| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | RA Capital Management LP | 10,281,496 | 0 | 2,329,992,623.52 | 24.2887 | 16.4829 | 06/30/2026 |
| 2 | T. Rowe Price Investment Management, Inc. | 6,754,846 | 592,804 | 1,530,783,200.52 | 1.0048 | 10.8291 | 06/30/2026 |
| 3 | Avoro Capital Advisor LLC | 5,111,111 | 48,611 | 1,158,279,974.82 | 12.5563 | 8.1939 | 06/30/2026 |
| 4 | Westfield Capital Management Co. LP | 4,798,267 | -15,173 | 1,087,383,267.54 | 3.7951 | 7.6924 | 06/30/2026 |
| 5 | Janus Henderson Investors US LLC | 3,594,673 | -124,779 | 814,624,795.26 | 0.3666 | 5.7628 | 06/30/2026 |
| 6 | Fidelity Management & Research Co. LLC | 3,240,762 | -317,324 | 734,421,484.44 | 0.0353 | 5.1955 | 06/30/2026 |
| 7 | Artisan Partners LP | 2,634,024 | -596,164 | 596,922,518.88 | 0.4855 | 4.2228 | 06/30/2026 |
| 8 | Capital Research & Management Co. (International Investors) | 1,988,614 | 29,771 | 450,659,704.68 | 0.0789 | 3.1881 | 06/30/2026 |
| 9 | BlackRock Fund Advisors | 1,846,188 | 1,493,825 | 418,383,124.56 | 0.0077 | 2.9597 | 06/30/2026 |
| 10 | Massachusetts Financial Services Co. | 1,815,615 | 14,357 | 411,454,671.3 | 0.1316 | 2.9107 | 06/30/2026 |
| 11 | Franklin Advisers, Inc. | 1,654,989 | -103,334 | 375,053,607.18 | 0.1628 | 2.6532 | 06/30/2026 |
| 12 | Wellington Management Co. LLP | 1,504,786 | -206,037 | 341,014,603.32 | 0.0548 | 2.4124 | 06/30/2026 |
| 13 | American Century Investment Management, Inc. | 1,400,575 | 3,456 | 317,398,306.5 | 0.103 | 2.2453 | 06/30/2026 |
| 14 | Perceptive Advisors LLC | 1,163,721 | -367,700 | 263,722,453.02 | 4.946 | 1.8656 | 06/30/2026 |
| 15 | T. Rowe Price Associates, Inc. (IM) | 1,097,778 | -432,567 | 248,778,450.36 | 0.0272 | 1.7599 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | T. Rowe Price Capital Appreciation Fund | 3,364,767 | 624,000 | 762,523,497.54 | 1.4638 | 5.3943 | 06/30/2026 |
| 2 | MFS Mid Cap Growth Fund | 1,273,836 | 0 | 288,676,714.32 | 2.2226 | 2.0422 | 07/31/2026 |
| 3 | American Funds Growth Fund of America | 1,209,675 | 0 | 274,136,548.5 | 0.079 | 1.9393 | 06/30/2026 |
| 4 | Vanguard Health Care Fund | 1,099,854 | -3,615 | 249,248,913.48 | 0.6223 | 1.7632 | 07/31/2026 |
| 5 | Franklin DynaTech Fund | 1,000,000 | -100,000 | 226,620,000 | 0.7823 | 1.6032 | 08/31/2026 |
| 6 | JNL/T Rowe Price Capital Appreciation Fund | 795,727 | 192,408 | 180,327,652.74 | 1.7573 | 1.2757 | 06/30/2026 |
| 7 | T. Rowe Price Capital Appreciation Equity ETF | 702,705 | 369,475 | 159,247,007.1 | 1.8023 | 1.1265 | 09/30/2026 |
| 8 | American Century Ultra Fund | 664,000 | 0 | 150,475,680 | 0.5515 | 1.0645 | 06/30/2026 |
| 9 | T Rowe Price Mid Cap Growth Fund | 639,106 | -144,294 | 144,834,201.72 | 0.6313 | 1.0246 | 06/30/2026 |
| 10 | Polar Capital Funds Plc - Biotechnology Fund | 613,671 | -2,261 | 139,070,122.02 | 3.9047 | 0.9838 | 08/28/2026 |
| 11 | American Funds Small Cap World Fund | 570,650 | -8,515 | 129,320,703 | 0.1538 | 0.9148 | 06/30/2026 |
| 12 | Artisan Mid Cap Fund | 539,946 | -138,397 | 122,362,562.52 | 4.1102 | 0.8656 | 06/30/2026 |
| 13 | Fidelity Select Port. - Health Care Portfolio | 500,000 | -200,000 | 113,310,000 | 1.6611 | 0.8016 | 08/31/2026 |
| 14 | iShares Biotechnology ETF | 484,703 | 144,755 | 109,843,393.86 | 0.9952 | 0.7771 | 09/30/2026 |
| 15 | Fidelity Select Port. - Biotechnology Portfolio | 480,401 | -22,000 | 108,868,474.62 | 1.8677 | 0.7702 | 08/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | BlackRock Fund Advisors | 1,846,188 | 1,493,825 | 418,383,124.56 | 0.0077 | 2.9597 | 06/30/2026 |
| 2 | T. Rowe Price Investment Management, Inc. | 6,754,846 | 592,804 | 1,530,783,200.52 | 1.0048 | 10.8291 | 06/30/2026 |
| 3 | SSgA Funds Management, Inc. | 513,969 | 426,635 | 116,475,654.78 | 0.0033 | 0.824 | 06/30/2026 |
| 4 | Geode Capital Management LLC | 403,151 | 330,210 | 91,362,079.62 | 0.0039 | 0.6463 | 06/30/2026 |
| 5 | UBS Securities LLC | 338,820 | 201,157 | 76,783,388.4 | 0.029 | 0.5432 | 06/30/2026 |
| 6 | Jane Street Capital LLC | 187,141 | 187,141 | 42,409,893.42 | 0.0253 | 0.3 | 06/30/2026 |
| 7 | Neuberger Berman Investment Advisers LLC | 142,705 | 142,705 | 32,339,807.1 | 0.021 | 0.2288 | 06/30/2026 |
| 8 | USS Investment Management Ltd. | 141,010 | 141,010 | 31,955,686.2 | 0.1213 | 0.2261 | 06/30/2026 |
| 9 | Empowered Funds LLC | 187,271 | 136,136 | 42,439,354.02 | 0.1932 | 0.3002 | 06/30/2026 |
| 10 | Walleye Capital LLC | 126,205 | 126,168 | 28,600,577.1 | 0.1029 | 0.2023 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Artisan Partners LP | 2,634,024 | -596,164 | 596,922,518.88 | 0.4855 | 4.2228 | 06/30/2026 |
| 2 | Nomura Investment Management Business Trust | 0 | -556,427 | 0 | 0 | 0 | |
| 3 | T. Rowe Price Associates, Inc. (IM) | 1,097,778 | -432,567 | 248,778,450.36 | 0.0272 | 1.7599 | 06/30/2026 |
| 4 | Perceptive Advisors LLC | 1,163,721 | -367,700 | 263,722,453.02 | 4.946 | 1.8656 | 06/30/2026 |
| 5 | Fidelity Management & Research Co. LLC | 3,240,762 | -317,324 | 734,421,484.44 | 0.0353 | 5.1955 | 06/30/2026 |
| 6 | Candriam Belgium SA | 0 | -230,278 | 0 | 0 | 0 | |
| 7 | Wellington Management Co. LLP | 1,504,786 | -206,037 | 341,014,603.32 | 0.0548 | 2.4124 | 06/30/2026 |
| 8 | abrdn Investment Management Ltd. | 0 | -173,642 | 0 | 0 | 0 | |
| 9 | Columbia Management Investment Advisers LLC | 320,463 | -155,953 | 72,623,325.06 | 0.0153 | 0.5138 | 06/30/2026 |
| 10 | Spyglass Capital Management LLC | 215,398 | -152,574 | 48,813,494.76 | 2.7356 | 0.3453 | 06/30/2026 |
Data provided by FactSet Research Systems Inc.