# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Sarissa Capital Management LP 1,242,527 -4 19,470,398.09 9.6642 6.0005 06/30/2025
2 Kynam Capital Management LP 576,111 -44,620 9,027,659.37 0.7001 2.7822 06/30/2025
3 Acadian Asset Management LLC 241,048 51,472 3,777,222.16 0.0063 1.1641 06/30/2025
4 Eversept Partners LP 167,276 -2,684 2,621,214.92 0.2136 0.8078 06/30/2025
5 Morgan Stanley & Co. LLC 147,270 31,225 2,307,720.9 0.0008 0.7112 06/30/2025
6 SCP Investment LP 125,000 0 1,958,750 1.7086 0.6037 06/30/2025
7 Waterfront Wealth, Inc. 77,960 -47,771 1,221,633.2 0.2468 0.3765 09/30/2025
8 BNP Paribas Financial Markets 75,941 4,348 1,189,995.47 0.0008 0.3667 06/30/2025
9 Two Sigma Investments LP 59,024 -33,773 924,906.08 0.0016 0.285 06/30/2025
10 Quinn Opportunity Partners LLC 58,461 -1 916,083.87 0.0777 0.2823 06/30/2025
11 PSM Vermogensverwaltung GmbH Langen v.d.Goltz, Dr. Prinz 53,508 0 838,470.36 10.2221 0.2584 12/31/2024
12 Hayek Kallen Investment Management LLC 51,211 -5 802,476.37 0.252 0.2473 06/30/2025
13 Millennium Management LLC 45,244 44,254 708,973.48 0.0006 0.2185 06/30/2025
14 Raymond James Financial Services Advisors, Inc. 43,825 10,761 686,737.75 0.0008 0.2116 06/30/2025
15 LCM Capital Management, Inc. 42,762 -151 670,080.54 0.3214 0.2065 09/30/2025
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 PSM Macro Strategy 51,008 0 799,295.36 7.1343 0.2463 12/31/2024
2 Old Westbury Small & Mid Cap Strategies Fund 48,910 30,513 766,419.7 0.0086 0.2362 07/31/2025
3 SPDR Portfolio Developed World ex-US ETF 15,454 1,398 242,164.18 0.0008 0.0746 10/31/2025
4 Fidelity Nasdaq Composite Index Fund 14,249 6,517 223,281.83 0.001 0.0688 09/30/2025
5 iShares IV Plc - NASDAQ US Biotechnology UCITS ETF 13,824 3,611 216,622.08 0.0289 0.0668 10/31/2025
6 SEI Institutional Intl. Trust-International Equity 13,654 9,379 213,958.18 0.0061 0.0659 10/31/2025
7 Macquarie Healthcare Fund 9,500 0 148,865 0.0218 0.0459 09/30/2025
8 SPDR S&P International Small Cap ETF 7,784 1,292 121,975.28 0.0159 0.0376 10/31/2025
9 Invesco Markets Plc - NASDAQ Biotech UCITS ETF 7,121 1,437 111,586.07 0.0272 0.0344 10/31/2025
10 Voya Multi Manager International Small Cap Fund 7,057 -1 110,583.19 0.0273 0.0341 06/30/2025
11 LUNIS Biotech Growth Opportunities Fund 6,900 0 108,123 5.9904 0.0333 09/30/2024
12 China Universal Nasdaq Biotechnology Index ETF 4,021 -222 63,009.07 0.0284 0.0194 06/30/2025
13 Hector SICAV - Fide Growth 3,250 0 50,927.5 0.0935 0.0157 06/30/2025
14 PSM Dynamik 2,500 0 39,175 3.212 0.0121 12/31/2024
15 Steward Values Enhanced International Fund 1,169 1,169 18,318.23 0.0069 0.0056 09/30/2025
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Acadian Asset Management LLC 241,048 51,472 3,777,222.16 0.0063 1.1641 06/30/2025
2 Millennium Management LLC 45,244 44,254 708,973.48 0.0006 0.2185 06/30/2025
3 George Kaiser Family Foundation 38,197 38,197 598,546.99 0.0843 0.1845 06/30/2025
4 Citadel Securities LLC 38,064 38,064 596,462.88 0.0018 0.1838 06/30/2025
5 Leap Investments LP 38,063 38,063 596,447.21 0.0092 0.1838 06/30/2025
6 Trexquant Investment LP 32,686 32,686 512,189.62 0.0056 0.1578 06/30/2025
7 Morgan Stanley & Co. LLC 147,270 31,225 2,307,720.9 0.0008 0.7112 06/30/2025
8 G1 Execution Services LLC 28,716 25,371 449,979.72 0.0283 0.1387 06/30/2025
9 Mercer Global Advisors, Inc. 35,027 17,502 548,873.09 0.0012 0.1692 06/30/2025
10 Jane Street Capital LLC 17,321 17,321 271,420.07 0.0004 0.0836 06/30/2025
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Waterfront Wealth, Inc. 77,960 -47,771 1,221,633.2 0.2468 0.3765 09/30/2025
2 Two Sigma Advisers LP 17,370 -47,290 272,187.9 0.0005 0.0839 06/30/2025
3 Kynam Capital Management LP 576,111 -44,620 9,027,659.37 0.7001 2.7822 06/30/2025
4 GSA Capital Partners LLP 0 -42,667 0 0 0
5 Two Sigma Investments LP 59,024 -33,773 924,906.08 0.0016 0.285 06/30/2025
6 Stonepine Capital Management LLC 0 -32,581 0 0 0
7 Macquarie Investment Management Business Trust 0 -14,311 0 0 0
8 Cutter & Co. Brokerage, Inc. (Investment Management) 0 -11,501 0 0 0
9 UBS Securities LLC 2,503 -10,507 39,222.01 0 0.0121 06/30/2025
10 Commonwealth Equity Services LLC 0 -7,970 0 0 0

Data provided by FactSet Research Systems Inc.