| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | RA Capital Management LP | 10,281,496 | 0 | 2,704,444,707.84 | 22.2371 | 16.4829 | 06/30/2026 |
| 2 | T. Rowe Price Investment Management, Inc. | 6,754,846 | 5,087,221 | 1,776,794,691.84 | 1.1451 | 10.8291 | 06/30/2026 |
| 3 | Avoro Capital Advisor LLC | 5,111,111 | 0 | 1,344,426,637.44 | 12.1572 | 8.1939 | 06/30/2026 |
| 4 | Westfield Capital Management Co. LP | 4,798,267 | -387,429 | 1,262,136,151.68 | 4.2603 | 7.6924 | 06/30/2026 |
| 5 | Janus Henderson Investors US LLC | 3,594,673 | -326,394 | 945,542,785.92 | 0.4149 | 5.7628 | 06/30/2026 |
| 6 | Fidelity Management & Research Co. LLC | 3,240,762 | -561,024 | 852,450,036.48 | 0.041 | 5.1955 | 06/30/2026 |
| 7 | Artisan Partners LP | 2,634,024 | -591,861 | 692,853,672.96 | 0.5453 | 4.2228 | 06/30/2026 |
| 8 | Capital Research & Management Co. (International Investors) | 1,988,614 | -1,075,329 | 523,085,026.56 | 0.091 | 3.1881 | 06/30/2026 |
| 9 | BlackRock Fund Advisors | 1,846,188 | 1,501,106 | 485,621,291.52 | 0.0089 | 2.9597 | 06/30/2026 |
| 10 | Massachusetts Financial Services Co. | 1,815,615 | -10,719 | 477,579,369.6 | 0.1501 | 2.9107 | 06/30/2026 |
| 11 | Franklin Advisers, Inc. | 1,654,989 | 80,565 | 435,328,306.56 | 0.1868 | 2.6532 | 06/30/2026 |
| 12 | Wellington Management Co. LLP | 1,504,786 | -212,505 | 395,818,909.44 | 0.063 | 2.4124 | 06/30/2026 |
| 13 | American Century Investment Management, Inc. | 1,400,575 | -42,566 | 368,407,248 | 0.1179 | 2.2453 | 06/30/2026 |
| 14 | Perceptive Advisors LLC | 1,163,721 | 82,300 | 306,105,171.84 | 4.6218 | 1.8656 | 06/30/2026 |
| 15 | T. Rowe Price Associates, Inc. (IM) | 1,097,778 | -472,482 | 288,759,525.12 | 0.0316 | 1.7599 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | T. Rowe Price Capital Appreciation Fund | 3,364,767 | 3,364,767 | 885,068,311.68 | 1.7312 | 5.3943 | 06/30/2026 |
| 2 | MFS Mid Cap Growth Fund | 1,273,836 | -5,902 | 335,069,821.44 | 2.5158 | 2.0422 | 07/31/2026 |
| 3 | American Funds Growth Fund of America | 1,209,675 | 0 | 318,192,912 | 0.0916 | 1.9393 | 06/30/2026 |
| 4 | Vanguard Health Care Fund | 1,049,942 | -53,527 | 276,176,743.68 | 0.6719 | 1.6832 | 04/30/2026 |
| 5 | Franklin DynaTech Fund | 1,000,000 | 0 | 263,040,000 | 0.8942 | 1.6032 | 06/30/2026 |
| 6 | JNL/T Rowe Price Capital Appreciation Fund | 795,727 | 795,727 | 209,308,030.08 | 2.0844 | 1.2757 | 06/30/2026 |
| 7 | American Century Ultra Fund | 664,000 | 0 | 174,658,560 | 0.6459 | 1.0645 | 06/30/2026 |
| 8 | T Rowe Price Mid Cap Growth Fund | 639,106 | -144,994 | 168,110,442.24 | 0.7343 | 1.0246 | 06/30/2026 |
| 9 | Polar Capital Funds Plc - Biotechnology Fund | 583,990 | 183,990 | 153,612,729.6 | 3.9744 | 0.9362 | 06/30/2026 |
| 10 | American Funds Small Cap World Fund | 570,650 | -8,515 | 150,103,776 | 0.1696 | 0.9148 | 06/30/2026 |
| 11 | Fidelity Select Port. - Health Care Portfolio | 540,000 | -176,000 | 142,041,600 | 2.094 | 0.8657 | 06/30/2026 |
| 12 | Artisan Mid Cap Fund | 539,946 | -165,224 | 142,027,395.84 | 4.627 | 0.8656 | 06/30/2026 |
| 13 | Harbor Small Cap Growth Fund | 499,143 | -23,070 | 131,294,574.72 | 5.269 | 0.8002 | 04/30/2026 |
| 14 | Fidelity Select Port. - Biotechnology Portfolio | 480,401 | -89,300 | 126,364,679.04 | 2.0534 | 0.7702 | 06/30/2026 |
| 15 | T. Rowe Price Capital Appreciation Equity ETF | 469,599 | 469,599 | 123,523,320.96 | 1.4984 | 0.7528 | 07/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | T. Rowe Price Investment Management, Inc. | 6,754,846 | 5,087,221 | 1,776,794,691.84 | 1.1451 | 10.8291 | 06/30/2026 |
| 2 | BlackRock Fund Advisors | 1,846,188 | 1,501,106 | 485,621,291.52 | 0.0089 | 2.9597 | 06/30/2026 |
| 3 | Capital Research & Management Co. (World Investors) | 906,081 | 906,081 | 238,335,546.24 | 0.021 | 1.4526 | 06/30/2026 |
| 4 | SSgA Funds Management, Inc. | 513,969 | 446,020 | 135,194,405.76 | 0.0038 | 0.824 | 06/30/2026 |
| 5 | Geode Capital Management LLC | 403,151 | 334,296 | 106,044,839.04 | 0.0045 | 0.6463 | 06/30/2026 |
| 6 | Polar Capital LLP | 616,908 | 246,435 | 162,271,480.32 | 0.3087 | 0.989 | 06/30/2026 |
| 7 | Vestal Point Capital LP | 375,000 | 200,000 | 98,640,000 | 2.2904 | 0.6012 | 06/30/2026 |
| 8 | Jane Street Capital LLC | 187,141 | 165,916 | 49,225,568.64 | 0.029 | 0.3 | 06/30/2026 |
| 9 | Pictet Asset Management SA | 234,039 | 160,621 | 61,561,618.56 | 0.0384 | 0.3752 | 06/30/2026 |
| 10 | SilverArc Capital Management LLC | 206,234 | 157,006 | 54,247,791.36 | 6.0755 | 0.3306 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Capital Research & Management Co. (International Investors) | 1,988,614 | -1,075,329 | 523,085,026.56 | 0.091 | 3.1881 | 06/30/2026 |
| 2 | Artisan Partners LP | 2,634,024 | -591,861 | 692,853,672.96 | 0.5453 | 4.2228 | 06/30/2026 |
| 3 | Fidelity Management & Research Co. LLC | 3,240,762 | -561,024 | 852,450,036.48 | 0.041 | 5.1955 | 06/30/2026 |
| 4 | Nomura Investment Management Business Trust | 0 | -496,837 | 0 | 0 | 0 | |
| 5 | T. Rowe Price Associates, Inc. (IM) | 1,097,778 | -472,482 | 288,759,525.12 | 0.0316 | 1.7599 | 06/30/2026 |
| 6 | Susquehanna Financial Group LLLP | 1,215 | -469,736 | 319,593.6 | 0.0003 | 0.0019 | 06/30/2026 |
| 7 | Westfield Capital Management Co. LP | 4,798,267 | -387,429 | 1,262,136,151.68 | 4.2603 | 7.6924 | 06/30/2026 |
| 8 | Citadel Advisors LLC | 125,411 | -371,470 | 32,988,109.44 | 0.0243 | 0.2011 | 06/30/2026 |
| 9 | Janus Henderson Investors US LLC | 3,594,673 | -326,394 | 945,542,785.92 | 0.4149 | 5.7628 | 06/30/2026 |
| 10 | DWS Investments (UK) Ltd. | 0 | -254,118 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.