| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Baker Bros. Advisors LP | 33,722,974 | 9,298,109 | 886,576,986.46 | 5.7844 | 4.5715 | 06/30/2025 |
| 2 | Fidelity Management & Research Co. LLC | 9,225,412 | 1,208,396 | 242,536,081.48 | 0.0139 | 1.2506 | 06/30/2025 |
| 3 | The Vanguard Group, Inc. | 8,552,104 | -2,906,266 | 224,834,814.16 | 0.0031 | 1.1593 | 06/30/2025 |
| 4 | BlackRock Fund Advisors | 5,919,517 | -1,629,501 | 155,624,101.93 | 0.0036 | 0.8025 | 06/30/2025 |
| 5 | SSgA Funds Management, Inc. | 4,017,697 | -1,585,213 | 105,625,254.13 | 0.0037 | 0.5446 | 06/30/2025 |
| 6 | T. Rowe Price Associates, Inc. (IM) | 3,800,678 | -2,666,987 | 99,919,824.62 | 0.012 | 0.5152 | 06/30/2025 |
| 7 | Geode Capital Management LLC | 2,934,815 | -266,032 | 77,156,286.35 | 0.0043 | 0.3978 | 06/30/2025 |
| 8 | Pictet Asset Management SA | 2,163,873 | 776,626 | 56,888,221.17 | 0.039 | 0.2933 | 06/30/2025 |
| 9 | UBS Securities LLC | 2,081,126 | 906,419 | 54,712,802.54 | 0.0237 | 0.2821 | 06/30/2025 |
| 10 | Norges Bank Investment Management | 1,389,862 | 1,289,862 | 36,539,471.98 | 0.0025 | 0.1884 | 06/30/2025 |
| 11 | Charles Schwab Investment Management, Inc. | 1,291,671 | -193,401 | 33,958,030.59 | 0.0041 | 0.1751 | 06/30/2025 |
| 12 | Apeiron Capital Ltd. (Hong Kong) | 1,200,941 | 1,200,941 | 31,572,738.89 | 24.7867 | 0.1628 | 06/30/2025 |
| 13 | abrdn, Inc. | 1,139,530 | -150,895 | 29,958,243.7 | 0.303 | 0.1545 | 06/30/2025 |
| 14 | Polar Capital LLP | 1,000,000 | 1,000,000 | 26,290,000 | 0.0799 | 0.1356 | 06/30/2025 |
| 15 | Polymer Capital Management (HK) Ltd. | 890,029 | 670,209 | 23,398,862.41 | 3.3715 | 0.1207 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | T Rowe Price Health Sciences Fund | 2,747,413 | 2,747,413 | 72,229,487.77 | 0.6328 | 0.3724 | 06/30/2025 |
| 2 | Fidelity Growth Company Commingled Pool | 2,692,795 | 832,227 | 70,793,580.55 | 0.0711 | 0.365 | 06/30/2025 |
| 3 | SPDR S&P Biotech ETF | 2,414,096 | -947,775 | 63,466,583.84 | 1.2605 | 0.3273 | 07/31/2025 |
| 4 | Vanguard Total Stock Market ETF | 2,365,328 | -1,096,034 | 62,184,473.12 | 0.0032 | 0.3206 | 07/31/2025 |
| 5 | Fidelity Growth Company Fund | 2,080,940 | 749,163 | 54,707,912.6 | 0.0745 | 0.2821 | 06/30/2025 |
| 6 | Vanguard Small Cap Index Fund | 1,801,654 | -1,020,183 | 47,365,483.66 | 0.0297 | 0.2442 | 07/31/2025 |
| 7 | Fidelity Select Port. - Biotechnology Portfolio | 1,687,478 | -885,180 | 44,363,796.62 | 1.0654 | 0.2288 | 06/30/2025 |
| 8 | Vanguard Extended Market Index Fund | 1,516,846 | -612,158 | 39,877,881.34 | 0.0488 | 0.2056 | 07/31/2025 |
| 9 | Vanguard Small Cap Value Index Fund | 1,156,876 | -709,690 | 30,414,270.04 | 0.0523 | 0.1568 | 07/31/2025 |
| 10 | Polar Capital Funds Plc - Biotechnology Fund | 1,000,000 | 1,000,000 | 26,290,000 | 1.2743 | 0.1356 | 06/30/2025 |
| 11 | Fidelity Small Cap Index Fund | 932,024 | 24,609 | 24,502,910.96 | 0.0897 | 0.1263 | 05/31/2025 |
| 12 | abrdn Healthcare Investors | 838,886 | -13,396 | 22,054,312.94 | 2.2109 | 0.1137 | 03/31/2025 |
| 13 | iShares Russell Mid Cap Growth ETF | 780,901 | 780,901 | 20,529,887.29 | 0.102 | 0.1059 | 07/31/2025 |
| 14 | Fidelity Extended Market Index Fund | 756,456 | -8,284 | 19,887,228.24 | 0.0492 | 0.1025 | 06/30/2025 |
| 15 | iShares Biotechnology ETF | 679,807 | 24,437 | 17,872,126.03 | 0.3181 | 0.0922 | 07/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Baker Bros. Advisors LP | 33,722,974 | 9,298,109 | 886,576,986.46 | 5.7844 | 4.5715 | 06/30/2025 |
| 2 | Norges Bank Investment Management | 1,389,862 | 1,289,862 | 36,539,471.98 | 0.0025 | 0.1884 | 06/30/2025 |
| 3 | Fidelity Management & Research Co. LLC | 9,225,412 | 1,208,396 | 242,536,081.48 | 0.0139 | 1.2506 | 06/30/2025 |
| 4 | Apeiron Capital Ltd. (Hong Kong) | 1,200,941 | 1,200,941 | 31,572,738.89 | 24.7867 | 0.1628 | 06/30/2025 |
| 5 | Polar Capital LLP | 1,000,000 | 1,000,000 | 26,290,000 | 0.0799 | 0.1356 | 06/30/2025 |
| 6 | UBS Securities LLC | 2,081,126 | 906,419 | 54,712,802.54 | 0.0237 | 0.2821 | 06/30/2025 |
| 7 | Pictet Asset Management SA | 2,163,873 | 776,626 | 56,888,221.17 | 0.039 | 0.2933 | 06/30/2025 |
| 8 | Fiera Capital, Inc. | 759,430 | 759,430 | 19,965,414.7 | 0.2288 | 0.1029 | 06/30/2025 |
| 9 | Polymer Capital Management (HK) Ltd. | 890,029 | 670,209 | 23,398,862.41 | 3.3715 | 0.1207 | 06/30/2025 |
| 10 | Rockland Trust Co. | 400,000 | 400,000 | 10,516,000 | 0.4976 | 0.0542 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | The Vanguard Group, Inc. | 8,552,104 | -2,906,266 | 224,834,814.16 | 0.0031 | 1.1593 | 06/30/2025 |
| 2 | T. Rowe Price Associates, Inc. (IM) | 3,800,678 | -2,666,987 | 99,919,824.62 | 0.012 | 0.5152 | 06/30/2025 |
| 3 | BlackRock Fund Advisors | 5,919,517 | -1,629,501 | 155,624,101.93 | 0.0036 | 0.8025 | 06/30/2025 |
| 4 | SSgA Funds Management, Inc. | 4,017,697 | -1,585,213 | 105,625,254.13 | 0.0037 | 0.5446 | 06/30/2025 |
| 5 | Millennium Management LLC | 556,009 | -1,493,820 | 14,617,476.61 | 0.0127 | 0.0754 | 06/30/2025 |
| 6 | Goldman Sachs & Co. LLC (Private Banking) | 176,412 | -612,675 | 4,637,871.48 | 0.002 | 0.0239 | 06/30/2025 |
| 7 | Twin Tree Management LP | 0 | -495,782 | 0 | 0 | 0 | |
| 8 | BNP Paribas Financial Markets | 29,844 | -463,345 | 784,598.76 | 0.0006 | 0.004 | 06/30/2025 |
| 9 | Balyasny Asset Management LP | 0 | -387,242 | 0 | 0 | 0 | |
| 10 | TD Asset Management, Inc. | 484,010 | -353,944 | 12,724,622.9 | 0.007 | 0.0656 | 06/30/2025 |
Data provided by FactSet Research Systems Inc.