| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Janus Henderson Investors US LLC | 11,080,442 | -2,941,742 | 168,865,936.08 | 0.0836 | 11.4988 | 06/30/2025 |
| 2 | Brandes Investment Partners LP | 6,487,642 | 4,314,503 | 98,871,664.08 | 0.4733 | 6.7326 | 06/30/2025 |
| 3 | Two Seas Capital LP | 6,155,074 | 1,858,625 | 93,803,327.76 | 7.4294 | 6.3875 | 06/30/2025 |
| 4 | BlackRock Fund Advisors | 5,980,006 | 1,237,067 | 91,135,291.44 | 0.0021 | 6.2058 | 06/30/2025 |
| 5 | The Vanguard Group, Inc. | 5,361,014 | 1,630,235 | 81,701,853.36 | 0.0011 | 5.5634 | 06/30/2025 |
| 6 | Tontine Associates LLC | 5,176,611 | -1,153,824 | 78,891,551.64 | 1.7293 | 5.3721 | 06/30/2025 |
| 7 | Polar Capital LLP | 3,999,338 | -414,862 | 60,949,911.12 | 0.1866 | 4.1503 | 06/30/2025 |
| 8 | Wealth Effects LLC | 2,354,822 | 10,692 | 35,887,487.28 | 12.1306 | 2.4437 | 06/30/2025 |
| 9 | Geode Capital Management LLC | 2,169,018 | 1,003,767 | 33,055,834.32 | 0.0019 | 2.2509 | 06/30/2025 |
| 10 | Tang Capital Management LLC | 2,097,500 | 600,000 | 31,965,900 | 1.3973 | 2.1767 | 06/30/2025 |
| 11 | SSgA Funds Management, Inc. | 2,071,409 | 385,270 | 31,568,273.16 | 0.0011 | 2.1496 | 06/30/2025 |
| 12 | Tri Locum Partners LP | 1,014,456 | -923,528 | 15,460,309.44 | 4.2573 | 1.0528 | 06/30/2025 |
| 13 | Kennedy Capital Management LLC | 981,271 | -75,663 | 14,954,570.04 | 0.3273 | 1.0183 | 06/30/2025 |
| 14 | Krensavage Asset Management LLC | 958,877 | 958,877 | 14,613,285.48 | 7.098 | 0.9951 | 06/30/2025 |
| 15 | Woodline Partners LP | 897,086 | 395,265 | 13,671,590.64 | 0.0697 | 0.931 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Polar Capital Funds Plc - Healthcare Opportunities Fund | 3,686,446 | 70,000 | 56,181,437.04 | 3.2095 | 3.8256 | 06/30/2025 |
| 2 | Vanguard Total Stock Market ETF | 2,874,464 | 38,147 | 43,806,831.36 | 0.0023 | 2.983 | 07/31/2025 |
| 3 | Janus Henderson Global Life Sciences Fund | 2,273,682 | -267,907 | 34,650,913.68 | 0.7618 | 2.3595 | 06/30/2025 |
| 4 | iShares Russell 2000 ETF | 2,138,984 | -393,040 | 32,598,116.16 | 0.0499 | 2.2197 | 07/31/2025 |
| 5 | Janus Henderson Capital Funds Plc - Global Life Sciences Fund | 1,886,303 | -144,852 | 28,747,257.72 | 0.7641 | 1.9575 | 06/30/2025 |
| 6 | Janus Henderson Venture Fund | 1,480,446 | 728 | 22,561,997.04 | 0.6994 | 1.5363 | 06/30/2025 |
| 7 | Brandes International Small Cap Equity Fund | 1,403,427 | 1,038,874 | 21,388,227.48 | 1.6098 | 1.4564 | 07/31/2025 |
| 8 | Vanguard Extended Market Index Fund | 1,049,189 | 1,049,189 | 15,989,640.36 | 0.0194 | 1.0888 | 07/31/2025 |
| 9 | Fidelity Small Cap Index Fund | 939,280 | 17,717 | 14,314,627.2 | 0.0514 | 0.9747 | 05/31/2025 |
| 10 | iShares Russell 2000 Growth ETF | 787,958 | -37,591 | 12,008,479.92 | 0.0984 | 0.8177 | 07/31/2025 |
| 11 | Janus Henderson Horizon Fund - Biotechnology Fund | 714,719 | -225,087 | 10,892,317.56 | 1.8697 | 0.7417 | 06/30/2025 |
| 12 | Invesco Pharmaceuticals ETF | 685,595 | 685,595 | 10,448,467.8 | 4.0371 | 0.7115 | 07/31/2025 |
| 13 | Brandes Global Small Cap Equity Fund | 596,426 | 242,092 | 9,089,532.24 | 1.2602 | 0.6189 | 07/31/2025 |
| 14 | SEB Lakemedelsfond | 550,518 | -153,977 | 8,389,894.32 | 0.5972 | 0.5713 | 07/31/2025 |
| 15 | DWS Small Cap Core Fund | 525,000 | 100,000 | 8,001,000 | 0.8514 | 0.5448 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Brandes Investment Partners LP | 6,487,642 | 4,314,503 | 98,871,664.08 | 0.4733 | 6.7326 | 06/30/2025 |
| 2 | Two Seas Capital LP | 6,155,074 | 1,858,625 | 93,803,327.76 | 7.4294 | 6.3875 | 06/30/2025 |
| 3 | The Vanguard Group, Inc. | 5,361,014 | 1,630,235 | 81,701,853.36 | 0.0011 | 5.5634 | 06/30/2025 |
| 4 | BlackRock Fund Advisors | 5,980,006 | 1,237,067 | 91,135,291.44 | 0.0021 | 6.2058 | 06/30/2025 |
| 5 | Geode Capital Management LLC | 2,169,018 | 1,003,767 | 33,055,834.32 | 0.0019 | 2.2509 | 06/30/2025 |
| 6 | Krensavage Asset Management LLC | 958,877 | 958,877 | 14,613,285.48 | 7.098 | 0.9951 | 06/30/2025 |
| 7 | Invenomic Capital Management LP | 802,994 | 802,994 | 12,237,628.56 | 0.5896 | 0.8333 | 06/30/2025 |
| 8 | Invesco Capital Management LLC | 746,306 | 696,733 | 11,373,703.44 | 0.003 | 0.7745 | 06/30/2025 |
| 9 | Tang Capital Management LLC | 2,097,500 | 600,000 | 31,965,900 | 1.3973 | 2.1767 | 06/30/2025 |
| 10 | Charles Schwab Investment Management, Inc. | 786,446 | 563,648 | 11,985,437.04 | 0.0014 | 0.8161 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Braidwell LP | 0 | -4,105,726 | 0 | 0 | 0 | |
| 2 | Janus Henderson Investors US LLC | 11,080,442 | -2,941,742 | 168,865,936.08 | 0.0836 | 11.4988 | 06/30/2025 |
| 3 | Goldman Sachs & Co. LLC (Private Banking) | 319,008 | -1,787,380 | 4,861,681.92 | 0.0021 | 0.3311 | 06/30/2025 |
| 4 | Citadel Advisors LLC | 823,669 | -1,286,651 | 12,552,715.56 | 0.0143 | 0.8548 | 06/30/2025 |
| 5 | Millennium Management LLC | 18,000 | -1,194,004 | 274,320 | 0.0002 | 0.0187 | 06/30/2025 |
| 6 | Tontine Associates LLC | 5,176,611 | -1,153,824 | 78,891,551.64 | 1.7293 | 5.3721 | 06/30/2025 |
| 7 | Checkpoint Capital LP | 0 | -1,004,790 | 0 | 0 | 0 | |
| 8 | Tri Locum Partners LP | 1,014,456 | -923,528 | 15,460,309.44 | 4.2573 | 1.0528 | 06/30/2025 |
| 9 | UBS Securities LLC | 843,598 | -656,086 | 12,856,433.52 | 0.0055 | 0.8755 | 06/30/2025 |
| 10 | Altium Capital Management LLC | 0 | -452,475 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.