| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Janus Henderson Investors US LLC | 22,735,121 | 5,612,558 | 62,748,933.96 | 0.0319 | 14.6541 | 03/31/2025 |
| 2 | Rubric Capital Management LP | 15,307,347 | 0 | 42,248,277.72 | 0.6962 | 9.8664 | 03/31/2025 |
| 3 | Mangrove Partners IM LLC | 8,636,485 | 0 | 23,836,698.6 | 2.4511 | 5.5667 | 03/31/2025 |
| 4 | Rock Springs Capital Management LP | 6,684,247 | -2,914,923 | 18,448,521.72 | 0.9965 | 4.3084 | 03/31/2025 |
| 5 | Alkeon Capital Management LLC | 4,698,100 | 0 | 12,966,756 | 0.0617 | 3.0282 | 03/31/2025 |
| 6 | 683 Capital Management LLC | 4,635,000 | 85,000 | 12,792,600 | 1.1795 | 2.9875 | 03/31/2025 |
| 7 | Clearline Capital LP | 3,217,894 | 0 | 8,881,387.44 | 0.7471 | 2.0741 | 03/31/2025 |
| 8 | Tejara Capital Ltd. | 2,521,324 | 204,239 | 6,958,854.24 | 3.3697 | 1.6251 | 03/31/2025 |
| 9 | abrdn, Inc. | 2,188,354 | 2,188,354 | 6,039,857.04 | 0.0587 | 1.4105 | 03/31/2025 |
| 10 | Morgan Stanley & Co. LLC | 2,175,605 | -1,368,696 | 6,004,669.8 | 0.0021 | 1.4023 | 03/31/2025 |
| 11 | Goldman Sachs & Co. LLC (Private Banking) | 2,125,920 | 6,068 | 5,867,539.2 | 0.0031 | 1.3703 | 03/31/2025 |
| 12 | Adage Capital Management LP | 1,700,756 | -7,014,257 | 4,694,086.56 | 0.0079 | 1.0962 | 03/31/2025 |
| 13 | Schonfeld Strategic Advisors LLC | 1,591,056 | 1,097,156 | 4,391,314.56 | 0.0267 | 1.0255 | 03/31/2025 |
| 14 | UBS Asset Management Switzerland AG | 1,569,100 | 604,200 | 4,330,716 | 0.0012 | 1.0114 | 03/31/2025 |
| 15 | Renaissance Technologies LLC | 1,350,471 | 161,000 | 3,727,299.96 | 0.0051 | 0.8705 | 03/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | abrdn World Healthcare Fund | 1,681,804 | 1,681,804 | 4,641,779.04 | 0.9788 | 1.084 | 05/31/2025 |
| 2 | UBS (Lux) Equity Fund - Biotech (USD) | 1,569,100 | 593,500 | 4,330,716 | 1.1316 | 1.0114 | 03/31/2025 |
| 3 | abrdn Life Sciences Investors | 812,053 | 812,053 | 2,241,266.28 | 0.545 | 0.5234 | 03/31/2025 |
| 4 | Fidelity Advisor Series VII - Biotechnology Fund | 759,100 | 759,100 | 2,095,116 | 0.1567 | 0.4893 | 05/31/2025 |
| 5 | iShares Genomics Immunology & Healthcare ETF | 347,993 | 98,541 | 960,460.68 | 0.9039 | 0.2243 | 06/27/2025 |
| 6 | HealthInvest Sustainable Healthcare | 270,000 | 0 | 745,200 | 0.2867 | 0.174 | 12/31/2024 |
| 7 | BIT Biotech Opportunities | 190,059 | 190,059 | 524,562.84 | 1.5995 | 0.1225 | 02/28/2025 |
| 8 | Fubon NYSE FactSet Global Genomics and Immuno Biopharma ETF | 143,161 | 45,292 | 395,124.36 | 0.9009 | 0.0923 | 06/30/2025 |
| 9 | HealthInvest Small & Micro Cap Fund | 120,000 | 0 | 331,200 | 0.4027 | 0.0773 | 12/31/2024 |
| 10 | Fidelity Nasdaq Composite Index Fund | 92,156 | 0 | 254,350.56 | 0.0013 | 0.0594 | 05/31/2025 |
| 11 | Tema Heart & Health ETF | 62,500 | -478,231 | 172,500 | 0.3381 | 0.0403 | 06/30/2025 |
| 12 | SPDR S&P International Small Cap ETF | 44,942 | -2,143 | 124,039.92 | 0.0175 | 0.029 | 06/30/2025 |
| 13 | Tema Oncology ETF | 40,083 | -309,734 | 110,629.08 | 0.1536 | 0.0258 | 06/30/2025 |
| 14 | Virtus LifeSci Biotech Clinical Trials ETF | 33,341 | 14,281 | 92,021.16 | 0.8627 | 0.0215 | 06/30/2025 |
| 15 | Arctic Funds Plc - Aurora Biotech Select | 16,904 | 565 | 46,655.04 | 1.229 | 0.0109 | 04/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Janus Henderson Investors US LLC | 22,735,121 | 5,612,558 | 62,748,933.96 | 0.0319 | 14.6541 | 03/31/2025 |
| 2 | abrdn, Inc. | 2,188,354 | 2,188,354 | 6,039,857.04 | 0.0587 | 1.4105 | 03/31/2025 |
| 3 | Schonfeld Strategic Advisors LLC | 1,591,056 | 1,097,156 | 4,391,314.56 | 0.0267 | 1.0255 | 03/31/2025 |
| 4 | Fidelity Management & Research Co. LLC | 759,100 | 759,100 | 2,095,116 | 0.0001 | 0.4893 | 03/31/2025 |
| 5 | UBS Asset Management Switzerland AG | 1,569,100 | 604,200 | 4,330,716 | 0.0012 | 1.0114 | 03/31/2025 |
| 6 | Diadema Partners LP | 492,215 | 492,215 | 1,358,513.4 | 1.0895 | 0.3173 | 03/31/2025 |
| 7 | Bank of America, NA (Private Banking) | 437,602 | 436,350 | 1,207,781.52 | 0.0004 | 0.2821 | 03/31/2025 |
| 8 | Woodline Partners LP | 947,986 | 329,202 | 2,616,441.36 | 0.0157 | 0.611 | 03/31/2025 |
| 9 | Citadel Advisors LLC | 343,653 | 278,309 | 948,482.28 | 0.0012 | 0.2215 | 03/31/2025 |
| 10 | Tejara Capital Ltd. | 2,521,324 | 204,239 | 6,958,854.24 | 3.3697 | 1.6251 | 03/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Adage Capital Management LP | 1,700,756 | -7,014,257 | 4,694,086.56 | 0.0079 | 1.0962 | 03/31/2025 |
| 2 | Millennium Management LLC | 394,431 | -3,571,001 | 1,088,629.56 | 0.001 | 0.2542 | 03/31/2025 |
| 3 | Rock Springs Capital Management LP | 6,684,247 | -2,914,923 | 18,448,521.72 | 0.9965 | 4.3084 | 03/31/2025 |
| 4 | UBS Securities LLC | 558,597 | -1,727,794 | 1,541,727.72 | 0.0006 | 0.36 | 03/31/2025 |
| 5 | Morgan Stanley & Co. LLC | 2,175,605 | -1,368,696 | 6,004,669.8 | 0.0021 | 1.4023 | 03/31/2025 |
| 6 | Eversept Partners LP | 0 | -777,890 | 0 | 0 | 0 | |
| 7 | Citadel Securities LLC | 0 | -248,606 | 0 | 0 | 0 | |
| 8 | Verition Fund Management LLC | 0 | -237,777 | 0 | 0 | 0 | |
| 9 | Tema ETFs LLC | 654,666 | -235,882 | 1,806,878.16 | 0.4841 | 0.422 | 03/31/2025 |
| 10 | Susquehanna Financial Group LLLP | 174,378 | -217,212 | 481,283.28 | 0.0007 | 0.1124 | 03/31/2025 |
Data provided by FactSet Research Systems Inc.