| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Redmile Group LLC | 2,733,926 | 2,577,676 | 25,316,154.76 | 1.7019 | 5.5513 | 06/30/2026 |
| 2 | Cormorant Asset Management LP | 2,465,348 | 0 | 22,829,122.48 | 1.5971 | 5.006 | 06/30/2026 |
| 3 | Federated Global Investment Management Corp. | 1,618,000 | 0 | 14,982,680 | 0.1367 | 3.2854 | 06/30/2026 |
| 4 | Nantahala Capital Management LLC | 1,568,188 | 368,188 | 14,521,420.88 | 0.9135 | 3.1843 | 06/30/2026 |
| 5 | Casdin Capital LLC | 1,550,000 | 0 | 14,353,000 | 0.7135 | 3.1473 | 06/30/2026 |
| 6 | Fidelity Management & Research Co. LLC | 1,458,677 | 0 | 13,507,349.02 | 0.0007 | 2.9619 | 06/30/2026 |
| 7 | abrdn, Inc. | 846,695 | 139,039 | 7,840,395.7 | 0.0729 | 1.7192 | 06/30/2026 |
| 8 | Perceptive Advisors LLC | 600,000 | 0 | 5,556,000 | 0.0991 | 1.2183 | 06/30/2026 |
| 9 | ALPS Advisors, Inc. | 49,984 | 49,984 | 462,851.84 | 0.0019 | 0.1015 | 06/30/2026 |
| 10 | Bellevue Asset Management AG | 49,248 | -752 | 456,036.48 | 0.008 | 0.1 | 06/30/2026 |
| 11 | Seven Grand Managers LLC | 47,600 | -152,400 | 440,776 | 0.0213 | 0.0967 | 06/30/2026 |
| 12 | Sectoral Asset Management, Inc. | 43,500 | 0 | 402,810 | 0.2585 | 0.0883 | 06/30/2026 |
| 13 | Burkehill Global Management LP | 35,000 | 0 | 324,100 | 0.014 | 0.0711 | 06/30/2026 |
| 14 | Crossmark Global Investments, Inc. | 23,096 | 23,096 | 213,868.96 | 0.0028 | 0.0469 | 09/30/2026 |
| 15 | Quadrature Capital Ltd. | 20,461 | 20,461 | 189,468.86 | 0.0017 | 0.0415 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Federated Hermes Kaufmann Fund | 981,184 | 0 | 9,085,763.84 | 0.19 | 1.9923 | 06/30/2026 |
| 2 | Fidelity Growth Company Commingled Pool | 671,144 | -1,476,593 | 6,214,793.44 | 0.0049 | 1.3628 | 08/31/2026 |
| 3 | Federated Hermes Kaufmann Small Cap Fund | 615,708 | 0 | 5,701,456.08 | 0.2171 | 1.2502 | 06/30/2026 |
| 4 | Fidelity Growth Company Fund | 507,250 | -627 | 4,697,135 | 0.0049 | 1.03 | 08/31/2026 |
| 5 | abrdn Healthcare Investors | 463,275 | 463,275 | 4,289,926.5 | 0.3368 | 0.9407 | 09/30/2026 |
| 6 | abrdn World Healthcare Fund | 421,320 | 146,320 | 3,901,423.2 | 0.6397 | 0.8555 | 09/30/2026 |
| 7 | abrdn Life Sciences Investors | 170,464 | 28,677 | 1,578,496.64 | 0.282 | 0.3461 | 06/30/2026 |
| 8 | Fidelity Growth Company K6 Fund | 141,983 | -291 | 1,314,762.58 | 0.0047 | 0.2883 | 08/31/2026 |
| 9 | Fidelity Series Growth Company Fund | 129,200 | 0 | 1,196,392 | 0.005 | 0.2623 | 08/31/2026 |
| 10 | ALPS Medical Breakthroughs ETF | 64,778 | 64,778 | 599,844.28 | 0.3035 | 0.1315 | 09/30/2026 |
| 11 | Steward Values Enhanced International Fund | 23,096 | 23,096 | 213,868.96 | 0.0619 | 0.0469 | 09/30/2026 |
| 12 | Federated Hermes Kaufmann Fund II | 21,108 | 0 | 195,460.08 | 0.1913 | 0.0429 | 06/30/2026 |
| 13 | Blackstone Alternative Multi Strategy Fund | 17,665 | 17,665 | 163,577.9 | 0.0104 | 0.0359 | 06/30/2026 |
| 14 | Fidelity Nasdaq Composite Index Fund | 9,531 | 785 | 88,257.06 | 0.0003 | 0.0194 | 08/31/2026 |
| 15 | Fidelity Select Pharmaceuticals Portfolio | 9,100 | 0 | 84,266 | 0.005 | 0.0185 | 08/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Redmile Group LLC | 2,733,926 | 2,577,676 | 25,316,154.76 | 1.7019 | 5.5513 | 06/30/2026 |
| 2 | Nantahala Capital Management LLC | 1,568,188 | 368,188 | 14,521,420.88 | 0.9135 | 3.1843 | 06/30/2026 |
| 3 | abrdn, Inc. | 846,695 | 139,039 | 7,840,395.7 | 0.0729 | 1.7192 | 06/30/2026 |
| 4 | ALPS Advisors, Inc. | 49,984 | 49,984 | 462,851.84 | 0.0019 | 0.1015 | 06/30/2026 |
| 5 | Crossmark Global Investments, Inc. | 23,096 | 23,096 | 213,868.96 | 0.0028 | 0.0469 | 09/30/2026 |
| 6 | Quadrature Capital Ltd. | 20,461 | 20,461 | 189,468.86 | 0.0017 | 0.0415 | 06/30/2026 |
| 7 | XTX Markets LLC | 10,271 | 10,271 | 95,109.46 | 0.0012 | 0.0209 | 06/30/2026 |
| 8 | Citigroup Global Markets, Inc. (Investment Management) | 9,496 | 9,496 | 87,932.96 | 0 | 0.0193 | 06/30/2026 |
| 9 | Two Sigma Investments LP | 18,072 | 3,831 | 167,346.72 | 0.0001 | 0.0367 | 06/30/2026 |
| 10 | GAMMA Investing LLC | 1,396 | 1,396 | 12,926.96 | 0.0004 | 0.0028 | 09/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | LMR Partners LLP | 0 | -300,000 | 0 | 0 | 0 | |
| 2 | Seven Grand Managers LLC | 47,600 | -152,400 | 440,776 | 0.0213 | 0.0967 | 06/30/2026 |
| 3 | Millennium Management LLC | 0 | -95,233 | 0 | 0 | 0 | |
| 4 | Alyeska Investment Group LP | 0 | -75,000 | 0 | 0 | 0 | |
| 5 | Laurion Capital Management LP | 0 | -50,000 | 0 | 0 | 0 | |
| 6 | Citadel Advisors LLC | 0 | -35,000 | 0 | 0 | 0 | |
| 7 | Goldman Sachs & Co. LLC (Private Banking) | 11,800 | -23,939 | 109,268 | 0 | 0.024 | 06/30/2026 |
| 8 | D. E. Shaw & Co. LP | 0 | -15,326 | 0 | 0 | 0 | |
| 9 | Jane Street Capital LLC | 0 | -12,794 | 0 | 0 | 0 | |
| 10 | HRT Financial LP | 17,075 | -6,651 | 158,114.5 | 0.0004 | 0.0347 | 06/30/2026 |
Data provided by FactSet Research Systems Inc.