| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Darwin Global Management Ltd. | 3,621,583 | 443,082 | 437,233,715.59 | 9.1367 | 4.1506 | 06/30/2026 |
| 2 | Helikon Investments Ltd. | 2,787,131 | 2,787,131 | 336,490,325.63 | 3.6732 | 3.1943 | 06/30/2026 |
| 3 | Vestal Point Capital LP | 2,349,443 | 449,443 | 283,648,253.39 | 6.4579 | 2.6927 | 06/30/2026 |
| 4 | Janus Henderson Investors US LLC | 1,909,022 | 1,241,261 | 230,476,226.06 | 0.0989 | 2.1879 | 06/30/2026 |
| 5 | UBS Securities LLC | 1,842,467 | -2,580,628 | 222,441,040.91 | 0.0804 | 2.1116 | 06/30/2026 |
| 6 | Adar1 Capital Management LLC | 1,804,703 | 487,374 | 217,881,793.19 | 9.5384 | 2.0683 | 06/30/2026 |
| 7 | Caligan Partners LP | 1,557,924 | 106,000 | 188,088,164.52 | 8.7277 | 1.7855 | 06/30/2026 |
| 8 | Westfield Capital Management Co. LP | 1,309,825 | 299,859 | 158,135,172.25 | 0.5131 | 1.5012 | 06/30/2026 |
| 9 | RA Capital Management LP | 1,132,557 | 1,132,557 | 136,733,606.61 | 1.1229 | 1.298 | 06/30/2026 |
| 10 | Norges Bank Investment Management | 1,100,000 | 1,100,000 | 132,803,000 | 0.0075 | 1.2607 | 06/30/2026 |
| 11 | Susquehanna Financial Group LLLP | 1,053,896 | 299,060 | 127,236,864.08 | 0.115 | 1.2079 | 06/30/2026 |
| 12 | Logos Global Management LP | 1,024,000 | 624,000 | 123,627,520 | 5.2006 | 1.1736 | 06/30/2026 |
| 13 | Octagon Capital Advisors LP | 993,000 | 237,000 | 119,884,890 | 11.0778 | 1.1381 | 06/30/2026 |
| 14 | Eversept Partners LP | 913,880 | 256,046 | 110,332,732.4 | 6.0528 | 1.0474 | 06/30/2026 |
| 15 | Citadel Securities LLC | 851,611 | 642,100 | 102,814,996.03 | 0.2406 | 0.976 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | iShares Biotechnology ETF | 476,101 | 87,854 | 57,479,673.73 | 0.5763 | 0.5457 | 07/31/2026 |
| 2 | Lord Abbett Growth Leaders Fund | 468,485 | 0 | 56,560,194.05 | 0.6818 | 0.5369 | 04/30/2026 |
| 3 | Worldwide Healthcare Trust Plc | 320,500 | 201,600 | 38,693,965 | 1.9422 | 0.3673 | 07/31/2026 |
| 4 | Eventide Healthcare & Life Sciences Fund | 320,311 | -7,540 | 38,671,147.03 | 2.0751 | 0.3671 | 03/31/2026 |
| 5 | Harbor Small Cap Growth Fund | 287,800 | 10,850 | 34,746,094 | 1.3022 | 0.3298 | 04/30/2026 |
| 6 | Alger Funds II - Alger Spectra Fund | 280,615 | 0 | 33,878,648.95 | 0.719 | 0.3216 | 05/31/2026 |
| 7 | Janus Henderson Horizon Fund - Biotechnology Fund | 275,853 | 246,418 | 33,303,732.69 | 1.5563 | 0.3162 | 06/30/2026 |
| 8 | Alger Focus Equity Fund | 257,673 | -70,553 | 31,108,861.29 | 0.446 | 0.2953 | 05/31/2026 |
| 9 | FTIF SICAV - Biotechnology Discovery Fund | 190,716 | -93,791 | 23,025,142.68 | 1.0883 | 0.2186 | 06/30/2026 |
| 10 | abrdn World Healthcare Fund | 189,508 | -72,133 | 22,879,300.84 | 3.5016 | 0.2172 | 06/30/2026 |
| 11 | Lord Abbett Developing Growth Fund | 183,074 | 0 | 22,102,524.02 | 0.9189 | 0.2098 | 04/30/2026 |
| 12 | abrdn Healthcare Investors | 178,106 | 99,477 | 21,502,737.38 | 1.5143 | 0.2041 | 07/31/2026 |
| 13 | Alger Capital Appreciation Institutional Fund | 169,998 | -21,513 | 20,523,858.54 | 0.5572 | 0.1948 | 05/31/2026 |
| 14 | Alger Small Cap Focus Fund | 152,474 | 0 | 18,408,186.02 | 1.8851 | 0.1747 | 05/31/2026 |
| 15 | abrdn Healthcare Opportunities Fund | 141,841 | 81,332 | 17,124,463.93 | 1.7369 | 0.1626 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Helikon Investments Ltd. | 2,787,131 | 2,787,131 | 336,490,325.63 | 3.6732 | 3.1943 | 06/30/2026 |
| 2 | Janus Henderson Investors US LLC | 1,909,022 | 1,241,261 | 230,476,226.06 | 0.0989 | 2.1879 | 06/30/2026 |
| 3 | RA Capital Management LP | 1,132,557 | 1,132,557 | 136,733,606.61 | 1.1229 | 1.298 | 06/30/2026 |
| 4 | Norges Bank Investment Management | 1,100,000 | 1,100,000 | 132,803,000 | 0.0075 | 1.2607 | 06/30/2026 |
| 5 | Citadel Securities LLC | 851,611 | 642,100 | 102,814,996.03 | 0.2406 | 0.976 | 06/30/2026 |
| 6 | Logos Global Management LP | 1,024,000 | 624,000 | 123,627,520 | 5.2006 | 1.1736 | 06/30/2026 |
| 7 | Goldman Sachs & Co. LLC (Private Banking) | 683,227 | 499,116 | 82,485,995.71 | 0.0142 | 0.783 | 06/30/2026 |
| 8 | Adar1 Capital Management LLC | 1,804,703 | 487,374 | 217,881,793.19 | 9.5384 | 2.0683 | 06/30/2026 |
| 9 | Boxer Capital Management LLC | 605,000 | 480,000 | 73,041,650 | 5.5563 | 0.6934 | 06/30/2026 |
| 10 | Vestal Point Capital LP | 2,349,443 | 449,443 | 283,648,253.39 | 6.4579 | 2.6927 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | UBS Securities LLC | 1,842,467 | -2,580,628 | 222,441,040.91 | 0.0804 | 2.1116 | 06/30/2026 |
| 2 | Point72 Asset Management LP | 5,028 | -2,404,126 | 607,030.44 | 0.0009 | 0.0058 | 06/30/2026 |
| 3 | Paradigm BioCapital Advisors LP | 0 | -1,417,473 | 0 | 0 | 0 | |
| 4 | Morgan Stanley & Co. LLC | 511,427 | -1,220,726 | 61,744,581.71 | 0.0177 | 0.5861 | 06/30/2026 |
| 5 | Fidelity Management & Research Co. LLC | 191,662 | -1,173,995 | 23,139,353.26 | 0.0011 | 0.2197 | 06/30/2026 |
| 6 | Baker Bros. Advisors LP | 0 | -875,796 | 0 | 0 | 0 | |
| 7 | Lord, Abbett & Co. LLC | 9,500 | -840,232 | 1,146,935 | 0.003 | 0.0109 | 06/30/2026 |
| 8 | DWS Investments (UK) Ltd. | 0 | -764,899 | 0 | 0 | 0 | |
| 9 | Cormorant Asset Management LP | 675,000 | -675,000 | 81,492,750 | 3.8611 | 0.7736 | 06/30/2026 |
| 10 | Adage Capital Management LP | 26,500 | -523,500 | 3,199,345 | 0.0043 | 0.0304 | 06/30/2026 |
Data provided by FactSet Research Systems Inc.