| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Wellington Management Co. LLP | 7,578,125 | 10,853 | 134,890,625 | 0.0224 | 13.2344 | 03/31/2025 |
| 2 | Fidelity Management & Research Co. LLC | 5,779,580 | -218,598 | 102,876,524 | 0.006 | 10.0935 | 03/31/2025 |
| 3 | Janus Henderson Investors US LLC | 4,291,625 | 179,335 | 76,390,925 | 0.0378 | 7.4949 | 03/31/2025 |
| 4 | Deep Track Capital LP | 4,100,000 | 1,300,000 | 72,980,000 | 1.9954 | 7.1602 | 03/31/2025 |
| 5 | Capital Research & Management Co. (Global Investors) | 2,164,145 | -1,373,196 | 38,521,781 | 0.0061 | 3.7795 | 03/31/2025 |
| 6 | Vestal Point Capital LP | 1,788,990 | 63,990 | 31,844,022 | 2.0668 | 3.1243 | 03/31/2025 |
| 7 | BVF Partners LP | 1,771,417 | 0 | 31,531,222.6 | 0.9374 | 3.0936 | 03/31/2025 |
| 8 | Capital Research & Management Co. (International Investors) | 1,619,026 | -55 | 28,818,662.8 | 0.0047 | 2.8275 | 03/31/2025 |
| 9 | RA Capital Management LP | 1,517,418 | 0 | 27,010,040.4 | 0.3889 | 2.65 | 03/31/2025 |
| 10 | Driehaus Capital Management LLC | 1,272,743 | -784,667 | 22,654,825.4 | 0.1422 | 2.2227 | 03/31/2025 |
| 11 | Federated Global Investment Management Corp. | 1,170,948 | -875,010 | 20,842,874.4 | 0.1616 | 2.0449 | 03/31/2025 |
| 12 | Rock Springs Capital Management LP | 1,132,979 | 52,016 | 20,167,026.2 | 1.0743 | 1.9786 | 03/31/2025 |
| 13 | FIL Investments International | 1,110,193 | -114,616 | 19,761,435.4 | 0.0149 | 1.9388 | 03/31/2025 |
| 14 | Threadneedle Asset Management Ltd. | 1,076,817 | 71,542 | 19,167,342.6 | 0.0237 | 1.8806 | 03/31/2025 |
| 15 | Millennium Management LLC | 790,159 | 39,146 | 14,064,830.2 | 0.0122 | 1.3799 | 03/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Vanguard Health Care Fund | 4,414,573 | 239,066 | 78,579,399.4 | 0.2147 | 7.7096 | 04/30/2025 |
| 2 | American Funds Small Cap World Fund | 1,599,660 | -2,836,626 | 28,473,948 | 0.0374 | 2.7936 | 06/30/2025 |
| 3 | Fidelity Select Port. - Health Care Portfolio | 780,000 | 110,000 | 13,884,000 | 0.2385 | 1.3622 | 05/31/2025 |
| 4 | Federated Hermes Kaufmann Small Cap Fund | 708,148 | -326,319 | 12,605,034.4 | 0.356 | 1.2367 | 03/31/2025 |
| 5 | COLUMBIA THREADNEEDLE LUX I - American Smaller Companies | 706,232 | 110,147 | 12,570,929.6 | 0.602 | 1.2334 | 06/30/2025 |
| 6 | Fidelity Growth Company Commingled Pool | 667,485 | -718,917 | 11,881,233 | 0.0123 | 1.1657 | 05/31/2025 |
| 7 | Fidelity Advisor Series I -Growth Opportunities Fund | 619,200 | 356,100 | 11,021,760 | 0.0394 | 1.0814 | 05/31/2025 |
| 8 | Janus Henderson Global Life Sciences Fund | 586,345 | -91,322 | 10,436,941 | 0.2323 | 1.024 | 03/31/2025 |
| 9 | Vanguard Explorer Fund | 582,447 | 0 | 10,367,556.6 | 0.0473 | 1.0172 | 03/31/2025 |
| 10 | Fidelity Growth Company Fund | 529,721 | -478,489 | 9,429,033.8 | 0.0131 | 0.9251 | 05/31/2025 |
| 11 | Bellevue Healthcare Trust Plc | 466,550 | 0 | 8,304,590 | 1.7875 | 0.8148 | 11/30/2024 |
| 12 | Janus Henderson Capital Funds Plc - Global Life Sciences Fund | 458,708 | -91,657 | 8,165,002.4 | 0.2269 | 0.8011 | 05/31/2025 |
| 13 | Federated Hermes Kaufmann Fund | 450,000 | -533,662 | 8,010,000 | 0.1552 | 0.7859 | 03/31/2025 |
| 14 | Fidelity Advisor Health Care Fund | 450,000 | 38,000 | 8,010,000 | 0.2423 | 0.7859 | 05/31/2025 |
| 15 | Wellington Mgmt. Funds IE Plc - Global Health Care Eq. | 426,078 | 0 | 7,584,188.4 | 0.4076 | 0.7441 | 12/31/2024 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Deep Track Capital LP | 4,100,000 | 1,300,000 | 72,980,000 | 1.9954 | 7.1602 | 03/31/2025 |
| 2 | Schroder Investment Management Ltd. | 476,136 | 476,136 | 8,475,220.8 | 0.0039 | 0.8315 | 03/31/2025 |
| 3 | Morgan Stanley & Co. LLC | 399,914 | 285,602 | 7,118,469.2 | 0.0024 | 0.6984 | 03/31/2025 |
| 4 | Readystate Asset Management LP | 481,241 | 271,899 | 8,566,089.8 | 0.4893 | 0.8404 | 03/31/2025 |
| 5 | abrdn, Inc. | 401,624 | 230,236 | 7,148,907.2 | 0.0729 | 0.7014 | 06/30/2025 |
| 6 | Handelsbanken Fonder AB | 380,000 | 215,000 | 6,764,000 | 0.0085 | 0.6636 | 03/31/2025 |
| 7 | Balyasny Asset Management LP | 202,483 | 202,483 | 3,604,197.4 | 0.0082 | 0.3536 | 03/31/2025 |
| 8 | Janus Henderson Investors US LLC | 4,291,625 | 179,335 | 76,390,925 | 0.0378 | 7.4949 | 03/31/2025 |
| 9 | Monashee Investment Management LLC | 292,862 | 160,862 | 5,212,943.6 | 0.5407 | 0.5115 | 03/31/2025 |
| 10 | Susquehanna Investment Group LLC | 157,961 | 157,961 | 2,811,705.8 | 0.0342 | 0.2759 | 03/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Capital Research & Management Co. (Global Investors) | 2,164,145 | -1,373,196 | 38,521,781 | 0.0061 | 3.7795 | 03/31/2025 |
| 2 | Federated Global Investment Management Corp. | 1,170,948 | -875,010 | 20,842,874.4 | 0.1616 | 2.0449 | 03/31/2025 |
| 3 | Driehaus Capital Management LLC | 1,272,743 | -784,667 | 22,654,825.4 | 0.1422 | 2.2227 | 03/31/2025 |
| 4 | Citadel Advisors LLC | 741,265 | -620,783 | 13,194,517 | 0.0165 | 1.2945 | 03/31/2025 |
| 5 | T. Rowe Price Associates, Inc. (IM) | 777,173 | -617,133 | 13,833,679.4 | 0.0016 | 1.3573 | 03/31/2025 |
| 6 | Marshall Wace LLP | 30,626 | -552,581 | 545,142.8 | 0.0006 | 0.0535 | 03/31/2025 |
| 7 | Boxer Capital Management LLC | 0 | -500,000 | 0 | 0 | 0 | |
| 8 | Ensign Peak Advisors, Inc. | 0 | -308,241 | 0 | 0 | 0 | |
| 9 | Logos Global Management LP | 425,000 | -275,000 | 7,565,000 | 1.0208 | 0.7422 | 03/31/2025 |
| 10 | First Light Asset Management LLC | 132,380 | -266,475 | 2,356,364 | 0.2806 | 0.2312 | 03/31/2025 |
Data provided by FactSet Research Systems Inc.