# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Redmile Group LLC 2,733,926 2,733,926 37,017,358.04 2.1033 5.5513 06/30/2026
2 Cormorant Asset Management LP 2,465,348 2,465,348 33,380,811.92 1.6798 5.006 06/30/2026
3 Federated Global Investment Management Corp. 1,618,000 1,618,000 21,907,720 0.1873 3.2854 06/30/2026
4 Nantahala Capital Management LLC 1,568,188 1,568,188 21,233,265.52 1.205 3.1843 06/30/2026
5 Casdin Capital LLC 1,550,000 1,550,000 20,987,000 0.9715 3.1473 06/30/2026
6 Fidelity Management & Research Co. LLC 1,458,677 1,458,677 19,750,486.58 0.001 2.9619 06/30/2026
7 abrdn, Inc. 846,695 846,695 11,464,250.3 0.1012 1.7192 06/30/2026
8 Perceptive Advisors LLC 600,000 600,000 8,124,000 0.1225 1.2183 06/30/2026
9 ALPS Advisors, Inc. 49,984 49,984 676,783.36 0.0026 0.1015 06/30/2026
10 Bellevue Asset Management AG 49,248 49,248 666,817.92 0.0106 0.1 06/30/2026
11 Seven Grand Managers LLC 47,600 47,600 644,504 0.0287 0.0967 06/30/2026
12 Sectoral Asset Management, Inc. 43,500 43,500 588,990 0.3502 0.0883 06/30/2026
13 Burkehill Global Management LP 35,000 35,000 473,900 0.019 0.0711 06/30/2026
14 Quadrature Capital Ltd. 20,461 20,461 277,041.94 0.0024 0.0415 06/30/2026
15 Two Sigma Investments LP 18,072 18,072 244,694.88 0.0002 0.0367 06/30/2026
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Fidelity Growth Company Commingled Pool 2,148,655 1,844 29,092,788.7 0.0228 4.3629 07/31/2026
2 Federated Hermes Kaufmann Fund 981,184 981,184 13,285,231.36 0.2628 1.9923 06/30/2026
3 Federated Hermes Kaufmann Small Cap Fund 615,708 615,708 8,336,686.32 0.2872 1.2502 06/30/2026
4 Fidelity Growth Company Fund 507,250 -627 6,868,165 0.0071 1.03 07/31/2026
5 abrdn Healthcare Investors 363,500 363,500 4,921,790 0.3492 0.7381 07/31/2026
6 abrdn World Healthcare Fund 312,731 37,731 4,234,377.74 0.6574 0.635 07/31/2026
7 abrdn Life Sciences Investors 170,464 170,464 2,308,082.56 0.3323 0.3461 06/30/2026
8 Fidelity Growth Company K6 Fund 141,983 -1,217 1,922,449.82 0.0069 0.2883 07/31/2026
9 Fidelity Series Growth Company Fund 129,200 0 1,749,368 0.0075 0.2623 07/31/2026
10 Biotech Growth Trust Plc (The) 111,540 111,540 1,510,251.6 0.3314 0.2265 07/31/2026
11 ALPS Medical Breakthroughs ETF 60,956 60,956 825,344.24 0.3433 0.1238 08/31/2026
12 Protea Fund - Sectoral Healthcare Opportunities Fund 26,935 -13,500 364,699.9 0.4396 0.0547 07/31/2026
13 Federated Hermes Kaufmann Fund II 21,108 21,108 285,802.32 0.2645 0.0429 06/30/2026
14 Blackstone Alternative Multi Strategy Fund 17,665 17,665 239,184.1 0.0149 0.0359 06/30/2026
15 Protea Fund - Sectoral Biotech Opportunities Fund 16,565 0 224,290.1 0.714 0.0336 07/31/2026
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Redmile Group LLC 2,733,926 2,733,926 37,017,358.04 2.1033 5.5513 06/30/2026
2 Cormorant Asset Management LP 2,465,348 2,465,348 33,380,811.92 1.6798 5.006 06/30/2026
3 Federated Global Investment Management Corp. 1,618,000 1,618,000 21,907,720 0.1873 3.2854 06/30/2026
4 Nantahala Capital Management LLC 1,568,188 1,568,188 21,233,265.52 1.205 3.1843 06/30/2026
5 Casdin Capital LLC 1,550,000 1,550,000 20,987,000 0.9715 3.1473 06/30/2026
6 Fidelity Management & Research Co. LLC 1,458,677 1,458,677 19,750,486.58 0.001 2.9619 06/30/2026
7 abrdn, Inc. 846,695 846,695 11,464,250.3 0.1012 1.7192 06/30/2026
8 Perceptive Advisors LLC 600,000 600,000 8,124,000 0.1225 1.2183 06/30/2026
9 ALPS Advisors, Inc. 49,984 49,984 676,783.36 0.0026 0.1015 06/30/2026
10 Bellevue Asset Management AG 49,248 49,248 666,817.92 0.0106 0.1 06/30/2026
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
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Data provided by FactSet Research Systems Inc.