| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | RA Capital Management LP | 10,281,496 | 571,068 | 1,756,079,516.8 | 27.2687 | 16.863 | 03/31/2025 |
| 2 | Westfield Capital Management Co. LP | 5,479,259 | 345,493 | 935,857,437.2 | 4.0699 | 8.9867 | 03/31/2025 |
| 3 | Avoro Capital Advisor LLC | 5,218,000 | 229,112 | 891,234,400 | 13.8336 | 8.5582 | 03/31/2025 |
| 4 | Janus Henderson Investors US LLC | 4,410,144 | 232,194 | 753,252,595.2 | 0.3967 | 7.2332 | 03/31/2025 |
| 5 | Fidelity Management & Research Co. LLC | 4,304,345 | -249,057 | 735,182,126 | 0.0457 | 7.0597 | 03/31/2025 |
| 6 | Artisan Partners LP | 4,256,627 | -154,484 | 727,031,891.6 | 0.6002 | 6.9814 | 03/31/2025 |
| 7 | T. Rowe Price Investment Management, Inc. | 3,053,824 | 1,288,782 | 521,593,139.2 | 0.3341 | 5.0087 | 03/31/2025 |
| 8 | Capital Research & Management Co. (International Investors) | 2,874,792 | 765,402 | 491,014,473.6 | 0.0854 | 4.715 | 03/31/2025 |
| 9 | T. Rowe Price Associates, Inc. (IM) | 2,256,102 | 134,974 | 385,342,221.6 | 0.0484 | 3.7003 | 03/31/2025 |
| 10 | Morgan Stanley & Co. LLC | 1,864,684 | 1,603,496 | 318,488,027.2 | 0.1166 | 3.0583 | 03/31/2025 |
| 11 | Massachusetts Financial Services Co. | 1,791,170 | 14,295 | 305,931,836 | 0.0989 | 2.9378 | 03/31/2025 |
| 12 | Invesco Advisers, Inc. | 1,157,828 | 39,690 | 197,757,022.4 | 0.0803 | 1.899 | 03/31/2025 |
| 13 | Citadel Advisors LLC | 1,125,094 | 572,683 | 192,166,055.2 | 0.2526 | 1.8453 | 03/31/2025 |
| 14 | Franklin Advisers, Inc. | 1,078,316 | 319,974 | 184,176,372.8 | 0.0896 | 1.7686 | 03/31/2025 |
| 15 | Columbia Management Investment Advisers LLC | 679,931 | 10,214 | 116,132,214.8 | 0.0322 | 1.1152 | 03/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | MFS Mid Cap Growth Fund | 1,304,613 | -14,221 | 222,827,900.4 | 1.4472 | 2.1397 | 04/30/2025 |
| 2 | American Funds Growth Fund of America | 1,062,134 | -1,775 | 181,412,487.2 | 0.0612 | 1.742 | 03/31/2025 |
| 3 | T Rowe Price Mid Cap Growth Fund | 1,020,000 | 284,700 | 174,216,000 | 0.6109 | 1.6729 | 03/31/2025 |
| 4 | Janus Henderson Enterprise Fund | 976,876 | 0 | 166,850,420.8 | 0.7505 | 1.6022 | 03/31/2025 |
| 5 | T Rowe Price Health Sciences Fund | 948,311 | 30,480 | 161,971,518.8 | 1.3399 | 1.5554 | 03/31/2025 |
| 6 | Artisan Mid Cap Fund | 938,852 | -93,473 | 160,355,921.6 | 4.0989 | 1.5398 | 03/31/2025 |
| 7 | Fidelity Select Port. - Health Care Portfolio | 750,000 | -70,000 | 128,100,000 | 2.1229 | 1.2301 | 04/30/2025 |
| 8 | T Rowe Price New Horizons Fund | 634,821 | -23,729 | 108,427,426.8 | 0.6432 | 1.0412 | 03/31/2025 |
| 9 | CTIVP - Morgan Stanley Advantage Fund | 631,977 | 14,376 | 107,941,671.6 | 6.0185 | 1.0365 | 03/31/2025 |
| 10 | Fidelity Select Port. - Biotechnology Portfolio | 631,809 | -27,600 | 107,912,977.2 | 2.7826 | 1.0363 | 04/30/2025 |
| 11 | American Funds New Perspective Fund | 623,163 | 623,163 | 106,436,240.4 | 0.072 | 1.0221 | 03/31/2025 |
| 12 | Harbor Small Cap Growth Fund | 620,390 | 103,190 | 105,962,612 | 5.4263 | 1.0175 | 01/31/2025 |
| 13 | American Funds Small Cap World Fund | 579,165 | 0 | 98,921,382 | 0.1366 | 0.9499 | 03/31/2025 |
| 14 | Bridge Builder Small/Mid Cap Growth Fund | 572,030 | 68,895 | 97,702,724 | 1.0867 | 0.9382 | 05/30/2025 |
| 15 | Polar Capital Funds Plc - Biotechnology Fund | 500,000 | 200,000 | 85,400,000 | 4.6769 | 0.8201 | 04/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Morgan Stanley & Co. LLC | 1,864,684 | 1,603,496 | 318,488,027.2 | 0.1166 | 3.0583 | 03/31/2025 |
| 2 | T. Rowe Price Investment Management, Inc. | 3,053,824 | 1,288,782 | 521,593,139.2 | 0.3341 | 5.0087 | 03/31/2025 |
| 3 | Capital Research & Management Co. (International Investors) | 2,874,792 | 765,402 | 491,014,473.6 | 0.0854 | 4.715 | 03/31/2025 |
| 4 | Citadel Advisors LLC | 1,125,094 | 572,683 | 192,166,055.2 | 0.2526 | 1.8453 | 03/31/2025 |
| 5 | RA Capital Management LP | 10,281,496 | 571,068 | 1,756,079,516.8 | 27.2687 | 16.863 | 03/31/2025 |
| 6 | Westfield Capital Management Co. LP | 5,479,259 | 345,493 | 935,857,437.2 | 4.0699 | 8.9867 | 03/31/2025 |
| 7 | Franklin Advisers, Inc. | 1,078,316 | 319,974 | 184,176,372.8 | 0.0896 | 1.7686 | 03/31/2025 |
| 8 | Polar Capital LLP | 525,000 | 300,000 | 89,670,000 | 0.2973 | 0.8611 | 03/31/2025 |
| 9 | Janus Henderson Investors US LLC | 4,410,144 | 232,194 | 753,252,595.2 | 0.3967 | 7.2332 | 03/31/2025 |
| 10 | Avoro Capital Advisor LLC | 5,218,000 | 229,112 | 891,234,400 | 13.8336 | 8.5582 | 03/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Wellington Management Co. LLP | 549,425 | -657,228 | 93,841,790 | 0.0162 | 0.9011 | 03/31/2025 |
| 2 | Spyglass Capital Management LLC | 0 | -652,841 | 0 | 0 | 0 | |
| 3 | TimesSquare Capital Management LLC | 0 | -500,920 | 0 | 0 | 0 | |
| 4 | Brown Advisory LLC | 25,860 | -440,627 | 4,416,888 | 0.0067 | 0.0424 | 03/31/2025 |
| 5 | Camber Capital Management LP | 350,000 | -350,000 | 59,780,000 | 4.0442 | 0.574 | 03/31/2025 |
| 6 | Fidelity Management & Research Co. LLC | 4,304,345 | -249,057 | 735,182,126 | 0.0457 | 7.0597 | 03/31/2025 |
| 7 | Millennium Management LLC | 264,867 | -236,823 | 45,239,283.6 | 0.0418 | 0.4344 | 03/31/2025 |
| 8 | Marshall Wace LLP | 22,294 | -198,781 | 3,807,815.2 | 0.0046 | 0.0366 | 03/31/2025 |
| 9 | Fred Alger Management LLC | 64,806 | -193,404 | 11,068,864.8 | 0.0567 | 0.1063 | 03/31/2025 |
| 10 | FIL Investments International | 457,988 | -178,045 | 78,224,350.4 | 0.0608 | 0.7512 | 03/31/2025 |
Data provided by FactSet Research Systems Inc.