| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | RA Capital Management LP | 10,281,496 | 0 | 2,671,132,660.8 | 21.7519 | 16.4829 | 03/31/2026 |
| 2 | T. Rowe Price Investment Management, Inc. | 6,506,219 | 4,838,594 | 1,690,315,696.2 | 1.0204 | 10.4305 | 04/30/2026 |
| 3 | Avoro Capital Advisor LLC | 5,062,500 | -48,611 | 1,315,237,500 | 12.8985 | 8.116 | 03/31/2026 |
| 4 | Westfield Capital Management Co. LP | 4,813,440 | -372,256 | 1,250,531,712 | 4.4789 | 7.7167 | 03/31/2026 |
| 5 | Fidelity Management & Research Co. LLC | 3,558,086 | -243,700 | 924,390,742.8 | 0.0461 | 5.7042 | 03/31/2026 |
| 6 | Artisan Partners LP | 3,230,188 | 4,303 | 839,202,842.4 | 0.6097 | 5.1785 | 03/31/2026 |
| 7 | Capital Research & Management Co. (International Investors) | 1,958,843 | -1,105,100 | 508,907,411.4 | 0.0909 | 3.1403 | 03/31/2026 |
| 8 | Massachusetts Financial Services Co. | 1,801,258 | -25,076 | 467,966,828.4 | 0.1446 | 2.8877 | 03/31/2026 |
| 9 | Franklin Advisers, Inc. | 1,758,323 | 183,899 | 456,812,315.4 | 0.1974 | 2.8189 | 03/31/2026 |
| 10 | Wellington Management Co. LLP | 1,710,823 | -6,468 | 444,471,815.4 | 0.07 | 2.7427 | 03/31/2026 |
| 11 | Perceptive Advisors LLC | 1,531,421 | 450,000 | 397,863,175.8 | 6.7395 | 2.4551 | 03/31/2026 |
| 12 | T. Rowe Price Associates, Inc. (IM) | 1,530,345 | -39,915 | 397,583,631 | 0.0441 | 2.4534 | 03/31/2026 |
| 13 | American Century Investment Management, Inc. | 1,397,119 | -46,022 | 362,971,516.2 | 0.1214 | 2.2398 | 03/31/2026 |
| 14 | Capital Research & Management Co. (World Investors) | 900,517 | 900,517 | 233,954,316.6 | 0.0208 | 1.4437 | 03/31/2026 |
| 15 | Principal Global Investors LLC | 896,397 | -130,010 | 232,883,940.6 | 0.0991 | 1.4371 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | T. Rowe Price Capital Appreciation Fund | 2,740,767 | 2,740,767 | 712,051,266.6 | 1.3999 | 4.3939 | 03/31/2026 |
| 2 | MFS Mid Cap Growth Fund | 1,273,836 | -5,902 | 330,942,592.8 | 2.431 | 2.0422 | 05/31/2026 |
| 3 | American Funds Growth Fund of America | 1,209,675 | 0 | 314,273,565 | 0.0914 | 1.9393 | 03/31/2026 |
| 4 | Franklin DynaTech Fund | 1,100,000 | 100,000 | 285,780,000 | 0.9783 | 1.7635 | 05/31/2026 |
| 5 | Vanguard Health Care Fund | 1,049,942 | -53,527 | 272,774,931.6 | 0.6864 | 1.6832 | 04/30/2026 |
| 6 | T Rowe Price Mid Cap Growth Fund | 783,400 | -700 | 203,527,320 | 0.8354 | 1.2559 | 03/31/2026 |
| 7 | T Rowe Price Health Sciences Fund | 699,373 | -7,746 | 181,697,105.4 | 1.4936 | 1.1212 | 03/31/2026 |
| 8 | Artisan Mid Cap Fund | 678,343 | -26,827 | 176,233,511.4 | 5.274 | 1.0875 | 03/31/2026 |
| 9 | American Century Ultra Fund | 664,000 | 0 | 172,507,200 | 0.621 | 1.0645 | 03/31/2026 |
| 10 | JNL/T Rowe Price Capital Appreciation Fund | 603,319 | 603,319 | 156,742,276.2 | 1.5386 | 0.9672 | 03/31/2026 |
| 11 | Polar Capital Funds Plc - Biotechnology Fund | 583,990 | 233,990 | 151,720,602 | 4.0601 | 0.9362 | 05/29/2026 |
| 12 | American Funds Small Cap World Fund | 579,165 | 0 | 150,467,067 | 0.1713 | 0.9285 | 03/31/2026 |
| 13 | Fidelity Select Port. - Health Care Portfolio | 560,000 | -180,000 | 145,488,000 | 2.2585 | 0.8978 | 05/31/2026 |
| 14 | Harbor Small Cap Growth Fund | 499,143 | -65,610 | 129,677,351.4 | 5.018 | 0.8002 | 04/30/2026 |
| 15 | Fidelity Select Port. - Biotechnology Portfolio | 480,401 | -89,300 | 124,808,179.8 | 2.1542 | 0.7702 | 05/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | T. Rowe Price Investment Management, Inc. | 6,506,219 | 4,838,594 | 1,690,315,696.2 | 1.0204 | 10.4305 | 04/30/2026 |
| 2 | Capital Research & Management Co. (World Investors) | 900,517 | 900,517 | 233,954,316.6 | 0.0208 | 1.4437 | 03/31/2026 |
| 3 | Perceptive Advisors LLC | 1,531,421 | 450,000 | 397,863,175.8 | 6.7395 | 2.4551 | 03/31/2026 |
| 4 | Polar Capital LLP | 651,712 | 281,239 | 169,314,777.6 | 0.3409 | 1.0448 | 03/31/2026 |
| 5 | Vestal Point Capital LP | 375,000 | 200,000 | 97,425,000 | 2.3384 | 0.6012 | 03/31/2026 |
| 6 | Franklin Advisers, Inc. | 1,758,323 | 183,899 | 456,812,315.4 | 0.1974 | 2.8189 | 03/31/2026 |
| 7 | Pictet Asset Management SA | 251,833 | 178,415 | 65,426,213.4 | 0.0402 | 0.4037 | 03/31/2026 |
| 8 | Renaissance Technologies LLC | 117,332 | 117,332 | 30,482,853.6 | 0.042 | 0.1881 | 03/31/2026 |
| 9 | Wells Fargo Securities LLC | 114,003 | 114,003 | 29,617,979.4 | 0.3882 | 0.1828 | 03/31/2026 |
| 10 | SG Americas Securities LLC | 120,790 | 109,577 | 31,381,242 | 0.0292 | 0.1936 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Janus Henderson Investors US LLC | 0 | -3,921,067 | 0 | 0 | 0 | |
| 2 | Capital Research & Management Co. (International Investors) | 1,958,843 | -1,105,100 | 508,907,411.4 | 0.0909 | 3.1403 | 03/31/2026 |
| 3 | Citadel Advisors LLC | 0 | -496,881 | 0 | 0 | 0 | |
| 4 | Susquehanna Financial Group LLLP | 28,062 | -442,889 | 7,290,507.6 | 0.0083 | 0.045 | 03/31/2026 |
| 5 | Westfield Capital Management Co. LP | 4,813,440 | -372,256 | 1,250,531,712 | 4.4789 | 7.7167 | 03/31/2026 |
| 6 | Fidelity Management & Research Co. LLC | 3,558,086 | -243,700 | 924,390,742.8 | 0.0461 | 5.7042 | 03/31/2026 |
| 7 | Invesco Advisers, Inc. | 303,575 | -227,411 | 78,868,785 | 0.0312 | 0.4867 | 03/31/2026 |
| 8 | Jain Global LLC | 17,207 | -199,319 | 4,470,378.6 | 0.0504 | 0.0276 | 03/31/2026 |
| 9 | DWS Investments (UK) Ltd. | 87,487 | -166,631 | 22,729,122.6 | 0.0083 | 0.1403 | 03/31/2026 |
| 10 | Qube Research & Technologies Ltd. | 52,753 | -140,711 | 13,705,229.4 | 0.0175 | 0.0846 | 03/31/2026 |
Data provided by FactSet Research Systems Inc.