| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Fidelity Management & Research Co. LLC | 5,368,560 | 265,112 | 4,551,035,683.2 | 0.2419 | 8.7196 | 09/30/2025 |
| 2 | T. Rowe Price Associates, Inc. (IM) | 2,811,634 | -1,280,471 | 2,383,478,374.48 | 0.2707 | 4.5666 | 09/30/2025 |
| 3 | Janus Henderson Investors US LLC | 2,540,242 | -23,670 | 2,153,413,948.24 | 0.9998 | 4.1259 | 09/30/2025 |
| 4 | Artisan Partners LP | 2,186,510 | -163,266 | 1,853,548,257.2 | 1.3818 | 3.5513 | 09/30/2025 |
| 5 | Capital Research & Management Co. (World Investors) | 1,959,504 | 8,422 | 1,661,110,730.88 | 0.155 | 3.1826 | 09/30/2025 |
| 6 | Avoro Capital Advisor LLC | 990,000 | -185,000 | 839,242,800 | 9.5831 | 1.608 | 09/30/2025 |
| 7 | T. Rowe Price International Ltd. | 828,775 | -59,096 | 702,569,143 | 0.3941 | 1.3461 | 09/30/2025 |
| 8 | ClearBridge Investments LLC | 756,862 | -16,004 | 641,607,054.64 | 0.4441 | 1.2293 | 09/30/2025 |
| 9 | Citadel Advisors LLC | 708,950 | -156,572 | 600,991,094 | 0.6287 | 1.1515 | 09/30/2025 |
| 10 | RTW Investments LP | 673,497 | 0 | 570,936,876.84 | 6.5735 | 1.0939 | 09/30/2025 |
| 11 | Wilmington Trust Investment Advisors, Inc. | 637,208 | 635,639 | 540,173,965.76 | 2.5692 | 1.035 | 12/31/2025 |
| 12 | Bellevue Asset Management AG | 536,247 | -24,711 | 454,587,306.84 | 6.8865 | 0.871 | 09/30/2025 |
| 13 | Wellington Management Co. LLP | 507,056 | 163,836 | 429,841,512.32 | 0.066 | 0.8236 | 09/30/2025 |
| 14 | Millennium Management LLC | 347,518 | -82,326 | 294,597,958.96 | 0.2213 | 0.5644 | 09/30/2025 |
| 15 | SEI Investments Management Corp. | 312,268 | -4,131 | 264,715,828.96 | 0.2505 | 0.5072 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | American Funds EuroPacific Growth Fund | 1,085,870 | -30,371 | 920,513,716.4 | 0.6493 | 1.7637 | 12/31/2025 |
| 2 | Fidelity Growth Company Commingled Pool | 841,031 | -36,340 | 712,958,799.32 | 0.6488 | 1.366 | 11/30/2025 |
| 3 | T Rowe Price Health Sciences Fund | 683,030 | -153 | 579,018,191.6 | 4.6865 | 1.1094 | 09/30/2025 |
| 4 | Fidelity Growth Company Fund | 612,500 | -14,563 | 519,228,500 | 0.634 | 0.9948 | 11/30/2025 |
| 5 | Janus Henderson Forty Fund | 572,746 | 0 | 485,528,239.12 | 2.0054 | 0.9303 | 09/30/2025 |
| 6 | Fidelity OTC Portfolio | 541,426 | 48,600 | 458,977,648.72 | 1.2645 | 0.8794 | 11/30/2025 |
| 7 | American Funds New Economy Fund | 431,691 | 21,669 | 365,953,094.52 | 0.8091 | 0.7012 | 12/31/2025 |
| 8 | Janus Henderson Enterprise Fund | 328,515 | 16,425 | 278,488,735.8 | 1.1531 | 0.5336 | 09/30/2025 |
| 9 | iShares Biotechnology ETF | 298,350 | 59,877 | 252,917,262 | 2.9362 | 0.4846 | 12/31/2025 |
| 10 | T Rowe Price New Horizons Fund | 283,734 | -340,572 | 240,526,986.48 | 1.5452 | 0.4608 | 09/30/2025 |
| 11 | St. James's Place Unit Trust - Global Growth | 274,186 | 38,433 | 232,432,955.92 | 1.0848 | 0.4453 | 07/31/2025 |
| 12 | Fidelity Contrafund | 259,248 | 36,206 | 219,769,714.56 | 0.122 | 0.4211 | 11/30/2025 |
| 13 | Fidelity Select Port. - Health Care Portfolio | 254,000 | -26,000 | 215,320,880 | 3.289 | 0.4125 | 11/30/2025 |
| 14 | Fidelity Puritan Fund | 251,089 | 27,066 | 212,853,167.08 | 0.9577 | 0.4078 | 11/30/2025 |
| 15 | Artisan Global Opportunity Trust | 237,618 | -1,858 | 201,433,530.96 | 5.2517 | 0.3859 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Wilmington Trust Investment Advisors, Inc. | 637,208 | 635,639 | 540,173,965.76 | 2.5692 | 1.035 | 12/31/2025 |
| 2 | Fidelity Management & Research Co. LLC | 5,368,560 | 265,112 | 4,551,035,683.2 | 0.2419 | 8.7196 | 09/30/2025 |
| 3 | Two Sigma Investments LP | 294,160 | 250,278 | 249,365,315.2 | 0.3686 | 0.4778 | 09/30/2025 |
| 4 | Wellington Management Co. LLP | 507,056 | 163,836 | 429,841,512.32 | 0.066 | 0.8236 | 09/30/2025 |
| 5 | Wilmington Funds Management Corp. | 139,600 | 139,004 | 118,341,712 | 3.4287 | 0.2267 | 12/31/2025 |
| 6 | Woodline Partners LP | 169,476 | 129,205 | 143,668,194.72 | 0.633 | 0.2753 | 09/30/2025 |
| 7 | Two Sigma Advisers LP | 139,700 | 125,700 | 118,426,484 | 0.2264 | 0.2269 | 09/30/2025 |
| 8 | Alkeon Capital Management LLC | 175,000 | 100,000 | 148,351,000 | 0.5308 | 0.2842 | 09/30/2025 |
| 9 | Lord, Abbett & Co. LLC | 196,877 | 95,798 | 166,896,570.44 | 0.4266 | 0.3198 | 09/30/2025 |
| 10 | TIAA-CREF Investment Management LLC | 81,400 | 81,400 | 69,004,408 | 0.0256 | 0.1322 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | T. Rowe Price Associates, Inc. (IM) | 2,811,634 | -1,280,471 | 2,383,478,374.48 | 0.2707 | 4.5666 | 09/30/2025 |
| 2 | Adage Capital Management LP | 0 | -297,113 | 0 | 0 | 0 | |
| 3 | Avoro Capital Advisor LLC | 990,000 | -185,000 | 839,242,800 | 9.5831 | 1.608 | 09/30/2025 |
| 4 | Marshall Wace LLP | 12,525 | -165,199 | 10,617,693 | 0.0112 | 0.0203 | 09/30/2025 |
| 5 | Artisan Partners LP | 2,186,510 | -163,266 | 1,853,548,257.2 | 1.3818 | 3.5513 | 09/30/2025 |
| 6 | Invesco Asset Management Ltd. | 0 | -160,214 | 0 | 0 | 0 | |
| 7 | Citadel Advisors LLC | 708,950 | -156,572 | 600,991,094 | 0.6287 | 1.1515 | 09/30/2025 |
| 8 | Braidwell LP | 76,091 | -118,400 | 64,503,862.52 | 1.7202 | 0.1236 | 09/30/2025 |
| 9 | Balyasny Asset Management LP | 0 | -89,296 | 0 | 0 | 0 | |
| 10 | Assenagon Asset Management SA (Germany) | 24,347 | -87,710 | 20,639,438.84 | 0.0279 | 0.0395 | 12/31/2025 |
Data provided by FactSet Research Systems Inc.