| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Sarissa Capital Management LP | 1,242,527 | -4 | 20,240,764.83 | 8.4364 | 6.0005 | 09/30/2025 |
| 2 | Kynam Capital Management LP | 576,111 | -44,620 | 9,384,848.19 | 0.4991 | 2.7822 | 09/30/2025 |
| 3 | Acadian Asset Management LLC | 456,580 | 267,004 | 7,437,688.2 | 0.0112 | 2.205 | 09/30/2025 |
| 4 | Morgan Stanley & Co. LLC | 254,547 | 138,502 | 4,146,570.63 | 0.0014 | 1.2293 | 09/30/2025 |
| 5 | Eversept Partners LP | 167,276 | -2,684 | 2,724,926.04 | 0.1803 | 0.8078 | 09/30/2025 |
| 6 | Millennium Management LLC | 132,391 | 131,401 | 2,156,649.39 | 0.0017 | 0.6394 | 09/30/2025 |
| 7 | SCP Investment LP | 100,000 | -25,000 | 1,629,000 | 1.2799 | 0.4829 | 09/30/2025 |
| 8 | BNP Paribas Financial Markets | 87,366 | 15,773 | 1,423,192.14 | 0.0011 | 0.4219 | 09/30/2025 |
| 9 | Waterfront Wealth, Inc. | 77,960 | -47,771 | 1,269,968.4 | 0.2504 | 0.3765 | 09/30/2025 |
| 10 | Citadel Securities LLC | 65,063 | 65,063 | 1,059,876.27 | 0.003 | 0.3142 | 09/30/2025 |
| 11 | Two Sigma Investments LP | 60,071 | -32,726 | 978,556.59 | 0.0015 | 0.2901 | 09/30/2025 |
| 12 | Quinn Opportunity Partners LLC | 58,461 | -1 | 952,329.69 | 0.0699 | 0.2823 | 09/30/2025 |
| 13 | Citadel Advisors LLC | 57,228 | 57,228 | 932,244.12 | 0.001 | 0.2764 | 09/30/2025 |
| 14 | PSM Vermogensverwaltung GmbH Langen v.d.Goltz, Dr. Prinz | 53,508 | 0 | 871,645.32 | 10.396 | 0.2584 | 12/31/2024 |
| 15 | Susquehanna Financial Group LLLP | 48,160 | 37,869 | 784,526.4 | 0.0012 | 0.2326 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | PSM Macro Strategy | 51,008 | 0 | 830,920.32 | 7.2991 | 0.2463 | 12/31/2024 |
| 2 | Old Westbury Small & Mid Cap Strategies Fund | 48,910 | 30,513 | 796,743.9 | 0.0087 | 0.2362 | 07/31/2025 |
| 3 | SPDR Portfolio Developed World ex-US ETF | 15,774 | 1,478 | 256,958.46 | 0.0008 | 0.0762 | 11/28/2025 |
| 4 | iShares IV Plc - NASDAQ US Biotechnology UCITS ETF | 13,824 | 3,611 | 225,192.96 | 0.0265 | 0.0668 | 11/28/2025 |
| 5 | SEI Institutional Intl. Trust-International Equity | 13,654 | 11,661 | 222,423.66 | 0.0062 | 0.0659 | 10/31/2025 |
| 6 | Fidelity Nasdaq Composite Index Fund | 11,771 | 4,039 | 191,749.59 | 0.0008 | 0.0568 | 10/31/2025 |
| 7 | Macquarie Healthcare Fund | 9,500 | 0 | 154,755 | 0.0213 | 0.0459 | 10/31/2025 |
| 8 | SPDR S&P International Small Cap ETF | 7,664 | 1,172 | 124,846.56 | 0.0161 | 0.037 | 11/28/2025 |
| 9 | Invesco Markets Plc - NASDAQ Biotech UCITS ETF | 7,122 | 1,548 | 116,017.38 | 0.0261 | 0.0344 | 11/28/2025 |
| 10 | Voya Multi Manager International Small Cap Fund | 7,057 | -1 | 114,958.53 | 0.0276 | 0.0341 | 06/30/2025 |
| 11 | LUNIS Biotech Growth Opportunities Fund | 6,900 | 0 | 112,401 | 5.2909 | 0.0333 | 09/30/2024 |
| 12 | MGI Funds Plc - Acadian European Small Cap Equity | 5,141 | 5,141 | 83,746.89 | 0.1146 | 0.0248 | 06/30/2025 |
| 13 | China Universal Nasdaq Biotechnology Index ETF | 4,021 | -222 | 65,502.09 | 0.0276 | 0.0194 | 06/30/2025 |
| 14 | Hector SICAV - Fide Growth | 3,250 | 0 | 52,942.5 | 0.0965 | 0.0157 | 06/30/2025 |
| 15 | PSM Dynamik | 2,500 | 0 | 40,725 | 3.3349 | 0.0121 | 12/31/2024 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Acadian Asset Management LLC | 456,580 | 267,004 | 7,437,688.2 | 0.0112 | 2.205 | 09/30/2025 |
| 2 | Morgan Stanley & Co. LLC | 254,547 | 138,502 | 4,146,570.63 | 0.0014 | 1.2293 | 09/30/2025 |
| 3 | Millennium Management LLC | 132,391 | 131,401 | 2,156,649.39 | 0.0017 | 0.6394 | 09/30/2025 |
| 4 | Citadel Securities LLC | 65,063 | 65,063 | 1,059,876.27 | 0.003 | 0.3142 | 09/30/2025 |
| 5 | Citadel Advisors LLC | 57,228 | 57,228 | 932,244.12 | 0.001 | 0.2764 | 09/30/2025 |
| 6 | Susquehanna Financial Group LLLP | 48,160 | 37,869 | 784,526.4 | 0.0012 | 0.2326 | 09/30/2025 |
| 7 | G1 Execution Services LLC | 31,949 | 28,604 | 520,449.21 | 0.022 | 0.1543 | 09/30/2025 |
| 8 | Jane Street Capital LLC | 27,924 | 27,924 | 454,881.96 | 0.0005 | 0.1349 | 09/30/2025 |
| 9 | Osaic Institutions, Inc. | 23,500 | 23,500 | 382,815 | 0.0358 | 0.1135 | 09/30/2025 |
| 10 | JPMorgan Securities LLC (Investment Management) | 21,754 | 19,732 | 354,372.66 | 0.0002 | 0.1051 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Two Sigma Advisers LP | 16,795 | -47,865 | 273,590.55 | 0.0005 | 0.0811 | 09/30/2025 |
| 2 | Waterfront Wealth, Inc. | 77,960 | -47,771 | 1,269,968.4 | 0.2504 | 0.3765 | 09/30/2025 |
| 3 | Kynam Capital Management LP | 576,111 | -44,620 | 9,384,848.19 | 0.4991 | 2.7822 | 09/30/2025 |
| 4 | GSA Capital Partners LLP | 0 | -42,667 | 0 | 0 | 0 | |
| 5 | Two Sigma Investments LP | 60,071 | -32,726 | 978,556.59 | 0.0015 | 0.2901 | 09/30/2025 |
| 6 | Stonepine Capital Management LLC | 0 | -32,581 | 0 | 0 | 0 | |
| 7 | Hayek Kallen Investment Management LLC | 25,821 | -25,395 | 420,624.09 | 0.1296 | 0.1247 | 09/30/2025 |
| 8 | SCP Investment LP | 100,000 | -25,000 | 1,629,000 | 1.2799 | 0.4829 | 09/30/2025 |
| 9 | Macquarie Investment Management Business Trust | 0 | -14,311 | 0 | 0 | 0 | |
| 10 | Cutter & Co. Brokerage, Inc. (Investment Management) | 0 | -11,501 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.