| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Perceptive Advisors LLC | 6,563,340 | 171,234 | 690,266,467.8 | 20.4924 | 8.0206 | 03/31/2025 |
| 2 | Janus Henderson Investors US LLC | 5,467,005 | 3,809,860 | 574,964,915.85 | 0.2842 | 6.6808 | 03/31/2025 |
| 3 | Darwin Global Management Ltd. | 3,923,204 | 3,112,755 | 412,603,364.68 | 20.1859 | 4.7943 | 03/31/2025 |
| 4 | Eventide Asset Management LLC | 2,893,437 | -238,690 | 304,302,769.29 | 5.1728 | 3.5359 | 03/31/2025 |
| 5 | RTW Investments LP | 2,848,800 | 1,027,781 | 299,608,296 | 4.326 | 3.4813 | 03/31/2025 |
| 6 | Summit Partners Public Asset Management LLC | 2,323,115 | 421,089 | 244,322,004.55 | 8.8257 | 2.8389 | 03/31/2025 |
| 7 | Wellington Management Co. LLP | 1,940,246 | -790,377 | 204,055,671.82 | 0.0339 | 2.371 | 03/31/2025 |
| 8 | T. Rowe Price Associates, Inc. (IM) | 1,866,280 | 32,748 | 196,276,667.6 | 0.0233 | 2.2806 | 03/31/2025 |
| 9 | Maverick Capital Ltd. | 1,783,498 | -1,345,018 | 187,570,484.66 | 2.8669 | 2.1795 | 03/31/2025 |
| 10 | Adage Capital Management LP | 1,631,000 | 1,292,575 | 171,532,270 | 0.2812 | 1.9931 | 03/31/2025 |
| 11 | Morgan Stanley & Co. LLC | 1,592,783 | 153,754 | 167,512,988.11 | 0.0575 | 1.9464 | 03/31/2025 |
| 12 | Hood River Capital Management LLC | 1,532,348 | 47,092 | 161,157,039.16 | 2.2552 | 1.8726 | 03/31/2025 |
| 13 | Caligan Partners LP | 1,436,878 | 0 | 151,116,459.26 | 22.8216 | 1.7559 | 03/31/2025 |
| 14 | Holocene Advisors, LP | 1,366,680 | 1,366,680 | 143,733,735.6 | 0.3767 | 1.6701 | 03/31/2025 |
| 15 | Federated Global Investment Management Corp. | 1,267,761 | -557,532 | 133,330,424.37 | 1.0339 | 1.5492 | 03/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Eventide Gilead Fund | 1,889,627 | 0 | 198,732,071.59 | 6.7325 | 2.3092 | 03/31/2025 |
| 2 | T Rowe Price Health Sciences Fund | 1,357,044 | 1,357,044 | 142,720,317.48 | 1.2718 | 1.6583 | 06/30/2025 |
| 3 | Eventide Healthcare & Life Sciences Fund | 988,174 | -241,826 | 103,926,259.58 | 8.2153 | 1.2076 | 03/31/2025 |
| 4 | Polar Capital Funds Plc - Biotechnology Fund | 875,000 | 875,000 | 92,023,750 | 4.8446 | 1.0693 | 05/30/2025 |
| 5 | Hood River Small-Cap Growth Fund | 838,909 | 0 | 88,228,059.53 | 2.2188 | 1.0252 | 03/31/2025 |
| 6 | Janus Henderson Capital Funds Plc - Global Life Sciences Fund | 824,498 | 824,498 | 86,712,454.66 | 2.4099 | 1.0076 | 05/31/2025 |
| 7 | Federated Hermes Kaufmann Small Cap Fund | 777,400 | -161,100 | 81,759,158 | 2.309 | 0.95 | 03/31/2025 |
| 8 | Janus Henderson Global Life Sciences Fund | 761,585 | 761,585 | 80,095,894.45 | 1.7824 | 0.9307 | 03/31/2025 |
| 9 | Putnam Small Cap Growth Fund | 734,132 | 116,732 | 77,208,662.44 | 2.5865 | 0.8971 | 06/30/2025 |
| 10 | SEB Lakemedelsfond | 681,921 | -50,816 | 71,717,631.57 | 5.1667 | 0.8333 | 06/30/2025 |
| 11 | Government Pension Fund - Global (The) | 591,159 | 0 | 62,172,192.03 | 0.0041 | 0.7224 | 12/31/2024 |
| 12 | Bellevue Healthcare Trust Plc | 552,135 | 0 | 58,068,037.95 | 12.4985 | 0.6747 | 11/30/2024 |
| 13 | Janus Henderson Triton Fund | 537,302 | 285,662 | 56,508,051.34 | 0.9189 | 0.6566 | 03/31/2025 |
| 14 | Janus Henderson Research Fund | 518,978 | 518,978 | 54,580,916.26 | 0.1973 | 0.6342 | 03/31/2025 |
| 15 | Lord Abbett Developing Growth Fund | 487,881 | 487,881 | 51,310,444.77 | 2.551 | 0.5962 | 04/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Janus Henderson Investors US LLC | 5,467,005 | 3,809,860 | 574,964,915.85 | 0.2842 | 6.6808 | 03/31/2025 |
| 2 | Darwin Global Management Ltd. | 3,923,204 | 3,112,755 | 412,603,364.68 | 20.1859 | 4.7943 | 03/31/2025 |
| 3 | Holocene Advisors, LP | 1,366,680 | 1,366,680 | 143,733,735.6 | 0.3767 | 1.6701 | 03/31/2025 |
| 4 | Adage Capital Management LP | 1,631,000 | 1,292,575 | 171,532,270 | 0.2812 | 1.9931 | 03/31/2025 |
| 5 | Farallon Capital Management LLC | 1,084,989 | 1,084,989 | 114,108,293.13 | 0.651 | 1.3259 | 03/31/2025 |
| 6 | RTW Investments LP | 2,848,800 | 1,027,781 | 299,608,296 | 4.326 | 3.4813 | 03/31/2025 |
| 7 | Lord, Abbett & Co. LLC | 924,798 | 924,798 | 97,261,005.66 | 0.2813 | 1.1301 | 03/31/2025 |
| 8 | Goldman Sachs & Co. LLC (Private Banking) | 1,034,621 | 762,377 | 108,811,090.57 | 0.0554 | 1.2643 | 03/31/2025 |
| 9 | Pictet Asset Management SA | 703,063 | 703,063 | 73,941,135.71 | 0.0504 | 0.8592 | 03/31/2025 |
| 10 | D. E. Shaw & Co. LP | 613,997 | 613,997 | 64,574,064.49 | 0.0669 | 0.7503 | 03/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | RA Capital Management LP | 0 | -1,766,830 | 0 | 0 | 0 | |
| 2 | Maverick Capital Ltd. | 1,783,498 | -1,345,018 | 187,570,484.66 | 2.8669 | 2.1795 | 03/31/2025 |
| 3 | Citadel Advisors LLC | 260,871 | -992,870 | 27,435,803.07 | 0.0343 | 0.3188 | 03/31/2025 |
| 4 | Deep Track Capital LP | 0 | -850,000 | 0 | 0 | 0 | |
| 5 | Wellington Management Co. LLP | 1,940,246 | -790,377 | 204,055,671.82 | 0.0339 | 2.371 | 03/31/2025 |
| 6 | Jennison Associates LLC | 1,261,153 | -628,389 | 132,635,461.01 | 0.0724 | 1.5412 | 03/31/2025 |
| 7 | Point72 Asset Management LP | 132,457 | -617,919 | 13,930,502.69 | 0.0294 | 0.1619 | 03/31/2025 |
| 8 | Federated Global Investment Management Corp. | 1,267,761 | -557,532 | 133,330,424.37 | 1.0339 | 1.5492 | 03/31/2025 |
| 9 | Bellevue Asset Management (UK) Ltd. | 44,419 | -508,636 | 4,671,546.23 | 1.4534 | 0.0543 | 03/31/2025 |
| 10 | Aisling Capital Management LP | 615,352 | -500,000 | 64,716,569.84 | 16.6912 | 0.752 | 03/31/2025 |
Data provided by FactSet Research Systems Inc.