| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Fidelity Management & Research Co. LLC | 5,292,883 | -720,455 | 3,608,952,273.55 | 0.2072 | 8.553 | 12/31/2025 |
| 2 | T. Rowe Price Associates, Inc. (IM) | 2,671,245 | -1,420,860 | 1,821,388,403.25 | 0.2275 | 4.3166 | 12/31/2025 |
| 3 | Janus Henderson Investors US LLC | 2,422,410 | -141,502 | 1,651,720,258.5 | 0.833 | 3.9145 | 12/31/2025 |
| 4 | Capital Research & Management Co. (World Investors) | 1,916,234 | -34,848 | 1,306,584,152.9 | 0.1357 | 3.0965 | 12/31/2025 |
| 5 | Artisan Partners LP | 1,756,942 | -592,834 | 1,197,970,902.7 | 0.9927 | 2.8391 | 12/31/2025 |
| 6 | Avoro Capital Advisor LLC | 990,000 | -185,000 | 675,031,500 | 7.0976 | 1.5998 | 12/31/2025 |
| 7 | T. Rowe Price International Ltd. | 691,079 | -196,792 | 471,212,216.15 | 0.2911 | 1.1167 | 12/31/2025 |
| 8 | RTW Investments LP | 673,497 | 0 | 459,223,929.45 | 5.0438 | 1.0883 | 12/31/2025 |
| 9 | ClearBridge Investments LLC | 513,764 | -259,102 | 350,309,983.4 | 0.2841 | 0.8302 | 12/31/2025 |
| 10 | Wellington Management Co. LLP | 471,709 | 128,489 | 321,634,781.65 | 0.0547 | 0.7623 | 12/31/2025 |
| 11 | Bellevue Asset Management AG | 459,839 | -101,119 | 313,541,222.15 | 5.0937 | 0.7431 | 12/31/2025 |
| 12 | AllianceBernstein LP | 414,182 | 360,347 | 282,409,996.7 | 0.0877 | 0.6693 | 12/31/2025 |
| 13 | Invesco Advisers, Inc. | 387,447 | 318,615 | 264,180,736.95 | 0.117 | 0.6261 | 12/31/2025 |
| 14 | Sands Capital Management LLC | 356,870 | 356,870 | 243,331,809.5 | 0.6101 | 0.5767 | 12/31/2025 |
| 15 | Citadel Advisors LLC | 335,109 | -530,413 | 228,494,071.65 | 0.234 | 0.5415 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | American Funds EUPAC Fund | 1,085,870 | -30,371 | 740,400,459.5 | 0.5865 | 1.7547 | 12/31/2025 |
| 2 | Fidelity Growth Company Commingled Pool | 823,350 | -23,174 | 561,401,197.5 | 0.5308 | 1.3305 | 01/31/2026 |
| 3 | Fidelity Growth Company Fund | 609,066 | -4,266 | 415,291,652.1 | 0.5202 | 0.9842 | 01/31/2026 |
| 4 | T Rowe Price Health Sciences Fund | 556,828 | -126,355 | 379,673,171.8 | 3.5167 | 0.8998 | 12/31/2025 |
| 5 | Janus Henderson Forty Fund | 537,873 | -34,873 | 366,748,705.05 | 1.7218 | 0.8692 | 12/31/2025 |
| 6 | Fidelity OTC Portfolio | 532,626 | 4,483 | 363,171,038.1 | 1.0547 | 0.8607 | 01/31/2026 |
| 7 | American Funds New Economy Fund | 431,691 | 21,669 | 294,348,508.35 | 0.7026 | 0.6976 | 12/31/2025 |
| 8 | Invesco American Franchise Fund | 333,089 | 333,089 | 227,116,734.65 | 1.4026 | 0.5383 | 01/31/2026 |
| 9 | Janus Henderson Enterprise Fund | 323,451 | 11,361 | 220,545,064.35 | 1.0455 | 0.5227 | 12/31/2025 |
| 10 | iShares Biotechnology ETF | 302,052 | 69,611 | 205,954,156.2 | 2.523 | 0.4881 | 02/27/2026 |
| 11 | St. James's Place Global Growth Unit Trust | 274,186 | 0 | 186,953,724.1 | 0.9459 | 0.4431 | 07/31/2025 |
| 12 | Fidelity Puritan Fund | 251,089 | -10,534 | 171,205,034.65 | 0.8304 | 0.4057 | 12/31/2025 |
| 13 | T Rowe Price Growth Stock Fund | 250,080 | -302,542 | 170,517,048 | 0.3785 | 0.4041 | 12/31/2025 |
| 14 | Fidelity Contrafund | 249,415 | -9,187 | 170,063,617.75 | 0.1042 | 0.403 | 01/31/2026 |
| 15 | Artisan Global Opportunity Trust | 237,618 | -1,858 | 162,019,833.3 | 4.5298 | 0.384 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | AllianceBernstein LP | 414,182 | 360,347 | 282,409,996.7 | 0.0877 | 0.6693 | 12/31/2025 |
| 2 | Sands Capital Management LLC | 356,870 | 356,870 | 243,331,809.5 | 0.6101 | 0.5767 | 12/31/2025 |
| 3 | Invesco Advisers, Inc. | 387,447 | 318,615 | 264,180,736.95 | 0.117 | 0.6261 | 12/31/2025 |
| 4 | William Blair Investment Management LLC | 223,666 | 223,666 | 152,506,662.1 | 0.3768 | 0.3614 | 12/31/2025 |
| 5 | Two Sigma Investments LP | 258,556 | 214,674 | 176,296,408.6 | 0.2703 | 0.4178 | 12/31/2025 |
| 6 | Voya Investment Management Co. LLC | 169,098 | 153,243 | 115,299,471.3 | 0.1038 | 0.2733 | 12/31/2025 |
| 7 | Wellington Management Co. LLP | 471,709 | 128,489 | 321,634,781.65 | 0.0547 | 0.7623 | 12/31/2025 |
| 8 | AGF Investments, Inc. | 124,691 | 124,691 | 85,020,558.35 | 0.3892 | 0.2015 | 12/31/2025 |
| 9 | Two Sigma Advisers LP | 135,500 | 121,500 | 92,390,675 | 0.1837 | 0.219 | 12/31/2025 |
| 10 | Acadian Asset Management LLC | 117,887 | 117,887 | 80,381,250.95 | 0.1158 | 0.1905 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | T. Rowe Price Associates, Inc. (IM) | 2,671,245 | -1,420,860 | 1,821,388,403.25 | 0.2275 | 4.3166 | 12/31/2025 |
| 2 | Fidelity Management & Research Co. LLC | 5,292,883 | -720,455 | 3,608,952,273.55 | 0.2072 | 8.553 | 12/31/2025 |
| 3 | Artisan Partners LP | 1,756,942 | -592,834 | 1,197,970,902.7 | 0.9927 | 2.8391 | 12/31/2025 |
| 4 | Citadel Advisors LLC | 335,109 | -530,413 | 228,494,071.65 | 0.234 | 0.5415 | 12/31/2025 |
| 5 | Millennium Management LLC | 60,458 | -369,386 | 41,223,287.3 | 0.0308 | 0.0977 | 12/31/2025 |
| 6 | Adage Capital Management LP | 0 | -297,113 | 0 | 0 | 0 | |
| 7 | ClearBridge Investments LLC | 513,764 | -259,102 | 350,309,983.4 | 0.2841 | 0.8302 | 12/31/2025 |
| 8 | T. Rowe Price International Ltd. | 691,079 | -196,792 | 471,212,216.15 | 0.2911 | 1.1167 | 12/31/2025 |
| 9 | Avoro Capital Advisor LLC | 990,000 | -185,000 | 675,031,500 | 7.0976 | 1.5998 | 12/31/2025 |
| 10 | Marshall Wace LLP | 13,508 | -164,216 | 9,210,429.8 | 0.0091 | 0.0218 | 12/31/2025 |
Data provided by FactSet Research Systems Inc.