| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Capital Research & Management Co. (World Investors) | 6,036,185 | -397,239 | 215,431,442.65 | 0.0225 | 5.506 | 06/30/2025 |
| 2 | RTW Investments LP | 5,536,876 | 3,027,757 | 197,611,104.44 | 2.5203 | 5.0506 | 06/30/2025 |
| 3 | Fidelity Management & Research Co. LLC | 4,724,362 | 1,152,713 | 168,612,479.78 | 0.0097 | 4.3094 | 06/30/2025 |
| 4 | ClearBridge Investments LLC | 4,011,956 | 2,149,114 | 143,186,709.64 | 0.1067 | 3.6596 | 06/30/2025 |
| 5 | Janus Henderson Investors US LLC | 2,193,181 | -4,366,373 | 78,274,629.89 | 0.0387 | 2.0006 | 06/30/2025 |
| 6 | BAMCO, Inc. | 1,587,814 | -321,274 | 56,669,081.66 | 0.1396 | 1.4484 | 06/30/2025 |
| 7 | FIAM LLC | 1,310,361 | -430,795 | 46,766,784.09 | 0.0266 | 1.1953 | 06/30/2025 |
| 8 | Woodline Partners LP | 1,201,016 | -558,781 | 42,864,261.04 | 0.2198 | 1.0955 | 06/30/2025 |
| 9 | Wellington Management Co. LLP | 1,058,838 | -4,627,286 | 37,789,928.22 | 0.0063 | 0.9658 | 06/30/2025 |
| 10 | Allianz Global Investors Asia Pacific Ltd. | 932,000 | -561,050 | 33,263,080 | 0.4084 | 0.8501 | 06/30/2025 |
| 11 | Rock Springs Capital Management LP | 871,392 | -433,945 | 31,099,980.48 | 1.8107 | 0.7949 | 06/30/2025 |
| 12 | Adar1 Capital Management LLC | 850,437 | -195,400 | 30,352,096.53 | 3.5431 | 0.7757 | 06/30/2025 |
| 13 | Jennison Associates LLC | 592,332 | 592,332 | 21,140,329.08 | 0.0115 | 0.5403 | 06/30/2025 |
| 14 | C WorldWide Asset Management Fondsmaeglerselskab A/S | 510,000 | 10,000 | 18,201,900 | 0.1675 | 0.4652 | 06/30/2025 |
| 15 | BlackRock Fund Advisors | 425,197 | -128,876 | 15,175,280.93 | 0.0004 | 0.3879 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | American Funds New World Fund | 3,274,106 | -598,952 | 116,852,843.14 | 0.1747 | 2.9865 | 06/30/2025 |
| 2 | American Funds Small Cap World Fund | 2,083,023 | 127,832 | 74,343,090.87 | 0.0967 | 1.9001 | 06/30/2025 |
| 3 | ClearBridge International Growth Fund | 2,015,294 | 868,956 | 71,925,842.86 | 1.0339 | 1.8383 | 06/30/2025 |
| 4 | Government Pension Fund - Global (The) | 1,489,653 | 0 | 53,165,715.57 | 0.0034 | 1.3588 | 12/31/2024 |
| 5 | Fidelity Contrafund | 1,398,304 | 795,304 | 49,905,469.76 | 0.0289 | 1.2755 | 06/30/2025 |
| 6 | Baron Emerging Markets Fund | 1,355,698 | 1,506 | 48,384,861.62 | 1.1621 | 1.2366 | 06/30/2025 |
| 7 | Janus Henderson Global Life Sciences Fund | 799,798 | -74,920 | 28,544,790.62 | 0.6198 | 0.7296 | 03/31/2025 |
| 8 | Allianz Global Investors Fund - Oriental Income | 783,000 | 140,000 | 27,945,270 | 2.314 | 0.7142 | 04/30/2025 |
| 9 | Janus Henderson Overseas Fund | 772,957 | -1,993,233 | 27,586,835.33 | 0.7358 | 0.7051 | 03/31/2025 |
| 10 | Vanguard Health Care Fund | 700,766 | -2,195,132 | 25,010,338.54 | 0.0671 | 0.6392 | 04/30/2025 |
| 11 | Strategic Advisers Fidelity Emerging Markets Fund | 620,000 | -157,100 | 22,127,800 | 0.0787 | 0.5655 | 06/30/2025 |
| 12 | Fidelity Series Emerging Markets Fund | 615,804 | -348,196 | 21,978,044.76 | 0.3555 | 0.5617 | 06/30/2025 |
| 13 | Fidelity Contrafund Commingled Pool | 531,965 | 292,084 | 18,985,830.85 | 0.0308 | 0.4852 | 06/30/2025 |
| 14 | Janus Henderson Capital Funds Plc - Global Life Sciences Fund | 507,347 | -189,718 | 18,107,214.43 | 0.4827 | 0.4628 | 06/30/2025 |
| 15 | C Worldwide - Healthcare Select | 500,000 | 0 | 17,845,000 | 2.3689 | 0.4561 | 12/31/2024 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | RTW Investments LP | 5,536,876 | 3,027,757 | 197,611,104.44 | 2.5203 | 5.0506 | 06/30/2025 |
| 2 | ClearBridge Investments LLC | 4,011,956 | 2,149,114 | 143,186,709.64 | 0.1067 | 3.6596 | 06/30/2025 |
| 3 | Fidelity Management & Research Co. LLC | 4,724,362 | 1,152,713 | 168,612,479.78 | 0.0097 | 4.3094 | 06/30/2025 |
| 4 | Jennison Associates LLC | 592,332 | 592,332 | 21,140,329.08 | 0.0115 | 0.5403 | 06/30/2025 |
| 5 | XY Capital Ltd. | 362,627 | 362,627 | 12,942,157.63 | 8.5974 | 0.3308 | 06/30/2025 |
| 6 | Nan Fung Trinity (HK) Ltd. | 269,975 | 269,975 | 9,635,407.75 | 1.116 | 0.2463 | 06/30/2025 |
| 7 | StemPoint Capital LP | 250,438 | 250,438 | 8,938,132.22 | 2.3681 | 0.2284 | 06/30/2025 |
| 8 | Citadel Advisors LLC | 244,365 | 229,862 | 8,721,386.85 | 0.0101 | 0.2229 | 06/30/2025 |
| 9 | D. E. Shaw & Co. LP | 279,661 | 206,249 | 9,981,101.09 | 0.0097 | 0.2551 | 06/30/2025 |
| 10 | Envestnet Asset Management, Inc. | 239,247 | 201,969 | 8,538,725.43 | 0.0024 | 0.2182 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Wellington Management Co. LLP | 1,058,838 | -4,627,286 | 37,789,928.22 | 0.0063 | 0.9658 | 06/30/2025 |
| 2 | Janus Henderson Investors US LLC | 2,193,181 | -4,366,373 | 78,274,629.89 | 0.0387 | 2.0006 | 06/30/2025 |
| 3 | Morgan Stanley & Co. LLC | 204,050 | -2,776,481 | 7,282,544.5 | 0.0026 | 0.1861 | 06/30/2025 |
| 4 | T. Rowe Price Associates, Inc. (IM) | 153,037 | -2,200,083 | 5,461,890.53 | 0.0007 | 0.1396 | 06/30/2025 |
| 5 | Principal Global Investors LLC | 104,513 | -1,658,441 | 3,730,068.97 | 0.0018 | 0.0953 | 06/30/2025 |
| 6 | RA Capital Management LP | 0 | -1,295,040 | 0 | 0 | 0 | |
| 7 | UBS Securities LLC | 232,785 | -627,717 | 8,308,096.65 | 0.0036 | 0.2123 | 06/30/2025 |
| 8 | Allianz Global Investors Asia Pacific Ltd. | 932,000 | -561,050 | 33,263,080 | 0.4084 | 0.8501 | 06/30/2025 |
| 9 | Woodline Partners LP | 1,201,016 | -558,781 | 42,864,261.04 | 0.2198 | 1.0955 | 06/30/2025 |
| 10 | Connor, Clark & Lunn Investment Management Ltd. | 387,362 | -454,373 | 13,824,949.78 | 0.0429 | 0.3533 | 06/30/2025 |
Data provided by FactSet Research Systems Inc.