| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | EcoR1 Capital, LLC | 8,714,522 | 8,559,516 | 278,864,704 | 12.2039 | 13.2244 | 07/24/2025 |
| 2 | Tang Capital Management LLC | 3,990,111 | 1,828,911 | 127,683,552 | 5.4607 | 6.0551 | 06/30/2025 |
| 3 | Madison Avenue Partners LP | 1,877,011 | 1,877,011 | 60,064,352 | 3.0998 | 2.8484 | 06/30/2025 |
| 4 | Prosight Management LP | 1,773,649 | 748,649 | 56,756,768 | 11.9573 | 2.6915 | 06/30/2025 |
| 5 | Fidelity Management & Research Co. LLC | 1,482,996 | -34,217 | 47,455,872 | 0.0027 | 2.2505 | 06/30/2025 |
| 6 | Hudson Bay Capital Management LP | 515,000 | -39,300 | 16,480,000 | 0.1078 | 0.7815 | 06/30/2025 |
| 7 | Segall Bryant & Hamill LLC | 501,077 | -184,790 | 16,034,464 | 0.193 | 0.7604 | 06/30/2025 |
| 8 | DME Capital Management LP | 482,746 | 3,383 | 15,447,872 | 0.6504 | 0.7326 | 06/30/2025 |
| 9 | Renaissance Technologies LLC | 464,700 | 168,600 | 14,870,400 | 0.019 | 0.7052 | 06/30/2025 |
| 10 | Point72 Asset Management LP | 341,500 | 341,500 | 10,928,000 | 0.0218 | 0.5182 | 06/30/2025 |
| 11 | UBS Securities LLC | 238,434 | 162,945 | 7,629,888 | 0.0033 | 0.3618 | 06/30/2025 |
| 12 | BlackRock Fund Advisors | 192,101 | -138,506 | 6,147,232 | 0.0001 | 0.2915 | 06/30/2025 |
| 13 | Millennium Management LLC | 190,709 | 148,434 | 6,102,688 | 0.0052 | 0.2894 | 06/30/2025 |
| 14 | D. E. Shaw & Co. LP | 153,185 | 153,185 | 4,901,920 | 0.0047 | 0.2325 | 06/30/2025 |
| 15 | PRIMECAP Management Co. | 143,310 | -487,900 | 4,585,920 | 0.0034 | 0.2175 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Fidelity Advisor Series I - Equity Growth Fund | 431,371 | 0 | 13,803,872 | 0.1073 | 0.6546 | 06/30/2025 |
| 2 | Fidelity VIP - Growth Portfolio | 395,700 | 0 | 12,662,400 | 0.1085 | 0.6005 | 06/30/2025 |
| 3 | Fidelity Capital Appreciation Fund | 354,700 | 0 | 11,350,400 | 0.16 | 0.5383 | 06/30/2025 |
| 4 | Fidelity Growth Discovery Fund | 229,554 | 0 | 7,345,728 | 0.1111 | 0.3484 | 06/30/2025 |
| 5 | iShares Biotechnology ETF | 190,257 | -131,510 | 6,088,224 | 0.1073 | 0.2887 | 07/31/2025 |
| 6 | Segall Bryant & Hamill Small Cap Value Fund | 113,522 | -61,421 | 3,632,704 | 0.8457 | 0.1723 | 07/31/2025 |
| 7 | PRIMECAP Odyssey Aggressive Growth Fund | 99,800 | -431,500 | 3,193,600 | 0.0507 | 0.1514 | 06/30/2025 |
| 8 | Pacific Select Fund - Large Cap Growth Portfolio | 53,065 | -12,435 | 1,698,080 | 0.11 | 0.0805 | 06/30/2025 |
| 9 | Fidelity Advisor Series I - Series Equity Growth Fund | 49,386 | 0 | 1,580,352 | 0.1108 | 0.0749 | 06/30/2025 |
| 10 | Variable Portfolio - Partners Small Cap Value Fund | 48,609 | -11,280 | 1,555,488 | 0.3662 | 0.0738 | 06/30/2025 |
| 11 | Columbia Overseas Core Fund | 46,537 | 46,537 | 1,489,184 | 0.1458 | 0.0706 | 07/31/2025 |
| 12 | Steward International Enhanced Index Fund | 46,426 | -1,802 | 1,485,632 | 0.5764 | 0.0705 | 07/31/2025 |
| 13 | ALPS Medical Breakthroughs ETF | 31,370 | -21,657 | 1,003,840 | 1.2116 | 0.0476 | 07/31/2025 |
| 14 | Avantis International Equity ETF | 20,499 | 0 | 655,968 | 0.0078 | 0.0311 | 07/31/2025 |
| 15 | ActivePassive International Equity ETF | 19,522 | -25,757 | 624,704 | 0.0703 | 0.0296 | 07/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | EcoR1 Capital, LLC | 8,714,522 | 8,559,516 | 278,864,704 | 12.2039 | 13.2244 | 07/24/2025 |
| 2 | Madison Avenue Partners LP | 1,877,011 | 1,877,011 | 60,064,352 | 3.0998 | 2.8484 | 06/30/2025 |
| 3 | Tang Capital Management LLC | 3,990,111 | 1,828,911 | 127,683,552 | 5.4607 | 6.0551 | 06/30/2025 |
| 4 | Prosight Management LP | 1,773,649 | 748,649 | 56,756,768 | 11.9573 | 2.6915 | 06/30/2025 |
| 5 | Point72 Asset Management LP | 341,500 | 341,500 | 10,928,000 | 0.0218 | 0.5182 | 06/30/2025 |
| 6 | Renaissance Technologies LLC | 464,700 | 168,600 | 14,870,400 | 0.019 | 0.7052 | 06/30/2025 |
| 7 | UBS Securities LLC | 238,434 | 162,945 | 7,629,888 | 0.0033 | 0.3618 | 06/30/2025 |
| 8 | D. E. Shaw & Co. LP | 153,185 | 153,185 | 4,901,920 | 0.0047 | 0.2325 | 06/30/2025 |
| 9 | Millennium Management LLC | 190,709 | 148,434 | 6,102,688 | 0.0052 | 0.2894 | 06/30/2025 |
| 10 | Centiva Capital LP | 94,905 | 94,905 | 3,036,960 | 0.1943 | 0.144 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | BVF Partners LP | 0 | -1,569,422 | 0 | 0 | 0 | |
| 2 | Deep Track Capital LP | 0 | -780,778 | 0 | 0 | 0 | |
| 3 | Finepoint Capital LP | 0 | -674,762 | 0 | 0 | 0 | |
| 4 | PRIMECAP Management Co. | 143,310 | -487,900 | 4,585,920 | 0.0034 | 0.2175 | 06/30/2025 |
| 5 | Newtyn Management LLC | 0 | -270,000 | 0 | 0 | 0 | |
| 6 | Stonepine Capital Management LLC | 0 | -200,000 | 0 | 0 | 0 | |
| 7 | Segall Bryant & Hamill LLC | 501,077 | -184,790 | 16,034,464 | 0.193 | 0.7604 | 06/30/2025 |
| 8 | Vestal Point Capital LP | 0 | -180,000 | 0 | 0 | 0 | |
| 9 | BlackRock Fund Advisors | 192,101 | -138,506 | 6,147,232 | 0.0001 | 0.2915 | 06/30/2025 |
| 10 | Morgan Stanley & Co. LLC | 48,435 | -72,687 | 1,549,920 | 0.0005 | 0.0735 | 06/30/2025 |
Data provided by FactSet Research Systems Inc.