| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Baillie Gifford & Co. | 8,159,682 | -148,389 | 869,577,310.74 | 0.4551 | 3.3943 | 03/31/2025 |
| 2 | Fidelity Management & Research Co. LLC | 4,898,644 | 38,028 | 522,048,491.08 | 0.0324 | 2.0378 | 03/31/2025 |
| 3 | Flossbach von Storch SE | 4,259,631 | -99,976 | 453,948,875.67 | 1.1487 | 1.7719 | 03/31/2025 |
| 4 | PRIMECAP Management Co. | 4,046,425 | -470,093 | 431,227,512.25 | 0.325 | 1.6833 | 03/31/2025 |
| 5 | Temasek Holdings Pte Ltd. (Investment Management) | 1,807,232 | 0 | 192,596,714.24 | 0.4557 | 0.7518 | 03/31/2025 |
| 6 | Capital Research & Management Co. (International Investors) | 1,428,441 | 407,309 | 152,228,957.37 | 0.0265 | 0.5942 | 03/31/2025 |
| 7 | FIAM LLC | 1,329,792 | 210,863 | 141,715,933.44 | 0.0861 | 0.5532 | 03/31/2025 |
| 8 | BNP Paribas Financial Markets | 1,195,470 | 1,195,470 | 127,401,237.9 | 0.0914 | 0.4973 | 03/31/2025 |
| 9 | BlackRock Fund Advisors | 1,087,120 | -455,499 | 115,854,378.4 | 0.0029 | 0.4522 | 03/31/2025 |
| 10 | Strategic Advisers LLC | 1,054,975 | 734,591 | 112,428,685.75 | 0.0419 | 0.4389 | 03/31/2025 |
| 11 | Viking Global Investors LP | 879,972 | 833,678 | 93,778,616.04 | 0.27 | 0.3661 | 03/31/2025 |
| 12 | Candriam Belgium SA | 670,955 | -256,209 | 71,503,674.35 | 0.2093 | 0.2791 | 03/31/2025 |
| 13 | Newton Investment Management North America LLC | 669,676 | 669,676 | 71,367,371.32 | 0.1675 | 0.2786 | 03/31/2025 |
| 14 | Gilder, Gagnon, Howe & Co. LLC | 649,284 | 373,453 | 69,194,195.88 | 0.7744 | 0.2701 | 03/31/2025 |
| 15 | Morgan Stanley & Co. LLC | 643,904 | 38,808 | 68,620,849.28 | 0.0251 | 0.2679 | 03/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Flossbach von Storch - Multiple Opportunities | 2,850,000 | 0 | 303,724,500 | 1.2494 | 1.1856 | 09/30/2024 |
| 2 | Vanguard Capital Opportunity Fund | 2,162,294 | -108,622 | 230,435,671.58 | 1.0296 | 0.8995 | 03/31/2025 |
| 3 | Flossbach von Storch - Multiple Opportunities II | 1,331,100 | 0 | 141,855,327 | 1.2542 | 0.5537 | 09/30/2024 |
| 4 | PRIMECAP Odyssey Aggressive Growth Fund | 1,044,356 | -181,146 | 111,297,018.92 | 1.7231 | 0.4344 | 03/31/2025 |
| 5 | iShares Biotechnology ETF | 988,815 | -408,559 | 105,378,014.55 | 1.9633 | 0.4113 | 05/30/2025 |
| 6 | Fidelity Strategic Advisers US Total Stock Fund | 897,300 | 119,100 | 95,625,261 | 0.0611 | 0.3733 | 04/30/2025 |
| 7 | American Funds EuroPacific Growth Fund | 741,308 | 354,846 | 79,001,193.56 | 0.0603 | 0.3084 | 03/31/2025 |
| 8 | Fidelity Series Value Discovery Fund | 720,200 | 13,100 | 76,751,714 | 0.6125 | 0.2996 | 04/30/2025 |
| 9 | Invesco Developing Markets Fund | 652,562 | 652,562 | 69,543,532.34 | 0.4601 | 0.2715 | 04/30/2025 |
| 10 | Baillie Gifford Worldwide Funds Plc - Long Term Global Growth | 630,928 | -18,397 | 67,237,996.96 | 1.413 | 0.2625 | 05/31/2025 |
| 11 | American Funds Insurance Series - Growth Fund | 562,734 | 0 | 59,970,562.38 | 0.124 | 0.2341 | 03/31/2025 |
| 12 | Deka - GlobalChampions | 470,000 | 0 | 50,087,900 | 0.4535 | 0.1955 | 11/30/2024 |
| 13 | Fidelity Advisor Series I - Equity Growth Fund | 442,167 | 74,600 | 47,121,737.19 | 0.3983 | 0.1839 | 04/30/2025 |
| 14 | Candriam Equities L - Biotechnology | 431,501 | 0 | 45,985,061.57 | 3.3906 | 0.1795 | 11/29/2024 |
| 15 | Fidelity Puritan Fund | 430,689 | 163,600 | 45,898,526.73 | 0.2259 | 0.1792 | 03/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | BNP Paribas Financial Markets | 1,195,470 | 1,195,470 | 127,401,237.9 | 0.0914 | 0.4973 | 03/31/2025 |
| 2 | Viking Global Investors LP | 879,972 | 833,678 | 93,778,616.04 | 0.27 | 0.3661 | 03/31/2025 |
| 3 | Strategic Advisers LLC | 1,054,975 | 734,591 | 112,428,685.75 | 0.0419 | 0.4389 | 03/31/2025 |
| 4 | Newton Investment Management North America LLC | 669,676 | 669,676 | 71,367,371.32 | 0.1675 | 0.2786 | 03/31/2025 |
| 5 | Invesco Advisers, Inc. | 551,230 | 544,164 | 58,744,581.1 | 0.0239 | 0.2293 | 03/31/2025 |
| 6 | Millennium Management LLC | 544,970 | 520,875 | 58,077,452.9 | 0.0537 | 0.2267 | 03/31/2025 |
| 7 | Capital Research & Management Co. (International Investors) | 1,428,441 | 407,309 | 152,228,957.37 | 0.0265 | 0.5942 | 03/31/2025 |
| 8 | Union Investment Privatfonds GmbH | 450,748 | 406,357 | 48,036,214.36 | 0.0379 | 0.1875 | 03/31/2025 |
| 9 | Gilder, Gagnon, Howe & Co. LLC | 649,284 | 373,453 | 69,194,195.88 | 0.7744 | 0.2701 | 03/31/2025 |
| 10 | UBS Securities LLC | 401,990 | 334,435 | 42,840,074.3 | 0.0186 | 0.1672 | 03/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Balyasny Asset Management LP | 37,756 | -582,710 | 4,023,656.92 | 0.0098 | 0.0157 | 03/31/2025 |
| 2 | PRIMECAP Management Co. | 4,046,425 | -470,093 | 431,227,512.25 | 0.325 | 1.6833 | 03/31/2025 |
| 3 | BlackRock Fund Advisors | 1,087,120 | -455,499 | 115,854,378.4 | 0.0029 | 0.4522 | 03/31/2025 |
| 4 | Fred Alger Management LLC | 61,930 | -438,914 | 6,599,880.1 | 0.0338 | 0.0258 | 03/31/2025 |
| 5 | Point72 Asset Management LP | 0 | -389,238 | 0 | 0 | 0 | |
| 6 | T. Rowe Price Associates, Inc. (IM) | 0 | -318,869 | 0 | 0 | 0 | |
| 7 | Capital International, Inc. | 638,099 | -292,375 | 68,002,210.43 | 0.4927 | 0.2654 | 03/31/2025 |
| 8 | Candriam Belgium SA | 670,955 | -256,209 | 71,503,674.35 | 0.2093 | 0.2791 | 03/31/2025 |
| 9 | Braidwell LP | 0 | -247,750 | 0 | 0 | 0 | |
| 10 | Quinn Opportunity Partners LLC | 197,946 | -206,554 | 21,095,105.22 | 1.3242 | 0.0823 | 03/31/2025 |
Data provided by FactSet Research Systems Inc.