| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Fidelity Management & Research Co. LLC | 7,975,296 | 3,704,285 | 426,518,830.08 | 0.0244 | 4.6155 | 12/31/2025 |
| 2 | Wellington Management Co. LLP | 6,748,380 | 1,292,200 | 360,903,362.4 | 0.0607 | 3.9055 | 12/31/2025 |
| 3 | Avoro Capital Advisor LLC | 6,555,555 | 1,400,000 | 350,591,081.4 | 3.275 | 3.7939 | 12/31/2025 |
| 4 | Janus Henderson Investors US LLC | 4,953,301 | 631,909 | 264,902,537.48 | 0.1333 | 2.8666 | 12/31/2025 |
| 5 | Deep Track Capital LP | 4,111,782 | -104,029 | 219,898,101.36 | 4.6984 | 2.3796 | 12/31/2025 |
| 6 | BVF Partners LP | 3,479,022 | 275,105 | 186,058,096.56 | 5.4909 | 2.0134 | 12/31/2025 |
| 7 | Morgan Stanley & Co. LLC | 1,727,274 | 1,492,341 | 92,374,613.52 | 0.0338 | 0.9996 | 12/31/2025 |
| 8 | T. Rowe Price Associates, Inc. (IM) | 1,671,138 | 1,381,745 | 89,372,460.24 | 0.0111 | 0.9671 | 12/31/2025 |
| 9 | Driehaus Capital Management LLC | 1,642,444 | 768,940 | 87,837,905.12 | 0.4346 | 0.9505 | 12/31/2025 |
| 10 | Baker Bros. Advisors LP | 1,432,529 | -123,580 | 76,611,650.92 | 0.3756 | 0.829 | 12/31/2025 |
| 11 | Principal Global Investors LLC | 1,284,210 | 496,726 | 68,679,550.8 | 0.0325 | 0.7432 | 12/31/2025 |
| 12 | Casdin Capital LLC | 1,175,000 | -380,000 | 62,839,000 | 4.4616 | 0.68 | 12/31/2025 |
| 13 | Capitolis Liquid Global Markets LLC | 878,300 | 878,300 | 46,971,484 | 0.2961 | 0.5083 | 12/31/2025 |
| 14 | Franklin Advisers, Inc. | 870,446 | 124,805 | 46,551,452.08 | 0.0213 | 0.5037 | 12/31/2025 |
| 15 | AllianceBernstein LP | 848,851 | 819,292 | 45,396,551.48 | 0.0141 | 0.4913 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Vanguard Health Care Fund | 2,811,254 | 820,794 | 150,345,863.92 | 0.3922 | 1.6269 | 01/31/2026 |
| 2 | T Rowe Price Health Sciences Fund | 1,053,266 | 840,209 | 56,328,665.68 | 0.5048 | 0.6096 | 12/31/2025 |
| 3 | Fidelity Contrafund | 851,525 | 851,525 | 45,539,557 | 0.0284 | 0.4928 | 02/28/2026 |
| 4 | Fidelity Advisor Series I -Growth Opportunities Fund | 733,500 | 114,300 | 39,227,580 | 0.1409 | 0.4245 | 02/28/2026 |
| 5 | Vanguard Explorer Fund | 646,713 | 64,266 | 34,586,211.24 | 0.1691 | 0.3743 | 12/31/2025 |
| 6 | Fidelity Select Port. - Health Care Portfolio | 620,000 | 20,000 | 33,157,600 | 0.5654 | 0.3588 | 02/28/2026 |
| 7 | Worldwide Healthcare Trust Plc | 581,300 | 105,300 | 31,087,924 | 1.6403 | 0.3364 | 02/28/2026 |
| 8 | Janus Henderson Global Life Sciences Fund | 574,288 | 97,547 | 30,712,922.24 | 0.5945 | 0.3324 | 12/31/2025 |
| 9 | Fidelity Select Port. - Biotechnology Portfolio | 564,438 | 180,674 | 30,186,144.24 | 0.579 | 0.3267 | 02/28/2026 |
| 10 | Principal Funds, Inc. - Global Emerging Markets Fund | 562,416 | 562,416 | 30,078,007.68 | 0.4351 | 0.3255 | 02/28/2026 |
| 11 | Janus Henderson Capital Funds Plc - Global Life Sciences Fund | 511,384 | 115,917 | 27,348,816.32 | 0.5939 | 0.296 | 01/31/2026 |
| 12 | Janus Henderson Horizon Fund - Biotechnology Fund | 482,023 | 216,809 | 25,778,590.04 | 1.8653 | 0.279 | 12/31/2025 |
| 13 | Fidelity Advisor Series VII - Biotechnology Fund | 481,200 | 179,500 | 25,734,576 | 1.3738 | 0.2785 | 02/28/2026 |
| 14 | Janus Henderson Triton Fund | 470,766 | -28,951 | 25,176,565.68 | 0.4515 | 0.2724 | 12/31/2025 |
| 15 | Fidelity Stock Selector Small Cap Fund | 418,100 | -59,500 | 22,359,988 | 0.3654 | 0.242 | 01/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Fidelity Management & Research Co. LLC | 7,975,296 | 3,704,285 | 426,518,830.08 | 0.0244 | 4.6155 | 12/31/2025 |
| 2 | Morgan Stanley & Co. LLC | 1,727,274 | 1,492,341 | 92,374,613.52 | 0.0338 | 0.9996 | 12/31/2025 |
| 3 | Avoro Capital Advisor LLC | 6,555,555 | 1,400,000 | 350,591,081.4 | 3.275 | 3.7939 | 12/31/2025 |
| 4 | T. Rowe Price Associates, Inc. (IM) | 1,671,138 | 1,381,745 | 89,372,460.24 | 0.0111 | 0.9671 | 12/31/2025 |
| 5 | Wellington Management Co. LLP | 6,748,380 | 1,292,200 | 360,903,362.4 | 0.0607 | 3.9055 | 12/31/2025 |
| 6 | Capitolis Liquid Global Markets LLC | 878,300 | 878,300 | 46,971,484 | 0.2961 | 0.5083 | 12/31/2025 |
| 7 | DWS Investments (UK) Ltd. | 841,162 | 841,162 | 44,985,343.76 | 0.0195 | 0.4868 | 12/31/2025 |
| 8 | AllianceBernstein LP | 848,851 | 819,292 | 45,396,551.48 | 0.0141 | 0.4913 | 12/31/2025 |
| 9 | Driehaus Capital Management LLC | 1,642,444 | 768,940 | 87,837,905.12 | 0.4346 | 0.9505 | 12/31/2025 |
| 10 | Janus Henderson Investors US LLC | 4,953,301 | 631,909 | 264,902,537.48 | 0.1333 | 2.8666 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | RA Capital Management LP | 0 | -1,517,418 | 0 | 0 | 0 | |
| 2 | Millennium Management LLC | 152,560 | -1,121,991 | 8,158,908.8 | 0.006 | 0.0883 | 12/31/2025 |
| 3 | Threadneedle Asset Management Ltd. | 206,121 | -919,913 | 11,023,351.08 | 0.0152 | 0.1193 | 12/31/2025 |
| 4 | Point72 Asset Management LP | 0 | -524,398 | 0 | 0 | 0 | |
| 5 | Invesco Advisers, Inc. | 0 | -434,277 | 0 | 0 | 0 | |
| 6 | Catalio Capital Management LP (Investment Management) | 252,901 | -398,909 | 13,525,145.48 | 2.5246 | 0.1464 | 12/31/2025 |
| 7 | Casdin Capital LLC | 1,175,000 | -380,000 | 62,839,000 | 4.4616 | 0.68 | 12/31/2025 |
| 8 | Paradigm BioCapital Advisors LP | 0 | -372,869 | 0 | 0 | 0 | |
| 9 | Nantahala Capital Management LLC | 0 | -368,553 | 0 | 0 | 0 | |
| 10 | abrdn, Inc. | 264,869 | -322,000 | 14,165,194.12 | 0.1357 | 0.1533 | 12/31/2025 |
Data provided by FactSet Research Systems Inc.