| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Baker Bros. Advisors LP | 8,799,053 | -732,827 | 2,762,638,670.41 | 17.8902 | 8.9912 | 06/30/2025 |
| 2 | PRIMECAP Management Co. | 5,088,279 | -10,625 | 1,597,566,957.63 | 1.1952 | 5.1994 | 06/30/2025 |
| 3 | Capital Research & Management Co. (International Investors) | 4,885,006 | -1,228,159 | 1,533,745,333.82 | 0.2498 | 4.9917 | 06/30/2025 |
| 4 | Fidelity Management & Research Co. LLC | 3,388,932 | 1,625,591 | 1,064,022,980.04 | 0.0623 | 3.4629 | 06/30/2025 |
| 5 | HHLR Advisors Ltd. | 1,034,306 | -2,770,100 | 324,741,054.82 | 2.5794 | 1.0569 | 06/30/2025 |
| 6 | Temasek Holdings Pte Ltd. (Investment Management) | 1,010,465 | -514,864 | 317,255,696.05 | 0.7499 | 1.0325 | 06/30/2025 |
| 7 | T. Rowe Price International Ltd. | 931,897 | -512,452 | 292,587,701.09 | 0.1831 | 0.9522 | 06/30/2025 |
| 8 | Marshall Wace LLP | 467,590 | 436,428 | 146,809,232.3 | 0.1681 | 0.4778 | 06/30/2025 |
| 9 | Citadel Advisors LLC | 455,009 | 157,816 | 142,859,175.73 | 0.165 | 0.4649 | 06/30/2025 |
| 10 | BlackRock Fund Advisors | 394,136 | -50,175 | 123,746,879.92 | 0.0029 | 0.4027 | 06/30/2025 |
| 11 | Paradigm BioCapital Advisors LP | 347,787 | -268,237 | 109,194,684.39 | 3.9454 | 0.3554 | 06/30/2025 |
| 12 | Capital International, Inc. | 345,559 | -209,367 | 108,495,159.23 | 0.7082 | 0.3531 | 06/30/2025 |
| 13 | Robert W. Baird & Co., Inc. (Private Banking) | 342,442 | 46,880 | 107,516,514.74 | 0.1836 | 0.3499 | 06/30/2025 |
| 14 | Connor, Clark & Lunn Investment Management Ltd. | 302,999 | 18,605 | 95,132,596.03 | 0.2975 | 0.3096 | 06/30/2025 |
| 15 | TIAA-CREF Investment Management LLC | 298,881 | -26,864 | 93,839,667.57 | 0.0365 | 0.3054 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | American Funds New Perspective Fund | 2,372,767 | -428,951 | 744,977,654.99 | 0.4854 | 2.4246 | 06/30/2025 |
| 2 | Vanguard PRIMECAP Fund | 2,305,190 | 0 | 723,760,504.3 | 0.9528 | 2.3555 | 06/30/2025 |
| 3 | Vanguard Capital Opportunity Fund | 1,116,821 | -1,700 | 350,648,289.37 | 1.5068 | 1.1412 | 03/31/2025 |
| 4 | Fidelity Growth Company Commingled Pool | 837,342 | 54,677 | 262,900,267.74 | 0.2707 | 0.8556 | 06/30/2025 |
| 5 | PRIMECAP Odyssey Aggressive Growth Fund | 698,347 | -540 | 219,260,007.59 | 3.5724 | 0.7136 | 06/30/2025 |
| 6 | PRIMECAP Odyssey Growth Fund | 650,537 | -20,890 | 204,249,101.89 | 4.1182 | 0.6647 | 06/30/2025 |
| 7 | American Funds EuroPacific Growth Fund | 647,056 | 9,163 | 203,156,172.32 | 0.1566 | 0.6612 | 06/30/2025 |
| 8 | Fidelity Growth Company Fund | 627,301 | 73,908 | 196,953,694.97 | 0.2749 | 0.641 | 06/30/2025 |
| 9 | American Funds New World Fund | 569,629 | -585,428 | 178,846,417.13 | 0.2698 | 0.5821 | 06/30/2025 |
| 10 | Fidelity Contrafund | 520,952 | 437,952 | 163,563,299.44 | 0.0964 | 0.5323 | 06/30/2025 |
| 11 | T Rowe Price International Stock Fund | 401,347 | -250,644 | 126,010,917.59 | 0.9149 | 0.4101 | 06/30/2025 |
| 12 | iShares Biotechnology ETF | 341,062 | -49,195 | 107,083,236.14 | 1.9011 | 0.3485 | 07/31/2025 |
| 13 | CIF - Capital Group New Perspective Fund (Lux) | 278,056 | -33,551 | 87,301,242.32 | 0.4857 | 0.2841 | 06/30/2025 |
| 14 | Chautauqua International Growth Fund | 208,823 | 13,506 | 65,564,157.31 | 4.5166 | 0.2134 | 06/30/2025 |
| 15 | American Funds Global Insight Fund | 204,272 | -63,824 | 64,135,279.84 | 0.3786 | 0.2087 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Fidelity Management & Research Co. LLC | 3,388,932 | 1,625,591 | 1,064,022,980.04 | 0.0623 | 3.4629 | 06/30/2025 |
| 2 | Marshall Wace LLP | 467,590 | 436,428 | 146,809,232.3 | 0.1681 | 0.4778 | 06/30/2025 |
| 3 | Candriam Belgium SA | 280,286 | 280,286 | 88,001,395.42 | 0.2504 | 0.2864 | 06/30/2025 |
| 4 | Numeric Investors LLC | 243,861 | 234,269 | 76,565,038.17 | 0.2281 | 0.2492 | 06/30/2025 |
| 5 | Driehaus Capital Management LLC | 198,203 | 188,417 | 62,229,795.91 | 0.3657 | 0.2025 | 06/30/2025 |
| 6 | D. E. Shaw & Co. LP | 158,200 | 158,200 | 49,670,054 | 0.049 | 0.1617 | 06/30/2025 |
| 7 | Citadel Advisors LLC | 455,009 | 157,816 | 142,859,175.73 | 0.165 | 0.4649 | 06/30/2025 |
| 8 | UBS Securities LLC | 173,561 | 93,740 | 54,492,947.17 | 0.0238 | 0.1774 | 06/30/2025 |
| 9 | Qube Research & Technologies Ltd. | 107,546 | 92,353 | 33,766,217.62 | 0.0463 | 0.1099 | 06/30/2025 |
| 10 | Old Mission Capital LLC | 87,896 | 87,896 | 27,596,707.12 | 0.7443 | 0.0898 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Baillie Gifford & Co. | 0 | -3,671,195 | 0 | 0 | 0 | |
| 2 | HHLR Advisors Ltd. | 1,034,306 | -2,770,100 | 324,741,054.82 | 2.5794 | 1.0569 | 06/30/2025 |
| 3 | T. Rowe Price Associates, Inc. (IM) | 88,230 | -1,404,591 | 27,701,573.1 | 0.0034 | 0.0902 | 06/30/2025 |
| 4 | Capital Research & Management Co. (International Investors) | 4,885,006 | -1,228,159 | 1,533,745,333.82 | 0.2498 | 4.9917 | 06/30/2025 |
| 5 | Baker Bros. Advisors LP | 8,799,053 | -732,827 | 2,762,638,670.41 | 17.8902 | 8.9912 | 06/30/2025 |
| 6 | Temasek Holdings Pte Ltd. (Investment Management) | 1,010,465 | -514,864 | 317,255,696.05 | 0.7499 | 1.0325 | 06/30/2025 |
| 7 | T. Rowe Price International Ltd. | 931,897 | -512,452 | 292,587,701.09 | 0.1831 | 0.9522 | 06/30/2025 |
| 8 | Morgan Stanley & Co. LLC | 137,836 | -330,403 | 43,276,368.92 | 0.0155 | 0.1408 | 06/30/2025 |
| 9 | Paradigm BioCapital Advisors LP | 347,787 | -268,237 | 109,194,684.39 | 3.9454 | 0.3554 | 06/30/2025 |
| 10 | Capital International, Inc. | 345,559 | -209,367 | 108,495,159.23 | 0.7082 | 0.3531 | 06/30/2025 |
Data provided by FactSet Research Systems Inc.