| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | UBS Securities LLC | 4,526,414 | 343,029 | 460,155,247.24 | 0.1614 | 5.6797 | 03/31/2026 |
| 2 | Darwin Global Management Ltd. | 3,468,657 | 304,156 | 352,623,670.62 | 10.1966 | 4.3524 | 03/31/2026 |
| 3 | Vestal Point Capital LP | 1,500,000 | 500,000 | 152,490,000 | 3.896 | 1.8822 | 03/31/2026 |
| 4 | Caligan Partners LP | 1,461,924 | 10,000 | 148,619,193.84 | 7.9664 | 1.8344 | 03/31/2026 |
| 5 | Morgan Stanley & Co. International Plc | 1,420,549 | 644,569 | 144,413,011.34 | 1.1937 | 1.7825 | 03/31/2026 |
| 6 | Adar1 Capital Management LLC | 1,394,019 | 43,193 | 141,715,971.54 | 7.9799 | 1.7492 | 03/31/2026 |
| 7 | Westfield Capital Management Co. LP | 1,322,938 | 1,322,938 | 134,489,877.08 | 0.4689 | 1.66 | 03/31/2026 |
| 8 | Fidelity Management & Research Co. LLC | 1,286,373 | -144,300 | 130,772,679.18 | 0.0064 | 1.6141 | 03/31/2026 |
| 9 | Helikon Investments Ltd. | 1,013,324 | 1,013,324 | 103,014,517.84 | 1.3693 | 1.2715 | 03/31/2026 |
| 10 | Eversept Partners LP | 934,423 | 507,924 | 94,993,442.18 | 6.1022 | 1.1725 | 03/31/2026 |
| 11 | Janus Henderson Investors US LLC | 878,829 | 524,095 | 89,341,756.14 | 0.0393 | 1.1027 | 03/31/2026 |
| 12 | Baker Bros. Advisors LP | 875,796 | 0 | 89,033,421.36 | 0.4235 | 1.0989 | 03/31/2026 |
| 13 | Lord, Abbett & Co. LLC | 854,920 | 518,214 | 86,911,167.2 | 0.2299 | 1.0727 | 03/31/2026 |
| 14 | Paradigm BioCapital Advisors LP | 772,473 | -791,723 | 78,529,605.18 | 1.6317 | 0.9693 | 03/31/2026 |
| 15 | Nationale-Nederlanden Powszechne Towarzystwo Emerytalne SA | 765,915 | 34,392 | 77,862,918.9 | 0.3894 | 0.9611 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Lord Abbett Growth Leaders Fund | 468,485 | 468,485 | 47,626,185.1 | 0.5661 | 0.5879 | 01/31/2026 |
| 2 | T Rowe Price Health Sciences Fund | 427,254 | 427,254 | 43,434,641.64 | 0.3785 | 0.5361 | 03/31/2026 |
| 3 | Fidelity Growth Company Commingled Pool | 358,793 | -33,114 | 36,474,896.38 | 0.0285 | 0.4502 | 04/30/2026 |
| 4 | iShares Biotechnology ETF | 358,494 | 358,494 | 36,444,500.04 | 0.4472 | 0.4498 | 05/29/2026 |
| 5 | Eventide Healthcare & Life Sciences Fund | 320,311 | -76,593 | 32,562,816.26 | 1.8952 | 0.4019 | 03/31/2026 |
| 6 | Alger Funds II - Alger Spectra Fund | 280,615 | 22,164 | 28,527,320.9 | 0.6081 | 0.3521 | 04/30/2026 |
| 7 | Fidelity Growth Company Fund | 279,580 | -32,193 | 28,422,102.8 | 0.0292 | 0.3508 | 04/30/2026 |
| 8 | Harbor Small Cap Growth Fund | 276,950 | 98,740 | 28,154,737 | 1.0632 | 0.3475 | 01/31/2026 |
| 9 | Alger Focus Equity Fund | 257,673 | -18,535 | 26,195,037.18 | 0.3914 | 0.3233 | 04/30/2026 |
| 10 | FTIF SICAV - Biotechnology Discovery Fund | 225,400 | -59,107 | 22,914,164 | 1.2318 | 0.2828 | 05/31/2026 |
| 11 | Worldwide Healthcare Trust Plc | 225,200 | 225,200 | 22,893,832 | 1.2378 | 0.2826 | 05/31/2026 |
| 12 | Lord Abbett Developing Growth Fund | 183,074 | -23,700 | 18,611,302.84 | 0.7379 | 0.2297 | 01/31/2026 |
| 13 | Alger Capital Appreciation Institutional Fund | 169,998 | 4,765 | 17,281,996.68 | 0.4738 | 0.2133 | 04/30/2026 |
| 14 | Alger Small Cap Focus Fund | 152,474 | -24,433 | 15,500,506.84 | 1.696 | 0.1913 | 04/30/2026 |
| 15 | FCP Medical - BioHealth | 149,547 | -51,675 | 15,202,948.02 | 1.4637 | 0.1877 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Westfield Capital Management Co. LP | 1,322,938 | 1,322,938 | 134,489,877.08 | 0.4689 | 1.66 | 03/31/2026 |
| 2 | Helikon Investments Ltd. | 1,013,324 | 1,013,324 | 103,014,517.84 | 1.3693 | 1.2715 | 03/31/2026 |
| 3 | Morgan Stanley & Co. International Plc | 1,420,549 | 644,569 | 144,413,011.34 | 1.1937 | 1.7825 | 03/31/2026 |
| 4 | JPMorgan Securities LLC (Investment Management) | 635,023 | 635,023 | 64,556,438.18 | 0.0299 | 0.7968 | 03/31/2026 |
| 5 | Bank of America, NA (Private Banking) | 607,521 | 531,629 | 61,760,584.86 | 0.0166 | 0.7623 | 03/31/2026 |
| 6 | Janus Henderson Investors US LLC | 878,829 | 524,095 | 89,341,756.14 | 0.0393 | 1.1027 | 03/31/2026 |
| 7 | Lord, Abbett & Co. LLC | 854,920 | 518,214 | 86,911,167.2 | 0.2299 | 1.0727 | 03/31/2026 |
| 8 | Eversept Partners LP | 934,423 | 507,924 | 94,993,442.18 | 6.1022 | 1.1725 | 03/31/2026 |
| 9 | Vestal Point Capital LP | 1,500,000 | 500,000 | 152,490,000 | 3.896 | 1.8822 | 03/31/2026 |
| 10 | Artia Global Partners LP | 600,747 | 375,294 | 61,071,940.02 | 14.3726 | 0.7538 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Point72 Asset Management LP | 637,736 | -2,287,616 | 64,832,241.76 | 0.093 | 0.8002 | 03/31/2026 |
| 2 | Cormorant Asset Management LP | 760,000 | -1,190,000 | 77,261,600 | 3.6161 | 0.9536 | 03/31/2026 |
| 3 | Farallon Capital Management LLC | 2,000 | -803,000 | 203,320 | 0.0011 | 0.0025 | 03/31/2026 |
| 4 | Paradigm BioCapital Advisors LP | 772,473 | -791,723 | 78,529,605.18 | 1.6317 | 0.9693 | 03/31/2026 |
| 5 | Fairmount Funds Management LLC | 0 | -713,434 | 0 | 0 | 0 | |
| 6 | Octagon Capital Advisors LP | 677,000 | -648,000 | 68,823,820 | 6.6651 | 0.8495 | 03/31/2026 |
| 7 | Adage Capital Management LP | 400,539 | -577,090 | 40,718,794.74 | 0.0556 | 0.5026 | 03/31/2026 |
| 8 | BVF Partners LP | 0 | -558,031 | 0 | 0 | 0 | |
| 9 | Millennium Management LLC | 605,992 | -494,038 | 61,605,146.72 | 0.042 | 0.7604 | 03/31/2026 |
| 10 | Morgan Stanley & Co. LLC | 155,108 | -481,141 | 15,768,279.28 | 0.0046 | 0.1946 | 03/31/2026 |
Data provided by FactSet Research Systems Inc.