| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Baker Bros. Advisors LP | 10,885,357 | 1,485,397 | 88,171,391.7 | 0.8251 | 22.8155 | 03/31/2025 |
| 2 | Point72 Asset Management LP | 3,692,069 | 2,792,270 | 29,905,758.9 | 0.069 | 7.7385 | 03/31/2025 |
| 3 | Deep Track Capital LP | 2,821,171 | -726,830 | 22,851,485.1 | 0.8333 | 5.9131 | 05/15/2025 |
| 4 | Armistice Capital LLC | 2,672,000 | 716,000 | 21,643,200 | 0.5499 | 5.6005 | 03/31/2025 |
| 5 | Westfield Capital Management Co. LP | 2,657,305 | 806,360 | 21,524,170.5 | 0.0944 | 5.5697 | 03/31/2025 |
| 6 | T. Rowe Price Associates, Inc. (IM) | 1,536,584 | -185,456 | 12,446,330.4 | 0.0016 | 3.2207 | 03/31/2025 |
| 7 | Long Focus Capital Management LLC | 1,293,753 | 1,293,753 | 10,479,399.3 | 0.701 | 2.7117 | 03/31/2025 |
| 8 | BNP Paribas Asset Management USA, Inc. | 1,219,688 | 459,801 | 9,879,472.8 | 0.085 | 2.5564 | 03/31/2025 |
| 9 | Candriam Belgium SA | 1,205,207 | 154,609 | 9,762,176.7 | 0.0285 | 2.5261 | 03/31/2025 |
| 10 | RA Capital Management LP | 1,093,477 | -1,159,523 | 8,857,163.7 | 0.1364 | 2.2919 | 03/31/2025 |
| 11 | EcoR1 Capital, LLC | 910,000 | 0 | 7,371,000 | 0.4243 | 1.9073 | 03/31/2025 |
| 12 | Morgan Stanley & Co. LLC | 884,963 | -399,163 | 7,168,200.3 | 0.0026 | 1.8549 | 03/31/2025 |
| 13 | Principal Global Investors LLC | 631,260 | 188,119 | 5,113,206 | 0.0025 | 1.3231 | 03/31/2025 |
| 14 | Tybourne Capital Management (HK) Ltd. | 576,343 | -818,192 | 4,668,378.3 | 17.1053 | 1.208 | 03/31/2025 |
| 15 | Bank of America, NA (Private Banking) | 562,975 | 178,704 | 4,560,097.5 | 0.0016 | 1.18 | 03/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | T Rowe Price Health Sciences Fund | 1,168,468 | -163,809 | 9,464,590.8 | 0.0809 | 2.4491 | 03/31/2025 |
| 2 | Harbor Small Cap Growth Fund | 1,000,820 | 132,320 | 8,106,642 | 0.42 | 2.0977 | 01/31/2025 |
| 3 | BNP Paribas Funds - Health Care Innovators | 568,225 | 1,663 | 4,602,622.5 | 0.2667 | 1.191 | 04/30/2025 |
| 4 | Candriam Equities L - Biotechnology | 558,461 | 0 | 4,523,534.1 | 0.324 | 1.1705 | 10/31/2024 |
| 5 | Candriam Equities L - Oncology | 492,114 | 0 | 3,986,123.4 | 0.2477 | 1.0315 | 10/31/2024 |
| 6 | BNP Paribas Funds - US Small Cap | 473,898 | 184,279 | 3,838,573.8 | 0.2645 | 0.9933 | 04/30/2025 |
| 7 | FCP Medical - BioHealth | 376,065 | 169,535 | 3,046,126.5 | 0.4623 | 0.7882 | 01/31/2025 |
| 8 | Principal Funds, Inc. - Small Cap Fund | 288,900 | 89,200 | 2,340,090 | 0.1129 | 0.6055 | 03/31/2025 |
| 9 | AXA Framlington Health Fund | 273,983 | 0 | 2,219,262.3 | 0.35 | 0.5743 | 03/31/2025 |
| 10 | AXA Framlington Biotech Fund | 268,724 | 0 | 2,176,664.4 | 0.5419 | 0.5632 | 03/31/2025 |
| 11 | Handelsbanken Haelsovard Tema | 200,000 | 0 | 1,620,000 | 0.0833 | 0.4192 | 04/30/2025 |
| 12 | iShares Biotechnology ETF | 183,084 | -91,330 | 1,482,980.4 | 0.0281 | 0.3837 | 04/30/2025 |
| 13 | Belfius Equities - Cure | 181,974 | 0 | 1,473,989.4 | 0.2468 | 0.3814 | 10/31/2024 |
| 14 | Westfield Small/Mid Cap Growth Equity | 166,029 | -480 | 1,344,834.9 | 0.113 | 0.348 | 03/31/2025 |
| 15 | Embark Small Cap Equity Fund | 149,250 | 22,220 | 1,208,925 | 0.0699 | 0.3128 | 04/29/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Point72 Asset Management LP | 3,692,069 | 2,792,270 | 29,905,758.9 | 0.069 | 7.7385 | 03/31/2025 |
| 2 | Baker Bros. Advisors LP | 10,885,357 | 1,485,397 | 88,171,391.7 | 0.8251 | 22.8155 | 03/31/2025 |
| 3 | Long Focus Capital Management LLC | 1,293,753 | 1,293,753 | 10,479,399.3 | 0.701 | 2.7117 | 03/31/2025 |
| 4 | Westfield Capital Management Co. LP | 2,657,305 | 806,360 | 21,524,170.5 | 0.0944 | 5.5697 | 03/31/2025 |
| 5 | Armistice Capital LLC | 2,672,000 | 716,000 | 21,643,200 | 0.5499 | 5.6005 | 03/31/2025 |
| 6 | BNP Paribas Asset Management USA, Inc. | 1,219,688 | 459,801 | 9,879,472.8 | 0.085 | 2.5564 | 03/31/2025 |
| 7 | Millennium Management LLC | 453,428 | 453,428 | 3,672,766.8 | 0.0034 | 0.9504 | 03/31/2025 |
| 8 | Jefferies LLC | 408,889 | 408,889 | 3,312,000.9 | 0.326 | 0.857 | 03/31/2025 |
| 9 | Woodline Partners LP | 363,751 | 363,751 | 2,946,383.1 | 0.0184 | 0.7624 | 03/31/2025 |
| 10 | Pinnacle Associates Ltd. | 214,278 | 214,278 | 1,735,651.8 | 0.0244 | 0.4491 | 03/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | RA Capital Management LP | 1,093,477 | -1,159,523 | 8,857,163.7 | 0.1364 | 2.2919 | 03/31/2025 |
| 2 | Polar Capital LLP | 0 | -1,002,780 | 0 | 0 | 0 | |
| 3 | First Light Asset Management LLC | 0 | -967,006 | 0 | 0 | 0 | |
| 4 | Camber Capital Management LP | 0 | -915,000 | 0 | 0 | 0 | |
| 5 | Ridgeback Capital Management LLC | 0 | -844,235 | 0 | 0 | 0 | |
| 6 | Tybourne Capital Management (HK) Ltd. | 576,343 | -818,192 | 4,668,378.3 | 17.1053 | 1.208 | 03/31/2025 |
| 7 | Deep Track Capital LP | 2,821,171 | -726,830 | 22,851,485.1 | 0.8333 | 5.9131 | 05/15/2025 |
| 8 | Logos Global Management LP | 0 | -500,000 | 0 | 0 | 0 | |
| 9 | Parkman Healthcare Partners LLC | 0 | -445,396 | 0 | 0 | 0 | |
| 10 | Schonfeld Strategic Advisors LLC | 0 | -423,000 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.