| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | MAK Capital One LLC | 33,621,487 | 0 | 53,121,949.46 | 7.4308 | 12.6319 | 06/30/2026 |
| 2 | Syncona Investment Management Ltd. | 16,640,720 | 0 | 26,292,337.6 | 36.6761 | 6.2521 | 06/30/2026 |
| 3 | Armistice Capital LLC | 15,000,000 | -800,000 | 23,700,000 | 0.6456 | 5.6357 | 06/30/2026 |
| 4 | Qatar Investment Authority (Investment Management) | 15,000,000 | 0 | 23,700,000 | 0.1283 | 5.6357 | 03/01/2026 |
| 5 | Tetragon Partners UK LLP | 9,500,000 | 0 | 15,010,000 | 1.4802 | 3.5692 | 06/30/2026 |
| 6 | Schroder Investment Management Ltd. | 7,833,282 | -1,656,063 | 12,376,585.56 | 0.0047 | 2.943 | 06/30/2026 |
| 7 | AXA Investment Managers UK Ltd. | 3,361,156 | 0 | 5,310,626.48 | 0.0167 | 1.2628 | 06/30/2026 |
| 8 | Laurion Capital Management LP | 3,316,626 | 0 | 5,240,269.08 | 0.4349 | 1.2461 | 06/30/2026 |
| 9 | Renaissance Technologies LLC | 1,984,700 | -314,799 | 3,135,826 | 0.0043 | 0.7457 | 06/30/2026 |
| 10 | Bank of America, NA (Private Banking) | 1,592,504 | -222,376 | 2,516,156.32 | 0.0007 | 0.5983 | 06/30/2026 |
| 11 | BlackRock Fund Advisors | 1,443,879 | 119,450 | 2,281,328.82 | 0 | 0.5425 | 06/30/2026 |
| 12 | Millennium Management LLC | 1,224,818 | 1,020,090 | 1,935,212.44 | 0.0013 | 0.4602 | 06/30/2026 |
| 13 | Morgan Stanley & Co. LLC | 1,202,830 | 321,834 | 1,900,471.4 | 0.0006 | 0.4519 | 06/30/2026 |
| 14 | Cetera Investment Advisers LLC | 1,157,324 | 28,250 | 1,828,571.92 | 0.0017 | 0.4348 | 06/30/2026 |
| 15 | Balyasny Asset Management LP | 972,748 | 1,057 | 1,536,941.84 | 0.0029 | 0.3655 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | AXA Framlington Health Fund | 3,361,156 | 0 | 5,310,626.48 | 0.8839 | 1.2628 | 08/28/2026 |
| 2 | iShares Biotechnology ETF | 1,347,514 | 25,833 | 2,129,072.12 | 0.0191 | 0.5063 | 09/30/2026 |
| 3 | JPMorgan Funds - Thematics - Genetic Therapies | 880,101 | -29,443 | 1,390,559.58 | 0.3493 | 0.3307 | 08/31/2026 |
| 4 | HealthInvest Sustainable Healthcare | 760,173 | 0 | 1,201,073.34 | 0.3261 | 0.2856 | 12/31/2025 |
| 5 | Sentinel Fund (The) - Sentinel Income Portfolio | 287,149 | 81,948 | 453,695.42 | 0.6266 | 0.1079 | 07/31/2026 |
| 6 | Ashburton Investments SICAV - Global Equity Growth Fund | 284,119 | 91,476 | 448,908.02 | 0.8105 | 0.1067 | 08/28/2026 |
| 7 | Tema Oncology ETF | 273,617 | 273,617 | 432,314.86 | 0.2102 | 0.1028 | 09/30/2026 |
| 8 | Erste Stock Biotec | 195,000 | 0 | 308,100 | 0.0965 | 0.0733 | 06/30/2026 |
| 9 | iShares IV Plc - NASDAQ US Biotechnology UCITS ETF | 170,990 | 14,687 | 270,164.2 | 0.0219 | 0.0642 | 09/30/2026 |
| 10 | State Street SPDR S&P International Small Cap ETF | 101,955 | 18,415 | 161,088.9 | 0.018 | 0.0383 | 09/30/2026 |
| 11 | Galileo - Biotech Innovation Fund | 100,000 | 0 | 158,000 | 0.3675 | 0.0376 | 12/31/2025 |
| 12 | Invesco Markets Plc - NASDAQ Biotech UCITS ETF | 65,506 | -2,432 | 103,499.48 | 0.0209 | 0.0246 | 09/30/2026 |
| 13 | Invesco NASDAQ Future Gen 200 ETF | 50,741 | 9,385 | 80,170.78 | 0.3787 | 0.0191 | 09/30/2026 |
| 14 | China Universal Nasdaq Biotechnology Index ETF | 31,925 | -762 | 50,441.5 | 0.0211 | 0.012 | 06/30/2026 |
| 15 | ActivePassive International Equity ETF | 31,733 | 31,733 | 50,138.14 | 0.0045 | 0.0119 | 09/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Millennium Management LLC | 1,224,818 | 1,020,090 | 1,935,212.44 | 0.0013 | 0.4602 | 06/30/2026 |
| 2 | Morgan Stanley & Co. LLC | 1,202,830 | 321,834 | 1,900,471.4 | 0.0006 | 0.4519 | 06/30/2026 |
| 3 | Tema Global Ltd. | 273,617 | 273,617 | 432,314.86 | 0.0785 | 0.1028 | 09/30/2026 |
| 4 | XTX Markets LLC | 287,456 | 231,051 | 454,180.48 | 0.006 | 0.108 | 06/30/2026 |
| 5 | Citadel Advisors LLC | 198,944 | 198,944 | 314,331.52 | 0.0002 | 0.0747 | 06/30/2026 |
| 6 | UBS Financial Services, Inc. | 594,607 | 177,036 | 939,479.06 | 0.0003 | 0.2234 | 06/30/2026 |
| 7 | BlackRock Fund Advisors | 1,443,879 | 119,450 | 2,281,328.82 | 0 | 0.5425 | 06/30/2026 |
| 8 | HRT Financial LP | 89,363 | 89,363 | 141,193.54 | 0.0004 | 0.0336 | 06/30/2026 |
| 9 | Marshall Wace LLP | 94,654 | 67,972 | 149,553.32 | 0.0001 | 0.0356 | 06/30/2026 |
| 10 | Quadrature Capital Ltd. | 114,883 | 60,150 | 181,515.14 | 0.0016 | 0.0432 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Schroder Investment Management Ltd. | 7,833,282 | -1,656,063 | 12,376,585.56 | 0.0047 | 2.943 | 06/30/2026 |
| 2 | Armistice Capital LLC | 15,000,000 | -800,000 | 23,700,000 | 0.6456 | 5.6357 | 06/30/2026 |
| 3 | Marex Financial | 17,857 | -525,000 | 28,214.06 | 0.0008 | 0.0067 | 06/30/2026 |
| 4 | Point72 Asset Management LP | 71,227 | -355,756 | 112,538.66 | 0.0002 | 0.0268 | 06/30/2026 |
| 5 | Renaissance Technologies LLC | 1,984,700 | -314,799 | 3,135,826 | 0.0043 | 0.7457 | 06/30/2026 |
| 6 | Susquehanna Financial Group LLLP | 132,076 | -267,067 | 208,680.08 | 0.0002 | 0.0496 | 06/30/2026 |
| 7 | Bank of America, NA (Private Banking) | 1,592,504 | -222,376 | 2,516,156.32 | 0.0007 | 0.5983 | 06/30/2026 |
| 8 | Diametric Capital LP | 0 | -178,731 | 0 | 0 | 0 | |
| 9 | Aubrey Capital Management Ltd. | 0 | -130,000 | 0 | 0 | 0 | |
| 10 | Aquatic Capital Management LLC | 0 | -114,398 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.