| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Baillie Gifford & Co. | 8,038,872 | -181,709 | 904,775,043.6 | 0.4543 | 3.3441 | 06/30/2025 |
| 2 | Fidelity Management & Research Co. LLC | 5,868,813 | 716,381 | 660,534,903.15 | 0.0378 | 2.4413 | 06/30/2025 |
| 3 | Flossbach von Storch SE | 4,230,098 | -176,745 | 476,097,529.9 | 1.1173 | 1.7597 | 06/30/2025 |
| 4 | PRIMECAP Management Co. | 4,001,466 | -294,351 | 450,364,998.3 | 0.3339 | 1.6646 | 06/30/2025 |
| 5 | T. Rowe Price Investment Management, Inc. | 3,598,472 | 3,545,136 | 405,008,023.6 | 0.2476 | 1.4969 | 06/30/2025 |
| 6 | Temasek Holdings Pte Ltd. (Investment Management) | 1,506,027 | -301,205 | 169,503,338.85 | 0.3973 | 0.6265 | 06/30/2025 |
| 7 | BNP Paribas Financial Markets | 1,275,475 | 661,178 | 143,554,711.25 | 0.1071 | 0.5306 | 06/30/2025 |
| 8 | FIAM LLC | 1,180,469 | -71,535 | 132,861,785.95 | 0.0754 | 0.4911 | 06/30/2025 |
| 9 | Capital Research & Management Co. (International Investors) | 1,133,473 | -282,093 | 127,572,386.15 | 0.0205 | 0.4715 | 06/30/2025 |
| 10 | Strategic Advisers LLC | 1,109,729 | -187,311 | 124,899,998.95 | 0.0427 | 0.4616 | 06/30/2025 |
| 11 | BlackRock Fund Advisors | 964,535 | -295,559 | 108,558,414.25 | 0.0025 | 0.4012 | 06/30/2025 |
| 12 | Dodge & Cox | 877,437 | 877,437 | 98,755,534.35 | 0.0409 | 0.365 | 06/30/2025 |
| 13 | Newton Investment Management North America LLC | 778,188 | 778,147 | 87,585,059.4 | 0.191 | 0.3237 | 06/30/2025 |
| 14 | Franklin Templeton Institutional LLC | 679,825 | 679,825 | 76,514,303.75 | 1.761 | 0.2828 | 06/30/2025 |
| 15 | Gilder, Gagnon, Howe & Co. LLC | 667,635 | 386,223 | 75,142,319.25 | 0.7777 | 0.2777 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Flossbach von Storch - Multiple Opportunities | 2,726,536 | -123,464 | 306,871,626.8 | 1.1372 | 1.1342 | 03/31/2025 |
| 2 | Vanguard Capital Opportunity Fund | 2,162,294 | -108,622 | 243,366,189.7 | 1.0358 | 0.8995 | 03/31/2025 |
| 3 | Flossbach von Storch - Multiple Opportunities II | 1,261,959 | -69,141 | 142,033,485.45 | 1.172 | 0.525 | 03/31/2025 |
| 4 | T Rowe Price Mid Cap Growth Fund | 1,025,000 | 1,025,000 | 115,363,750 | 0.4116 | 0.4264 | 06/30/2025 |
| 5 | PRIMECAP Odyssey Aggressive Growth Fund | 975,656 | -161,610 | 109,810,082.8 | 1.7649 | 0.4059 | 06/30/2025 |
| 6 | iShares Biotechnology ETF | 915,519 | -265,113 | 103,041,663.45 | 1.834 | 0.3808 | 07/31/2025 |
| 7 | Fidelity Strategic Advisers US Total Stock Fund | 697,800 | -80,400 | 78,537,390 | 0.0468 | 0.2903 | 06/30/2025 |
| 8 | Fidelity Growth Company Commingled Pool | 625,621 | 366,156 | 70,413,643.55 | 0.0708 | 0.2602 | 06/30/2025 |
| 9 | Baillie Gifford Worldwide Funds Plc - Long Term Global Growth | 611,249 | -38,076 | 68,796,074.95 | 1.3541 | 0.2543 | 07/31/2025 |
| 10 | Deka - GlobalChampions | 600,000 | 130,000 | 67,530,000 | 0.5188 | 0.2496 | 05/31/2025 |
| 11 | Invesco Developing Markets Fund | 583,018 | 583,018 | 65,618,675.9 | 0.4463 | 0.2425 | 06/30/2025 |
| 12 | American Funds Insurance Series - Growth Fund | 562,734 | 0 | 63,335,711.7 | 0.1222 | 0.2341 | 06/30/2025 |
| 13 | Fidelity Series Value Discovery Fund | 544,700 | -175,500 | 61,305,985 | 0.4581 | 0.2266 | 06/30/2025 |
| 14 | Fidelity Growth Company Fund | 493,299 | 317,706 | 55,520,802.45 | 0.0756 | 0.2052 | 06/30/2025 |
| 15 | American Funds EuroPacific Growth Fund | 478,902 | -262,406 | 53,900,420.1 | 0.0413 | 0.1992 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | T. Rowe Price Investment Management, Inc. | 3,598,472 | 3,545,136 | 405,008,023.6 | 0.2476 | 1.4969 | 06/30/2025 |
| 2 | Dodge & Cox | 877,437 | 877,437 | 98,755,534.35 | 0.0409 | 0.365 | 06/30/2025 |
| 3 | Newton Investment Management North America LLC | 778,188 | 778,147 | 87,585,059.4 | 0.191 | 0.3237 | 06/30/2025 |
| 4 | Fidelity Management & Research Co. LLC | 5,868,813 | 716,381 | 660,534,903.15 | 0.0378 | 2.4413 | 06/30/2025 |
| 5 | Franklin Templeton Institutional LLC | 679,825 | 679,825 | 76,514,303.75 | 1.761 | 0.2828 | 06/30/2025 |
| 6 | BNP Paribas Financial Markets | 1,275,475 | 661,178 | 143,554,711.25 | 0.1071 | 0.5306 | 06/30/2025 |
| 7 | Invesco Asset Management Ltd. | 586,170 | 586,170 | 65,973,433.5 | 0.0751 | 0.2438 | 06/30/2025 |
| 8 | Gilder, Gagnon, Howe & Co. LLC | 667,635 | 386,223 | 75,142,319.25 | 0.7777 | 0.2777 | 06/30/2025 |
| 9 | abrdn Investment Management Ltd. | 336,260 | 336,260 | 37,846,063 | 0.0479 | 0.1399 | 06/30/2025 |
| 10 | Baker Bros. Advisors LP | 368,923 | 323,892 | 41,522,283.65 | 0.2709 | 0.1535 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Viking Global Investors LP | 0 | -940,850 | 0 | 0 | 0 | |
| 2 | Fred Alger Management LLC | 13,839 | -451,538 | 1,557,579.45 | 0.0069 | 0.0058 | 06/30/2025 |
| 3 | UBS Securities LLC | 78,180 | -333,668 | 8,799,159 | 0.0038 | 0.0325 | 06/30/2025 |
| 4 | Quinn Opportunity Partners LLC | 25,075 | -331,119 | 2,822,191.25 | 0.2245 | 0.0104 | 06/30/2025 |
| 5 | T. Rowe Price Associates, Inc. (IM) | 0 | -313,789 | 0 | 0 | 0 | |
| 6 | Braidwell LP | 0 | -309,865 | 0 | 0 | 0 | |
| 7 | Temasek Holdings Pte Ltd. (Investment Management) | 1,506,027 | -301,205 | 169,503,338.85 | 0.3973 | 0.6265 | 06/30/2025 |
| 8 | Logos Global Management LP | 0 | -300,000 | 0 | 0 | 0 | |
| 9 | BlackRock Fund Advisors | 964,535 | -295,559 | 108,558,414.25 | 0.0025 | 0.4012 | 06/30/2025 |
| 10 | PRIMECAP Management Co. | 4,001,466 | -294,351 | 450,364,998.3 | 0.3339 | 1.6646 | 06/30/2025 |
Data provided by FactSet Research Systems Inc.