| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | RA Capital Management LP | 10,281,496 | 0 | 2,244,964,651.6 | 24.5094 | 16.863 | 12/31/2025 |
| 2 | Westfield Capital Management Co. LP | 5,185,696 | -265,705 | 1,132,296,721.6 | 5.0581 | 8.5052 | 12/31/2025 |
| 3 | Avoro Capital Advisor LLC | 5,111,111 | 131,111 | 1,116,011,086.85 | 11.4201 | 8.3829 | 12/31/2025 |
| 4 | Janus Henderson Investors US LLC | 3,921,067 | -407,705 | 856,164,979.45 | 0.45 | 6.4311 | 12/31/2025 |
| 5 | Fidelity Management & Research Co. LLC | 3,801,786 | -377,151 | 830,119,973.1 | 0.0498 | 6.2354 | 12/31/2025 |
| 6 | Artisan Partners LP | 3,225,885 | -764,539 | 704,371,989.75 | 0.5986 | 5.2909 | 12/31/2025 |
| 7 | Capital Research & Management Co. (International Investors) | 3,063,943 | 17,012 | 669,011,954.05 | 0.1041 | 5.0253 | 12/31/2025 |
| 8 | Massachusetts Financial Services Co. | 1,826,334 | 6,858 | 398,780,028.9 | 0.1362 | 2.9954 | 12/31/2025 |
| 9 | Wellington Management Co. LLP | 1,717,291 | 838,245 | 374,970,489.85 | 0.0652 | 2.8166 | 12/31/2025 |
| 10 | T. Rowe Price Investment Management, Inc. | 1,667,625 | -1,915,921 | 364,125,918.75 | 0.2474 | 2.7351 | 12/31/2025 |
| 11 | Franklin Advisers, Inc. | 1,574,424 | 318,762 | 343,775,480.4 | 0.163 | 2.5823 | 12/31/2025 |
| 12 | T. Rowe Price Associates, Inc. (IM) | 1,570,260 | -305,231 | 342,866,271 | 0.0445 | 2.5754 | 12/31/2025 |
| 13 | American Century Investment Management, Inc. | 1,443,141 | 912,332 | 315,109,837.35 | 0.1238 | 2.3669 | 12/31/2025 |
| 14 | Perceptive Advisors LLC | 1,081,421 | 117,535 | 236,128,275.35 | 4.4843 | 1.7737 | 12/31/2025 |
| 15 | Principal Global Investors LLC | 1,026,407 | 998,291 | 224,115,968.45 | 0.1098 | 1.6834 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | MFS Mid Cap Growth Fund | 1,279,738 | -3,148 | 279,430,792.3 | 2.216 | 2.0989 | 02/28/2026 |
| 2 | American Funds Growth Fund of America | 1,209,675 | 147,541 | 264,132,536.25 | 0.0908 | 1.984 | 12/31/2025 |
| 3 | Vanguard Health Care Fund | 1,103,469 | 277,797 | 240,942,456.15 | 0.6291 | 1.8098 | 10/31/2025 |
| 4 | Franklin DynaTech Fund | 1,000,000 | 469,100 | 218,350,000 | 0.9182 | 1.6401 | 02/28/2026 |
| 5 | T Rowe Price Mid Cap Growth Fund | 784,100 | -234,700 | 171,208,235 | 0.7249 | 1.286 | 12/31/2025 |
| 6 | Janus Henderson Enterprise Fund | 731,867 | -245,009 | 159,803,159.45 | 0.7817 | 1.2004 | 12/31/2025 |
| 7 | Fidelity Select Port. - Health Care Portfolio | 716,000 | -24,000 | 156,338,600 | 2.7544 | 1.1743 | 01/31/2026 |
| 8 | T Rowe Price Health Sciences Fund | 707,119 | 13,766 | 154,399,433.65 | 1.443 | 1.1598 | 12/31/2025 |
| 9 | Artisan Mid Cap Fund | 705,170 | -170,476 | 153,973,869.5 | 5.1764 | 1.1566 | 12/31/2025 |
| 10 | American Century Ultra Fund | 664,000 | 664,000 | 144,984,400 | 0.6177 | 1.0891 | 12/31/2025 |
| 11 | American Funds Small Cap World Fund | 579,165 | 0 | 126,460,677.75 | 0.1641 | 0.9499 | 12/31/2025 |
| 12 | Fidelity Select Port. - Biotechnology Portfolio | 569,701 | -12,800 | 124,394,213.35 | 2.4923 | 0.9344 | 01/31/2026 |
| 13 | Harbor Small Cap Growth Fund | 564,753 | 28,976 | 123,313,817.55 | 6.013 | 0.9263 | 10/31/2025 |
| 14 | Bridge Builder Small/Mid Cap Growth Fund | 551,515 | -70,356 | 120,423,300.25 | 1.3662 | 0.9046 | 02/27/2026 |
| 15 | American Funds New Perspective Fund | 463,385 | -159,778 | 101,180,114.75 | 0.0698 | 0.76 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Principal Global Investors LLC | 1,026,407 | 998,291 | 224,115,968.45 | 0.1098 | 1.6834 | 12/31/2025 |
| 2 | American Century Investment Management, Inc. | 1,443,141 | 912,332 | 315,109,837.35 | 0.1238 | 2.3669 | 12/31/2025 |
| 3 | Wellington Management Co. LLP | 1,717,291 | 838,245 | 374,970,489.85 | 0.0652 | 2.8166 | 12/31/2025 |
| 4 | Susquehanna Financial Group LLLP | 470,951 | 470,951 | 102,832,150.85 | 0.1571 | 0.7724 | 12/31/2025 |
| 5 | Spyglass Capital Management LLC | 415,549 | 415,549 | 90,735,124.15 | 6.1345 | 0.6816 | 12/31/2025 |
| 6 | Nomura Investment Management Business Trust | 496,837 | 380,102 | 108,484,358.95 | 0.1542 | 0.8149 | 12/31/2025 |
| 7 | Franklin Advisers, Inc. | 1,574,424 | 318,762 | 343,775,480.4 | 0.163 | 2.5823 | 12/31/2025 |
| 8 | JPMorgan Securities LLC (Investment Management) | 352,189 | 304,498 | 76,900,468.15 | 0.0555 | 0.5776 | 12/31/2025 |
| 9 | Fred Alger Management LLC | 257,221 | 253,426 | 56,164,205.35 | 0.275 | 0.4219 | 12/31/2025 |
| 10 | Two Sigma Investments LP | 247,892 | 244,777 | 54,127,218.2 | 0.0856 | 0.4066 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | T. Rowe Price Investment Management, Inc. | 1,667,625 | -1,915,921 | 364,125,918.75 | 0.2474 | 2.7351 | 12/31/2025 |
| 2 | Artisan Partners LP | 3,225,885 | -764,539 | 704,371,989.75 | 0.5986 | 5.2909 | 12/31/2025 |
| 3 | Polar Capital LLP | 370,473 | -467,304 | 80,892,779.55 | 0.2265 | 0.6076 | 12/31/2025 |
| 4 | Adage Capital Management LP | 0 | -459,606 | 0 | 0 | 0 | |
| 5 | Janus Henderson Investors US LLC | 3,921,067 | -407,705 | 856,164,979.45 | 0.45 | 6.4311 | 12/31/2025 |
| 6 | Invesco Advisers, Inc. | 530,986 | -380,384 | 115,940,793.1 | 0.053 | 0.8709 | 12/31/2025 |
| 7 | Fidelity Management & Research Co. LLC | 3,801,786 | -377,151 | 830,119,973.1 | 0.0498 | 6.2354 | 12/31/2025 |
| 8 | T. Rowe Price Associates, Inc. (IM) | 1,570,260 | -305,231 | 342,866,271 | 0.0445 | 2.5754 | 12/31/2025 |
| 9 | Westfield Capital Management Co. LP | 5,185,696 | -265,705 | 1,132,296,721.6 | 5.0581 | 8.5052 | 12/31/2025 |
| 10 | Camber Capital Management LP | 0 | -250,000 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.