | 402,316 | 1,684,580,895.52 | 25.7408 | 17.5242 | 12/31/2024 |
| 2 | Westfield Capital Management Co. LP | 5,528,239 | 394,473 | 920,894,052.62 | 4.4086 | 9.5798 | 12/31/2024 |
| 3 | Avoro Capital Advisor LLC | 5,103,055 | 114,167 | 850,066,901.9 | 12.7029 | 8.843 | 12/31/2024 |
| 4 | Artisan Partners LP | 4,450,420 | 39,309 | 741,350,963.6 | 0.6499 | 7.712 | 12/31/2024 |
| 5 | Janus Henderson Investors US LLC | 4,364,369 | 186,419 | 727,016,588.02 | 0.4123 | 7.5629 | 12/31/2024 |
| 6 | Fidelity Management & Research Co. LLC | 4,356,912 | -196,490 | 725,774,400.96 | 0.0486 | 7.55 | 12/31/2024 |
| 7 | Capital Research & Management Co. (International Investors) | 2,863,249 | 753,859 | 476,960,018.42 | 0.0893 | 4.9617 | 12/31/2024 |
| 8 | T. Rowe Price Investment Management, Inc. | 2,725,546 | 960,504 | 454,021,452.68 | 0.3016 | 4.723 | 12/31/2024 |
| 9 | T. Rowe Price Associates, Inc. (IM) | 2,283,207 | 162,079 | 380,336,622.06 | 0.0501 | 3.9565 | 12/31/2024 |
| 10 | Massachusetts Financial Services Co. | 1,780,861 | 3,986 | 296,655,825.38 | 0.1001 | 3.086 | 12/31/2024 |
| 11 | Invesco Advisers, Inc. | 1,114,858 | -3,280 | 185,713,045.64 | 0.079 | 1.9319 | 12/31/2024 |
| 12 | Citadel Advisors LLC | 890,533 | 338,122 | 148,344,987.14 | 0.1968 | 1.5432 | 12/31/2024 |
| 13 | Camber Capital Management LP | 800,000 | 100,000 | 133,264,000 | 5.3616 | 1.3863 | 12/31/2024 |
| 14 | Morgan Stanley & Co. LLC | 782,597 | 521,409 | 130,365,008.26 | 0.0525 | 1.3561 | 12/31/2024 |
| 15 | Franklin Advisers, Inc. | 757,393 | 4,301 | 126,166,525.94 | 0.0719 | 1.3125 | 12/31/2024 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | MFS Mid Cap Growth Fund | 1,304,613 | -1,429 | 217,322,433.54 | 1.5375 | 2.2607 | 03/31/2025 |
| 2 | American Funds Growth Fund of America | 1,062,134 | -1,775 | 176,930,281.72 | 0.0657 | 1.8405 | 03/31/2025 |
| 3 | T Rowe Price Mid Cap Growth Fund | 1,020,000 | 284,700 | 169,911,600 | 0.6323 | 1.7675 | 03/31/2025 |
| 4 | Janus Henderson Enterprise Fund | 976,876 | 0 | 162,728,004.08 | 0.7652 | 1.6928 | 12/31/2024 |
| 5 | T Rowe Price Health Sciences Fund | 948,311 | 30,480 | 157,969,646.38 | 1.2973 | 1.6433 | 03/31/2025 |
| 6 | Artisan Mid Cap Fund | 938,852 | -93,473 | 156,393,966.16 | 4.3631 | 1.6269 | 03/31/2025 |
| 7 | Fidelity Select Port. - Health Care Portfolio | 750,000 | -70,000 | 124,935,000 | 1.9565 | 1.2997 | 02/28/2025 |
| 8 | Fidelity Select Port. - Biotechnology Portfolio | 659,409 | 0 | 109,844,351.22 | 2.7569 | 1.1427 | 02/28/2025 |
| 9 | CTIVP - Morgan Stanley Advantage Fund | 654,422 | 36,821 | 109,013,616.76 | 6.6423 | 1.134 | 12/31/2024 |
| 10 | T Rowe Price New Horizons Fund | 634,821 | -23,729 | 105,748,482.18 | 0.6589 | 1.1001 | 03/31/2025 |
| 11 | American Funds New Perspective Fund | 623,163 | 623,163 | 103,806,492.54 | 0.0764 | 1.0799 | 03/31/2025 |
| 12 | Harbor Small Cap Growth Fund | 620,390 | 131,990 | 103,344,566.2 | 5.7328 | 1.0751 | 01/31/2025 |
| 13 | American Funds Small Cap World Fund | 579,165 | 0 | 96,477,305.7 | 0.1444 | 1.0036 | 03/31/2025 |
| 14 | Bridge Builder Small/Mid Cap Growth Fund | 551,804 | 23,523 | 91,919,510.32 | 1.0925 | 0.9562 | 03/31/2025 |
| 15 | Polar Capital Funds Plc - Biotechnology Fund | 500,000 | 275,000 | 83,290,000 | 4.6196 | 0.8664 | 02/28/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | T. Rowe Price Investment Management, Inc. | 2,725,546 | 960,504 | 454,021,452.68 | 0.3016 | 4.723 | 12/31/2024 |
| 2 | Capital Research & Management Co. (International Investors) | 2,863,249 | 753,859 | 476,960,018.42 | 0.0893 | 4.9617 | 12/31/2024 |
| 3 | Morgan Stanley & Co. LLC | 782,597 | 521,409 | 130,365,008.26 | 0.0525 | 1.3561 | 12/31/2024 |
| 4 | RA Capital Management LP | 10,112,744 | 402,316 | 1,684,580,895.52 | 25.7408 | 17.5242 | 12/31/2024 |
| 5 | Westfield Capital Management Co. LP | 5,528,239 | 394,473 | 920,894,052.62 | 4.4086 | 9.5798 | 12/31/2024 |
| 6 | Citadel Advisors LLC | 890,533 | 338,122 | 148,344,987.14 | 0.1968 | 1.5432 | 12/31/2024 |
| 7 | Vestal Point Capital LP | 520,000 | 270,000 | 86,621,600 | 5.5248 | 0.9011 | 12/31/2024 |
| 8 | Catalio Capital Management LP (Investment Management) | 215,587 | 215,587 | 35,912,482.46 | 8.4915 | 0.3736 | 12/31/2024 |
| 9 | UBS Securities LLC | 217,905 | 214,580 | 36,298,614.9 | 0.0185 | 0.3776 | 12/31/2024 |
| 10 | Janus Henderson Investors US LLC | 4,364,369 | 186,419 | 727,016,588.02 | 0.4123 | 7.5629 | 12/31/2024 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Spyglass Capital Management LLC | 0 | -652,841 | 0 | 0 | 0 | |
| 2 | Wellington Management Co. LLP | 657,156 | -549,497 | 109,469,046.48 | 0.0197 | 1.1388 | 12/31/2024 |
| 3 | TimesSquare Capital Management LLC | 0 | -500,920 | 0 | 0 | 0 | |
| 4 | Adage Capital Management LP | 0 | -486,957 | 0 | 0 | 0 | |
| 5 | Brown Advisory LLC | 35,389 | -431,098 | 5,895,099.62 | 0.0093 | 0.0613 | 12/31/2024 |
| 6 | Fidelity Management & Research Co. LLC | 4,356,912 | -196,490 | 725,774,400.96 | 0.0486 | 7.55 | 12/31/2024 |
| 7 | Fred Alger Management LLC | 111,854 | -146,356 | 18,632,639.32 | 0.106 | 0.1938 | 12/31/2024 |
| 8 | Millennium Management LLC | 358,144 | -143,546 | 59,659,627.52 | 0.0549 | 0.6206 | 12/31/2024 |
| 9 | Putnam Investment Management LLC | 586,463 | -109,936 | 97,693,006.54 | 0.1195 | 1.0163 | 12/31/2024 |
| 10 | Medical Strategy GmbH | 152,761 | -108,879 | 25,446,927.38 | 3.2995 | 0.2647 | 12/30/2024 |
Data provided by FactSet Research Systems Inc.