| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Citadel Advisors LLC | 9,158,677 | 0 | 127,305,610.3 | 0.1377 | 30.8345 | 04/07/2025 |
| 2 | Baker Bros. Advisors LP | 1,461,425 | 0 | 20,313,807.5 | 0.1019 | 4.9202 | 09/30/2025 |
| 3 | Octagon Capital Advisors LP | 1,018,021 | 1,018,021 | 14,150,491.9 | 1.5961 | 3.4274 | 09/30/2025 |
| 4 | Yiheng Capital Management LP | 656,309 | 0 | 9,122,695.1 | 2.2551 | 2.2096 | 09/30/2025 |
| 5 | Great Point Partners LLC | 378,594 | 378,594 | 5,262,456.6 | 1.7161 | 1.2746 | 09/30/2025 |
| 6 | Adage Capital Management LP | 345,934 | 345,934 | 4,808,482.6 | 0.0073 | 1.1647 | 09/30/2025 |
| 7 | Millennium Management LLC | 337,863 | 337,863 | 4,696,295.7 | 0.0037 | 1.1375 | 09/30/2025 |
| 8 | Artisan Partners LP | 51,920 | 51,920 | 721,688 | 0.0006 | 0.1748 | 09/30/2025 |
| 9 | Nan Fung Trinity (HK) Ltd. | 37,095 | 37,095 | 515,620.5 | 0.0511 | 0.1249 | 09/30/2025 |
| 10 | Barclays Bank Plc (Private Banking) | 30,005 | 29,707 | 417,069.5 | 0.0002 | 0.101 | 09/30/2025 |
| 11 | DLD Asset Management LP | 25,000 | 25,000 | 347,500 | 0.0609 | 0.0842 | 09/30/2025 |
| 12 | Citadel Securities LLC | 22,049 | -13,381 | 306,481.1 | 0.0009 | 0.0742 | 09/30/2025 |
| 13 | Two Sigma Investments LP | 16,682 | 16,682 | 231,879.8 | 0.0004 | 0.0562 | 09/30/2025 |
| 14 | Optiver US LLC | 8,347 | 0 | 116,023.3 | 0.0018 | 0.0281 | 09/30/2025 |
| 15 | Morgan Stanley & Co. International Plc | 8,098 | -29,120 | 112,562.2 | 0.0011 | 0.0273 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Artisan International Small-Mid Fund | 31,768 | 31,768 | 441,575.2 | 0.0143 | 0.107 | 09/30/2025 |
| 2 | Fidelity Nasdaq Composite Index Fund | 3,877 | 0 | 53,890.3 | 0.0002 | 0.0131 | 10/31/2025 |
| 3 | Artisan Multiple Invt. Tr. - International Small-Mid Tr. | 1,034 | 1,034 | 14,372.6 | 0.014 | 0.0035 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Octagon Capital Advisors LP | 1,018,021 | 1,018,021 | 14,150,491.9 | 1.5961 | 3.4274 | 09/30/2025 |
| 2 | Great Point Partners LLC | 378,594 | 378,594 | 5,262,456.6 | 1.7161 | 1.2746 | 09/30/2025 |
| 3 | Adage Capital Management LP | 345,934 | 345,934 | 4,808,482.6 | 0.0073 | 1.1647 | 09/30/2025 |
| 4 | Millennium Management LLC | 337,863 | 337,863 | 4,696,295.7 | 0.0037 | 1.1375 | 09/30/2025 |
| 5 | Artisan Partners LP | 51,920 | 51,920 | 721,688 | 0.0006 | 0.1748 | 09/30/2025 |
| 6 | Nan Fung Trinity (HK) Ltd. | 37,095 | 37,095 | 515,620.5 | 0.0511 | 0.1249 | 09/30/2025 |
| 7 | Barclays Bank Plc (Private Banking) | 30,005 | 29,707 | 417,069.5 | 0.0002 | 0.101 | 09/30/2025 |
| 8 | DLD Asset Management LP | 25,000 | 25,000 | 347,500 | 0.0609 | 0.0842 | 09/30/2025 |
| 9 | Two Sigma Investments LP | 16,682 | 16,682 | 231,879.8 | 0.0004 | 0.0562 | 09/30/2025 |
| 10 | New York State Common Retirement Fund | 3,420 | 3,420 | 47,538 | 0.0001 | 0.0115 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | UBS Securities LLC | 148 | -163,339 | 2,057.2 | 0 | 0.0005 | 09/30/2025 |
| 2 | Cantor Fitzgerald Europe | 0 | -95,460 | 0 | 0 | 0 | |
| 3 | Morgan Stanley & Co. International Plc | 8,098 | -29,120 | 112,562.2 | 0.0011 | 0.0273 | 09/30/2025 |
| 4 | Citadel Securities LLC | 22,049 | -13,381 | 306,481.1 | 0.0009 | 0.0742 | 09/30/2025 |
| 5 | Morgan Stanley Smith Barney LLC (Investment Management) | 366 | -2,687 | 5,087.4 | 0 | 0.0012 | 09/30/2025 |
| 6 | RhumbLine Advisers LP | 3,611 | -279 | 50,192.9 | 0 | 0.0122 | 09/30/2025 |
| 7 | Desjardins Securities, Inc. | 150 | -275 | 2,085 | 0 | 0.0005 | 09/30/2025 |
| 8 | JPMorgan Securities LLC (Investment Management) | 20 | -100 | 278 | 0 | 0.0001 | 09/30/2025 |
Data provided by FactSet Research Systems Inc.