| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Wellington Management Co. LLP | 26,928,707 | 1,817,774 | 47,125,237.25 | 0.0078 | 10.1189 | 06/30/2025 |
| 2 | MAK Capital One LLC | 16,955,098 | 16,955,098 | 29,671,421.5 | 4.3257 | 6.3712 | 06/30/2025 |
| 3 | Deep Track Capital LP | 16,852,147 | 2,633,244 | 29,491,257.25 | 0.7115 | 6.3325 | 06/30/2025 |
| 4 | Syncona Investment Management Ltd. | 16,640,720 | 0 | 29,121,260 | 97.7961 | 6.253 | 06/30/2025 |
| 5 | Armistice Capital LLC | 12,000,000 | 2,800,000 | 21,000,000 | 0.6487 | 4.5092 | 06/30/2025 |
| 6 | TFG Asset Management UK LLP | 9,500,000 | 1,250,000 | 16,625,000 | 2.2076 | 3.5698 | 06/30/2025 |
| 7 | FIAM LLC | 5,795,880 | 842,567 | 10,142,790 | 0.0057 | 2.1779 | 06/30/2025 |
| 8 | Schroder Investment Management North America, Inc. | 3,608,490 | 3,608,490 | 6,314,857.5 | 0.0068 | 1.356 | 06/30/2025 |
| 9 | Laurion Capital Management LP | 3,316,626 | 127,079 | 5,804,095.5 | 0.8675 | 1.2463 | 06/30/2025 |
| 10 | AXA Investment Managers UK Ltd. | 3,126,167 | 1,301,482 | 5,470,792.25 | 0.0181 | 1.1747 | 06/30/2025 |
| 11 | Affinity Asset Advisors LLC | 3,045,000 | -1,455,000 | 5,328,750 | 0.7153 | 1.1442 | 06/30/2025 |
| 12 | T. Rowe Price Associates, Inc. (IM) | 2,694,202 | -245,039 | 4,714,853.5 | 0.0006 | 1.0124 | 06/30/2025 |
| 13 | Renaissance Technologies LLC | 1,751,200 | 1,132,258 | 3,064,600 | 0.0039 | 0.658 | 06/30/2025 |
| 14 | Candriam SCA | 1,678,418 | 0 | 2,937,231.5 | 0.0997 | 0.6307 | 01/31/2025 |
| 15 | BlackRock Advisors LLC | 1,378,368 | -371,570 | 2,412,144 | 0.0011 | 0.5179 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Vanguard Health Care Fund | 19,356,365 | 0 | 33,873,638.75 | 0.0893 | 7.2735 | 04/30/2025 |
| 2 | AXA Framlington Health Fund | 3,126,167 | 1,301,482 | 5,470,792.25 | 0.8452 | 1.1747 | 06/30/2025 |
| 3 | FIAM Small Capitalization Core Commingled Pool | 3,069,500 | -144,700 | 5,371,625 | 0.1137 | 1.1534 | 05/31/2025 |
| 4 | T Rowe Price New Horizons Fund | 2,019,297 | -247,208 | 3,533,769.75 | 0.0227 | 0.7588 | 06/30/2025 |
| 5 | Wellington Mgmt. Funds IE Plc - Global Health Care Eq. | 1,847,563 | 0 | 3,233,235.25 | 0.1673 | 0.6943 | 12/31/2024 |
| 6 | Candriam Equities L - Oncology | 1,678,418 | 0 | 2,937,231.5 | 0.1823 | 0.6307 | 01/31/2025 |
| 7 | Candriam Equities L - Biotechnology | 1,512,903 | 0 | 2,647,580.25 | 0.1842 | 0.5685 | 01/31/2025 |
| 8 | Fidelity Strategic Advisers US Total Stock Fund | 1,154,830 | 274,900 | 2,020,952.5 | 0.0012 | 0.4339 | 06/30/2025 |
| 9 | Vanguard International Explorer Fund | 1,138,297 | 630,101 | 1,992,019.75 | 0.1339 | 0.4277 | 04/30/2025 |
| 10 | Fidelity Series Small Cap Core Fund | 950,235 | 59,400 | 1,662,911.25 | 0.1079 | 0.3571 | 05/31/2025 |
| 11 | iShares Biotechnology ETF | 917,051 | -255,409 | 1,604,839.25 | 0.0283 | 0.3446 | 07/31/2025 |
| 12 | BlackRock Health Sciences Opportunities Portfolio | 850,117 | 0 | 1,487,704.75 | 0.0231 | 0.3194 | 07/31/2025 |
| 13 | BlackRock Health Sciences Trust II | 795,718 | 0 | 1,392,506.5 | 0.0811 | 0.299 | 03/31/2025 |
| 14 | BIT Biotech Opportunities | 781,481 | 445,987 | 1,367,591.75 | 4.2498 | 0.2937 | 02/28/2025 |
| 15 | BlackRock Global Funds - World Healthscience Fund | 715,560 | 0 | 1,252,230 | 0.0096 | 0.2689 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | MAK Capital One LLC | 16,955,098 | 16,955,098 | 29,671,421.5 | 4.3257 | 6.3712 | 06/30/2025 |
| 2 | Schroder Investment Management North America, Inc. | 3,608,490 | 3,608,490 | 6,314,857.5 | 0.0068 | 1.356 | 06/30/2025 |
| 3 | Armistice Capital LLC | 12,000,000 | 2,800,000 | 21,000,000 | 0.6487 | 4.5092 | 06/30/2025 |
| 4 | Deep Track Capital LP | 16,852,147 | 2,633,244 | 29,491,257.25 | 0.7115 | 6.3325 | 06/30/2025 |
| 5 | Wellington Management Co. LLP | 26,928,707 | 1,817,774 | 47,125,237.25 | 0.0078 | 10.1189 | 06/30/2025 |
| 6 | AXA Investment Managers UK Ltd. | 3,126,167 | 1,301,482 | 5,470,792.25 | 0.0181 | 1.1747 | 06/30/2025 |
| 7 | TFG Asset Management UK LLP | 9,500,000 | 1,250,000 | 16,625,000 | 2.2076 | 3.5698 | 06/30/2025 |
| 8 | Renaissance Technologies LLC | 1,751,200 | 1,132,258 | 3,064,600 | 0.0039 | 0.658 | 06/30/2025 |
| 9 | Bank of America, NA (Private Banking) | 962,784 | 956,243 | 1,684,872 | 0.0005 | 0.3618 | 06/30/2025 |
| 10 | FIAM LLC | 5,795,880 | 842,567 | 10,142,790 | 0.0057 | 2.1779 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Avoro Capital Advisor LLC | 0 | -9,910,642 | 0 | 0 | 0 | |
| 2 | Fidelity Management & Research Co. LLC | 1,309,705 | -9,369,252 | 2,291,983.75 | 0.0001 | 0.4921 | 06/30/2025 |
| 3 | Candriam Belgium SA | 0 | -3,191,401 | 0 | 0 | 0 | |
| 4 | Great Point Partners LLC | 0 | -3,009,392 | 0 | 0 | 0 | |
| 5 | Schroder Investment Management Ltd. | 0 | -2,864,632 | 0 | 0 | 0 | |
| 6 | Millennium Management LLC | 0 | -1,653,241 | 0 | 0 | 0 | |
| 7 | Newton Investment Management North America LLC | 0 | -1,631,741 | 0 | 0 | 0 | |
| 8 | Affinity Asset Advisors LLC | 3,045,000 | -1,455,000 | 5,328,750 | 0.7153 | 1.1442 | 06/30/2025 |
| 9 | Rock Springs Capital Management LP | 0 | -1,032,988 | 0 | 0 | 0 | |
| 10 | Two Sigma Investments LP | 146,797 | -759,970 | 256,894.75 | 0.0004 | 0.0552 | 06/30/2025 |
Data provided by FactSet Research Systems Inc.