| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Baker Bros. Advisors LP | 10,885,357 | -32,800 | 77,068,327.56 | 0.4993 | 22.8155 | 06/30/2025 |
| 2 | Armistice Capital LLC | 2,800,000 | 604,000 | 19,824,000 | 0.6089 | 5.8688 | 06/30/2025 |
| 3 | Westfield Capital Management Co. LP | 2,780,491 | 170,154 | 19,685,876.28 | 0.0794 | 5.8279 | 06/30/2025 |
| 4 | Point72 Asset Management LP | 1,772,600 | -2,782,300 | 12,550,008 | 0.0246 | 3.7153 | 06/30/2025 |
| 5 | T. Rowe Price Associates, Inc. (IM) | 1,468,393 | -116,734 | 10,396,222.44 | 0.0012 | 3.0777 | 06/30/2025 |
| 6 | Millennium Management LLC | 1,443,619 | 1,266,862 | 10,220,822.52 | 0.0087 | 3.0258 | 06/30/2025 |
| 7 | Long Focus Capital Management LLC | 1,317,293 | 774,201 | 9,326,434.44 | 0.5489 | 2.761 | 06/30/2025 |
| 8 | Deep Track Capital LP | 1,203,244 | -72,837 | 8,518,967.52 | 0.2056 | 2.522 | 06/30/2025 |
| 9 | Candriam Belgium SA | 1,172,387 | 84,511 | 8,300,499.96 | 0.0234 | 2.4573 | 06/30/2025 |
| 10 | BNP Paribas Asset Management USA, Inc. | 1,041,456 | -114,195 | 7,373,508.48 | 0.062 | 2.1829 | 06/30/2025 |
| 11 | Tybourne Capital Management (HK) Ltd. | 993,743 | -275,792 | 7,035,700.44 | 18.1125 | 2.0829 | 06/30/2025 |
| 12 | Morgan Stanley & Co. LLC | 903,685 | 154,987 | 6,398,089.8 | 0.0022 | 1.8941 | 06/30/2025 |
| 13 | Acadian Asset Management LLC | 698,501 | 698,501 | 4,945,387.08 | 0.0085 | 1.464 | 06/30/2025 |
| 14 | Principal Global Investors LLC | 697,267 | 290,797 | 4,936,650.36 | 0.0023 | 1.4615 | 06/30/2025 |
| 15 | Bank of America, NA (Private Banking) | 560,538 | 548,269 | 3,968,609.04 | 0.0013 | 1.1749 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | T Rowe Price Health Sciences Fund | 1,094,999 | -103,952 | 7,752,592.92 | 0.0672 | 2.2951 | 06/30/2025 |
| 2 | Harbor Small Cap Growth Fund | 1,000,820 | 0 | 7,085,805.6 | 0.3294 | 2.0977 | 04/30/2025 |
| 3 | BNP Paribas Funds - Health Care Innovators | 568,225 | -108,808 | 4,023,033 | 0.2155 | 1.191 | 07/31/2025 |
| 4 | Candriam Equities L - Oncology | 556,312 | 0 | 3,938,688.96 | 0.248 | 1.166 | 01/31/2025 |
| 5 | Candriam Equities L - Biotechnology | 528,184 | 0 | 3,739,542.72 | 0.2633 | 1.1071 | 01/31/2025 |
| 6 | BNP Paribas Funds - US Small Cap | 477,855 | -26,544 | 3,383,213.4 | 0.2249 | 1.0016 | 07/31/2025 |
| 7 | FCP Medical - BioHealth | 343,416 | -32,649 | 2,431,385.28 | 0.325 | 0.7198 | 05/30/2025 |
| 8 | Principal Funds, Inc. - Small Cap Fund | 338,300 | 44,100 | 2,395,164 | 0.1079 | 0.7091 | 06/30/2025 |
| 9 | AXA Framlington Biotech Fund | 268,724 | 0 | 1,902,565.92 | 0.4161 | 0.5632 | 06/30/2025 |
| 10 | Belfius Equities - Cure | 224,130 | 0 | 1,586,840.4 | 0.2479 | 0.4698 | 01/31/2025 |
| 11 | Handelsbanken Haelsovard Tema | 200,000 | 0 | 1,416,000 | 0.0671 | 0.4192 | 07/31/2025 |
| 12 | Westfield Small/Mid Cap Growth Equity | 183,932 | 17,423 | 1,302,238.56 | 0.0916 | 0.3855 | 06/30/2025 |
| 13 | iShares Biotechnology ETF | 161,890 | -61,925 | 1,146,181.2 | 0.0204 | 0.3393 | 07/31/2025 |
| 14 | Embark Small Cap Equity Fund | 117,111 | -13,443 | 829,145.88 | 0.0575 | 0.2455 | 07/31/2025 |
| 15 | TD Health Sciences Fund | 108,008 | 0 | 764,696.64 | 0.0703 | 0.2264 | 12/31/2024 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Millennium Management LLC | 1,443,619 | 1,266,862 | 10,220,822.52 | 0.0087 | 3.0258 | 06/30/2025 |
| 2 | Long Focus Capital Management LLC | 1,317,293 | 774,201 | 9,326,434.44 | 0.5489 | 2.761 | 06/30/2025 |
| 3 | Acadian Asset Management LLC | 698,501 | 698,501 | 4,945,387.08 | 0.0085 | 1.464 | 06/30/2025 |
| 4 | Armistice Capital LLC | 2,800,000 | 604,000 | 19,824,000 | 0.6089 | 5.8688 | 06/30/2025 |
| 5 | Bank of America, NA (Private Banking) | 560,538 | 548,269 | 3,968,609.04 | 0.0013 | 1.1749 | 06/30/2025 |
| 6 | Jefferies LLC | 461,100 | 461,100 | 3,264,588 | 0.3039 | 0.9665 | 06/30/2025 |
| 7 | Woodline Partners LP | 362,325 | 362,325 | 2,565,261 | 0.0129 | 0.7594 | 06/30/2025 |
| 8 | Principal Global Investors LLC | 697,267 | 290,797 | 4,936,650.36 | 0.0023 | 1.4615 | 06/30/2025 |
| 9 | Eversept Partners LP | 211,469 | 211,469 | 1,497,200.52 | 0.142 | 0.4432 | 06/30/2025 |
| 10 | Westfield Capital Management Co. LP | 2,780,491 | 170,154 | 19,685,876.28 | 0.0794 | 5.8279 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Point72 Asset Management LP | 1,772,600 | -2,782,300 | 12,550,008 | 0.0246 | 3.7153 | 06/30/2025 |
| 2 | RA Capital Management LP | 0 | -1,093,477 | 0 | 0 | 0 | |
| 3 | EcoR1 Capital, LLC | 0 | -910,000 | 0 | 0 | 0 | |
| 4 | Parkman Healthcare Partners LLC | 0 | -352,481 | 0 | 0 | 0 | |
| 5 | Verition Fund Management LLC | 0 | -280,327 | 0 | 0 | 0 | |
| 6 | Tybourne Capital Management (HK) Ltd. | 993,743 | -275,792 | 7,035,700.44 | 18.1125 | 2.0829 | 06/30/2025 |
| 7 | AXA Investment Managers UK Ltd. | 280,152 | -273,807 | 1,983,476.16 | 0.0066 | 0.5872 | 06/30/2025 |
| 8 | Aquilo Capital Management LLC | 0 | -221,911 | 0 | 0 | 0 | |
| 9 | Perceptive Advisors LLC | 0 | -197,108 | 0 | 0 | 0 | |
| 10 | Caption Management LLC | 0 | -163,076 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.