| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | T. Rowe Price Investment Management, Inc. | 7,051,818 | 351,610 | 230,947,039.5 | 0.1429 | 14.0844 | 03/31/2025 |
| 2 | Wellington Management Co. LLP | 6,030,761 | -466,386 | 197,507,422.75 | 0.0332 | 12.0451 | 03/31/2025 |
| 3 | RTW Investments LP | 4,869,798 | 0 | 159,485,884.5 | 2.3411 | 9.7263 | 03/31/2025 |
| 4 | Fidelity Management & Research Co. LLC | 4,804,043 | 24,165 | 157,332,408.25 | 0.0094 | 9.595 | 03/31/2025 |
| 5 | PRIMECAP Management Co. | 2,678,650 | 10,100 | 87,725,787.5 | 0.0637 | 5.35 | 03/31/2025 |
| 6 | Baker Bros. Advisors LP | 2,322,656 | 807,338 | 76,066,984 | 0.6626 | 4.639 | 03/31/2025 |
| 7 | Tang Capital Management LLC | 1,915,708 | 360,108 | 62,739,437 | 3.3058 | 3.8262 | 03/31/2025 |
| 8 | T. Rowe Price Associates, Inc. (IM) | 1,887,940 | -299,590 | 61,830,035 | 0.0075 | 3.7707 | 03/31/2025 |
| 9 | Kynam Capital Management LP | 1,695,576 | 470,000 | 55,530,114 | 4.6067 | 3.3865 | 03/31/2025 |
| 10 | Deep Track Capital LP | 1,411,402 | 892,026 | 46,223,415.5 | 1.4639 | 2.819 | 03/31/2025 |
| 11 | Bellevue Asset Management AG | 1,221,794 | 16,330 | 40,013,753.5 | 0.7038 | 2.4403 | 03/31/2025 |
| 12 | Armistice Capital LLC | 978,000 | -222,000 | 32,029,500 | 0.8112 | 1.9533 | 03/31/2025 |
| 13 | Fiera Capital, Inc. | 783,868 | 24,997 | 25,671,677 | 0.3006 | 1.5656 | 03/31/2025 |
| 14 | Citigroup Global Markets, Inc. (Investment Management) | 639,288 | 6,344 | 20,936,682 | 0.0174 | 1.2768 | 03/31/2025 |
| 15 | Point72 Asset Management LP | 628,292 | 224,988 | 20,576,563 | 0.0445 | 1.2549 | 03/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Vanguard Health Care Fund | 4,582,598 | 0 | 150,080,084.5 | 0.4048 | 9.1527 | 04/30/2025 |
| 2 | T Rowe Price Small Cap Stock Fund | 1,861,666 | 126,238 | 60,969,561.5 | 0.7398 | 3.7183 | 03/31/2025 |
| 3 | Vanguard Capital Opportunity Fund | 1,756,390 | 4,000 | 57,521,772.5 | 0.247 | 3.508 | 03/31/2025 |
| 4 | Fidelity Growth Company Commingled Pool | 1,433,698 | 163,459 | 46,953,609.5 | 0.0504 | 2.8635 | 05/31/2025 |
| 5 | T Rowe Price Small Cap Value Fund | 1,257,063 | -1,183 | 41,168,813.25 | 0.4082 | 2.5107 | 03/31/2025 |
| 6 | BB Biotech AG | 1,221,794 | 16,330 | 40,013,753.5 | 1.659 | 2.4403 | 03/31/2025 |
| 7 | Fidelity Growth Company Fund | 1,019,763 | 116,379 | 33,397,238.25 | 0.0483 | 2.0368 | 05/31/2025 |
| 8 | T Rowe Price Institutional Small Cap Stock Fund | 992,497 | 82,280 | 32,504,276.75 | 0.737 | 1.9823 | 03/31/2025 |
| 9 | T Rowe Price Health Sciences Fund | 916,568 | -222,059 | 30,017,602 | 0.249 | 1.8306 | 03/31/2025 |
| 10 | PRIMECAP Odyssey Aggressive Growth Fund | 748,430 | 5,400 | 24,511,082.5 | 0.3636 | 1.4948 | 03/31/2025 |
| 11 | T. Rowe Price Funds SICAV - US Smaller Companies Equity Fund | 580,962 | 27,579 | 19,026,505.5 | 0.4027 | 1.1603 | 03/31/2025 |
| 12 | T. Rowe Price All-Cap Opportunities Fund | 520,451 | 0 | 17,044,770.25 | 0.1039 | 1.0395 | 03/31/2025 |
| 13 | Fidelity Select Port. - Health Care Portfolio | 520,000 | 8,062 | 17,030,000 | 0.2867 | 1.0386 | 05/31/2025 |
| 14 | Fidelity Advisor Health Care Fund | 340,000 | 17,448 | 11,135,000 | 0.3301 | 0.6791 | 05/31/2025 |
| 15 | Fidelity Global Innovators Investment Trust | 334,400 | 0 | 10,951,600 | 0.0575 | 0.6679 | 04/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Deep Track Capital LP | 1,411,402 | 892,026 | 46,223,415.5 | 1.4639 | 2.819 | 03/31/2025 |
| 2 | Baker Bros. Advisors LP | 2,322,656 | 807,338 | 76,066,984 | 0.6626 | 4.639 | 03/31/2025 |
| 3 | Kynam Capital Management LP | 1,695,576 | 470,000 | 55,530,114 | 4.6067 | 3.3865 | 03/31/2025 |
| 4 | Tang Capital Management LLC | 1,915,708 | 360,108 | 62,739,437 | 3.3058 | 3.8262 | 03/31/2025 |
| 5 | T. Rowe Price Investment Management, Inc. | 7,051,818 | 351,610 | 230,947,039.5 | 0.1429 | 14.0844 | 03/31/2025 |
| 6 | Point72 Asset Management LP | 628,292 | 224,988 | 20,576,563 | 0.0445 | 1.2549 | 03/31/2025 |
| 7 | Cantor Fitzgerald & Co. | 100,000 | 100,000 | 3,275,000 | 1.0581 | 0.1997 | 03/31/2025 |
| 8 | Diadema Partners LP | 96,984 | 96,984 | 3,176,226 | 2.4996 | 0.1937 | 03/31/2025 |
| 9 | Barclays Bank Plc (Private Banking) | 106,176 | 86,322 | 3,477,264 | 0.002 | 0.2121 | 03/31/2025 |
| 10 | UBS Switzerland AG (Investment Management) | 123,700 | 80,900 | 4,051,175 | 0.0112 | 0.2471 | 03/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Wellington Management Co. LLP | 6,030,761 | -466,386 | 197,507,422.75 | 0.0332 | 12.0451 | 03/31/2025 |
| 2 | T. Rowe Price Associates, Inc. (IM) | 1,887,940 | -299,590 | 61,830,035 | 0.0075 | 3.7707 | 03/31/2025 |
| 3 | Millennium Management LLC | 285,270 | -288,092 | 9,342,592.5 | 0.0082 | 0.5698 | 03/31/2025 |
| 4 | Armistice Capital LLC | 978,000 | -222,000 | 32,029,500 | 0.8112 | 1.9533 | 03/31/2025 |
| 5 | BNP Paribas Financial Markets | 40,321 | -152,794 | 1,320,512.75 | 0.0009 | 0.0805 | 03/31/2025 |
| 6 | Polar Capital LLP | 0 | -114,023 | 0 | 0 | 0 | |
| 7 | Two Sigma Investments LP | 305,364 | -85,436 | 10,000,671 | 0.0197 | 0.6099 | 03/31/2025 |
| 8 | Two Sigma Advisers LP | 523,400 | -81,500 | 17,141,350 | 0.034 | 1.0454 | 03/31/2025 |
| 9 | Squarepoint OPS LLC | 0 | -69,954 | 0 | 0 | 0 | |
| 10 | Jefferies Investment Advisers LLC | 110,101 | -54,899 | 3,605,807.75 | 0.0681 | 0.2199 | 03/31/2025 |
Data provided by FactSet Research Systems Inc.