| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Redmile Group LLC | 2,164,777 | -234,540 | 10,412,577.37 | 0.9218 | 4.6395 | 06/30/2025 |
| 2 | Lombard Odier Asset Management (USA) Corp. | 1,849,734 | -6,289 | 8,897,220.54 | 1.7223 | 3.9643 | 06/30/2025 |
| 3 | Morgan Stanley & Co. LLC | 1,129,399 | -521,432 | 5,432,409.19 | 0.0019 | 2.4205 | 06/30/2025 |
| 4 | Nantahala Capital Management LLC | 1,042,427 | -7,249 | 5,014,073.87 | 0.2948 | 2.2341 | 06/30/2025 |
| 5 | Ikarian Capital LLC | 873,568 | 873,568 | 4,201,862.08 | 1.2066 | 1.8722 | 06/30/2025 |
| 6 | Cantor Fitzgerald Europe | 789,039 | 249,313 | 3,795,277.59 | 0.797 | 1.691 | 06/30/2025 |
| 7 | SG Americas Securities LLC | 308,331 | -9,297 | 1,483,072.11 | 0.0062 | 0.6608 | 06/30/2025 |
| 8 | Boothbay Fund Management LLC | 252,421 | -99,106 | 1,214,145.01 | 0.0355 | 0.541 | 06/30/2025 |
| 9 | UBS Securities LLC | 217,212 | -137,659 | 1,044,789.72 | 0.0004 | 0.4655 | 06/30/2025 |
| 10 | Millennium Management LLC | 198,647 | -274,905 | 955,492.07 | 0.0008 | 0.4257 | 06/30/2025 |
| 11 | M28 Capital Management LP | 185,100 | 0 | 890,331 | 0.734 | 0.3967 | 06/30/2025 |
| 12 | Marshall Wace LLP | 175,862 | -313,027 | 845,896.22 | 0.001 | 0.3769 | 06/30/2025 |
| 13 | HSBC Bank Plc (Broker) | 172,834 | 0 | 831,331.54 | 0.002 | 0.3704 | 06/30/2025 |
| 14 | BlackRock Fund Advisors | 146,852 | -42,056 | 706,358.12 | 0 | 0.3147 | 06/30/2025 |
| 15 | BMO Asset Management, Inc. | 140,812 | 78,805 | 677,305.72 | 0.0004 | 0.3018 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | iShares Biotechnology ETF | 143,489 | -40,349 | 690,182.09 | 0.0123 | 0.3075 | 07/31/2025 |
| 2 | Galileo - Biotech Innovation Fund | 58,645 | 0 | 282,082.45 | 0.9612 | 0.1257 | 12/31/2024 |
| 3 | RIM Global - Bioscience | 57,858 | 23,058 | 278,296.98 | 0.2873 | 0.124 | 04/30/2025 |
| 4 | iShares IV Plc - NASDAQ US Biotechnology UCITS ETF | 29,774 | 7,023 | 143,212.94 | 0.0245 | 0.0638 | 07/31/2025 |
| 5 | Fidelity Nasdaq Composite Index Fund | 29,417 | 0 | 141,495.77 | 0.0007 | 0.063 | 06/30/2025 |
| 6 | Virtus LifeSci Biotech Clinical Trials ETF | 21,787 | 12,578 | 104,795.47 | 0.6581 | 0.0467 | 07/31/2025 |
| 7 | Lumyna - MW TOPS UCITS Fund | 19,672 | 19,672 | 94,622.32 | 0.0037 | 0.0422 | 03/31/2025 |
| 8 | Invesco Markets Plc - NASDAQ Biotech UCITS ETF | 13,783 | 118 | 66,296.23 | 0.0231 | 0.0295 | 07/31/2025 |
| 9 | China Universal Nasdaq Biotechnology Index ETF | 9,963 | 0 | 47,922.03 | 0.0214 | 0.0214 | 12/31/2024 |
| 10 | SPDR S&P International Small Cap ETF | 7,790 | -287 | 37,469.9 | 0.005 | 0.0167 | 07/31/2025 |
| 11 | Steward International Enhanced Index Fund | 5,800 | 0 | 27,898 | 0.0109 | 0.0124 | 07/31/2025 |
| 12 | Mirae Asset Tiger NASDAQ Bio ETF | 2,102 | 344 | 10,110.62 | 0.0229 | 0.0045 | 07/31/2025 |
| 13 | ProShares Ultra NASDAQ Biotechnology | 1,735 | -445 | 8,345.35 | 0.0171 | 0.0037 | 07/31/2025 |
| 14 | Invesco Nasdaq Biotechnology ETF | 1,683 | -107 | 8,095.23 | 0.0228 | 0.0036 | 07/31/2025 |
| 15 | Blackstone Alternative Multi Strategy Fund | 1,600 | 200 | 7,696 | 0.0004 | 0.0034 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Ikarian Capital LLC | 873,568 | 873,568 | 4,201,862.08 | 1.2066 | 1.8722 | 06/30/2025 |
| 2 | Cantor Fitzgerald Europe | 789,039 | 249,313 | 3,795,277.59 | 0.797 | 1.691 | 06/30/2025 |
| 3 | BMO Asset Management, Inc. | 140,812 | 78,805 | 677,305.72 | 0.0004 | 0.3018 | 06/30/2025 |
| 4 | Morgan Stanley Smith Barney LLC (Investment Management) | 82,328 | 70,091 | 395,997.68 | 0.0001 | 0.1764 | 06/30/2025 |
| 5 | Jane Street Capital LLC | 37,813 | 37,813 | 181,880.53 | 0.0003 | 0.081 | 06/30/2025 |
| 6 | Susquehanna Financial Group LLLP | 27,797 | 27,797 | 133,703.57 | 0.0002 | 0.0596 | 06/30/2025 |
| 7 | Wexford Capital LP | 27,149 | 27,149 | 130,586.69 | 0.0215 | 0.0582 | 06/30/2025 |
| 8 | Reichmuth & Co. Integrale Vermogensverwaltung AG | 57,858 | 23,058 | 278,296.98 | 0.2294 | 0.124 | 04/30/2025 |
| 9 | Massar Capital Management LP | 19,863 | 19,863 | 95,541.03 | 0.0681 | 0.0426 | 06/30/2025 |
| 10 | Virtus Investment Advisers LLC | 16,837 | 16,837 | 80,985.97 | 0.0141 | 0.0361 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Eventide Asset Management LLC | 0 | -640,000 | 0 | 0 | 0 | |
| 2 | Point72 Asset Management LP | 0 | -633,100 | 0 | 0 | 0 | |
| 3 | Morgan Stanley & Co. LLC | 1,129,399 | -521,432 | 5,432,409.19 | 0.0019 | 2.4205 | 06/30/2025 |
| 4 | Bank of America, NA (Private Banking) | 528 | -497,988 | 2,539.68 | 0 | 0.0011 | 06/30/2025 |
| 5 | Parkman Healthcare Partners LLC | 0 | -491,080 | 0 | 0 | 0 | |
| 6 | Woodline Partners LP | 62,459 | -436,273 | 300,427.79 | 0.0015 | 0.1339 | 06/30/2025 |
| 7 | Aquilo Capital Management LLC | 0 | -367,214 | 0 | 0 | 0 | |
| 8 | Saturn V Capital Management LP | 34,737 | -360,287 | 167,084.97 | 0.042 | 0.0744 | 06/30/2025 |
| 9 | Marshall Wace LLP | 175,862 | -313,027 | 845,896.22 | 0.001 | 0.3769 | 06/30/2025 |
| 10 | Medical Strategy GmbH | 0 | -295,000 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.