| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Baker Bros. Advisors LP | 24,424,865 | 0 | 602,072,922.25 | 5.7199 | 3.311 | 12/31/2024 |
| 2 | The Vanguard Group, Inc. | 11,458,370 | 714,111 | 282,448,820.5 | 0.0044 | 1.5533 | 12/31/2024 |
| 3 | Fidelity Management & Research Co. LLC | 8,017,016 | -278,474 | 197,619,444.4 | 0.0129 | 1.0868 | 12/31/2024 |
| 4 | BlackRock Fund Advisors | 7,505,926 | 359,124 | 185,021,075.9 | 0.0048 | 1.0175 | 03/31/2025 |
| 5 | T. Rowe Price Associates, Inc. (IM) | 6,467,665 | 1,110,093 | 159,427,942.25 | 0.0206 | 0.8768 | 12/31/2024 |
| 6 | SSgA Funds Management, Inc. | 5,602,910 | 2,134,396 | 138,111,731.5 | 0.0055 | 0.7595 | 12/31/2024 |
| 7 | Geode Capital Management LLC | 3,200,847 | 101,039 | 78,900,878.55 | 0.0053 | 0.4339 | 12/31/2024 |
| 8 | Pictet Asset Management SA | 2,661,604 | 1,970,200 | 65,608,538.6 | 0.0487 | 0.3608 | 03/31/2025 |
| 9 | Millennium Management LLC | 2,049,829 | 827,483 | 50,528,284.85 | 0.0456 | 0.2779 | 12/31/2024 |
| 10 | Charles Schwab Investment Management, Inc. | 1,485,072 | 52,359 | 36,607,024.8 | 0.0005 | 0.2013 | 12/31/2024 |
| 11 | abrdn, Inc. | 1,290,425 | 154,139 | 31,808,976.25 | 0.3359 | 0.1749 | 12/31/2024 |
| 12 | UBS Securities LLC | 1,174,707 | 1,056,123 | 28,956,527.55 | 0.0145 | 0.1592 | 12/31/2024 |
| 13 | Rock Springs Capital Management LP | 1,054,000 | 14,000 | 25,981,100 | 1.0671 | 0.1429 | 12/31/2024 |
| 14 | Northern Trust Investments, Inc.(Investment Management) | 871,402 | 14,075 | 21,480,059.3 | 0.0036 | 0.1181 | 12/31/2024 |
| 15 | Candriam Belgium SA | 842,551 | -7,852 | 20,768,882.15 | 0.0623 | 0.1142 | 12/31/2024 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Vanguard Total Stock Market ETF | 3,497,582 | 84,456 | 86,215,396.3 | 0.005 | 0.4741 | 03/31/2025 |
| 2 | Vanguard Small Cap Index Fund | 2,758,143 | 34,991 | 67,988,224.95 | 0.0461 | 0.3739 | 03/31/2025 |
| 3 | SPDR S&P Biotech ETF | 2,738,505 | 1,544,018 | 67,504,148.25 | 1.4101 | 0.3712 | 04/30/2025 |
| 4 | Fidelity Growth Company Commingled Pool | 2,293,563 | 856,660 | 56,536,327.95 | 0.0683 | 0.3109 | 03/31/2025 |
| 5 | iShares Russell 2000 ETF | 2,274,733 | 12,866 | 56,072,168.45 | 0.0942 | 0.3084 | 04/30/2025 |
| 6 | Fidelity Select Port. - Biotechnology Portfolio | 2,247,958 | -1,475,200 | 55,412,164.7 | 1.5174 | 0.3047 | 03/31/2025 |
| 7 | Vanguard Extended Market Index Fund | 2,155,809 | 106,259 | 53,140,691.85 | 0.0486 | 0.2922 | 03/31/2025 |
| 8 | Vanguard Small Cap Value Index Fund | 1,790,127 | -52,034 | 44,126,630.55 | 0.0822 | 0.2427 | 03/31/2025 |
| 9 | Fidelity Growth Company Fund | 1,780,677 | 692,721 | 43,893,688.05 | 0.0724 | 0.2414 | 03/31/2025 |
| 10 | Fidelity Small Cap Index Fund | 911,689 | 18,043 | 22,473,133.85 | 0.0943 | 0.1236 | 02/28/2025 |
| 11 | abrdn Healthcare Investors | 852,282 | 106,928 | 21,008,751.3 | 2.3033 | 0.1155 | 12/31/2024 |
| 12 | Fidelity Extended Market Index Fund | 776,054 | 8,828 | 19,129,731.1 | 0.051 | 0.1052 | 03/31/2025 |
| 13 | iShares Russell 2000 Growth ETF | 774,499 | 37,084 | 19,091,400.35 | 0.1723 | 0.105 | 04/30/2025 |
| 14 | iShares Biotechnology ETF | 722,201 | 112,186 | 17,802,254.65 | 0.3426 | 0.0979 | 04/30/2025 |
| 15 | Schwab US Small Cap ETF | 665,773 | 24 | 16,411,304.45 | 0.101 | 0.0903 | 04/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | SSgA Funds Management, Inc. | 5,602,910 | 2,134,396 | 138,111,731.5 | 0.0055 | 0.7595 | 12/31/2024 |
| 2 | Pictet Asset Management SA | 2,661,604 | 1,970,200 | 65,608,538.6 | 0.0487 | 0.3608 | 03/31/2025 |
| 3 | T. Rowe Price Associates, Inc. (IM) | 6,467,665 | 1,110,093 | 159,427,942.25 | 0.0206 | 0.8768 | 12/31/2024 |
| 4 | UBS Securities LLC | 1,174,707 | 1,056,123 | 28,956,527.55 | 0.0145 | 0.1592 | 12/31/2024 |
| 5 | Millennium Management LLC | 2,049,829 | 827,483 | 50,528,284.85 | 0.0456 | 0.2779 | 12/31/2024 |
| 6 | The Vanguard Group, Inc. | 11,458,370 | 714,111 | 282,448,820.5 | 0.0044 | 1.5533 | 12/31/2024 |
| 7 | BNP Paribas Financial Markets | 493,189 | 493,189 | 12,157,108.85 | 0.0096 | 0.0669 | 12/31/2024 |
| 8 | Goldman Sachs & Co. LLC (Private Banking) | 789,087 | 448,629 | 19,450,994.55 | 0.0122 | 0.107 | 12/31/2024 |
| 9 | BlackRock Fund Advisors | 7,505,926 | 359,124 | 185,021,075.9 | 0.0048 | 1.0175 | 03/31/2025 |
| 10 | Invesco Capital Management LLC | 398,605 | 324,110 | 9,825,613.25 | 0.0031 | 0.054 | 12/31/2024 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Darwin Global Management Ltd. | 0 | -1,084,880 | 0 | 0 | 0 | |
| 2 | Citadel Advisors LLC | 131,590 | -519,243 | 3,243,693.5 | 0.0042 | 0.0178 | 12/31/2024 |
| 3 | First Trust Advisors LP | 0 | -422,950 | 0 | 0 | 0 | |
| 4 | D. E. Shaw & Co. LP | 36,021 | -366,146 | 887,917.65 | 0.001 | 0.0049 | 12/31/2024 |
| 5 | Susquehanna Financial Group LLLP | 77,224 | -289,171 | 1,903,571.6 | 0.003 | 0.0105 | 12/31/2024 |
| 6 | Soleus Capital Management LP (Investment Management) | 0 | -285,000 | 0 | 0 | 0 | |
| 7 | Fidelity Management & Research Co. LLC | 8,017,016 | -278,474 | 197,619,444.4 | 0.0129 | 1.0868 | 12/31/2024 |
| 8 | Jane Street Capital LLC | 135,100 | -216,051 | 3,330,215 | 0.0055 | 0.0183 | 12/31/2024 |
| 9 | Voloridge Investment Management LLC | 0 | -168,094 | 0 | 0 | 0 | |
| 10 | FORA Capital LLC | 0 | -128,894 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.