| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Deep Track Capital LP | 8,859,648 | 8,859,648 | 32,559,206.4 | 1.0005 | 9.5847 | 03/31/2025 |
| 2 | RTW Investments LP | 5,538,168 | 2,439,181 | 20,352,767.4 | 0.2941 | 5.9914 | 03/31/2025 |
| 3 | Nantahala Capital Management LLC | 2,829,232 | 1,829,232 | 10,397,427.6 | 0.6696 | 3.0608 | 03/31/2025 |
| 4 | Millennium Management LLC | 2,773,521 | -639,927 | 10,192,689.68 | 0.009 | 3.0005 | 03/31/2025 |
| 5 | Logos Global Management LP | 2,000,000 | 2,000,000 | 7,350,000 | 1.0237 | 2.1637 | 03/31/2025 |
| 6 | ARK Investment Management LLC | 1,804,803 | 68,601 | 6,632,651.02 | 0.0466 | 1.9525 | 03/31/2025 |
| 7 | GMT Capital Corp. | 1,781,718 | 233,918 | 6,547,813.65 | 0.1925 | 1.9275 | 03/31/2025 |
| 8 | Laurion Capital Management LP | 1,764,906 | 1,325,595 | 6,486,029.55 | 0.5311 | 1.9093 | 03/31/2025 |
| 9 | Woodline Partners LP | 1,754,856 | 1,292,927 | 6,449,095.8 | 0.0384 | 1.8985 | 03/31/2025 |
| 10 | Tang Capital Management LLC | 1,400,000 | 400,000 | 5,145,000 | 0.2589 | 1.5146 | 03/31/2025 |
| 11 | Aisling Capital Management LP | 1,198,418 | 233,918 | 4,404,186.15 | 1.1451 | 1.2965 | 03/31/2025 |
| 12 | UBS Securities LLC | 1,000,713 | 997,552 | 3,677,620.28 | 0.0015 | 1.0826 | 03/31/2025 |
| 13 | Rosalind Advisors, Inc. | 823,286 | 115,661 | 3,025,576.05 | 1.2478 | 0.8907 | 03/31/2025 |
| 14 | DAFNA Capital Management LLC | 711,046 | 467,836 | 2,613,094.05 | 0.6815 | 0.7692 | 03/31/2025 |
| 15 | Driehaus Capital Management LLC | 701,754 | 701,754 | 2,578,945.95 | 0.0167 | 0.7592 | 03/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | ARK Genomic Revolution ETF | 1,611,015 | -112,942 | 5,920,480.12 | 0.5579 | 1.7429 | 06/30/2025 |
| 2 | iShares Biotechnology ETF | 332,413 | 11,088 | 1,221,617.77 | 0.0223 | 0.3596 | 06/30/2025 |
| 3 | Nikko Asset Global All-Biogenome Equity Mother Fund | 255,832 | 0 | 940,182.6 | 0.5359 | 0.2768 | 12/09/2024 |
| 4 | BIT Biotech Opportunities | 242,967 | 242,967 | 892,903.72 | 2.5892 | 0.2629 | 02/28/2025 |
| 5 | AdvisorShares Psychedelics ETF | 173,541 | 106,939 | 637,763.18 | 5.7686 | 0.1877 | 06/30/2025 |
| 6 | 10XDNA - Disruptive Technologies | 147,858 | 147,858 | 543,378.15 | 0.7922 | 0.16 | 05/30/2025 |
| 7 | Saba Capital Income & Opportunities Fund | 61,188 | 0 | 224,865.9 | 0.0782 | 0.0662 | 04/30/2025 |
| 8 | ALPS Medical Breakthroughs ETF | 50,433 | -4,899 | 185,341.28 | 0.2164 | 0.0546 | 06/30/2025 |
| 9 | iShares IV Plc - NASDAQ US Biotechnology UCITS ETF | 45,415 | 20,959 | 166,900.12 | 0.0356 | 0.0491 | 06/30/2025 |
| 10 | Fidelity Nasdaq Composite Index Fund | 42,169 | 0 | 154,971.08 | 0.0008 | 0.0456 | 05/31/2025 |
| 11 | Virtus Small-Cap Fund | 31,472 | 31,472 | 115,659.6 | 0.1214 | 0.034 | 05/30/2025 |
| 12 | Invesco Markets Plc - NASDAQ Biotech UCITS ETF | 26,570 | 11,948 | 97,644.75 | 0.0357 | 0.0287 | 06/30/2025 |
| 13 | SPDR S&P International Small Cap ETF | 24,111 | -1,150 | 88,607.92 | 0.0124 | 0.0261 | 06/30/2025 |
| 14 | ARK Genomic Revolution UCITS ETF | 23,842 | 17,221 | 87,619.35 | 0.5536 | 0.0258 | 06/30/2025 |
| 15 | 10XDNA - Small & Mid Cap Technologies | 22,007 | 22,007 | 80,875.73 | 1.3429 | 0.0238 | 05/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Deep Track Capital LP | 8,859,648 | 8,859,648 | 32,559,206.4 | 1.0005 | 9.5847 | 03/31/2025 |
| 2 | RTW Investments LP | 5,538,168 | 2,439,181 | 20,352,767.4 | 0.2941 | 5.9914 | 03/31/2025 |
| 3 | Logos Global Management LP | 2,000,000 | 2,000,000 | 7,350,000 | 1.0237 | 2.1637 | 03/31/2025 |
| 4 | Nantahala Capital Management LLC | 2,829,232 | 1,829,232 | 10,397,427.6 | 0.6696 | 3.0608 | 03/31/2025 |
| 5 | Laurion Capital Management LP | 1,764,906 | 1,325,595 | 6,486,029.55 | 0.5311 | 1.9093 | 03/31/2025 |
| 6 | Woodline Partners LP | 1,754,856 | 1,292,927 | 6,449,095.8 | 0.0384 | 1.8985 | 03/31/2025 |
| 7 | UBS Securities LLC | 1,000,713 | 997,552 | 3,677,620.28 | 0.0015 | 1.0826 | 03/31/2025 |
| 8 | Driehaus Capital Management LLC | 701,754 | 701,754 | 2,578,945.95 | 0.0167 | 0.7592 | 03/31/2025 |
| 9 | 22NW LP | 646,559 | 646,559 | 2,376,104.33 | 1.0708 | 0.6995 | 03/31/2025 |
| 10 | DAFNA Capital Management LLC | 711,046 | 467,836 | 2,613,094.05 | 0.6815 | 0.7692 | 03/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Altium Capital Management LLC | 0 | -1,424,400 | 0 | 0 | 0 | |
| 2 | Affinity Asset Advisors LLC | 0 | -850,512 | 0 | 0 | 0 | |
| 3 | Millennium Management LLC | 2,773,521 | -639,927 | 10,192,689.68 | 0.009 | 3.0005 | 03/31/2025 |
| 4 | Marshall Wace LLP | 0 | -369,070 | 0 | 0 | 0 | |
| 5 | Citadel Advisors LLC | 694,402 | -204,763 | 2,551,927.35 | 0.0032 | 0.7512 | 03/31/2025 |
| 6 | Ikarian Capital LLC | 0 | -202,894 | 0 | 0 | 0 | |
| 7 | Integral Health Asset Management LLC | 0 | -200,000 | 0 | 0 | 0 | |
| 8 | Citadel Securities LLC | 51,045 | -155,466 | 187,590.38 | 0.0006 | 0.0552 | 03/31/2025 |
| 9 | Azimut Investments Ltd. | 0 | -150,000 | 0 | 0 | 0 | |
| 10 | Cubist Systematic Strategies LLC | 0 | -126,636 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.