| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Baillie Gifford & Co. | 8,220,581 | -87,490 | 854,940,424 | 0.465 | 3.4582 | 12/31/2024 |
| 2 | Fidelity Management & Research Co. LLC | 5,152,432 | 291,816 | 535,852,928 | 0.0359 | 2.1675 | 12/31/2024 |
| 3 | PRIMECAP Management Co. | 4,295,817 | -220,701 | 446,764,968 | 0.3504 | 1.8071 | 12/31/2024 |
| 4 | Flossbach von Storch SE | 4,259,631 | -99,976 | 443,001,624 | 1.1534 | 1.7919 | 03/31/2025 |
| 5 | Temasek Holdings Pte Ltd. (Investment Management) | 1,807,232 | 0 | 187,952,128 | 0.478 | 0.7602 | 12/31/2024 |
| 6 | Capital Research & Management Co. (International Investors) | 1,415,566 | 394,434 | 147,218,864 | 0.0276 | 0.5955 | 12/31/2024 |
| 7 | Strategic Advisers LLC | 1,297,040 | 976,656 | 134,892,160 | 0.0562 | 0.5456 | 12/31/2024 |
| 8 | BlackRock Fund Advisors | 1,260,094 | -282,525 | 131,049,776 | 0.0035 | 0.5301 | 12/31/2024 |
| 9 | FIAM LLC | 1,252,004 | 133,075 | 130,208,416 | 0.0903 | 0.5267 | 12/31/2024 |
| 10 | Viking Global Investors LP | 940,850 | 894,556 | 97,848,400 | 0.3088 | 0.3958 | 12/31/2024 |
| 11 | Candriam Belgium SA | 846,934 | -80,230 | 88,081,136 | 0.2659 | 0.3563 | 12/31/2024 |
| 12 | Newton Investment Management North America LLC | 669,676 | 669,676 | 69,646,304 | 0.1762 | 0.2817 | 03/31/2025 |
| 13 | Capital International, Inc. | 668,315 | -262,159 | 69,504,760 | 0.5421 | 0.2811 | 12/31/2024 |
| 14 | Morgan Stanley & Co. LLC | 653,209 | 48,113 | 67,933,736 | 0.0273 | 0.2748 | 12/31/2024 |
| 15 | Altrinsic Global Advisors LLC | 627,493 | -25,213 | 65,259,272 | 1.6728 | 0.264 | 12/31/2024 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Flossbach von Storch - Multiple Opportunities | 2,850,000 | 0 | 296,400,000 | 1.2438 | 1.1989 | 09/30/2024 |
| 2 | Vanguard Capital Opportunity Fund | 2,270,916 | 0 | 236,175,264 | 1.1151 | 0.9553 | 12/31/2024 |
| 3 | Flossbach von Storch - Multiple Opportunities II | 1,331,100 | 0 | 138,434,400 | 1.2546 | 0.56 | 09/30/2024 |
| 4 | PRIMECAP Odyssey Aggressive Growth Fund | 1,137,266 | -88,236 | 118,275,664 | 1.8879 | 0.4784 | 12/31/2024 |
| 5 | iShares Biotechnology ETF | 1,055,343 | -422,377 | 109,755,672 | 1.9362 | 0.444 | 03/31/2025 |
| 6 | Fidelity Strategic Advisers US Total Stock Fund | 788,200 | 374,900 | 81,972,800 | 0.0595 | 0.3316 | 02/28/2025 |
| 7 | American Funds EuroPacific Growth Fund | 741,308 | 354,846 | 77,096,032 | 0.0633 | 0.3118 | 03/31/2025 |
| 8 | Fidelity Series Value Discovery Fund | 720,200 | 465,000 | 74,900,800 | 0.6071 | 0.303 | 02/28/2025 |
| 9 | Baillie Gifford Worldwide Funds Plc - Long Term Global Growth | 630,928 | -18,397 | 65,616,512 | 1.5294 | 0.2654 | 03/31/2025 |
| 10 | American Funds Insurance Series - Growth Fund | 562,734 | 0 | 58,524,336 | 0.1338 | 0.2367 | 03/31/2025 |
| 11 | Fidelity Puritan Fund | 492,589 | 492,589 | 51,229,256 | 0.2679 | 0.2072 | 02/28/2025 |
| 12 | Candriam Equities L - Biotechnology | 472,405 | 0 | 49,130,120 | 3.2462 | 0.1987 | 09/30/2024 |
| 13 | Deka - GlobalChampions | 470,000 | 220,000 | 48,880,000 | 0.4776 | 0.1977 | 11/30/2024 |
| 14 | Fidelity Advisor Series I - Equity Growth Fund | 417,567 | 50,000 | 43,426,968 | 0.4 | 0.1757 | 02/28/2025 |
| 15 | Fidelity Emerging Markets Fund | 394,300 | -174,900 | 41,007,200 | 0.5765 | 0.1659 | 02/28/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Strategic Advisers LLC | 1,297,040 | 976,656 | 134,892,160 | 0.0562 | 0.5456 | 12/31/2024 |
| 2 | Viking Global Investors LP | 940,850 | 894,556 | 97,848,400 | 0.3088 | 0.3958 | 12/31/2024 |
| 3 | Newton Investment Management North America LLC | 669,676 | 669,676 | 69,646,304 | 0.1762 | 0.2817 | 03/31/2025 |
| 4 | BNP Paribas Financial Markets | 614,297 | 614,297 | 63,886,888 | 0.0515 | 0.2584 | 12/31/2024 |
| 5 | Union Investment Privatfonds GmbH | 477,895 | 433,504 | 49,701,080 | 0.0399 | 0.201 | 12/31/2024 |
| 6 | Capital Research & Management Co. (International Investors) | 1,415,566 | 394,434 | 147,218,864 | 0.0276 | 0.5955 | 12/31/2024 |
| 7 | UBS Securities LLC | 411,848 | 344,293 | 42,832,192 | 0.0219 | 0.1733 | 12/31/2024 |
| 8 | Logos Global Management LP | 300,000 | 300,000 | 31,200,000 | 4.4039 | 0.1262 | 12/31/2024 |
| 9 | Fidelity Management & Research Co. LLC | 5,152,432 | 291,816 | 535,852,928 | 0.0359 | 2.1675 | 12/31/2024 |
| 10 | Macquarie Investment Management Business Trust | 235,045 | 197,782 | 24,444,680 | 0.0264 | 0.0989 | 12/31/2024 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Balyasny Asset Management LP | 0 | -620,466 | 0 | 0 | 0 | |
| 2 | Point72 Asset Management LP | 0 | -389,238 | 0 | 0 | 0 | |
| 3 | BlackRock Fund Advisors | 1,260,094 | -282,525 | 131,049,776 | 0.0035 | 0.5301 | 12/31/2024 |
| 4 | Capital International, Inc. | 668,315 | -262,159 | 69,504,760 | 0.5421 | 0.2811 | 12/31/2024 |
| 5 | PRIMECAP Management Co. | 4,295,817 | -220,701 | 446,764,968 | 0.3504 | 1.8071 | 12/31/2024 |
| 6 | Fidelity Management & Research (Hong Kong) Ltd. | 394,300 | -174,900 | 41,007,200 | 0.301 | 0.1659 | 02/28/2025 |
| 7 | Avidity Partners Management LP | 0 | -145,000 | 0 | 0 | 0 | |
| 8 | Polar Asset Management Partners, Inc. | 0 | -124,900 | 0 | 0 | 0 | |
| 9 | Bank of America, NA (Private Banking) | 3,677 | -116,345 | 382,408 | 0.0002 | 0.0015 | 12/31/2024 |
| 10 | First Trust Advisors LP | 347,688 | -103,504 | 36,159,552 | 0.0322 | 0.1463 | 12/31/2024 |
Data provided by FactSet Research Systems Inc.