| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | UBS Securities LLC | 4,423,095 | 239,710 | 519,182,891.1 | 0.2028 | 5.587 | 12/31/2025 |
| 2 | Darwin Global Management Ltd. | 3,178,501 | 14,000 | 373,092,447.38 | 8.7392 | 4.0149 | 12/31/2025 |
| 3 | Point72 Asset Management LP | 2,409,154 | -516,198 | 282,786,496.52 | 0.4027 | 3.0431 | 12/31/2025 |
| 4 | Vestal Point Capital LP | 1,900,000 | 900,000 | 223,022,000 | 7.1294 | 2.4 | 12/31/2025 |
| 5 | Morgan Stanley & Co. LLC | 1,732,153 | 1,095,904 | 203,320,119.14 | 0.0681 | 2.188 | 12/31/2025 |
| 6 | Caligan Partners LP | 1,451,924 | 0 | 170,426,839.12 | 14.106 | 1.834 | 12/31/2025 |
| 7 | Paradigm BioCapital Advisors LP | 1,417,473 | -146,723 | 166,382,980.74 | 3.7534 | 1.7905 | 12/31/2025 |
| 8 | Fidelity Management & Research Co. LLC | 1,365,657 | -65,016 | 160,300,818.66 | 0.0082 | 1.725 | 12/31/2025 |
| 9 | Cormorant Asset Management LP | 1,350,000 | -600,000 | 158,463,000 | 8.6937 | 1.7052 | 12/31/2025 |
| 10 | Adar1 Capital Management LLC | 1,317,329 | -33,497 | 154,628,078.02 | 11.8347 | 1.664 | 12/31/2025 |
| 11 | Morgan Stanley & Co. International Plc | 1,293,879 | 517,899 | 151,875,517.02 | 1.3597 | 1.6344 | 12/31/2025 |
| 12 | Westfield Capital Management Co. LP | 1,009,966 | 1,009,966 | 118,549,809.08 | 0.4521 | 1.2757 | 12/31/2025 |
| 13 | Baker Bros. Advisors LP | 875,796 | 0 | 102,800,934.48 | 0.4968 | 1.1063 | 12/31/2025 |
| 14 | Lord, Abbett & Co. LLC | 849,732 | 513,026 | 99,741,542.16 | 0.2684 | 1.0733 | 12/31/2025 |
| 15 | DWS Investments (UK) Ltd. | 764,899 | 764,899 | 89,783,844.62 | 0.0359 | 0.9662 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Lord Abbett Growth Leaders Fund | 468,485 | 468,485 | 54,990,769.3 | 0.6957 | 0.5918 | 01/31/2026 |
| 2 | Fidelity Growth Company Commingled Pool | 452,154 | 100,524 | 53,073,836.52 | 0.044 | 0.5711 | 02/28/2026 |
| 3 | T Rowe Price Health Sciences Fund | 427,254 | 427,254 | 50,151,074.52 | 0.4555 | 0.5397 | 03/31/2026 |
| 4 | iShares Biotechnology ETF | 367,461 | 367,461 | 43,132,572.18 | 0.5316 | 0.4642 | 03/31/2026 |
| 5 | Fidelity Growth Company Fund | 343,880 | 61,110 | 40,364,634.4 | 0.044 | 0.4344 | 02/28/2026 |
| 6 | Alger Institutional Funds - Focus Equity Fund | 328,226 | 37,331 | 38,527,167.88 | 0.726 | 0.4146 | 01/31/2026 |
| 7 | Eventide Healthcare & Life Sciences Fund | 327,851 | -69,053 | 38,483,150.38 | 2.3591 | 0.4141 | 12/31/2025 |
| 8 | Alger Funds II - Alger Spectra Fund | 280,615 | 22,164 | 32,938,588.7 | 0.7576 | 0.3545 | 01/31/2026 |
| 9 | Harbor Small Cap Growth Fund | 276,950 | 276,950 | 32,508,391 | 1.3181 | 0.3498 | 01/31/2026 |
| 10 | FTIF SICAV - Biotechnology Discovery Fund | 241,727 | -92,821 | 28,373,915.26 | 1.6186 | 0.3053 | 03/31/2026 |
| 11 | abrdn World Healthcare Fund | 223,613 | -310,543 | 26,247,693.94 | 4.6836 | 0.2825 | 03/31/2026 |
| 12 | FCP Medical - BioHealth | 221,159 | 19,937 | 25,959,643.42 | 2.5143 | 0.2794 | 01/30/2026 |
| 13 | Worldwide Healthcare Trust Plc | 217,300 | 217,300 | 25,506,674 | 1.3964 | 0.2745 | 03/31/2026 |
| 14 | Pictet - Global Megatrend Selection | 202,971 | 0 | 23,824,735.98 | 0.199 | 0.2564 | 09/30/2025 |
| 15 | Alger Institutional Funds - Capital Appreciation Inst. Fund | 191,511 | 18,363 | 22,479,561.18 | 0.6883 | 0.2419 | 01/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Morgan Stanley & Co. LLC | 1,732,153 | 1,095,904 | 203,320,119.14 | 0.0681 | 2.188 | 12/31/2025 |
| 2 | Westfield Capital Management Co. LP | 1,009,966 | 1,009,966 | 118,549,809.08 | 0.4521 | 1.2757 | 12/31/2025 |
| 3 | Vestal Point Capital LP | 1,900,000 | 900,000 | 223,022,000 | 7.1294 | 2.4 | 12/31/2025 |
| 4 | DWS Investments (UK) Ltd. | 764,899 | 764,899 | 89,783,844.62 | 0.0359 | 0.9662 | 12/31/2025 |
| 5 | Susquehanna Financial Group LLLP | 754,836 | 720,222 | 88,602,649.68 | 0.1177 | 0.9535 | 12/31/2025 |
| 6 | Morgan Stanley & Co. International Plc | 1,293,879 | 517,899 | 151,875,517.02 | 1.3597 | 1.6344 | 12/31/2025 |
| 7 | Lord, Abbett & Co. LLC | 849,732 | 513,026 | 99,741,542.16 | 0.2684 | 1.0733 | 12/31/2025 |
| 8 | JPMorgan Securities LLC (Investment Management) | 455,919 | 455,919 | 53,515,772.22 | 0.0341 | 0.5759 | 12/31/2025 |
| 9 | BlackRock Fund Advisors | 384,227 | 384,227 | 45,100,565.26 | 0.0009 | 0.4853 | 12/31/2025 |
| 10 | Artia Global Partners LP | 600,747 | 375,294 | 70,515,682.86 | 13.0493 | 0.7588 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Fairmount Funds Management LLC | 0 | -713,434 | 0 | 0 | 0 | |
| 2 | Cormorant Asset Management LP | 1,350,000 | -600,000 | 158,463,000 | 8.6937 | 1.7052 | 12/31/2025 |
| 3 | Octagon Capital Advisors LP | 756,000 | -569,000 | 88,739,280 | 9.144 | 0.9549 | 12/31/2025 |
| 4 | Point72 Asset Management LP | 2,409,154 | -516,198 | 282,786,496.52 | 0.4027 | 3.0431 | 12/31/2025 |
| 5 | Adage Capital Management LP | 550,000 | -427,629 | 64,559,000 | 0.0917 | 0.6947 | 12/31/2025 |
| 6 | Farallon Capital Management LLC | 387,000 | -418,000 | 45,426,060 | 0.2489 | 0.4888 | 12/31/2025 |
| 7 | Nantahala Capital Management LLC | 153,235 | -404,329 | 17,986,724.3 | 1.0548 | 0.1936 | 12/31/2025 |
| 8 | Millennium Management LLC | 741,060 | -358,970 | 86,985,622.8 | 0.06 | 0.9361 | 12/31/2025 |
| 9 | abrdn, Inc. | 431,241 | -356,176 | 50,619,068.58 | 0.458 | 0.5447 | 03/31/2026 |
| 10 | RTW Investments LP | 0 | -350,000 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.