| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | RA Capital Management LP | 10,281,496 | 0 | 2,033,165,834 | 23.8021 | 16.863 | 06/30/2025 |
| 2 | Westfield Capital Management Co. LP | 5,451,401 | -27,858 | 1,078,014,547.75 | 4.221 | 8.941 | 06/30/2025 |
| 3 | Avoro Capital Advisor LLC | 4,980,000 | -238,000 | 984,795,000 | 12.3097 | 8.1679 | 06/30/2025 |
| 4 | Janus Henderson Investors US LLC | 4,328,772 | -81,372 | 856,014,663 | 0.4045 | 7.0998 | 06/30/2025 |
| 5 | Fidelity Management & Research Co. LLC | 4,178,937 | -125,408 | 826,384,791.75 | 0.0457 | 6.854 | 06/30/2025 |
| 6 | Artisan Partners LP | 3,990,424 | -266,203 | 789,106,346 | 0.6103 | 6.5448 | 06/30/2025 |
| 7 | T. Rowe Price Investment Management, Inc. | 3,583,546 | 529,722 | 708,646,221.5 | 0.425 | 5.8775 | 06/30/2025 |
| 8 | Capital Research & Management Co. (International Investors) | 3,046,931 | 172,139 | 602,530,605.25 | 0.0937 | 4.9974 | 06/30/2025 |
| 9 | T. Rowe Price Associates, Inc. (IM) | 1,875,491 | -380,611 | 370,878,345.25 | 0.0425 | 3.0761 | 06/30/2025 |
| 10 | Massachusetts Financial Services Co. | 1,802,228 | 11,058 | 356,390,587 | 0.1111 | 2.9559 | 09/30/2025 |
| 11 | Franklin Advisers, Inc. | 1,255,662 | 177,346 | 248,307,160.5 | 0.1094 | 2.0595 | 06/30/2025 |
| 12 | Perceptive Advisors LLC | 963,886 | 963,886 | 190,608,456.5 | 4.5509 | 1.5809 | 06/30/2025 |
| 13 | Invesco Advisers, Inc. | 911,370 | -246,458 | 180,223,417.5 | 0.0731 | 1.4948 | 06/30/2025 |
| 14 | Wellington Management Co. LLP | 879,046 | 329,621 | 173,831,346.5 | 0.0279 | 1.4418 | 06/30/2025 |
| 15 | Polar Capital LLP | 837,777 | 312,777 | 165,670,401.75 | 0.4432 | 1.3741 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | MFS Mid Cap Growth Fund | 1,279,738 | -24,875 | 253,068,189.5 | 1.72 | 2.0989 | 09/30/2025 |
| 2 | American Funds Growth Fund of America | 1,062,134 | 0 | 210,036,998.5 | 0.063 | 1.742 | 09/30/2025 |
| 3 | T Rowe Price Mid Cap Growth Fund | 1,015,400 | -4,600 | 200,795,350 | 0.7522 | 1.6654 | 09/30/2025 |
| 4 | Janus Henderson Enterprise Fund | 976,876 | 0 | 193,177,229 | 0.8202 | 1.6022 | 09/30/2025 |
| 5 | T Rowe Price Health Sciences Fund | 836,811 | -111,500 | 165,479,375.25 | 1.3977 | 1.3725 | 09/30/2025 |
| 6 | Vanguard Health Care Fund | 825,672 | 825,672 | 163,276,638 | 0.4191 | 1.3542 | 07/31/2025 |
| 7 | Artisan Mid Cap Fund | 818,052 | -120,800 | 161,769,783 | 4.1962 | 1.3417 | 09/30/2025 |
| 8 | Fidelity Select Port. - Health Care Portfolio | 740,000 | -10,000 | 146,335,000 | 2.3469 | 1.2137 | 09/30/2025 |
| 9 | American Funds New Perspective Fund | 623,163 | 0 | 123,230,483.25 | 0.0779 | 1.0221 | 09/30/2025 |
| 10 | Bridge Builder Small/Mid Cap Growth Fund | 602,758 | 50,498 | 119,195,394.5 | 1.2655 | 0.9886 | 10/31/2025 |
| 11 | Franklin DynaTech Fund | 600,000 | 375,000 | 118,650,000 | 0.3919 | 0.9841 | 09/30/2025 |
| 12 | Fidelity Select Port. - Biotechnology Portfolio | 582,501 | -49,308 | 115,189,572.75 | 2.4214 | 0.9554 | 09/30/2025 |
| 13 | American Funds Small Cap World Fund | 579,165 | 0 | 114,529,878.75 | 0.1464 | 0.9499 | 09/30/2025 |
| 14 | Harbor Small Cap Growth Fund | 535,777 | -51,909 | 105,949,901.75 | 4.9583 | 0.8787 | 07/31/2025 |
| 15 | CTIVP - Morgan Stanley Advantage Fund | 531,777 | -100,200 | 105,158,901.75 | 5.5248 | 0.8722 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Perceptive Advisors LLC | 963,886 | 963,886 | 190,608,456.5 | 4.5509 | 1.5809 | 06/30/2025 |
| 2 | Principal Global Investors LLC | 793,677 | 793,677 | 156,949,626.75 | 0.0728 | 1.3017 | 09/30/2025 |
| 3 | T. Rowe Price Investment Management, Inc. | 3,583,546 | 529,722 | 708,646,221.5 | 0.425 | 5.8775 | 06/30/2025 |
| 4 | Wellington Management Co. LLP | 879,046 | 329,621 | 173,831,346.5 | 0.0279 | 1.4418 | 06/30/2025 |
| 5 | Polar Capital LLP | 837,777 | 312,777 | 165,670,401.75 | 0.4432 | 1.3741 | 06/30/2025 |
| 6 | Franklin Advisers, Inc. | 1,255,662 | 177,346 | 248,307,160.5 | 0.1094 | 2.0595 | 06/30/2025 |
| 7 | Capital Research & Management Co. (International Investors) | 3,046,931 | 172,139 | 602,530,605.25 | 0.0937 | 4.9974 | 06/30/2025 |
| 8 | Lord, Abbett & Co. LLC | 154,176 | 154,176 | 30,488,304 | 0.0841 | 0.2529 | 06/30/2025 |
| 9 | Adage Capital Management LP | 459,606 | 132,201 | 90,887,086.5 | 0.1415 | 0.7538 | 06/30/2025 |
| 10 | Summit Partners Public Asset Management LLC | 130,000 | 130,000 | 25,707,500 | 0.8522 | 0.2132 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Morgan Stanley & Co. LLC | 194,168 | -1,670,516 | 38,396,722 | 0.0128 | 0.3185 | 06/30/2025 |
| 2 | Point72 Asset Management LP | 0 | -581,199 | 0 | 0 | 0 | |
| 3 | Citadel Advisors LLC | 587,270 | -537,824 | 116,132,642.5 | 0.129 | 0.9632 | 06/30/2025 |
| 4 | T. Rowe Price Associates, Inc. (IM) | 1,875,491 | -380,611 | 370,878,345.25 | 0.0425 | 3.0761 | 06/30/2025 |
| 5 | Artisan Partners LP | 3,990,424 | -266,203 | 789,106,346 | 0.6103 | 6.5448 | 06/30/2025 |
| 6 | Invesco Advisers, Inc. | 911,370 | -246,458 | 180,223,417.5 | 0.0731 | 1.4948 | 06/30/2025 |
| 7 | Avoro Capital Advisor LLC | 4,980,000 | -238,000 | 984,795,000 | 12.3097 | 8.1679 | 06/30/2025 |
| 8 | Millennium Management LLC | 72,888 | -191,979 | 14,413,602 | 0.012 | 0.1195 | 06/30/2025 |
| 9 | Finepoint Capital LP | 0 | -179,872 | 0 | 0 | 0 | |
| 10 | Saturn V Capital Management LP | 38,191 | -161,073 | 7,552,270.25 | 1.5516 | 0.0626 | 06/30/2025 |
Data provided by FactSet Research Systems Inc.