| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Suvretta Capital Management LLC | 9,876,506 | 916,497 | 130,468,644.26 | 4.5129 | 42.1146 | 06/30/2025 |
| 2 | Janus Henderson Investors US LLC | 2,902,794 | 286,367 | 38,345,908.74 | 0.019 | 12.3779 | 06/30/2025 |
| 3 | Franklin Advisers, Inc. | 2,701,443 | -237,844 | 35,686,062.03 | 0.0164 | 11.5193 | 06/30/2025 |
| 4 | Adage Capital Management LP | 1,972,524 | 0 | 26,057,042.04 | 0.0429 | 8.4111 | 06/30/2025 |
| 5 | HBM Partners AG (Investment Management) | 1,041,669 | 0 | 13,760,447.49 | 1.6102 | 4.4418 | 12/31/2024 |
| 6 | The Vanguard Group, Inc. | 946,412 | 656,433 | 12,502,102.52 | 0.0002 | 4.0356 | 06/30/2025 |
| 7 | Nantahala Capital Management LLC | 838,095 | 0 | 11,071,234.95 | 0.6616 | 3.5737 | 06/30/2025 |
| 8 | BlackRock Fund Advisors | 661,642 | 488,422 | 8,740,290.82 | 0.0002 | 2.8213 | 06/30/2025 |
| 9 | Infinitum Asset Management LLC | 500,000 | 290,000 | 6,605,000 | 1.3644 | 2.1321 | 06/30/2025 |
| 10 | Geode Capital Management LLC | 415,211 | 218,115 | 5,484,937.31 | 0.0003 | 1.7705 | 06/30/2025 |
| 11 | Schonfeld Strategic Advisors LLC | 260,417 | 0 | 3,440,108.57 | 0.0247 | 1.1105 | 06/30/2025 |
| 12 | SilverArc Capital Management LLC | 253,234 | 253,234 | 3,345,221.14 | 0.6036 | 1.0798 | 06/30/2025 |
| 13 | SSgA Funds Management, Inc. | 161,073 | 144,983 | 2,127,774.33 | 0.0001 | 0.6868 | 06/30/2025 |
| 14 | AWM Investment Co., Inc. | 137,977 | 35,950 | 1,822,676.17 | 0.1746 | 0.5884 | 06/30/2025 |
| 15 | Northern Trust Investments, Inc.(Investment Management) | 126,322 | 88,122 | 1,668,713.62 | 0.0002 | 0.5387 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | FTIF SICAV - Biotechnology Discovery Fund | 1,495,869 | -146,330 | 19,760,429.49 | 0.9466 | 6.3786 | 07/31/2025 |
| 2 | Franklin Biotechnology Discovery Fund | 1,150,214 | -146,801 | 15,194,326.94 | 0.7155 | 4.9047 | 07/31/2025 |
| 3 | Vanguard Total Stock Market ETF | 495,117 | 495,117 | 6,540,495.57 | 0.0003 | 2.1112 | 07/31/2025 |
| 4 | Janus Henderson Horizon Fund - Biotechnology Fund | 424,247 | -16,156 | 5,604,302.87 | 0.962 | 1.809 | 06/30/2025 |
| 5 | iShares Russell 2000 ETF | 323,170 | 323,170 | 4,269,075.7 | 0.0065 | 1.378 | 07/31/2025 |
| 6 | Vanguard Extended Market Index Fund | 233,909 | -56,070 | 3,089,937.89 | 0.0037 | 0.9974 | 07/31/2025 |
| 7 | iShares Russell 2000 Growth ETF | 122,998 | 122,998 | 1,624,803.58 | 0.0133 | 0.5245 | 07/31/2025 |
| 8 | Fidelity Extended Market Index Fund | 116,450 | 17,575 | 1,538,304.5 | 0.0038 | 0.4966 | 06/30/2025 |
| 9 | Vanguard Russell 2000 Index Fund | 69,196 | 69,196 | 914,079.16 | 0.0069 | 0.2951 | 07/31/2025 |
| 10 | Simplify Health Care ETF | 67,581 | -7,562 | 892,745.01 | 0.6998 | 0.2882 | 07/31/2025 |
| 11 | FCP Medical - BioHealth | 53,858 | 53,858 | 711,464.18 | 0.0971 | 0.2297 | 05/30/2025 |
| 12 | RIM Global - Bioscience | 43,064 | -17,535 | 568,875.44 | 0.5967 | 0.1836 | 04/30/2025 |
| 13 | Fidelity Total Market Index Fund | 39,817 | 2,975 | 525,982.57 | 0.0005 | 0.1698 | 06/30/2025 |
| 14 | Schwab Small Cap Index Fund | 36,274 | 36,274 | 479,179.54 | 0.0069 | 0.1547 | 07/31/2025 |
| 15 | iShares Tr. - Micro Cap ETF | 33,095 | 27,312 | 437,184.95 | 0.0485 | 0.1411 | 07/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Suvretta Capital Management LLC | 9,876,506 | 916,497 | 130,468,644.26 | 4.5129 | 42.1146 | 06/30/2025 |
| 2 | The Vanguard Group, Inc. | 946,412 | 656,433 | 12,502,102.52 | 0.0002 | 4.0356 | 06/30/2025 |
| 3 | BlackRock Fund Advisors | 661,642 | 488,422 | 8,740,290.82 | 0.0002 | 2.8213 | 06/30/2025 |
| 4 | Infinitum Asset Management LLC | 500,000 | 290,000 | 6,605,000 | 1.3644 | 2.1321 | 06/30/2025 |
| 5 | Janus Henderson Investors US LLC | 2,902,794 | 286,367 | 38,345,908.74 | 0.019 | 12.3779 | 06/30/2025 |
| 6 | SilverArc Capital Management LLC | 253,234 | 253,234 | 3,345,221.14 | 0.6036 | 1.0798 | 06/30/2025 |
| 7 | Geode Capital Management LLC | 415,211 | 218,115 | 5,484,937.31 | 0.0003 | 1.7705 | 06/30/2025 |
| 8 | SSgA Funds Management, Inc. | 161,073 | 144,983 | 2,127,774.33 | 0.0001 | 0.6868 | 06/30/2025 |
| 9 | Northern Trust Investments, Inc.(Investment Management) | 126,322 | 88,122 | 1,668,713.62 | 0.0002 | 0.5387 | 06/30/2025 |
| 10 | ExodusPoint Capital Management LP | 76,379 | 76,379 | 1,008,966.59 | 0.0118 | 0.3257 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Franklin Advisers, Inc. | 2,701,443 | -237,844 | 35,686,062.03 | 0.0164 | 11.5193 | 06/30/2025 |
| 2 | 683 Capital Management LLC | 0 | -35,817 | 0 | 0 | 0 | |
| 3 | Qube Research & Technologies Ltd. | 0 | -20,896 | 0 | 0 | 0 | |
| 4 | Reichmuth & Co. Integrale Vermogensverwaltung AG | 43,064 | -17,535 | 568,875.44 | 0.475 | 0.1836 | 04/30/2025 |
| 5 | Morgan Stanley & Co. LLC | 34,322 | -8,045 | 453,393.62 | 0.0002 | 0.1464 | 06/30/2025 |
| 6 | Citigroup Global Markets, Inc. (Investment Management) | 5,139 | -7,324 | 67,886.19 | 0.0001 | 0.0219 | 06/30/2025 |
| 7 | Simplify Asset Management, Inc. | 69,173 | -7,164 | 913,775.33 | 0.054 | 0.295 | 06/30/2025 |
| 8 | Susquehanna Financial Group LLLP | 17,728 | -7,044 | 234,186.88 | 0.0004 | 0.0756 | 06/30/2025 |
| 9 | Vanguard Global Advisers LLC | 8,660 | -1,382 | 114,398.6 | 0 | 0.0369 | 06/30/2025 |
| 10 | NewEdge Advisors LLC | 0 | -671 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.