| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Legal & General Investment Management Ltd. | 651,416 | 651,416 | 11,771,087.12 | 0.0038 | 0.5077 | 09/30/2025 |
| 2 | Morgan Stanley & Co. International Plc | 413,522 | 100,000 | 7,472,342.54 | 0.0705 | 0.3223 | 09/30/2025 |
| 3 | Goldman Sachs & Co. LLC (Private Banking) | 407,280 | 150,137 | 7,359,549.6 | 0.0032 | 0.3175 | 09/30/2025 |
| 4 | BlackRock Fund Advisors | 376,171 | -189,716 | 6,797,409.97 | 0.0001 | 0.2932 | 09/30/2025 |
| 5 | Susquehanna Financial Group LLLP | 271,488 | 10,547 | 4,905,788.16 | 0.0075 | 0.2116 | 09/30/2025 |
| 6 | UBS Securities LLC | 150,203 | 12,868 | 2,714,168.21 | 0.0011 | 0.1171 | 09/30/2025 |
| 7 | Aperio Group LLC | 137,228 | 4,739 | 2,479,709.96 | 0.0019 | 0.107 | 09/30/2025 |
| 8 | BofA Securities, Inc. | 105,092 | 100,575 | 1,899,012.44 | 0.0033 | 0.0819 | 09/30/2025 |
| 9 | RBC Dominion Securities, Inc. (Investment Management) | 90,827 | 80,827 | 1,641,243.89 | 0.0011 | 0.0708 | 09/30/2025 |
| 10 | Penbrook Management LLC | 87,675 | 0 | 1,584,287.25 | 1.0841 | 0.0683 | 09/30/2025 |
| 11 | Prosperity Wealth Management, Inc. | 49,950 | 1,250 | 902,596.5 | 0.3096 | 0.0389 | 09/30/2025 |
| 12 | LPL Financial LLC | 49,847 | 9,840 | 900,735.29 | 0.0003 | 0.0389 | 09/30/2025 |
| 13 | Rockbridge Investment Management LLC | 49,150 | 0 | 888,140.5 | 0.0863 | 0.0383 | 09/30/2025 |
| 14 | Lazari Capital Management, Inc. | 46,671 | 1,203 | 843,344.97 | 0.2812 | 0.0364 | 09/30/2025 |
| 15 | Morgan Stanley & Co. LLC | 43,065 | -181,194 | 778,184.55 | 0.0003 | 0.0336 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | iShares Biotechnology ETF | 477,913 | -58,330 | 8,635,887.91 | 0.1007 | 0.3725 | 11/28/2025 |
| 2 | Legal & General UCITS ETF Plc - Pharma Breakthrough | 33,469 | 33,469 | 604,784.83 | 3.1372 | 0.0261 | 11/28/2025 |
| 3 | iShares IV Plc - NASDAQ US Biotechnology UCITS ETF | 31,684 | 15,702 | 572,529.88 | 0.0679 | 0.0247 | 11/28/2025 |
| 4 | Fidelity Nasdaq Composite Index Fund | 30,737 | 12,492 | 555,417.59 | 0.0024 | 0.024 | 10/31/2025 |
| 5 | Invesco Markets Plc - NASDAQ Biotech UCITS ETF | 16,679 | 7,210 | 301,389.53 | 0.0684 | 0.013 | 11/28/2025 |
| 6 | China Universal Nasdaq Biotechnology Index ETF | 9,124 | 2,348 | 164,870.68 | 0.0701 | 0.0071 | 06/30/2025 |
| 7 | ActivePassive International Equity ETF | 3,893 | -297 | 70,346.51 | 0.0074 | 0.003 | 11/28/2025 |
| 8 | Mirae Asset Tiger NASDAQ Bio ETF | 2,322 | 901 | 41,958.54 | 0.0687 | 0.0018 | 11/28/2025 |
| 9 | ProShares Ultra NASDAQ Biotechnology | 2,205 | 954 | 39,844.35 | 0.046 | 0.0017 | 11/28/2025 |
| 10 | Invesco Nasdaq Biotechnology ETF | 2,156 | 822 | 38,958.92 | 0.0681 | 0.0017 | 11/28/2025 |
| 11 | Xtrackers IE Plc - MSCI Genomic Healthcare Innov UCITS ETF | 1,328 | 1,328 | 23,996.96 | 0.3176 | 0.001 | 11/28/2025 |
| 12 | GF Nasdaq Biotechnology Index Fund | 817 | 146 | 14,763.19 | 0.0429 | 0.0006 | 06/30/2025 |
| 13 | DFA International Core Equity 2 Portfolio | 796 | 0 | 14,383.72 | 0 | 0.0006 | 09/30/2025 |
| 14 | Capital Nasdaq Biotechnology Index ETF | 135 | 0 | 2,439.45 | 0.0262 | 0.0001 | 11/28/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Legal & General Investment Management Ltd. | 651,416 | 651,416 | 11,771,087.12 | 0.0038 | 0.5077 | 09/30/2025 |
| 2 | Goldman Sachs & Co. LLC (Private Banking) | 407,280 | 150,137 | 7,359,549.6 | 0.0032 | 0.3175 | 09/30/2025 |
| 3 | BofA Securities, Inc. | 105,092 | 100,575 | 1,899,012.44 | 0.0033 | 0.0819 | 09/30/2025 |
| 4 | Morgan Stanley & Co. International Plc | 413,522 | 100,000 | 7,472,342.54 | 0.0705 | 0.3223 | 09/30/2025 |
| 5 | RBC Dominion Securities, Inc. (Investment Management) | 90,827 | 80,827 | 1,641,243.89 | 0.0011 | 0.0708 | 09/30/2025 |
| 6 | UBS Switzerland AG (Investment Management) | 31,159 | 27,999 | 563,043.13 | 0.0012 | 0.0243 | 09/30/2025 |
| 7 | Two Sigma Investments LP | 25,849 | 25,849 | 467,091.43 | 0.0007 | 0.0201 | 09/30/2025 |
| 8 | 49 Wealth Management LLC | 18,279 | 18,279 | 330,301.53 | 0.0307 | 0.0142 | 09/30/2025 |
| 9 | Squarepoint OPS LLC | 31,656 | 16,596 | 572,023.92 | 0.0012 | 0.0247 | 09/30/2025 |
| 10 | XTX Markets LLC | 15,751 | 15,751 | 284,620.57 | 0.0144 | 0.0123 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Citadel Securities LLC | 0 | -486,793 | 0 | 0 | 0 | |
| 2 | Summit X LLC | 0 | -198,163 | 0 | 0 | 0 | |
| 3 | BlackRock Fund Advisors | 376,171 | -189,716 | 6,797,409.97 | 0.0001 | 0.2932 | 09/30/2025 |
| 4 | Morgan Stanley & Co. LLC | 43,065 | -181,194 | 778,184.55 | 0.0003 | 0.0336 | 09/30/2025 |
| 5 | Group One Trading LLC | 0 | -151,231 | 0 | 0 | 0 | |
| 6 | TD Securities (USA) LLC | 0 | -150,000 | 0 | 0 | 0 | |
| 7 | Cubist Systematic Strategies LLC | 0 | -71,891 | 0 | 0 | 0 | |
| 8 | Marshall Wace LLP | 0 | -71,651 | 0 | 0 | 0 | |
| 9 | Oasis Management (Hong Kong) LLC | 0 | -41,450 | 0 | 0 | 0 | |
| 10 | XY Capital Ltd. | 0 | -27,755 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.