| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Baker Bros. Advisors LP | 10,885,357 | 0 | 81,640,177.5 | 0.7185 | 22.8155 | 03/31/2025 |
| 2 | Point72 Asset Management LP | 3,692,069 | -862,831 | 27,690,517.5 | 0.0598 | 7.7385 | 03/31/2025 |
| 3 | Deep Track Capital LP | 2,821,171 | 1,545,090 | 21,158,782.5 | 0.6741 | 5.9131 | 05/15/2025 |
| 4 | Armistice Capital LLC | 2,672,000 | 476,000 | 20,040,000 | 0.5086 | 5.6005 | 03/31/2025 |
| 5 | Westfield Capital Management Co. LP | 2,657,305 | 46,968 | 19,929,787.5 | 0.0825 | 5.5697 | 03/31/2025 |
| 6 | T. Rowe Price Associates, Inc. (IM) | 1,536,584 | -48,543 | 11,524,380 | 0.0014 | 3.2207 | 03/31/2025 |
| 7 | Long Focus Capital Management LLC | 1,293,753 | 750,661 | 9,703,147.5 | 0.6055 | 2.7117 | 03/31/2025 |
| 8 | BNP Paribas Asset Management USA, Inc. | 1,219,688 | 64,037 | 9,147,660 | 0.0756 | 2.5564 | 03/31/2025 |
| 9 | Candriam Belgium SA | 1,205,207 | 117,331 | 9,039,052.5 | 0.0258 | 2.5261 | 03/31/2025 |
| 10 | RA Capital Management LP | 1,093,477 | 0 | 8,201,077.5 | 0.1244 | 2.2919 | 03/31/2025 |
| 11 | EcoR1 Capital, LLC | 910,000 | 0 | 6,825,000 | 0.3411 | 1.9073 | 03/31/2025 |
| 12 | Morgan Stanley & Co. LLC | 884,963 | 136,265 | 6,637,222.5 | 0.0023 | 1.8549 | 03/31/2025 |
| 13 | Principal Global Investors LLC | 631,260 | 224,790 | 4,734,450 | 0.0023 | 1.3231 | 03/31/2025 |
| 14 | Tybourne Capital Management (HK) Ltd. | 576,343 | -693,192 | 4,322,572.5 | 19.4242 | 1.208 | 03/31/2025 |
| 15 | Bank of America, NA (Private Banking) | 562,975 | 550,706 | 4,222,312.5 | 0.0014 | 1.18 | 03/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | T Rowe Price Health Sciences Fund | 1,168,468 | -30,483 | 8,763,510 | 0.0733 | 2.4491 | 03/31/2025 |
| 2 | Harbor Small Cap Growth Fund | 1,000,820 | 132,320 | 7,506,150 | 0.3689 | 2.0977 | 04/30/2025 |
| 3 | BNP Paribas Funds - Health Care Innovators | 568,225 | -108,808 | 4,261,687.5 | 0.2393 | 1.191 | 05/30/2025 |
| 4 | Candriam Equities L - Oncology | 556,312 | 0 | 4,172,340 | 0.2701 | 1.166 | 12/31/2024 |
| 5 | Candriam Equities L - Biotechnology | 531,534 | 0 | 3,986,505 | 0.2994 | 1.1141 | 12/31/2024 |
| 6 | BNP Paribas Funds - US Small Cap | 468,198 | -10,420 | 3,511,485 | 0.238 | 0.9813 | 05/30/2025 |
| 7 | FCP Medical - BioHealth | 343,416 | -16,114 | 2,575,620 | 0.3875 | 0.7198 | 04/30/2025 |
| 8 | Principal Funds, Inc. - Small Cap Fund | 289,900 | 92,800 | 2,174,250 | 0.1021 | 0.6076 | 05/31/2025 |
| 9 | AXA Framlington Biotech Fund | 268,724 | 0 | 2,015,430 | 0.4752 | 0.5632 | 05/30/2025 |
| 10 | Belfius Equities - Cure | 222,737 | 0 | 1,670,527.5 | 0.2695 | 0.4669 | 12/31/2024 |
| 11 | Handelsbanken Haelsovard Tema | 200,000 | 0 | 1,500,000 | 0.0733 | 0.4192 | 06/30/2025 |
| 12 | Westfield Small/Mid Cap Growth Equity | 174,909 | 8,400 | 1,311,817.5 | 0.1035 | 0.3666 | 05/31/2025 |
| 13 | iShares Biotechnology ETF | 166,268 | -65,368 | 1,247,010 | 0.0231 | 0.3485 | 06/30/2025 |
| 14 | Embark Small Cap Equity Fund | 138,661 | 11,631 | 1,039,957.5 | 0.0573 | 0.2906 | 06/27/2025 |
| 15 | TD Health Sciences Fund | 108,008 | 0 | 810,060 | 0.0761 | 0.2264 | 12/31/2024 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Deep Track Capital LP | 2,821,171 | 1,545,090 | 21,158,782.5 | 0.6741 | 5.9131 | 05/15/2025 |
| 2 | Long Focus Capital Management LLC | 1,293,753 | 750,661 | 9,703,147.5 | 0.6055 | 2.7117 | 03/31/2025 |
| 3 | Bank of America, NA (Private Banking) | 562,975 | 550,706 | 4,222,312.5 | 0.0014 | 1.18 | 03/31/2025 |
| 4 | Armistice Capital LLC | 2,672,000 | 476,000 | 20,040,000 | 0.5086 | 5.6005 | 03/31/2025 |
| 5 | Jefferies LLC | 408,889 | 408,889 | 3,066,667.5 | 0.2976 | 0.857 | 03/31/2025 |
| 6 | Woodline Partners LP | 363,751 | 363,751 | 2,728,132.5 | 0.0163 | 0.7624 | 03/31/2025 |
| 7 | Millennium Management LLC | 453,428 | 276,671 | 3,400,710 | 0.003 | 0.9504 | 03/31/2025 |
| 8 | Principal Global Investors LLC | 631,260 | 224,790 | 4,734,450 | 0.0023 | 1.3231 | 03/31/2025 |
| 9 | Morgan Stanley & Co. LLC | 884,963 | 136,265 | 6,637,222.5 | 0.0023 | 1.8549 | 03/31/2025 |
| 10 | Silvercrest Asset Management Group LLC | 265,693 | 127,953 | 1,992,697.5 | 0.0131 | 0.5569 | 03/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Point72 Asset Management LP | 3,692,069 | -862,831 | 27,690,517.5 | 0.0598 | 7.7385 | 03/31/2025 |
| 2 | Tybourne Capital Management (HK) Ltd. | 576,343 | -693,192 | 4,322,572.5 | 19.4242 | 1.208 | 03/31/2025 |
| 3 | BofA Securities, Inc. | 584 | -380,006 | 4,380 | 0 | 0.0012 | 03/31/2025 |
| 4 | Parkman Healthcare Partners LLC | 0 | -352,481 | 0 | 0 | 0 | |
| 5 | Verition Fund Management LLC | 0 | -280,327 | 0 | 0 | 0 | |
| 6 | Perceptive Advisors LLC | 0 | -197,108 | 0 | 0 | 0 | |
| 7 | HighVista Strategies LLC | 0 | -124,430 | 0 | 0 | 0 | |
| 8 | Springhill Fund Asset Management (HK) Co. Ltd. | 0 | -116,400 | 0 | 0 | 0 | |
| 9 | Caption Management LLC | 81,559 | -81,517 | 611,692.5 | 0.0229 | 0.1709 | 03/31/2025 |
| 10 | UBS Securities LLC | 70,280 | -59,659 | 527,100 | 0.0002 | 0.1473 | 03/31/2025 |
Data provided by FactSet Research Systems Inc.