| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | HHLR Advisors Ltd. | 5,980,568 | 0 | 28,826,337.76 | 0.2249 | 7.3941 | 06/30/2025 |
| 2 | Candriam Belgium SA | 1,132,563 | 1,132,563 | 5,458,953.66 | 0.0154 | 1.4003 | 06/30/2025 |
| 3 | SG Americas Securities LLC | 876,353 | 400,491 | 4,224,021.46 | 0.0179 | 1.0835 | 06/30/2025 |
| 4 | Abaris Investment Management AG | 282,000 | 0 | 1,359,240 | 2.2213 | 0.3487 | 12/31/2024 |
| 5 | Two Sigma Advisers LP | 209,383 | -221,417 | 1,009,226.06 | 0.002 | 0.2589 | 06/30/2025 |
| 6 | UBS Securities LLC | 184,845 | 81,791 | 890,952.9 | 0.0004 | 0.2285 | 06/30/2025 |
| 7 | abrdn, Inc. | 136,471 | -26,109 | 657,790.22 | 0.0066 | 0.1687 | 06/30/2025 |
| 8 | BNP Paribas Financial Markets | 122,405 | 13,196 | 589,992.1 | 0.0004 | 0.1513 | 06/30/2025 |
| 9 | Two Sigma Investments LP | 113,262 | -216,944 | 545,922.84 | 0.001 | 0.14 | 06/30/2025 |
| 10 | Ariose Capital Management Ltd. | 96,455 | 96,455 | 464,913.1 | 0.2768 | 0.1193 | 06/30/2025 |
| 11 | Saint Olive Gestion SNC | 80,000 | 0 | 385,600 | 0.0926 | 0.0989 | 12/29/2023 |
| 12 | Alberta Investment Management Corp. | 74,723 | 0 | 360,164.86 | 0.0037 | 0.0924 | 06/30/2025 |
| 13 | Renaissance Technologies LLC | 63,700 | -100 | 307,034 | 0.0004 | 0.0788 | 06/30/2025 |
| 14 | Morgan Stanley & Co. LLC | 58,295 | -3,485,089 | 280,981.9 | 0.0001 | 0.0721 | 06/30/2025 |
| 15 | Geode Capital Management LLC | 54,562 | 32,525 | 262,988.84 | 0 | 0.0675 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Abaris Emerging Markets Equity | 124,000 | 0 | 597,680 | 4.6819 | 0.1533 | 04/30/2024 |
| 2 | Abaris Biotechnology Opportunities | 100,000 | 0 | 482,000 | 2.551 | 0.1236 | 12/31/2024 |
| 3 | BSO Bio Sante | 80,000 | 0 | 385,600 | 0.1503 | 0.0989 | 12/29/2023 |
| 4 | Abaris Defensive Equity | 58,000 | 0 | 279,560 | 1.2312 | 0.0717 | 10/31/2023 |
| 5 | Fidelity Nasdaq Composite Index Fund | 54,339 | 32,302 | 261,913.98 | 0.0013 | 0.0672 | 06/30/2025 |
| 6 | abrdn Healthcare Investors | 53,885 | 0 | 259,725.7 | 0.0262 | 0.0666 | 03/31/2025 |
| 7 | abrdn Healthcare Opportunities Fund | 43,738 | 0 | 210,817.16 | 0.0262 | 0.0541 | 07/31/2025 |
| 8 | abrdn Life Sciences Investors | 26,109 | 0 | 125,845.38 | 0.0283 | 0.0323 | 03/31/2025 |
| 9 | DFA Emerging Markets Social Core Equity Portfolio | 18,909 | 0 | 91,141.38 | 0.0049 | 0.0234 | 04/30/2025 |
| 10 | Dimensional Funds II Plc - Emerging Markets Targeted Value Fd. | 15,021 | 0 | 72,401.22 | 0.0122 | 0.0186 | 11/30/2024 |
| 11 | DFA Emerging Markets Sustainability Core 1 Portfolio | 9,306 | 0 | 44,854.92 | 0.0035 | 0.0115 | 04/30/2025 |
| 12 | ActivePassive International Equity ETF | 8,074 | 8,074 | 38,916.68 | 0.0044 | 0.01 | 07/31/2025 |
| 13 | Blackstone Alternative Multi Strategy Fund | 6,500 | -1,500 | 31,330 | 0.0015 | 0.008 | 06/30/2025 |
| 14 | DFA World (ex-US) Core Equity Portfolio | 4,515 | 0 | 21,762.3 | 0.0004 | 0.0056 | 04/30/2025 |
| 15 | Dimensional Funds Plc - Em. Mr. Co. Eq. Lo. Ca. ESG. Scr. Fd. | 1,395 | -2 | 6,723.9 | 0.0014 | 0.0017 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Candriam Belgium SA | 1,132,563 | 1,132,563 | 5,458,953.66 | 0.0154 | 1.4003 | 06/30/2025 |
| 2 | SG Americas Securities LLC | 876,353 | 400,491 | 4,224,021.46 | 0.0179 | 1.0835 | 06/30/2025 |
| 3 | Ariose Capital Management Ltd. | 96,455 | 96,455 | 464,913.1 | 0.2768 | 0.1193 | 06/30/2025 |
| 4 | UBS Securities LLC | 184,845 | 81,791 | 890,952.9 | 0.0004 | 0.2285 | 06/30/2025 |
| 5 | Susquehanna Financial Group LLLP | 37,537 | 37,537 | 180,928.34 | 0.0003 | 0.0464 | 06/30/2025 |
| 6 | CreativeOne Wealth LLC | 37,430 | 37,430 | 180,412.6 | 0.0046 | 0.0463 | 06/30/2025 |
| 7 | Geode Capital Management LLC | 54,562 | 32,525 | 262,988.84 | 0 | 0.0675 | 06/30/2025 |
| 8 | Connor, Clark & Lunn Investment Management Ltd. | 27,800 | 27,800 | 133,996 | 0.0004 | 0.0344 | 06/30/2025 |
| 9 | BNP Paribas Financial Markets | 122,405 | 13,196 | 589,992.1 | 0.0004 | 0.1513 | 06/30/2025 |
| 10 | Two Sigma Securities LLC | 12,821 | 12,821 | 61,797.22 | 0.0074 | 0.0159 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Morgan Stanley & Co. LLC | 58,295 | -3,485,089 | 280,981.9 | 0.0001 | 0.0721 | 06/30/2025 |
| 2 | Two Sigma Advisers LP | 209,383 | -221,417 | 1,009,226.06 | 0.002 | 0.2589 | 06/30/2025 |
| 3 | Two Sigma Investments LP | 113,262 | -216,944 | 545,922.84 | 0.001 | 0.14 | 06/30/2025 |
| 4 | Cantor Fitzgerald Europe | 0 | -140,100 | 0 | 0 | 0 | |
| 5 | Millennium Management LLC | 0 | -97,749 | 0 | 0 | 0 | |
| 6 | abrdn, Inc. | 136,471 | -26,109 | 657,790.22 | 0.0066 | 0.1687 | 06/30/2025 |
| 7 | Legal & General Investment Management Ltd. | 0 | -1,191 | 0 | 0 | 0 | |
| 8 | RhumbLine Advisers LP | 333 | -1,034 | 1,605.06 | 0 | 0.0004 | 06/30/2025 |
| 9 | Citadel Advisors LLC | 0 | -931 | 0 | 0 | 0 | |
| 10 | Simplex Trading LLC | 0 | -814 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.