| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | UBS Securities LLC | 4,183,385 | 4,020,831 | 480,838,271.9 | 0.1957 | 5.37 | 09/30/2025 |
| 2 | Darwin Global Management Ltd. | 3,164,501 | 3,164,501 | 363,727,744.94 | 6.6562 | 4.0621 | 09/30/2025 |
| 3 | Point72 Asset Management LP | 2,925,352 | 2,895,934 | 336,239,958.88 | 0.6103 | 3.7551 | 09/30/2025 |
| 4 | Cormorant Asset Management LP | 1,950,000 | -180,000 | 224,133,000 | 11.6953 | 2.5031 | 09/30/2025 |
| 5 | Paradigm BioCapital Advisors LP | 1,564,196 | 1,564,196 | 179,788,688.24 | 4.1707 | 2.0079 | 09/30/2025 |
| 6 | Caligan Partners LP | 1,451,924 | 182,805 | 166,884,144.56 | 18 | 1.8638 | 09/30/2025 |
| 7 | Fidelity Management & Research Co. LLC | 1,430,673 | 1,430,673 | 164,441,554.62 | 0.0091 | 1.8365 | 09/30/2025 |
| 8 | Adar1 Capital Management LLC | 1,350,826 | -859,193 | 155,263,940.44 | 14.43 | 1.734 | 09/30/2025 |
| 9 | Octagon Capital Advisors LP | 1,325,000 | 95,000 | 152,295,500 | 16.977 | 1.7008 | 09/30/2025 |
| 10 | Millennium Management LLC | 1,100,030 | 112,616 | 126,437,448.2 | 0.0987 | 1.412 | 09/30/2025 |
| 11 | Vestal Point Capital LP | 1,000,000 | 1,000,000 | 114,940,000 | 4.1141 | 1.2836 | 09/30/2025 |
| 12 | Adage Capital Management LP | 977,629 | 977,629 | 112,368,677.26 | 0.1707 | 1.2549 | 09/30/2025 |
| 13 | Baker Bros. Advisors LP | 875,796 | 875,796 | 100,663,992.24 | 0.4985 | 1.1242 | 09/30/2025 |
| 14 | Farallon Capital Management LLC | 805,000 | 805,000 | 92,526,700 | 0.4653 | 1.0333 | 09/30/2025 |
| 15 | Saturn V Capital Management LP | 801,224 | 248,298 | 92,092,686.56 | 15.7851 | 1.0285 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Xtrackers SICAV - MSCI World Swap UCITS ETF | 764,899 | 764,899 | 87,917,491.06 | 0.8177 | 0.9819 | 11/28/2025 |
| 2 | Eventide Healthcare & Life Sciences Fund | 396,904 | 396,904 | 45,620,145.76 | 2.8223 | 0.5095 | 09/30/2025 |
| 3 | Fidelity Growth Company Commingled Pool | 374,807 | 374,807 | 43,080,316.58 | 0.0403 | 0.4811 | 10/31/2025 |
| 4 | Alger Institutional Funds - Focus Equity Fund | 314,786 | 314,786 | 36,181,502.84 | 0.8272 | 0.4041 | 10/31/2025 |
| 5 | FTIF SICAV - Biotechnology Discovery Fund | 307,602 | -565,693 | 35,355,773.88 | 1.9991 | 0.3949 | 10/31/2025 |
| 6 | Fidelity Growth Company Fund | 298,473 | 298,473 | 34,306,486.62 | 0.0432 | 0.3831 | 10/31/2025 |
| 7 | abrdn World Healthcare Fund | 261,641 | -448,875 | 30,073,016.54 | 5.166 | 0.3359 | 11/30/2025 |
| 8 | Alger Funds II - Alger Spectra Fund | 258,451 | 258,451 | 29,706,357.94 | 0.6788 | 0.3318 | 10/31/2025 |
| 9 | FCP Medical - BioHealth | 201,222 | 201,222 | 23,128,456.68 | 2.506 | 0.2583 | 09/30/2025 |
| 10 | Harbor Small Cap Growth Fund | 178,210 | 178,210 | 20,483,457.4 | 0.9499 | 0.2288 | 10/31/2025 |
| 11 | Franklin Biotechnology Discovery Fund | 173,710 | -323,982 | 19,966,227.4 | 1.932 | 0.223 | 10/31/2025 |
| 12 | Alger Institutional Funds - Capital Appreciation Inst. Fund | 173,148 | 173,148 | 19,901,631.12 | 0.6207 | 0.2223 | 10/31/2025 |
| 13 | Alger Small Cap Focus Fund | 154,768 | 154,768 | 17,789,033.92 | 1.9751 | 0.1987 | 10/31/2025 |
| 14 | Westfield Small/Mid Cap Growth Equity | 138,500 | 138,500 | 15,919,190 | 0.9713 | 0.1778 | 10/31/2025 |
| 15 | Lord Abbett Developing Growth Fund | 138,439 | 138,439 | 15,912,178.66 | 0.7221 | 0.1777 | 07/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | UBS Securities LLC | 4,183,385 | 4,020,831 | 480,838,271.9 | 0.1957 | 5.37 | 09/30/2025 |
| 2 | Darwin Global Management Ltd. | 3,164,501 | 3,164,501 | 363,727,744.94 | 6.6562 | 4.0621 | 09/30/2025 |
| 3 | Point72 Asset Management LP | 2,925,352 | 2,895,934 | 336,239,958.88 | 0.6103 | 3.7551 | 09/30/2025 |
| 4 | Paradigm BioCapital Advisors LP | 1,564,196 | 1,564,196 | 179,788,688.24 | 4.1707 | 2.0079 | 09/30/2025 |
| 5 | Fidelity Management & Research Co. LLC | 1,430,673 | 1,430,673 | 164,441,554.62 | 0.0091 | 1.8365 | 09/30/2025 |
| 6 | Vestal Point Capital LP | 1,000,000 | 1,000,000 | 114,940,000 | 4.1141 | 1.2836 | 09/30/2025 |
| 7 | Adage Capital Management LP | 977,629 | 977,629 | 112,368,677.26 | 0.1707 | 1.2549 | 09/30/2025 |
| 8 | Baker Bros. Advisors LP | 875,796 | 875,796 | 100,663,992.24 | 0.4985 | 1.1242 | 09/30/2025 |
| 9 | Farallon Capital Management LLC | 805,000 | 805,000 | 92,526,700 | 0.4653 | 1.0333 | 09/30/2025 |
| 10 | Nationale-Nederlanden PTE SA | 731,523 | 731,523 | 84,081,253.62 | 0.4935 | 0.939 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Deep Track Capital LP | 0 | -3,579,209 | 0 | 0 | 0 | |
| 2 | Great Point Partners LLC | 150,000 | -1,488,111 | 17,241,000 | 5.6868 | 0.1925 | 09/30/2025 |
| 3 | VHCP Management LLC | 0 | -998,570 | 0 | 0 | 0 | |
| 4 | Allostery Investments LP | 167,350 | -932,304 | 19,235,209 | 69.1492 | 0.2148 | 06/30/2025 |
| 5 | Nantahala Capital Management LLC | 557,564 | -925,430 | 64,086,406.16 | 3.497 | 0.7157 | 09/30/2025 |
| 6 | JPMorgan Securities LLC (Investment Management) | 0 | -907,679 | 0 | 0 | 0 | |
| 7 | Adar1 Capital Management LLC | 1,350,826 | -859,193 | 155,263,940.44 | 14.43 | 1.734 | 09/30/2025 |
| 8 | Franklin Advisers, Inc. | 516,090 | -854,960 | 59,319,384.6 | 0.0264 | 0.6625 | 09/30/2025 |
| 9 | Citadel Advisors LLC | 516,679 | -812,931 | 59,387,084.26 | 0.0639 | 0.6632 | 09/30/2025 |
| 10 | Kennedy Capital Management LLC | 0 | -225,191 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.