| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Adage Capital Management LP | 8,403,000 | 3,283,973 | 147,808,770 | 0.2439 | 6.2888 | 06/30/2025 |
| 2 | Janus Henderson Investors US LLC | 6,417,466 | 1,547,110 | 112,883,226.94 | 0.0558 | 4.8028 | 06/30/2025 |
| 3 | T. Rowe Price Associates, Inc. (IM) | 5,907,992 | 543,600 | 103,921,579.28 | 0.0124 | 4.4215 | 06/30/2025 |
| 4 | Avoro Capital Advisor LLC | 5,000,000 | 5,000,000 | 87,950,000 | 1.3369 | 3.742 | 06/30/2025 |
| 5 | Farallon Capital Management LLC | 4,529,318 | 1,030,609 | 79,670,703.62 | 0.3796 | 3.3897 | 06/30/2025 |
| 6 | First Light Asset Management LLC | 4,293,411 | -1,511,773 | 75,521,099.49 | 9.416 | 3.2132 | 06/30/2025 |
| 7 | Fidelity Management & Research Co. LLC | 3,826,194 | 174,600 | 67,302,752.46 | 0.0039 | 2.8635 | 06/30/2025 |
| 8 | Commodore Capital LP | 3,298,289 | 1,079,864 | 58,016,903.51 | 3.4606 | 2.4684 | 06/30/2025 |
| 9 | Point72 Asset Management LP | 2,591,596 | -835,003 | 45,586,173.64 | 0.0919 | 1.9395 | 06/30/2025 |
| 10 | Franklin Advisers, Inc. | 2,543,539 | 234,993 | 44,740,851.01 | 0.0205 | 1.9036 | 06/30/2025 |
| 11 | Cormorant Asset Management LP | 2,086,600 | -475,000 | 36,703,294 | 2.001 | 1.5616 | 06/30/2025 |
| 12 | Millennium Management LLC | 1,657,887 | 1,259,436 | 29,162,232.33 | 0.0253 | 1.2408 | 06/30/2025 |
| 13 | Morgan Stanley & Co. LLC | 1,629,813 | -244,612 | 28,668,410.67 | 0.0101 | 1.2197 | 06/30/2025 |
| 14 | RTW Investments LP | 1,529,836 | 1,479,836 | 26,909,815.24 | 0.3432 | 1.1449 | 06/30/2025 |
| 15 | StemPoint Capital LP | 1,265,672 | 623,708 | 22,263,170.48 | 5.8985 | 0.9472 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | T Rowe Price Health Sciences Fund | 3,207,428 | -269,195 | 56,418,658.52 | 0.4943 | 2.4004 | 06/30/2025 |
| 2 | Fidelity Select Port. - Biotechnology Portfolio | 2,976,494 | 0 | 52,356,529.46 | 1.2573 | 2.2276 | 06/30/2025 |
| 3 | FTIF SICAV - Biotechnology Discovery Fund | 1,176,814 | 0 | 20,700,158.26 | 0.9875 | 0.8807 | 06/30/2025 |
| 4 | Polar Capital Funds Plc - Biotechnology Fund | 1,000,000 | 1,000,000 | 17,590,000 | 0.8526 | 0.7484 | 06/30/2025 |
| 5 | Janus Henderson Triton Fund | 965,194 | -15,363 | 16,977,762.46 | 0.2763 | 0.7223 | 03/31/2025 |
| 6 | American Century Small Cap Growth Fund | 888,011 | 33,567 | 15,620,113.49 | 0.328 | 0.6646 | 06/30/2025 |
| 7 | Fidelity VIP - Mid Cap Portfolio | 702,200 | 0 | 12,351,698 | 0.1657 | 0.5255 | 06/30/2025 |
| 8 | T Rowe Price New Horizons Fund | 679,544 | 34,906 | 11,953,178.96 | 0.0789 | 0.5086 | 06/30/2025 |
| 9 | Franklin Biotechnology Discovery Fund | 678,965 | 0 | 11,942,994.35 | 0.5815 | 0.5081 | 06/30/2025 |
| 10 | Janus Henderson Horizon Fund - Biotechnology Fund | 622,062 | 266,102 | 10,942,070.58 | 1.8753 | 0.4655 | 06/30/2025 |
| 11 | Franklin Small Cap Growth Fund | 613,403 | 184,803 | 10,789,758.77 | 0.4289 | 0.4591 | 06/30/2025 |
| 12 | T. Rowe Price Integrated U.S. Small-Cap Growth Equity Fund | 529,100 | 529,100 | 9,306,869 | 0.1134 | 0.396 | 06/30/2025 |
| 13 | Janus Henderson Venture Fund | 498,852 | 246 | 8,774,806.68 | 0.271 | 0.3733 | 03/31/2025 |
| 14 | American Funds Small Cap World Fund | 416,823 | 416,823 | 7,331,916.57 | 0.0095 | 0.3119 | 06/30/2025 |
| 15 | iShares Biotechnology ETF | 329,316 | -116,446 | 5,792,668.44 | 0.1031 | 0.2465 | 07/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Avoro Capital Advisor LLC | 5,000,000 | 5,000,000 | 87,950,000 | 1.3369 | 3.742 | 06/30/2025 |
| 2 | Adage Capital Management LP | 8,403,000 | 3,283,973 | 147,808,770 | 0.2439 | 6.2888 | 06/30/2025 |
| 3 | Janus Henderson Investors US LLC | 6,417,466 | 1,547,110 | 112,883,226.94 | 0.0558 | 4.8028 | 06/30/2025 |
| 4 | RTW Investments LP | 1,529,836 | 1,479,836 | 26,909,815.24 | 0.3432 | 1.1449 | 06/30/2025 |
| 5 | Millennium Management LLC | 1,657,887 | 1,259,436 | 29,162,232.33 | 0.0253 | 1.2408 | 06/30/2025 |
| 6 | Commodore Capital LP | 3,298,289 | 1,079,864 | 58,016,903.51 | 3.4606 | 2.4684 | 06/30/2025 |
| 7 | Balyasny Asset Management LP | 1,221,610 | 1,046,182 | 21,488,119.9 | 0.0478 | 0.9143 | 06/30/2025 |
| 8 | Farallon Capital Management LLC | 4,529,318 | 1,030,609 | 79,670,703.62 | 0.3796 | 3.3897 | 06/30/2025 |
| 9 | Polar Capital LLP | 1,000,000 | 1,000,000 | 17,590,000 | 0.0535 | 0.7484 | 06/30/2025 |
| 10 | Saturn V Capital Management LP | 793,327 | 793,327 | 13,954,621.93 | 3.6613 | 0.5937 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Perceptive Advisors LLC | 1,146,935 | -5,202,285 | 20,174,586.65 | 0.6188 | 0.8584 | 06/30/2025 |
| 2 | T. Rowe Price Investment Management, Inc. | 401 | -3,418,199 | 7,053.59 | 0 | 0.0003 | 06/30/2025 |
| 3 | First Light Asset Management LLC | 4,293,411 | -1,511,773 | 75,521,099.49 | 9.416 | 3.2132 | 06/30/2025 |
| 4 | Baker Bros. Advisors LP | 0 | -1,227,178 | 0 | 0 | 0 | |
| 5 | Avidity Partners Management LP | 0 | -1,165,800 | 0 | 0 | 0 | |
| 6 | Driehaus Capital Management LLC | 510,779 | -1,087,404 | 8,984,602.61 | 0.052 | 0.3823 | 06/30/2025 |
| 7 | Octagon Capital Advisors LP | 1,030,000 | -963,052 | 18,117,700 | 2.8581 | 0.7708 | 06/30/2025 |
| 8 | UBS Securities LLC | 206,777 | -860,449 | 3,637,207.43 | 0.0016 | 0.1548 | 06/30/2025 |
| 9 | Deep Track Capital LP | 500,000 | -850,000 | 8,795,000 | 0.2182 | 0.3742 | 06/30/2025 |
| 10 | Point72 Asset Management LP | 2,591,596 | -835,003 | 45,586,173.64 | 0.0919 | 1.9395 | 06/30/2025 |
Data provided by FactSet Research Systems Inc.