# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Sphera Funds Management Ltd. 179,425 -45,682 444,974 0.0629 3.4564 09/30/2025
2 Morgan Stanley & Co. LLC 90,065 60,775 223,361.2 0.0001 1.735 09/30/2025
3 Ikarian Capital LLC 53,262 -1 132,089.76 0.0217 1.026 09/30/2025
4 Stonepine Capital Management LLC 30,000 30,000 74,400 0.0303 0.5779 09/30/2025
5 Jane Street Capital LLC 21,511 21,511 53,347.28 0.0001 0.4144 09/30/2025
6 RhumbLine Advisers LP 9,505 3,543 23,572.4 0 0.1831 09/30/2025
7 BNP Paribas Financial Markets 5,750 3,125 14,260 0 0.1108 09/30/2025
8 GAMMA Investing LLC 667 -2,090 1,654.16 0.0001 0.0128 09/30/2025
9 UBS Securities LLC 99 -122 245.52 0 0.0019 09/30/2025
10 SBI Securities Co., Ltd. 26 0 64.48 0 0.0005 09/30/2025
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Morgan Stanley & Co. LLC 90,065 60,775 223,361.2 0.0001 1.735 09/30/2025
2 Stonepine Capital Management LLC 30,000 30,000 74,400 0.0303 0.5779 09/30/2025
3 Jane Street Capital LLC 21,511 21,511 53,347.28 0.0001 0.4144 09/30/2025
4 RhumbLine Advisers LP 9,505 3,543 23,572.4 0 0.1831 09/30/2025
5 BNP Paribas Financial Markets 5,750 3,125 14,260 0 0.1108 09/30/2025
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Yelin Lapidot Mutual Fund Management Ltd. 0 -144,573 0 0 0
2 Sphera Funds Management Ltd. 179,425 -45,682 444,974 0.0629 3.4564 09/30/2025
3 Kestra Private Wealth Services LLC 0 -7,810 0 0 0
4 Virtu Americas LLC 0 -7,701 0 0 0
5 Boothbay Fund Management LLC 0 -6,547 0 0 0
6 Two Sigma Securities LLC 0 -5,526 0 0 0
7 XTX Markets LLC 0 -3,319 0 0 0
8 Wetzel Investment Advisors, Inc. 0 -2,750 0 0 0
9 Ayalon Provident Funds Management Co. 0 -2,500 0 0 0
10 GAMMA Investing LLC 667 -2,090 1,654.16 0.0001 0.0128 09/30/2025

Data provided by FactSet Research Systems Inc.