| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | T. Rowe Price Investment Management, Inc. | 7,067,659 | 367,451 | 232,738,010.87 | 0.1405 | 14.0696 | 06/30/2025 |
| 2 | Wellington Management Co. LLP | 5,132,898 | -1,364,249 | 169,026,331.14 | 0.0279 | 10.2181 | 07/31/2025 |
| 3 | RTW Investments LP | 4,869,798 | 0 | 160,362,448.14 | 1.9886 | 9.6943 | 06/30/2025 |
| 4 | Fidelity Management & Research Co. LLC | 4,819,349 | 39,471 | 158,701,162.57 | 0.0092 | 9.5939 | 06/30/2025 |
| 5 | PRIMECAP Management Co. | 3,771,474 | 1,102,924 | 124,194,638.82 | 0.0911 | 7.5079 | 06/30/2025 |
| 6 | Bellevue Asset Management AG | 2,441,830 | 1,236,366 | 80,409,461.9 | 1.3432 | 4.8609 | 06/30/2025 |
| 7 | Baker Bros. Advisors LP | 2,322,656 | 807,338 | 76,485,062.08 | 0.4915 | 4.6237 | 06/30/2025 |
| 8 | Tang Capital Management LLC | 2,105,608 | 550,008 | 69,337,671.44 | 2.9654 | 4.1916 | 06/30/2025 |
| 9 | Deep Track Capital LP | 1,800,000 | 1,280,624 | 59,274,000 | 1.4301 | 3.5833 | 06/30/2025 |
| 10 | BVF Partners LP | 1,024,288 | 1,024,288 | 33,729,803.84 | 0.9553 | 2.039 | 06/30/2025 |
| 11 | T. Rowe Price Associates, Inc. (IM) | 1,005,592 | -1,181,938 | 33,114,144.56 | 0.004 | 2.0018 | 06/30/2025 |
| 12 | Kynam Capital Management LP | 976,267 | -249,309 | 32,148,472.31 | 2.8845 | 1.9435 | 06/30/2025 |
| 13 | Point72 Asset Management LP | 820,425 | 417,121 | 27,016,595.25 | 0.0538 | 1.6332 | 06/30/2025 |
| 14 | Fiera Capital, Inc. | 790,810 | 31,939 | 26,041,373.3 | 0.296 | 1.5743 | 06/30/2025 |
| 15 | Armistice Capital LLC | 678,000 | -522,000 | 22,326,540 | 0.6897 | 1.3497 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Vanguard Health Care Fund | 4,582,598 | 0 | 150,904,952.14 | 0.398 | 9.1226 | 04/30/2025 |
| 2 | T Rowe Price Small Cap Stock Fund | 2,057,637 | 322,209 | 67,757,986.41 | 0.8052 | 4.0961 | 06/30/2025 |
| 3 | Vanguard Capital Opportunity Fund | 1,756,390 | 4,000 | 57,837,922.7 | 0.2434 | 3.4964 | 03/31/2025 |
| 4 | Fidelity Growth Company Commingled Pool | 1,442,142 | 171,746 | 47,489,736.06 | 0.0481 | 2.8709 | 06/30/2025 |
| 5 | BB Biotech AG | 1,221,794 | 16,330 | 40,233,676.42 | 1.5401 | 2.4322 | 03/31/2025 |
| 6 | PRIMECAP Odyssey Aggressive Growth Fund | 1,113,605 | 370,575 | 36,671,012.65 | 0.582 | 2.2169 | 06/30/2025 |
| 7 | T Rowe Price Institutional Small Cap Stock Fund | 1,079,245 | 169,028 | 35,539,537.85 | 0.8355 | 2.1485 | 06/30/2025 |
| 8 | T Rowe Price Small Cap Value Fund | 1,073,849 | -184,397 | 35,361,847.57 | 0.3457 | 2.1377 | 06/30/2025 |
| 9 | Fidelity Growth Company Fund | 1,019,763 | 118,224 | 33,580,795.59 | 0.046 | 2.03 | 06/30/2025 |
| 10 | T Rowe Price Health Sciences Fund | 773,698 | -364,929 | 25,477,875.14 | 0.2202 | 1.5402 | 06/30/2025 |
| 11 | Fidelity Select Port. - Health Care Portfolio | 520,000 | 8,062 | 17,123,600 | 0.2803 | 1.0352 | 06/30/2025 |
| 12 | T. Rowe Price Funds SICAV - US Smaller Companies Equity Fund | 485,689 | -67,694 | 15,993,738.77 | 0.463 | 0.9669 | 06/30/2025 |
| 13 | Fidelity Advisor Health Care Fund | 340,000 | 17,448 | 11,196,200 | 0.3242 | 0.6768 | 06/30/2025 |
| 14 | Fidelity Growth Company K6 Fund | 312,036 | 27,490 | 10,275,345.48 | 0.0475 | 0.6212 | 06/30/2025 |
| 15 | MFS New Discovery Fund | 304,295 | 0 | 10,020,434.35 | 0.4642 | 0.6058 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Deep Track Capital LP | 1,800,000 | 1,280,624 | 59,274,000 | 1.4301 | 3.5833 | 06/30/2025 |
| 2 | Bellevue Asset Management AG | 2,441,830 | 1,236,366 | 80,409,461.9 | 1.3432 | 4.8609 | 06/30/2025 |
| 3 | PRIMECAP Management Co. | 3,771,474 | 1,102,924 | 124,194,638.82 | 0.0911 | 7.5079 | 06/30/2025 |
| 4 | BVF Partners LP | 1,024,288 | 1,024,288 | 33,729,803.84 | 0.9553 | 2.039 | 06/30/2025 |
| 5 | Baker Bros. Advisors LP | 2,322,656 | 807,338 | 76,485,062.08 | 0.4915 | 4.6237 | 06/30/2025 |
| 6 | Logos Global Management LP | 575,000 | 575,000 | 18,934,750 | 2.1406 | 1.1447 | 06/30/2025 |
| 7 | Tang Capital Management LLC | 2,105,608 | 550,008 | 69,337,671.44 | 2.9654 | 4.1916 | 06/30/2025 |
| 8 | Point72 Asset Management LP | 820,425 | 417,121 | 27,016,595.25 | 0.0538 | 1.6332 | 06/30/2025 |
| 9 | T. Rowe Price Investment Management, Inc. | 7,067,659 | 367,451 | 232,738,010.87 | 0.1405 | 14.0696 | 06/30/2025 |
| 10 | Caption Management LLC | 179,503 | 179,503 | 5,911,033.79 | 0.5043 | 0.3573 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Wellington Management Co. LLP | 5,132,898 | -1,364,249 | 169,026,331.14 | 0.0279 | 10.2181 | 07/31/2025 |
| 2 | T. Rowe Price Associates, Inc. (IM) | 1,005,592 | -1,181,938 | 33,114,144.56 | 0.004 | 2.0018 | 06/30/2025 |
| 3 | Armistice Capital LLC | 678,000 | -522,000 | 22,326,540 | 0.6897 | 1.3497 | 06/30/2025 |
| 4 | Millennium Management LLC | 276,502 | -296,860 | 9,105,210.86 | 0.0078 | 0.5504 | 06/30/2025 |
| 5 | Kynam Capital Management LP | 976,267 | -249,309 | 32,148,472.31 | 2.8845 | 1.9435 | 06/30/2025 |
| 6 | Jefferies Investment Advisers LLC | 0 | -165,000 | 0 | 0 | 0 | |
| 7 | BNP Paribas Financial Markets | 38,176 | -154,939 | 1,257,135.68 | 0.0009 | 0.076 | 06/30/2025 |
| 8 | Polar Capital LLP | 0 | -114,023 | 0 | 0 | 0 | |
| 9 | Two Sigma Advisers LP | 512,430 | -92,470 | 16,874,319.9 | 0.0333 | 1.0201 | 06/30/2025 |
| 10 | Woodline Partners LP | 246,498 | -81,561 | 8,117,179.14 | 0.041 | 0.4907 | 06/30/2025 |
Data provided by FactSet Research Systems Inc.