| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Capital Research & Management Co. (World Investors) | 6,008,419 | -425,005 | 211,316,096.23 | 0.0227 | 5.4807 | 03/31/2025 |
| 2 | Fidelity Management & Research Co. LLC | 4,517,558 | 945,909 | 158,882,514.86 | 0.0095 | 4.1208 | 03/31/2025 |
| 3 | Janus Henderson Investors US LLC | 3,807,935 | -2,751,619 | 133,925,073.95 | 0.0682 | 3.4735 | 03/31/2025 |
| 4 | ClearBridge Investments LLC | 3,279,567 | 1,416,725 | 115,342,371.39 | 0.0862 | 2.9915 | 03/31/2025 |
| 5 | RTW Investments LP | 3,136,680 | 627,561 | 110,317,035.6 | 1.6375 | 2.8612 | 03/31/2025 |
| 6 | Wellington Management Co. LLP | 2,994,081 | -2,692,043 | 105,301,828.77 | 0.0177 | 2.7311 | 03/31/2025 |
| 7 | Principal Global Investors LLC | 2,884,810 | 1,121,856 | 101,458,767.7 | 0.0485 | 2.6314 | 03/31/2025 |
| 8 | Morgan Stanley & Co. LLC | 2,448,213 | -532,318 | 86,103,651.21 | 0.0304 | 2.2332 | 03/31/2025 |
| 9 | T. Rowe Price Associates, Inc. (IM) | 2,267,311 | -85,809 | 79,741,327.87 | 0.0097 | 2.0682 | 03/31/2025 |
| 10 | Mirae Asset Global Investments (Hong Kong) Ltd. | 2,105,553 | 2,105,553 | 74,052,299.01 | 0.4831 | 1.9206 | 03/31/2025 |
| 11 | Allianz Global Investors Asia Pacific Ltd. | 1,868,469 | 375,419 | 65,714,054.73 | 0.6668 | 1.7044 | 03/31/2025 |
| 12 | BAMCO, Inc. | 1,829,494 | -79,594 | 64,343,303.98 | 0.1575 | 1.6688 | 03/31/2025 |
| 13 | FIAM LLC | 1,697,870 | -43,286 | 59,714,087.9 | 0.035 | 1.5488 | 03/31/2025 |
| 14 | RA Capital Management LP | 1,295,040 | 0 | 45,546,556.8 | 0.7097 | 1.1813 | 03/31/2025 |
| 15 | Woodline Partners LP | 1,201,016 | -558,781 | 42,239,732.72 | 0.2538 | 1.0955 | 03/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | American Funds New World Fund | 3,274,106 | -598,952 | 115,150,308.02 | 0.1757 | 2.9865 | 03/31/2025 |
| 2 | American Funds Small Cap World Fund | 2,083,023 | 127,832 | 73,259,918.91 | 0.0968 | 1.9001 | 03/31/2025 |
| 3 | T Rowe Price Health Sciences Fund | 1,773,034 | -44,446 | 62,357,605.78 | 0.5149 | 1.6173 | 03/31/2025 |
| 4 | ClearBridge International Growth Fund | 1,656,109 | 509,771 | 58,245,353.53 | 0.852 | 1.5107 | 05/30/2025 |
| 5 | Fidelity Contrafund | 1,287,094 | 684,094 | 45,267,095.98 | 0.0274 | 1.1741 | 05/31/2025 |
| 6 | Baron Emerging Markets Fund | 1,255,508 | -137,510 | 44,156,216.36 | 1.0974 | 1.1452 | 04/30/2025 |
| 7 | Government Pension Fund - Global (The) | 983,237 | 0 | 34,580,445.29 | 0.0025 | 0.8969 | 06/30/2024 |
| 8 | Janus Henderson Global Life Sciences Fund | 799,798 | -74,920 | 28,128,895.66 | 0.6227 | 0.7296 | 03/31/2025 |
| 9 | Janus Henderson Overseas Fund | 772,957 | -1,993,233 | 27,184,897.69 | 0.7501 | 0.7051 | 03/31/2025 |
| 10 | Allianz Global Investors Fund - Oriental Income | 703,000 | 17,336 | 24,724,510 | 1.9811 | 0.6413 | 02/28/2025 |
| 11 | Vanguard Health Care Fund | 700,766 | -2,654,013 | 24,645,940.22 | 0.066 | 0.6392 | 04/30/2025 |
| 12 | Janus Henderson Capital Funds Plc - Global Life Sciences Fund | 620,289 | -117,625 | 21,815,564.13 | 0.6047 | 0.5658 | 04/30/2025 |
| 13 | Strategic Advisers Fidelity Emerging Markets Fund | 620,000 | -157,100 | 21,805,400 | 0.0822 | 0.5655 | 05/31/2025 |
| 14 | Fidelity Series Emerging Markets Fund | 615,804 | -348,196 | 21,657,826.68 | 0.3655 | 0.5617 | 05/31/2025 |
| 15 | C Worldwide - Healthcare Select | 500,000 | 0 | 17,585,000 | 2.3106 | 0.4561 | 12/31/2024 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Mirae Asset Global Investments (Hong Kong) Ltd. | 2,105,553 | 2,105,553 | 74,052,299.01 | 0.4831 | 1.9206 | 03/31/2025 |
| 2 | ClearBridge Investments LLC | 3,279,567 | 1,416,725 | 115,342,371.39 | 0.0862 | 2.9915 | 03/31/2025 |
| 3 | Principal Global Investors LLC | 2,884,810 | 1,121,856 | 101,458,767.7 | 0.0485 | 2.6314 | 03/31/2025 |
| 4 | Fidelity Management & Research Co. LLC | 4,517,558 | 945,909 | 158,882,514.86 | 0.0095 | 4.1208 | 03/31/2025 |
| 5 | Jennison Associates LLC | 712,300 | 712,300 | 25,051,591 | 0.014 | 0.6497 | 03/31/2025 |
| 6 | RTW Investments LP | 3,136,680 | 627,561 | 110,317,035.6 | 1.6375 | 2.8612 | 03/31/2025 |
| 7 | Allianz Global Investors Asia Pacific Ltd. | 1,868,469 | 375,419 | 65,714,054.73 | 0.6668 | 1.7044 | 03/31/2025 |
| 8 | XY Capital Ltd. | 305,397 | 305,397 | 10,740,812.49 | 7.0823 | 0.2786 | 03/31/2025 |
| 9 | Balyasny Asset Management LP | 296,278 | 272,770 | 10,420,097.26 | 0.0243 | 0.2703 | 03/31/2025 |
| 10 | Canada Pension Plan Investment Board | 262,500 | 262,500 | 9,232,125 | 0.005 | 0.2394 | 03/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Janus Henderson Investors US LLC | 3,807,935 | -2,751,619 | 133,925,073.95 | 0.0682 | 3.4735 | 03/31/2025 |
| 2 | Wellington Management Co. LLP | 2,994,081 | -2,692,043 | 105,301,828.77 | 0.0177 | 2.7311 | 03/31/2025 |
| 3 | Woodline Partners LP | 1,201,016 | -558,781 | 42,239,732.72 | 0.2538 | 1.0955 | 03/31/2025 |
| 4 | Morgan Stanley & Co. LLC | 2,448,213 | -532,318 | 86,103,651.21 | 0.0304 | 2.2332 | 03/31/2025 |
| 5 | UBS Securities LLC | 383,117 | -477,385 | 13,474,224.89 | 0.0056 | 0.3495 | 03/31/2025 |
| 6 | Capital Research & Management Co. (World Investors) | 6,008,419 | -425,005 | 211,316,096.23 | 0.0227 | 5.4807 | 03/31/2025 |
| 7 | Rock Springs Capital Management LP | 904,592 | -400,745 | 31,814,500.64 | 1.7185 | 0.8251 | 03/31/2025 |
| 8 | Vestal Point Capital LP | 0 | -300,000 | 0 | 0 | 0 | |
| 9 | Capital Research & Management Co. (International Investors) | 0 | -264,986 | 0 | 0 | 0 | |
| 10 | Marshall Wace LLP | 27,931 | -261,061 | 982,333.27 | 0.0012 | 0.0255 | 03/31/2025 |
Data provided by FactSet Research Systems Inc.