| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Baker Bros. Advisors LP | 8,809,471 | -1,759,426 | 2,078,506,587.74 | 19.7466 | 8.9269 | 02/28/2025 |
| 2 | Capital Research & Management Co. (International Investors) | 6,113,165 | -317,719 | 1,442,340,150.1 | 0.2623 | 6.1946 | 12/31/2024 |
| 3 | PRIMECAP Management Co. | 5,098,904 | 124,615 | 1,203,035,409.76 | 0.9368 | 5.1669 | 12/31/2024 |
| 4 | Baillie Gifford & Co. | 3,630,710 | -75,046 | 856,629,717.4 | 0.4693 | 3.6791 | 03/31/2025 |
| 5 | Fidelity Management & Research Co. LLC | 1,763,341 | 173,917 | 416,042,675.54 | 0.0272 | 1.7868 | 12/31/2024 |
| 6 | Temasek Holdings Pte Ltd. (Investment Management) | 1,525,329 | -863,247 | 359,886,124.26 | 0.9084 | 1.5457 | 12/31/2024 |
| 7 | T. Rowe Price Associates, Inc. (IM) | 1,492,821 | 109,680 | 352,216,186.74 | 0.0455 | 1.5127 | 12/31/2024 |
| 8 | T. Rowe Price International Ltd. | 1,444,349 | 127,402 | 340,779,703.06 | 0.239 | 1.4636 | 12/31/2024 |
| 9 | HHLR Advisors Ltd. | 1,324,406 | -3,852,500 | 312,480,351.64 | 3.1524 | 1.3421 | 03/03/2025 |
| 10 | Paradigm BioCapital Advisors LP | 616,024 | 415,688 | 145,344,702.56 | 6.2625 | 0.6242 | 12/31/2024 |
| 11 | Capital International, Inc. | 554,926 | -69,969 | 130,929,240.44 | 1.0014 | 0.5623 | 12/31/2024 |
| 12 | Morgan Stanley & Co. LLC | 468,239 | 411,780 | 110,476,309.66 | 0.0435 | 0.4745 | 12/31/2024 |
| 13 | BlackRock Fund Advisors | 446,764 | -184,642 | 105,409,498.16 | 0.0027 | 0.4527 | 03/31/2025 |
| 14 | TIAA-CREF Investment Management LLC | 325,745 | 218,532 | 76,856,275.3 | 0.0321 | 0.3301 | 12/31/2024 |
| 15 | Citadel Advisors LLC | 297,193 | 289,667 | 70,119,716.42 | 0.0913 | 0.3012 | 12/31/2024 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | American Funds New Perspective Fund | 2,518,953 | -282,765 | 594,321,770.82 | 0.4272 | 2.5525 | 03/31/2025 |
| 2 | Vanguard PRIMECAP Fund | 2,305,190 | 105,000 | 543,886,528.6 | 0.7556 | 2.3359 | 12/31/2024 |
| 3 | Vanguard Capital Opportunity Fund | 1,118,521 | 37,500 | 263,903,844.74 | 1.2315 | 1.1334 | 12/31/2024 |
| 4 | Fidelity Growth Company Commingled Pool | 821,633 | 164,376 | 193,856,090.02 | 0.2341 | 0.8326 | 03/31/2025 |
| 5 | PRIMECAP Odyssey Aggressive Growth Fund | 698,887 | -6,070 | 164,895,398.78 | 2.5791 | 0.7082 | 12/31/2024 |
| 6 | T Rowe Price Health Sciences Fund | 683,344 | -64,970 | 161,228,183.36 | 1.3764 | 0.6925 | 03/31/2025 |
| 7 | PRIMECAP Odyssey Growth Fund | 671,427 | -12,300 | 158,416,486.38 | 3.1216 | 0.6804 | 12/31/2024 |
| 8 | American Funds EuroPacific Growth Fund | 649,336 | 48,899 | 153,204,335.84 | 0.1227 | 0.658 | 03/31/2025 |
| 9 | Fidelity Growth Company Fund | 586,293 | 118,113 | 138,329,970.42 | 0.2282 | 0.5941 | 03/31/2025 |
| 10 | American Funds New World Fund | 569,629 | -585,428 | 134,398,266.26 | 0.2239 | 0.5772 | 03/31/2025 |
| 11 | T Rowe Price International Stock Fund | 569,215 | -48,856 | 134,300,587.1 | 0.9631 | 0.5768 | 03/31/2025 |
| 12 | Fidelity Contrafund | 520,964 | 520,964 | 122,916,246.16 | 0.082 | 0.5279 | 03/31/2025 |
| 13 | iShares Biotechnology ETF | 345,689 | -236,675 | 81,561,862.66 | 1.5697 | 0.3503 | 04/30/2025 |
| 14 | CIF - Capital Group New Perspective Fund (Lux) | 297,931 | -3,520 | 70,293,840.14 | 0.4271 | 0.3019 | 03/31/2025 |
| 15 | American Funds Global Insight Fund | 222,522 | -45,574 | 52,501,840.68 | 0.3451 | 0.2255 | 03/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Paradigm BioCapital Advisors LP | 616,024 | 415,688 | 145,344,702.56 | 6.2625 | 0.6242 | 12/31/2024 |
| 2 | Morgan Stanley & Co. LLC | 468,239 | 411,780 | 110,476,309.66 | 0.0435 | 0.4745 | 12/31/2024 |
| 3 | Citadel Advisors LLC | 297,193 | 289,667 | 70,119,716.42 | 0.0913 | 0.3012 | 12/31/2024 |
| 4 | TIAA-CREF Investment Management LLC | 325,745 | 218,532 | 76,856,275.3 | 0.0321 | 0.3301 | 12/31/2024 |
| 5 | Fidelity Management & Research Co. LLC | 1,763,341 | 173,917 | 416,042,675.54 | 0.0272 | 1.7868 | 12/31/2024 |
| 6 | Morgan Stanley & Co. International Plc | 205,850 | 153,554 | 48,568,249 | 0.4335 | 0.2086 | 12/31/2024 |
| 7 | T. Rowe Price International Ltd. | 1,444,349 | 127,402 | 340,779,703.06 | 0.239 | 1.4636 | 12/31/2024 |
| 8 | PRIMECAP Management Co. | 5,098,904 | 124,615 | 1,203,035,409.76 | 0.9368 | 5.1669 | 12/31/2024 |
| 9 | T. Rowe Price Associates, Inc. (IM) | 1,492,821 | 109,680 | 352,216,186.74 | 0.0455 | 1.5127 | 12/31/2024 |
| 10 | Norges Bank Investment Management | 100,006 | 100,006 | 23,595,415.64 | 0.0018 | 0.1013 | 12/31/2024 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | HHLR Advisors Ltd. | 1,324,406 | -3,852,500 | 312,480,351.64 | 3.1524 | 1.3421 | 03/03/2025 |
| 2 | Baker Bros. Advisors LP | 8,809,471 | -1,759,426 | 2,078,506,587.74 | 19.7466 | 8.9269 | 02/28/2025 |
| 3 | Temasek Holdings Pte Ltd. (Investment Management) | 1,525,329 | -863,247 | 359,886,124.26 | 0.9084 | 1.5457 | 12/31/2024 |
| 4 | Point72 Asset Management LP | 25,857 | -641,609 | 6,100,700.58 | 0.0151 | 0.0262 | 12/31/2024 |
| 5 | Capital Research & Management Co. (International Investors) | 6,113,165 | -317,719 | 1,442,340,150.1 | 0.2623 | 6.1946 | 12/31/2024 |
| 6 | BlackRock Fund Advisors | 446,764 | -184,642 | 105,409,498.16 | 0.0027 | 0.4527 | 03/31/2025 |
| 7 | BlackRock Advisors LLC | 1,188 | -176,821 | 280,296.72 | 0.0002 | 0.0012 | 03/31/2025 |
| 8 | Medical Strategy GmbH | 0 | -130,030 | 0 | 0 | 0 | |
| 9 | Pictet Asset Management SA | 890 | -107,239 | 209,986.6 | 0.0002 | 0.0009 | 03/31/2025 |
| 10 | Ikarian Capital LLC | 0 | -88,167 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.