| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Wellington Management Co. LLP | 26,855,207 | 1,744,274 | 63,378,288.52 | 0.0107 | 10.0913 | 03/31/2025 |
| 2 | Deep Track Capital LP | 17,849,482 | 3,630,579 | 42,124,777.52 | 1.3421 | 6.7073 | 03/31/2025 |
| 3 | Syncona Investment Management Ltd. | 16,640,720 | 0 | 39,272,099.2 | 98.2937 | 6.253 | 03/31/2025 |
| 4 | MAK Capital One LLC | 15,408,638 | 15,408,638 | 36,364,385.68 | 6.2862 | 5.7901 | 06/17/2025 |
| 5 | Armistice Capital LLC | 11,000,000 | 1,800,000 | 25,960,000 | 0.6589 | 4.1334 | 03/31/2025 |
| 6 | Avoro Capital Advisor LLC | 9,910,642 | 0 | 23,389,115.12 | 0.369 | 3.7241 | 03/31/2025 |
| 7 | TFG Asset Management UK LLP | 8,600,000 | 350,000 | 20,296,000 | 3.7668 | 3.2316 | 03/31/2025 |
| 8 | Fidelity Management & Research Co. LLC | 5,652,266 | -5,026,691 | 13,339,347.76 | 0.0008 | 2.1239 | 03/31/2025 |
| 9 | FIAM LLC | 4,510,082 | -443,231 | 10,643,793.52 | 0.0062 | 1.6947 | 03/31/2025 |
| 10 | Schroder Investment Management Ltd. | 3,608,490 | 743,858 | 8,516,036.4 | 0.0039 | 1.356 | 03/31/2025 |
| 11 | Laurion Capital Management LP | 3,369,248 | 179,701 | 7,951,425.28 | 0.6645 | 1.2661 | 03/31/2025 |
| 12 | Candriam Belgium SA | 3,191,401 | 0 | 7,531,706.36 | 0.0215 | 1.1992 | 03/31/2025 |
| 13 | AXA Investment Managers UK Ltd. | 3,126,167 | 1,301,482 | 7,377,754.12 | 0.0241 | 1.1747 | 03/31/2025 |
| 14 | Affinity Asset Advisors LLC | 3,045,000 | -1,455,000 | 7,186,200 | 1.026 | 1.1442 | 03/31/2025 |
| 15 | T. Rowe Price Associates, Inc. (IM) | 2,900,186 | -39,055 | 6,844,438.96 | 0.0008 | 1.0898 | 03/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Vanguard Health Care Fund | 19,356,365 | 0 | 45,681,021.4 | 0.1241 | 7.2735 | 04/30/2025 |
| 2 | AXA Framlington Health Fund | 3,126,167 | 1,301,482 | 7,377,754.12 | 1.1407 | 1.1747 | 05/30/2025 |
| 3 | FIAM Small Capitalization Core Commingled Pool | 3,095,700 | -70,473 | 7,305,852 | 0.1622 | 1.1633 | 04/30/2025 |
| 4 | T Rowe Price New Horizons Fund | 2,235,617 | -30,888 | 5,276,056.12 | 0.0302 | 0.8401 | 03/31/2025 |
| 5 | Wellington Mgmt. Funds IE Plc - Global Health Care Eq. | 1,847,563 | 0 | 4,360,248.68 | 0.2315 | 0.6943 | 12/31/2024 |
| 6 | Candriam Equities L - Oncology | 1,678,418 | 0 | 3,961,066.48 | 0.2564 | 0.6307 | 12/31/2024 |
| 7 | Candriam Equities L - Biotechnology | 1,512,903 | 0 | 3,570,451.08 | 0.2681 | 0.5685 | 12/31/2024 |
| 8 | Vanguard International Explorer Fund | 1,138,297 | 822,349 | 2,686,380.92 | 0.1878 | 0.4277 | 04/30/2025 |
| 9 | Fidelity Series Small Cap Core Fund | 950,235 | 96,100 | 2,242,554.6 | 0.1517 | 0.3571 | 04/30/2025 |
| 10 | iShares Biotechnology ETF | 941,889 | -271,524 | 2,222,858.04 | 0.0412 | 0.3539 | 06/30/2025 |
| 11 | Fidelity Strategic Advisers US Total Stock Fund | 879,930 | 0 | 2,076,634.8 | 0.0013 | 0.3306 | 05/31/2025 |
| 12 | BlackRock Health Sciences Opportunities Portfolio | 850,117 | -39,845 | 2,006,276.12 | 0.0306 | 0.3194 | 05/30/2025 |
| 13 | BlackRock Health Sciences Trust II | 795,718 | 0 | 1,877,894.48 | 0.1168 | 0.299 | 03/31/2025 |
| 14 | BIT Biotech Opportunities | 781,481 | 781,481 | 1,844,295.16 | 5.5114 | 0.2937 | 02/28/2025 |
| 15 | Regnan UK Umbrella Fund - Global Equity Impact Solutions | 728,558 | 0 | 1,719,396.88 | 1.7401 | 0.2738 | 11/30/2024 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | MAK Capital One LLC | 15,408,638 | 15,408,638 | 36,364,385.68 | 6.2862 | 5.7901 | 06/17/2025 |
| 2 | Deep Track Capital LP | 17,849,482 | 3,630,579 | 42,124,777.52 | 1.3421 | 6.7073 | 03/31/2025 |
| 3 | Armistice Capital LLC | 11,000,000 | 1,800,000 | 25,960,000 | 0.6589 | 4.1334 | 03/31/2025 |
| 4 | Wellington Management Co. LLP | 26,855,207 | 1,744,274 | 63,378,288.52 | 0.0107 | 10.0913 | 03/31/2025 |
| 5 | AXA Investment Managers UK Ltd. | 3,126,167 | 1,301,482 | 7,377,754.12 | 0.0241 | 1.1747 | 03/31/2025 |
| 6 | Renaissance Technologies LLC | 1,584,125 | 965,183 | 3,738,535 | 0.005 | 0.5953 | 03/31/2025 |
| 7 | HANSAINVEST Hanseatische Investment-GmbH | 781,481 | 781,481 | 1,844,295.16 | 0.3021 | 0.2937 | 02/28/2025 |
| 8 | Schroder Investment Management Ltd. | 3,608,490 | 743,858 | 8,516,036.4 | 0.0039 | 1.356 | 03/31/2025 |
| 9 | David M. Knott Partnership | 420,000 | 420,000 | 991,200 | 0.4122 | 0.1578 | 03/31/2025 |
| 10 | JPMorgan Securities LLC (Investment Management) | 695,542 | 354,808 | 1,641,479.12 | 0.0008 | 0.2614 | 03/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Fidelity Management & Research Co. LLC | 5,652,266 | -5,026,691 | 13,339,347.76 | 0.0008 | 2.1239 | 03/31/2025 |
| 2 | Newton Investment Management North America LLC | 0 | -1,631,741 | 0 | 0 | 0 | |
| 3 | Affinity Asset Advisors LLC | 3,045,000 | -1,455,000 | 7,186,200 | 1.026 | 1.1442 | 03/31/2025 |
| 4 | Rock Springs Capital Management LP | 0 | -1,032,988 | 0 | 0 | 0 | |
| 5 | HighVista Strategies LLC | 0 | -533,024 | 0 | 0 | 0 | |
| 6 | Two Sigma Investments LP | 395,443 | -511,324 | 933,245.48 | 0.0018 | 0.1486 | 03/31/2025 |
| 7 | Arctic Asset Management AS (Sweden) | 0 | -455,573 | 0 | 0 | 0 | |
| 8 | FIAM LLC | 4,510,082 | -443,231 | 10,643,793.52 | 0.0062 | 1.6947 | 03/31/2025 |
| 9 | BIT Capital GmbH | 199,359 | -437,620 | 470,487.24 | 0.0351 | 0.0749 | 03/31/2025 |
| 10 | MAI Capital Management LLC | 33,866 | -294,460 | 79,923.76 | 0.0006 | 0.0127 | 03/31/2025 |
Data provided by FactSet Research Systems Inc.