| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | RA Capital Management LP | 10,281,496 | 0 | 2,443,294,709.44 | 24.153 | 16.4829 | 03/31/2026 |
| 2 | T. Rowe Price Investment Management, Inc. | 6,506,219 | 3,839,601 | 1,546,137,883.16 | 0.9686 | 10.4305 | 04/30/2026 |
| 3 | Avoro Capital Advisor LLC | 5,062,500 | -47,500 | 1,203,052,500 | 11.3245 | 8.116 | 03/31/2026 |
| 4 | Westfield Capital Management Co. LP | 4,813,440 | -446,469 | 1,143,865,881.6 | 4.2191 | 7.7167 | 03/31/2026 |
| 5 | Janus Henderson Investors US LLC | 3,719,452 | -515,081 | 883,890,573.28 | 0.3997 | 5.9629 | 03/31/2026 |
| 6 | Fidelity Management & Research Co. LLC | 3,558,086 | -561,551 | 845,543,557.04 | 0.0429 | 5.7042 | 03/31/2026 |
| 7 | Artisan Partners LP | 3,230,188 | -490,692 | 767,621,876.32 | 0.5923 | 5.1785 | 03/31/2026 |
| 8 | Capital Research & Management Co. (International Investors) | 1,958,843 | -1,101,773 | 465,499,450.52 | 0.0868 | 3.1403 | 03/31/2026 |
| 9 | Massachusetts Financial Services Co. | 1,801,258 | -970 | 428,050,951.12 | 0.1367 | 2.8877 | 03/31/2026 |
| 10 | Franklin Advisers, Inc. | 1,758,323 | 584,934 | 417,847,877.72 | 0.1836 | 2.8189 | 03/31/2026 |
| 11 | Wellington Management Co. LLP | 1,710,823 | -41,278 | 406,559,977.72 | 0.0646 | 2.7427 | 03/31/2026 |
| 12 | Perceptive Advisors LLC | 1,531,421 | 442,920 | 363,926,886.44 | 6.8456 | 2.4551 | 03/31/2026 |
| 13 | T. Rowe Price Associates, Inc. (IM) | 1,530,345 | -195,883 | 363,671,185.8 | 0.0411 | 2.4534 | 03/31/2026 |
| 14 | American Century Investment Management, Inc. | 1,397,119 | 852,513 | 332,011,359.16 | 0.1146 | 2.2398 | 03/31/2026 |
| 15 | Capital Research & Management Co. (World Investors) | 900,517 | 900,517 | 213,998,859.88 | 0.0197 | 1.4437 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | T. Rowe Price Capital Appreciation Fund | 2,740,767 | 2,740,767 | 651,315,869.88 | 1.3119 | 4.3939 | 03/31/2026 |
| 2 | MFS Mid Cap Growth Fund | 1,273,836 | -5,902 | 302,714,387.04 | 2.227 | 2.0422 | 03/31/2026 |
| 3 | American Funds Growth Fund of America | 1,209,675 | 147,541 | 287,467,167 | 0.085 | 1.9393 | 03/31/2026 |
| 4 | Vanguard Health Care Fund | 1,103,469 | 0 | 262,228,373.16 | 0.6958 | 1.769 | 01/31/2026 |
| 5 | Franklin DynaTech Fund | 1,100,000 | 400,000 | 261,404,000 | 0.8858 | 1.7635 | 04/30/2026 |
| 6 | T Rowe Price Mid Cap Growth Fund | 783,400 | -232,000 | 186,167,176 | 0.7989 | 1.2559 | 03/31/2026 |
| 7 | Fidelity Select Port. - Health Care Portfolio | 700,000 | -40,000 | 166,348,000 | 2.9331 | 1.1222 | 03/31/2026 |
| 8 | T Rowe Price Health Sciences Fund | 699,373 | -137,438 | 166,198,999.72 | 1.5218 | 1.1212 | 03/31/2026 |
| 9 | Artisan Mid Cap Fund | 678,343 | -139,709 | 161,201,430.52 | 5.12 | 1.0875 | 03/31/2026 |
| 10 | American Century Ultra Fund | 664,000 | 664,000 | 157,792,960 | 0.5648 | 1.0645 | 03/31/2026 |
| 11 | Polar Capital Funds Plc - Biotechnology Fund | 615,932 | 265,932 | 146,370,080.48 | 4.7941 | 0.9874 | 03/31/2026 |
| 12 | JNL/T Rowe Price Capital Appreciation Fund | 603,319 | 603,319 | 143,372,727.16 | 1.46 | 0.9672 | 03/31/2026 |
| 13 | American Funds Small Cap World Fund | 579,165 | 0 | 137,632,770.6 | 0.1607 | 0.9285 | 03/31/2026 |
| 14 | Bridge Builder Small/Mid Cap Growth Fund | 531,734 | -71,024 | 126,361,267.76 | 1.2517 | 0.8525 | 04/30/2026 |
| 15 | Harbor Small Cap Growth Fund | 522,213 | -42,540 | 124,098,697.32 | 5.1073 | 0.8372 | 01/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | T. Rowe Price Investment Management, Inc. | 6,506,219 | 3,839,601 | 1,546,137,883.16 | 0.9686 | 10.4305 | 04/30/2026 |
| 2 | Capital Research & Management Co. (World Investors) | 900,517 | 900,517 | 213,998,859.88 | 0.0197 | 1.4437 | 03/31/2026 |
| 3 | American Century Investment Management, Inc. | 1,397,119 | 852,513 | 332,011,359.16 | 0.1146 | 2.2398 | 03/31/2026 |
| 4 | Franklin Advisers, Inc. | 1,758,323 | 584,934 | 417,847,877.72 | 0.1836 | 2.8189 | 03/31/2026 |
| 5 | Perceptive Advisors LLC | 1,531,421 | 442,920 | 363,926,886.44 | 6.8456 | 2.4551 | 03/31/2026 |
| 6 | JPMorgan Securities LLC (Investment Management) | 426,482 | 296,913 | 101,349,182.48 | 0.0481 | 0.6837 | 03/31/2026 |
| 7 | Nomura Investment Management Business Trust | 556,427 | 246,888 | 132,229,312.28 | 0.1735 | 0.892 | 03/31/2026 |
| 8 | BlackRock Investment Management (UK) Ltd. | 221,808 | 211,144 | 52,710,453.12 | 0.0061 | 0.3556 | 03/31/2026 |
| 9 | Pictet Asset Management SA | 251,833 | 174,775 | 59,845,594.12 | 0.0381 | 0.4037 | 03/31/2026 |
| 10 | abrdn Investment Management Ltd. | 173,642 | 173,642 | 41,264,284.88 | 0.0417 | 0.2784 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Capital Research & Management Co. (International Investors) | 1,958,843 | -1,101,773 | 465,499,450.52 | 0.0868 | 3.1403 | 03/31/2026 |
| 2 | Invesco Advisers, Inc. | 303,575 | -581,593 | 72,141,563 | 0.029 | 0.4867 | 03/31/2026 |
| 3 | Fidelity Management & Research Co. LLC | 3,558,086 | -561,551 | 845,543,557.04 | 0.0429 | 5.7042 | 03/31/2026 |
| 4 | Janus Henderson Investors US LLC | 3,719,452 | -515,081 | 883,890,573.28 | 0.3997 | 5.9629 | 03/31/2026 |
| 5 | Artisan Partners LP | 3,230,188 | -490,692 | 767,621,876.32 | 0.5923 | 5.1785 | 03/31/2026 |
| 6 | Westfield Capital Management Co. LP | 4,813,440 | -446,469 | 1,143,865,881.6 | 4.2191 | 7.7167 | 03/31/2026 |
| 7 | Qube Research & Technologies Ltd. | 52,753 | -237,419 | 12,536,222.92 | 0.0168 | 0.0846 | 03/31/2026 |
| 8 | Vestal Point Capital LP | 375,000 | -225,000 | 89,115,000 | 2.4493 | 0.6012 | 03/31/2026 |
| 9 | Polar Capital LLP | 651,712 | -206,199 | 154,872,839.68 | 0.3191 | 1.0448 | 03/31/2026 |
| 10 | T. Rowe Price Associates, Inc. (IM) | 1,530,345 | -195,883 | 363,671,185.8 | 0.0411 | 2.4534 | 03/31/2026 |
Data provided by FactSet Research Systems Inc.