| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | MAK Capital One LLC | 33,621,487 | 3,616,144 | 65,561,899.65 | 8.287 | 12.6323 | 03/31/2026 |
| 2 | Syncona Investment Management Ltd. | 16,640,720 | 0 | 32,449,404 | 35.6212 | 6.2522 | 03/31/2026 |
| 3 | Armistice Capital LLC | 15,800,000 | -1,700,000 | 30,810,000 | 0.7988 | 5.9364 | 03/31/2026 |
| 4 | Qatar Investment Authority (Investment Management) | 15,000,000 | 0 | 29,250,000 | 0.1594 | 5.6358 | 03/01/2025 |
| 5 | Tetragon Partners UK LLP | 9,500,000 | 0 | 18,525,000 | 1.8543 | 3.5693 | 03/31/2026 |
| 6 | Schroder Investment Management Ltd. | 9,489,345 | 0 | 18,504,222.75 | 0.0068 | 3.5653 | 03/31/2026 |
| 7 | AXA Investment Managers UK Ltd. | 3,361,156 | 0 | 6,554,254.2 | 0.0191 | 1.2629 | 03/31/2026 |
| 8 | Laurion Capital Management LP | 3,316,626 | 0 | 6,467,420.7 | 0.5521 | 1.2461 | 03/31/2026 |
| 9 | Renaissance Technologies LLC | 2,299,499 | -805,905 | 4,484,023.05 | 0.006 | 0.864 | 03/31/2026 |
| 10 | Bank of America, NA (Private Banking) | 1,814,880 | -129,474 | 3,539,016 | 0.0009 | 0.6819 | 03/31/2026 |
| 11 | BlackRock Fund Advisors | 1,324,429 | -23,052 | 2,582,636.55 | 0 | 0.4976 | 03/31/2026 |
| 12 | Cetera Investment Advisers LLC | 1,129,074 | 29,324 | 2,201,694.3 | 0.0021 | 0.4242 | 03/31/2026 |
| 13 | Balyasny Asset Management LP | 971,691 | 971,691 | 1,894,797.45 | 0.0034 | 0.3651 | 03/31/2026 |
| 14 | JPMorgan Asset Management (UK) Ltd. | 909,544 | -43,918 | 1,773,610.8 | 0.001 | 0.3417 | 03/31/2026 |
| 15 | Morgan Stanley & Co. LLC | 880,996 | -465,053 | 1,717,942.2 | 0.0005 | 0.331 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | AXA Framlington Health Fund | 3,361,156 | 0 | 6,554,254.2 | 1.1273 | 1.2629 | 06/30/2026 |
| 2 | Schroders Capital Global Innovation Trust plc | 1,664,076 | 0 | 3,244,948.2 | 1.776 | 0.6252 | 12/31/2025 |
| 3 | iShares Biotechnology ETF | 1,476,769 | 116,616 | 2,879,699.55 | 0.0307 | 0.5549 | 07/31/2026 |
| 4 | JPMorgan Funds - Thematics - Genetic Therapies | 914,888 | -38,574 | 1,784,031.6 | 0.4348 | 0.3437 | 04/30/2026 |
| 5 | Regnan UK Umbrella Fund - Global Equity Impact Solutions | 526,058 | 0 | 1,025,813.1 | 1.9001 | 0.1977 | 05/31/2025 |
| 6 | Sentinel Fund (The) - Sentinel Income Portfolio | 287,149 | 81,948 | 559,940.55 | 0.7333 | 0.1079 | 06/30/2026 |
| 7 | Ashburton Investments SICAV - Global Equity Growth Fund | 214,643 | 22,000 | 418,553.85 | 0.7175 | 0.0806 | 05/29/2026 |
| 8 | Erste Stock Biotec | 195,000 | 0 | 380,250 | 0.1201 | 0.0733 | 03/31/2026 |
| 9 | iShares IV Plc - NASDAQ US Biotechnology UCITS ETF | 174,733 | 43,522 | 340,729.35 | 0.0291 | 0.0657 | 07/31/2026 |
| 10 | BlackRock Health Sciences Trust II | 135,975 | -225,254 | 265,151.25 | 0.0241 | 0.0511 | 03/31/2026 |
| 11 | Fidelity Nasdaq Composite Index Fund | 120,878 | 10,300 | 235,712.1 | 0.0009 | 0.0454 | 06/30/2026 |
| 12 | Perpetual Investment - Regnan Global Equity Impact Solutions | 106,587 | 0 | 207,844.65 | 1.7979 | 0.04 | 05/31/2025 |
| 13 | Galileo - Biotech Innovation Fund | 100,000 | 0 | 195,000 | 0.4587 | 0.0376 | 12/31/2025 |
| 14 | State Street SPDR S&P International Small Cap ETF | 84,837 | 3,009 | 165,432.15 | 0.0187 | 0.0319 | 07/31/2026 |
| 15 | Invesco Markets Plc - NASDAQ Biotech UCITS ETF | 68,345 | 2,384 | 133,272.75 | 0.0275 | 0.0257 | 07/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | MAK Capital One LLC | 33,621,487 | 3,616,144 | 65,561,899.65 | 8.287 | 12.6323 | 03/31/2026 |
| 2 | Balyasny Asset Management LP | 971,691 | 971,691 | 1,894,797.45 | 0.0034 | 0.3651 | 03/31/2026 |
| 3 | Marex Financial | 542,857 | 542,857 | 1,058,571.15 | 0.0297 | 0.204 | 03/31/2026 |
| 4 | UBS Securities LLC | 755,508 | 349,016 | 1,473,240.6 | 0.0005 | 0.2839 | 03/31/2026 |
| 5 | Millennium Management LLC | 204,728 | 204,728 | 399,219.6 | 0.0003 | 0.0769 | 03/31/2026 |
| 6 | Point72 Asset Management LP | 426,983 | 121,624 | 832,616.85 | 0.0012 | 0.1604 | 03/31/2026 |
| 7 | Aquatic Capital Management LLC | 114,398 | 114,398 | 223,076.1 | 0.0057 | 0.043 | 03/31/2026 |
| 8 | Goldman Sachs & Co. LLC (Private Banking) | 116,413 | 88,664 | 227,005.35 | 0.0001 | 0.0437 | 03/31/2026 |
| 9 | UBS Financial Services, Inc. | 417,571 | 79,663 | 814,263.45 | 0.0003 | 0.1569 | 03/31/2026 |
| 10 | Wells Fargo Advisors Financial Network LLC | 143,731 | 53,968 | 280,275.45 | 0.0002 | 0.054 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Acadian Asset Management LLC | 27,597 | -1,776,520 | 53,814.15 | 0.0001 | 0.0104 | 03/31/2026 |
| 2 | Armistice Capital LLC | 15,800,000 | -1,700,000 | 30,810,000 | 0.7988 | 5.9364 | 03/31/2026 |
| 3 | Atle Fund Management AB | 0 | -1,169,634 | 0 | 0 | 0 | |
| 4 | BlackRock Advisors LLC | 0 | -1,158,347 | 0 | 0 | 0 | |
| 5 | BlackRock Investment Management (UK) Ltd. | 0 | -891,038 | 0 | 0 | 0 | |
| 6 | Renaissance Technologies LLC | 2,299,499 | -805,905 | 4,484,023.05 | 0.006 | 0.864 | 03/31/2026 |
| 7 | Citadel Securities LLC | 459,404 | -700,387 | 895,837.8 | 0.0018 | 0.1726 | 03/31/2026 |
| 8 | Morgan Stanley & Co. LLC | 880,996 | -465,053 | 1,717,942.2 | 0.0005 | 0.331 | 03/31/2026 |
| 9 | Jane Street Capital LLC | 245,785 | -435,215 | 479,280.75 | 0.0004 | 0.0923 | 03/31/2026 |
| 10 | Marshall Wace LLP | 26,682 | -243,595 | 52,029.9 | 0 | 0.01 | 03/31/2026 |
Data provided by FactSet Research Systems Inc.