| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | MAK Capital One LLC | 26,887,508 | 26,887,508 | 41,675,637.4 | 5.9179 | 10.1027 | 12/01/2025 |
| 2 | Syncona Investment Management Ltd. | 16,640,720 | 0 | 25,793,116 | 29.9019 | 6.2526 | 09/30/2025 |
| 3 | Armistice Capital LLC | 15,600,000 | 4,600,000 | 24,180,000 | 0.6121 | 5.8615 | 09/30/2025 |
| 4 | Qatar Investment Authority (Investment Management) | 15,000,000 | 0 | 23,250,000 | 0.1204 | 5.6361 | 03/01/2025 |
| 5 | TFG Asset Management UK LLP | 9,500,000 | 900,000 | 14,725,000 | 1.7622 | 3.5695 | 09/30/2025 |
| 6 | Schroder Investment Management Ltd. | 8,433,253 | 4,824,763 | 13,071,542.15 | 0.0053 | 3.1687 | 09/30/2025 |
| 7 | Citadel Securities LLC | 6,044,243 | 5,855,335 | 9,368,576.65 | 0.0263 | 2.2711 | 09/30/2025 |
| 8 | Renaissance Technologies LLC | 4,881,372 | 3,297,247 | 7,566,126.6 | 0.01 | 1.8341 | 09/30/2025 |
| 9 | AXA Investment Managers UK Ltd. | 3,361,156 | 234,989 | 5,209,791.8 | 0.0167 | 1.2629 | 09/30/2025 |
| 10 | Laurion Capital Management LP | 3,316,626 | -52,622 | 5,140,770.3 | 0.6231 | 1.2462 | 09/30/2025 |
| 11 | Deep Track Capital LP | 2,568,613 | -15,280,869 | 3,981,350.15 | 0.0757 | 0.9651 | 09/30/2025 |
| 12 | Bank of America, NA (Private Banking) | 2,017,358 | 1,995,958 | 3,126,904.9 | 0.0009 | 0.758 | 09/30/2025 |
| 13 | Acadian Asset Management LLC | 1,853,422 | 1,853,422 | 2,872,804.1 | 0.0043 | 0.6964 | 09/30/2025 |
| 14 | Affinity Asset Advisors LLC | 1,750,000 | -1,295,000 | 2,712,500 | 0.2063 | 0.6575 | 09/30/2025 |
| 15 | BlackRock Advisors LLC | 1,302,699 | -407,394 | 2,019,183.45 | 0.0009 | 0.4895 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Vanguard Health Care Fund | 19,356,365 | 0 | 30,002,365.75 | 0.0712 | 7.273 | 07/31/2025 |
| 2 | International Biotechnology Trust Plc (Top 10 Holdings) | 7,534,123 | 7,534,123 | 11,677,890.65 | 2.7149 | 2.8309 | 10/31/2025 |
| 3 | AXA Framlington Health Fund | 3,361,156 | 234,989 | 5,209,791.8 | 0.8111 | 1.2629 | 10/31/2025 |
| 4 | Wellington Mgmt. Funds IE Plc - Global Health Care Eq. | 1,790,131 | -57,432 | 2,774,703.05 | 0.1309 | 0.6726 | 06/30/2025 |
| 5 | Schroders Capital Global Innovation Trust plc | 1,672,668 | 1,672,668 | 2,592,635.4 | 1.1595 | 0.6285 | 06/30/2025 |
| 6 | Candriam Equities L - Oncology | 1,264,918 | 0 | 1,960,622.9 | 0.1054 | 0.4753 | 04/30/2025 |
| 7 | Candriam Equities L - Biotechnology | 1,172,570 | 0 | 1,817,483.5 | 0.1105 | 0.4406 | 04/30/2025 |
| 8 | Vanguard International Explorer Fund | 1,101,950 | -36,347 | 1,708,022.5 | 0.1153 | 0.414 | 07/31/2025 |
| 9 | iShares Biotechnology ETF | 1,002,827 | -38,972 | 1,554,381.85 | 0.022 | 0.3768 | 10/31/2025 |
| 10 | BlackRock Health Sciences Opportunities Portfolio | 755,756 | -94,361 | 1,171,421.8 | 0.0174 | 0.284 | 10/31/2025 |
| 11 | BlackRock Global Funds - World Healthscience Fund | 715,560 | 0 | 1,109,118 | 0.0082 | 0.2689 | 10/31/2025 |
| 12 | Regnan UK Umbrella Fund - Global Equity Impact Solutions | 654,589 | 0 | 1,014,612.95 | 1.3652 | 0.246 | 02/28/2025 |
| 13 | Crown Sigma UCITS Plc - LGT Crown Liquid Private Eq. Oppo | 475,000 | 0 | 736,250 | 0.379 | 0.1785 | 04/30/2024 |
| 14 | BlackRock Health Sciences Trust II | 463,993 | -331,725 | 719,189.15 | 0.0655 | 0.1743 | 09/30/2025 |
| 15 | HealthInvest Sustainable Healthcare | 306,423 | 0 | 474,955.65 | 0.1604 | 0.1151 | 12/31/2024 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | MAK Capital One LLC | 26,887,508 | 26,887,508 | 41,675,637.4 | 5.9179 | 10.1027 | 12/01/2025 |
| 2 | Citadel Securities LLC | 6,044,243 | 5,855,335 | 9,368,576.65 | 0.0263 | 2.2711 | 09/30/2025 |
| 3 | Schroder Investment Management Ltd. | 8,433,253 | 4,824,763 | 13,071,542.15 | 0.0053 | 3.1687 | 09/30/2025 |
| 4 | Armistice Capital LLC | 15,600,000 | 4,600,000 | 24,180,000 | 0.6121 | 5.8615 | 09/30/2025 |
| 5 | Renaissance Technologies LLC | 4,881,372 | 3,297,247 | 7,566,126.6 | 0.01 | 1.8341 | 09/30/2025 |
| 6 | Bank of America, NA (Private Banking) | 2,017,358 | 1,995,958 | 3,126,904.9 | 0.0009 | 0.758 | 09/30/2025 |
| 7 | Acadian Asset Management LLC | 1,853,422 | 1,853,422 | 2,872,804.1 | 0.0043 | 0.6964 | 09/30/2025 |
| 8 | TFG Asset Management UK LLP | 9,500,000 | 900,000 | 14,725,000 | 1.7622 | 3.5695 | 09/30/2025 |
| 9 | Morgan Stanley & Co. LLC | 1,137,021 | 879,696 | 1,762,382.55 | 0.0006 | 0.4272 | 09/30/2025 |
| 10 | Jane Street Capital LLC | 874,474 | 771,981 | 1,355,434.7 | 0.0016 | 0.3286 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Wellington Management Co. LLP | 0 | -26,855,207 | 0 | 0 | 0 | |
| 2 | Deep Track Capital LP | 2,568,613 | -15,280,869 | 3,981,350.15 | 0.0757 | 0.9651 | 09/30/2025 |
| 3 | Avoro Capital Advisor LLC | 0 | -9,910,642 | 0 | 0 | 0 | |
| 4 | Fidelity Management & Research Co. LLC | 0 | -5,652,266 | 0 | 0 | 0 | |
| 5 | FIAM LLC | 0 | -4,510,082 | 0 | 0 | 0 | |
| 6 | Candriam Belgium SA | 0 | -3,191,401 | 0 | 0 | 0 | |
| 7 | T. Rowe Price Associates, Inc. (IM) | 0 | -2,900,186 | 0 | 0 | 0 | |
| 8 | Great Point Partners LLC | 0 | -2,728,910 | 0 | 0 | 0 | |
| 9 | Millennium Management LLC | 391,833 | -1,594,357 | 607,341.15 | 0.0005 | 0.1472 | 09/30/2025 |
| 10 | Affinity Asset Advisors LLC | 1,750,000 | -1,295,000 | 2,712,500 | 0.2063 | 0.6575 | 09/30/2025 |
Data provided by FactSet Research Systems Inc.