| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Baker Bros. Advisors LP | 24,424,865 | 0 | 503,152,219 | 4.432 | 3.311 | 03/31/2025 |
| 2 | The Vanguard Group, Inc. | 11,467,970 | 723,711 | 236,240,182 | 0.0034 | 1.5546 | 03/31/2025 |
| 3 | Fidelity Management & Research Co. LLC | 9,309,615 | 1,014,125 | 191,778,069 | 0.0115 | 1.262 | 03/31/2025 |
| 4 | BlackRock Fund Advisors | 7,505,926 | 359,124 | 154,622,075.6 | 0.0037 | 1.0175 | 03/31/2025 |
| 5 | T. Rowe Price Associates, Inc. (IM) | 6,455,693 | 1,098,121 | 132,987,275.8 | 0.0162 | 0.8751 | 03/31/2025 |
| 6 | SSgA Funds Management, Inc. | 4,851,388 | 1,382,874 | 99,938,592.8 | 0.0037 | 0.6577 | 03/31/2025 |
| 7 | Geode Capital Management LLC | 3,284,882 | 185,074 | 67,668,569.2 | 0.004 | 0.4453 | 03/31/2025 |
| 8 | Pictet Asset Management SA | 2,661,604 | 1,970,200 | 54,829,042.4 | 0.0382 | 0.3608 | 03/31/2025 |
| 9 | Balyasny Asset Management LP | 1,703,180 | 1,272,004 | 35,085,508 | 0.0824 | 0.2309 | 03/31/2025 |
| 10 | Charles Schwab Investment Management, Inc. | 1,460,717 | 28,004 | 30,090,770.2 | 0.0038 | 0.198 | 03/31/2025 |
| 11 | UBS Securities LLC | 1,252,580 | 1,133,996 | 25,803,148 | 0.0108 | 0.1698 | 03/31/2025 |
| 12 | abrdn, Inc. | 1,200,810 | 64,524 | 24,736,686 | 0.2416 | 0.1628 | 03/31/2025 |
| 13 | BNP Paribas Financial Markets | 1,098,489 | 1,098,489 | 22,628,873.4 | 0.0156 | 0.1489 | 03/31/2025 |
| 14 | Rock Springs Capital Management LP | 995,000 | -45,000 | 20,497,000 | 1.1036 | 0.1349 | 03/31/2025 |
| 15 | Citadel Advisors LLC | 894,726 | 243,893 | 18,431,355.6 | 0.0235 | 0.1213 | 03/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Vanguard Total Stock Market ETF | 3,552,979 | 151,519 | 73,191,367.4 | 0.0038 | 0.4816 | 05/31/2025 |
| 2 | Vanguard Small Cap Index Fund | 2,793,469 | 54,267 | 57,545,461.4 | 0.0371 | 0.3787 | 05/31/2025 |
| 3 | SPDR S&P Biotech ETF | 2,627,922 | 1,462,155 | 54,135,193.2 | 1.1073 | 0.3562 | 05/30/2025 |
| 4 | Fidelity Growth Company Commingled Pool | 2,404,663 | 958,161 | 49,536,057.8 | 0.0533 | 0.326 | 04/30/2025 |
| 5 | iShares Russell 2000 ETF | 2,334,320 | -136,224 | 48,086,992 | 0.0735 | 0.3164 | 05/30/2025 |
| 6 | Vanguard Extended Market Index Fund | 2,182,659 | 122,961 | 44,962,775.4 | 0.0392 | 0.2959 | 05/31/2025 |
| 7 | Fidelity Select Port. - Biotechnology Portfolio | 2,158,158 | -1,322,900 | 44,458,054.8 | 1.158 | 0.2926 | 04/30/2025 |
| 8 | Fidelity Growth Company Fund | 1,856,977 | 763,765 | 38,253,726.2 | 0.0556 | 0.2517 | 04/30/2025 |
| 9 | Vanguard Small Cap Value Index Fund | 1,794,271 | -56,953 | 36,961,982.6 | 0.0657 | 0.2432 | 05/31/2025 |
| 10 | Fidelity Small Cap Index Fund | 918,734 | 31,022 | 18,925,920.4 | 0.0731 | 0.1245 | 03/31/2025 |
| 11 | abrdn Healthcare Investors | 838,886 | 93,532 | 17,281,051.6 | 1.8395 | 0.1137 | 03/31/2025 |
| 12 | Fidelity Extended Market Index Fund | 780,675 | 16,985 | 16,081,905 | 0.0398 | 0.1058 | 04/30/2025 |
| 13 | iShares Russell 2000 Growth ETF | 756,364 | 4,808 | 15,581,098.4 | 0.1335 | 0.1025 | 05/30/2025 |
| 14 | iShares Biotechnology ETF | 695,705 | 101,394 | 14,331,523 | 0.2699 | 0.0943 | 05/30/2025 |
| 15 | Schwab US Small Cap ETF | 665,811 | -2,194 | 13,715,706.6 | 0.0791 | 0.0903 | 05/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Pictet Asset Management SA | 2,661,604 | 1,970,200 | 54,829,042.4 | 0.0382 | 0.3608 | 03/31/2025 |
| 2 | SSgA Funds Management, Inc. | 4,851,388 | 1,382,874 | 99,938,592.8 | 0.0037 | 0.6577 | 03/31/2025 |
| 3 | Balyasny Asset Management LP | 1,703,180 | 1,272,004 | 35,085,508 | 0.0824 | 0.2309 | 03/31/2025 |
| 4 | UBS Securities LLC | 1,252,580 | 1,133,996 | 25,803,148 | 0.0108 | 0.1698 | 03/31/2025 |
| 5 | BNP Paribas Financial Markets | 1,098,489 | 1,098,489 | 22,628,873.4 | 0.0156 | 0.1489 | 03/31/2025 |
| 6 | T. Rowe Price Associates, Inc. (IM) | 6,455,693 | 1,098,121 | 132,987,275.8 | 0.0162 | 0.8751 | 03/31/2025 |
| 7 | Fidelity Management & Research Co. LLC | 9,309,615 | 1,014,125 | 191,778,069 | 0.0115 | 1.262 | 03/31/2025 |
| 8 | The Vanguard Group, Inc. | 11,467,970 | 723,711 | 236,240,182 | 0.0034 | 1.5546 | 03/31/2025 |
| 9 | Adage Capital Management LP | 538,000 | 538,000 | 11,082,800 | 0.0188 | 0.0729 | 03/31/2025 |
| 10 | JPMorgan Investment Management, Inc. | 452,044 | 404,809 | 9,312,106.4 | 0.001 | 0.0613 | 03/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Darwin Global Management Ltd. | 0 | -1,084,880 | 0 | 0 | 0 | |
| 2 | First Trust Advisors LP | 0 | -422,950 | 0 | 0 | 0 | |
| 3 | D. E. Shaw & Co. LP | 29,779 | -372,388 | 613,447.4 | 0.0007 | 0.004 | 03/31/2025 |
| 4 | Millennium Management LLC | 887,009 | -335,337 | 18,272,385.4 | 0.0163 | 0.1202 | 03/31/2025 |
| 5 | Soleus Capital Management LP (Investment Management) | 0 | -285,000 | 0 | 0 | 0 | |
| 6 | Group One Trading LLC | 0 | -186,918 | 0 | 0 | 0 | |
| 7 | Voloridge Investment Management LLC | 0 | -168,094 | 0 | 0 | 0 | |
| 8 | Morgan Stanley & Co. LLC | 311,729 | -139,944 | 6,421,617.4 | 0.0023 | 0.0423 | 03/31/2025 |
| 9 | Jane Street Capital LLC | 215,939 | -135,212 | 4,448,343.4 | 0.0069 | 0.0293 | 03/31/2025 |
| 10 | FORA Capital LLC | 0 | -128,894 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.