| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Wellington Management Co. LLP | 27,091,700 | 3,165,249 | 36,573,795 | 0.0065 | 10.1802 | 03/31/2025 |
| 2 | Syncona Investment Management Ltd. | 16,640,720 | -1,913,904 | 22,464,972 | 97.2688 | 6.253 | 03/31/2025 |
| 3 | Deep Track Capital LP | 14,218,903 | -1,053,269 | 19,195,519.05 | 0.7534 | 5.343 | 12/31/2024 |
| 4 | Fidelity Management & Research Co. LLC | 10,678,957 | -2,452,436 | 14,416,591.95 | 0.0009 | 4.0128 | 12/31/2024 |
| 5 | Avoro Capital Advisor LLC | 9,910,642 | -2,435,036 | 13,379,366.7 | 0.2138 | 3.7241 | 12/31/2024 |
| 6 | Armistice Capital LLC | 9,200,000 | 2,328,000 | 12,420,000 | 0.3242 | 3.4571 | 12/31/2024 |
| 7 | TFG Asset Management UK LLP | 8,250,000 | 250,000 | 11,137,500 | 2.4068 | 3.1001 | 12/31/2024 |
| 8 | FIAM LLC | 4,953,313 | 310,833 | 6,686,972.55 | 0.0045 | 1.8613 | 12/31/2024 |
| 9 | Affinity Asset Advisors LLC | 4,500,000 | 0 | 6,075,000 | 1.144 | 1.691 | 12/31/2024 |
| 10 | Candriam Belgium SA | 3,191,401 | 3,191,401 | 4,308,391.35 | 0.0129 | 1.1992 | 12/31/2024 |
| 11 | Laurion Capital Management LP | 3,189,547 | 0 | 4,305,888.45 | 0.2676 | 1.1985 | 12/31/2024 |
| 12 | Great Point Partners LLC | 3,009,392 | 197,437 | 4,062,679.2 | 2.487 | 1.1308 | 12/31/2024 |
| 13 | T. Rowe Price Associates, Inc. (IM) | 2,939,241 | -902,261 | 3,967,975.35 | 0.0005 | 1.1045 | 12/31/2024 |
| 14 | Schroder Investment Management Ltd. | 2,864,632 | 0 | 3,867,253.2 | 0.0019 | 1.0764 | 12/31/2024 |
| 15 | AXA Investment Managers UK Ltd. | 1,824,685 | 1,824,685 | 2,463,324.75 | 0.0087 | 0.6857 | 12/31/2024 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Vanguard Health Care Fund | 19,356,365 | 0 | 26,131,092.75 | 0.0696 | 7.2735 | 01/31/2025 |
| 2 | FIAM Small Capitalization Core Commingled Pool | 3,139,600 | -71,700 | 4,238,460 | 0.1008 | 1.1798 | 02/28/2025 |
| 3 | AXA Framlington Health Fund | 3,126,167 | 1,723,094 | 4,220,325.45 | 0.659 | 1.1747 | 03/31/2025 |
| 4 | Fidelity Small Cap Growth Fund | 2,571,371 | 0 | 3,471,350.85 | 0.0491 | 0.9662 | 02/28/2025 |
| 5 | T Rowe Price New Horizons Fund | 2,235,617 | -32,838 | 3,018,082.95 | 0.0184 | 0.8401 | 03/31/2025 |
| 6 | Candriam Equities L - Oncology | 1,743,437 | 0 | 2,353,639.95 | 0.1463 | 0.6551 | 10/31/2024 |
| 7 | Candriam Equities L - Biotechnology | 1,512,903 | 0 | 2,042,419.05 | 0.146 | 0.5685 | 10/31/2024 |
| 8 | Fidelity Small Cap Growth K6 Fund | 1,085,495 | 7,400 | 1,465,418.25 | 0.0431 | 0.4079 | 02/28/2025 |
| 9 | iShares Biotechnology ETF | 1,081,479 | -353,903 | 1,459,996.65 | 0.0281 | 0.4064 | 04/30/2025 |
| 10 | Wellington Mgmt. Funds (IE) Plc - Global Health Care Eq. | 897,645 | 0 | 1,211,820.75 | 0.0569 | 0.3373 | 06/30/2024 |
| 11 | Fidelity Series Small Cap Core Fund | 890,835 | 109,400 | 1,202,627.25 | 0.0945 | 0.3347 | 02/28/2025 |
| 12 | Fidelity Strategic Advisers US Total Stock Fund | 879,930 | 0 | 1,187,905.5 | 0.0008 | 0.3306 | 03/31/2025 |
| 13 | Regnan UK Umbrella Fund - Global Equity Impact Solutions | 870,106 | 0 | 1,174,643.1 | 0.9647 | 0.327 | 09/30/2024 |
| 14 | BlackRock Health Sciences Opportunities Portfolio | 850,117 | -39,845 | 1,147,657.95 | 0.0171 | 0.3194 | 03/31/2025 |
| 15 | BlackRock Health Sciences Trust II | 795,718 | 0 | 1,074,219.3 | 0.0686 | 0.299 | 12/31/2024 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Candriam Belgium SA | 3,191,401 | 3,191,401 | 4,308,391.35 | 0.0129 | 1.1992 | 12/31/2024 |
| 2 | Wellington Management Co. LLP | 27,091,700 | 3,165,249 | 36,573,795 | 0.0065 | 10.1802 | 03/31/2025 |
| 3 | Armistice Capital LLC | 9,200,000 | 2,328,000 | 12,420,000 | 0.3242 | 3.4571 | 12/31/2024 |
| 4 | AXA Investment Managers UK Ltd. | 1,824,685 | 1,824,685 | 2,463,324.75 | 0.0087 | 0.6857 | 12/31/2024 |
| 5 | Millennium Management LLC | 1,653,241 | 790,437 | 2,231,875.35 | 0.002 | 0.6212 | 12/31/2024 |
| 6 | Cetera Investment Advisers LLC | 524,872 | 392,872 | 708,577.2 | 0.0014 | 0.1972 | 03/31/2025 |
| 7 | Hennion & Walsh Asset Management, Inc. | 386,001 | 386,001 | 521,101.35 | 0.0232 | 0.145 | 03/31/2025 |
| 8 | BIT Capital GmbH | 636,979 | 379,050 | 859,921.65 | 0.0688 | 0.2394 | 12/31/2024 |
| 9 | Renaissance Technologies LLC | 618,942 | 368,071 | 835,571.7 | 0.0012 | 0.2326 | 12/31/2024 |
| 10 | FIAM LLC | 4,953,313 | 310,833 | 6,686,972.55 | 0.0045 | 1.8613 | 12/31/2024 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Adage Capital Management LP | 0 | -2,950,000 | 0 | 0 | 0 | |
| 2 | StemPoint Capital LP | 0 | -2,616,602 | 0 | 0 | 0 | |
| 3 | Fidelity Management & Research Co. LLC | 10,678,957 | -2,452,436 | 14,416,591.95 | 0.0009 | 4.0128 | 12/31/2024 |
| 4 | Avoro Capital Advisor LLC | 9,910,642 | -2,435,036 | 13,379,366.7 | 0.2138 | 3.7241 | 12/31/2024 |
| 5 | Syncona Investment Management Ltd. | 16,640,720 | -1,913,904 | 22,464,972 | 97.2688 | 6.253 | 03/31/2025 |
| 6 | Newton Investment Management North America LLC | 0 | -1,764,257 | 0 | 0 | 0 | |
| 7 | Morgan Stanley & Co. LLC | 500,838 | -1,279,569 | 676,131.3 | 0.0003 | 0.1882 | 12/31/2024 |
| 8 | Deep Track Capital LP | 14,218,903 | -1,053,269 | 19,195,519.05 | 0.7534 | 5.343 | 12/31/2024 |
| 9 | Walleye Capital LLC | 75,940 | -986,453 | 102,519 | 0.0007 | 0.0285 | 12/31/2024 |
| 10 | T. Rowe Price Associates, Inc. (IM) | 2,939,241 | -902,261 | 3,967,975.35 | 0.0005 | 1.1045 | 12/31/2024 |
Data provided by FactSet Research Systems Inc.