| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Janus Henderson Investors US LLC | 14,022,184 | 749,998 | 121,151,669.76 | 0.0676 | 14.5516 | 12/31/2024 |
| 2 | Tontine Associates LLC | 6,330,435 | 524,995 | 54,694,958.4 | 1.6203 | 6.5695 | 12/31/2024 |
| 3 | BlackRock Fund Advisors | 4,687,898 | 49,321 | 40,503,438.72 | 0.0011 | 4.8649 | 03/31/2025 |
| 4 | Polar Capital LLP | 4,414,200 | -419,828 | 38,138,688 | 0.1352 | 4.5809 | 12/31/2024 |
| 5 | Two Seas Capital LP | 4,296,449 | 2,042,669 | 37,121,319.36 | 5.0186 | 4.4587 | 12/31/2024 |
| 6 | Braidwell LP | 4,105,726 | 716,787 | 35,473,472.64 | 1.2693 | 4.2608 | 12/31/2024 |
| 7 | The Vanguard Group, Inc. | 3,730,779 | 76,960 | 32,233,930.56 | 0.0005 | 3.8716 | 12/31/2024 |
| 8 | Wealth Effects LLC | 2,369,122 | 135,351 | 20,469,214.08 | 8.5758 | 2.4586 | 03/31/2025 |
| 9 | Brandes Investment Partners LP | 2,173,139 | 798,415 | 18,775,920.96 | 0.1139 | 2.2552 | 12/31/2024 |
| 10 | Citadel Advisors LLC | 2,110,320 | -25,806 | 18,233,164.8 | 0.0239 | 2.19 | 12/31/2024 |
| 11 | Goldman Sachs & Co. LLC (Private Banking) | 2,106,388 | 295,876 | 18,199,192.32 | 0.0115 | 2.1859 | 12/31/2024 |
| 12 | Tri Locum Partners LP | 1,937,984 | 277,029 | 16,744,181.76 | 3.7593 | 2.0112 | 12/31/2024 |
| 13 | SSgA Funds Management, Inc. | 1,686,139 | 62,837 | 14,568,240.96 | 0.0006 | 1.7498 | 12/31/2024 |
| 14 | UBS Securities LLC | 1,499,684 | 903,000 | 12,957,269.76 | 0.0065 | 1.5563 | 12/31/2024 |
| 15 | Tang Capital Management LLC | 1,497,500 | 267,500 | 12,938,400 | 0.8466 | 1.554 | 12/31/2024 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Polar Capital Funds Plc - Healthcare Opportunities Fund | 3,616,446 | -320,098 | 31,246,093.44 | 1.8066 | 3.753 | 02/28/2025 |
| 2 | Vanguard Total Stock Market ETF | 2,836,317 | -154,472 | 24,505,778.88 | 0.0014 | 2.9434 | 03/31/2025 |
| 3 | Janus Henderson Global Life Sciences Fund | 2,541,589 | -139,669 | 21,959,328.96 | 0.4832 | 2.6376 | 12/31/2024 |
| 4 | iShares Russell 2000 ETF | 2,290,451 | -116,051 | 19,789,496.64 | 0.0339 | 2.3769 | 04/30/2025 |
| 5 | Janus Henderson Capital Funds Plc - Global Life Sciences Fund | 2,017,817 | -1,125 | 17,433,938.88 | 0.4796 | 2.094 | 03/31/2025 |
| 6 | Janus Henderson Venture Fund | 1,479,718 | 313,100 | 12,784,763.52 | 0.433 | 1.5356 | 12/31/2024 |
| 7 | Brandes International Small Cap Equity Fund | 1,064,956 | 783,133 | 9,201,219.84 | 1.0179 | 1.1052 | 04/30/2025 |
| 8 | Janus Henderson Horizon Fund - Biotechnology Fund | 1,051,400 | 313,167 | 9,084,096 | 1.9282 | 1.0911 | 03/31/2025 |
| 9 | Fidelity Small Cap Index Fund | 923,291 | -18,422 | 7,977,234.24 | 0.0341 | 0.9582 | 02/28/2025 |
| 10 | iShares Russell 2000 Growth ETF | 814,897 | -12,833 | 7,040,710.08 | 0.0648 | 0.8457 | 04/30/2025 |
| 11 | Janus Henderson Small Cap Value Fund | 551,722 | 142,591 | 4,766,878.08 | 0.3672 | 0.5726 | 12/31/2024 |
| 12 | SEB Lakemedelsfond | 550,518 | 5,923 | 4,756,475.52 | 0.3446 | 0.5713 | 03/31/2025 |
| 13 | Brandes Global Small Cap Equity Fund | 447,098 | 294,173 | 3,862,926.72 | 0.7358 | 0.464 | 04/30/2025 |
| 14 | Vanguard Russell 2000 Index Fund | 434,311 | 13,256 | 3,752,447.04 | 0.0331 | 0.4507 | 03/31/2025 |
| 15 | DWS Small Cap Core Fund | 425,000 | 0 | 3,672,000 | 0.4488 | 0.441 | 01/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Two Seas Capital LP | 4,296,449 | 2,042,669 | 37,121,319.36 | 5.0186 | 4.4587 | 12/31/2024 |
| 2 | UBS Securities LLC | 1,499,684 | 903,000 | 12,957,269.76 | 0.0065 | 1.5563 | 12/31/2024 |
| 3 | Brandes Investment Partners LP | 2,173,139 | 798,415 | 18,775,920.96 | 0.1139 | 2.2552 | 12/31/2024 |
| 4 | Janus Henderson Investors US LLC | 14,022,184 | 749,998 | 121,151,669.76 | 0.0676 | 14.5516 | 12/31/2024 |
| 5 | Braidwell LP | 4,105,726 | 716,787 | 35,473,472.64 | 1.2693 | 4.2608 | 12/31/2024 |
| 6 | Tontine Associates LLC | 6,330,435 | 524,995 | 54,694,958.4 | 1.6203 | 6.5695 | 12/31/2024 |
| 7 | Neuberger Berman Investment Advisers LLC | 484,145 | 484,145 | 4,183,012.8 | 0.0033 | 0.5024 | 12/31/2024 |
| 8 | Kennedy Capital Management LLC | 1,056,934 | 468,757 | 9,131,909.76 | 0.2167 | 1.0968 | 12/31/2024 |
| 9 | Renaissance Technologies LLC | 387,800 | 366,300 | 3,350,592 | 0.0049 | 0.4024 | 12/31/2024 |
| 10 | Goldman Sachs & Co. LLC (Private Banking) | 2,106,388 | 295,876 | 18,199,192.32 | 0.0115 | 2.1859 | 12/31/2024 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Woodline Partners LP | 501,821 | -1,185,492 | 4,335,733.44 | 0.032 | 0.5208 | 12/31/2024 |
| 2 | Medical Strategy GmbH | 0 | -859,757 | 0 | 0 | 0 | |
| 3 | Penn Capital Management Co LLC | 0 | -608,399 | 0 | 0 | 0 | |
| 4 | Lord, Abbett & Co. LLC | 0 | -489,073 | 0 | 0 | 0 | |
| 5 | Polar Capital LLP | 4,414,200 | -419,828 | 38,138,688 | 0.1352 | 4.5809 | 12/31/2024 |
| 6 | New York State Common Retirement Fund | 26,600 | -394,155 | 229,824 | 0.0003 | 0.0276 | 03/31/2025 |
| 7 | Cutter Capital Management LP | 0 | -385,172 | 0 | 0 | 0 | |
| 8 | Parkman Healthcare Partners LLC | 0 | -254,827 | 0 | 0 | 0 | |
| 9 | Qube Research & Technologies Ltd. | 0 | -225,970 | 0 | 0 | 0 | |
| 10 | Barclays Bank Plc (Private Banking) | 170,420 | -222,271 | 1,472,428.8 | 0.001 | 0.1769 | 12/31/2024 |
Data provided by FactSet Research Systems Inc.