| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Baker Bros. Advisors LP | 8,801,567 | 2,514 | 3,249,186,473.72 | 11.298 | 8.0218 | 06/30/2026 |
| 2 | PRIMECAP Management Co. | 5,007,931 | 27,350 | 1,848,727,807.96 | 1.1134 | 4.5643 | 06/30/2026 |
| 3 | Capital Research & Management Co. (International Investors) | 4,210,221 | -903,645 | 1,554,245,184.36 | 0.2709 | 3.8372 | 06/30/2026 |
| 4 | Fidelity Management & Research Co. LLC | 2,444,338 | -1,491,768 | 902,351,816.08 | 0.0434 | 2.2278 | 06/30/2026 |
| 5 | Capital Research & Management Co. (World Investors) | 2,249,582 | 2,249,582 | 830,455,691.12 | 0.073 | 2.0503 | 06/30/2026 |
| 6 | Citadel Advisors LLC | 1,402,343 | 929,238 | 517,688,941.88 | 0.3799 | 1.2781 | 06/30/2026 |
| 7 | Temasek Holdings Pte Ltd. (Investment Management) | 845,729 | -73,858 | 312,209,317.64 | 0.572 | 0.7708 | 06/30/2026 |
| 8 | T. Rowe Price International Ltd. | 677,266 | -128,698 | 250,019,516.56 | 0.1341 | 0.6173 | 06/30/2026 |
| 9 | BlackRock Fund Advisors | 603,603 | 55,885 | 222,826,083.48 | 0.0041 | 0.5501 | 06/30/2026 |
| 10 | Millennium Management LLC | 543,323 | 511,872 | 200,573,118.68 | 0.1353 | 0.4952 | 06/30/2026 |
| 11 | Robert W. Baird & Co., Inc. (Private Banking) | 368,978 | 64,639 | 136,211,918.48 | 0.1852 | 0.3363 | 06/30/2026 |
| 12 | Numeric Investors LLC | 307,463 | 58,949 | 113,503,041.08 | 0.2482 | 0.2802 | 06/30/2026 |
| 13 | Capital International, Inc. | 305,477 | -2,183 | 112,769,889.32 | 0.6116 | 0.2784 | 06/30/2026 |
| 14 | Candriam Belgium SA | 289,735 | 92,474 | 106,958,572.6 | 0.2464 | 0.2641 | 06/30/2026 |
| 15 | Two Sigma Investments LP | 286,552 | 278,152 | 105,783,536.32 | 0.079 | 0.2612 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | American Funds New Perspective Fund | 2,663,960 | 291,193 | 983,427,473.6 | 0.5883 | 2.428 | 06/30/2026 |
| 2 | Vanguard PRIMECAP Fund | 2,347,622 | 26,700 | 866,648,137.52 | 0.9399 | 2.1396 | 06/30/2026 |
| 3 | Vanguard Capital Opportunity Fund | 1,169,571 | -1,600 | 431,758,830.36 | 1.3604 | 1.066 | 03/31/2026 |
| 4 | Fidelity Growth Company Commingled Pool | 828,163 | -27,719 | 305,724,653.08 | 0.2351 | 0.7548 | 06/30/2026 |
| 5 | American Funds EUPAC Fund | 700,821 | 103,718 | 258,715,080.36 | 0.1874 | 0.6387 | 06/30/2026 |
| 6 | American Funds New World Fund | 677,287 | 108,999 | 250,027,268.92 | 0.2935 | 0.6173 | 06/30/2026 |
| 7 | PRIMECAP Odyssey Aggressive Growth Fund | 659,887 | -1,070 | 243,603,884.92 | 3.0489 | 0.6014 | 06/30/2026 |
| 8 | Fidelity Growth Company Fund | 624,125 | -771 | 230,401,985 | 0.2332 | 0.5688 | 06/30/2026 |
| 9 | PRIMECAP Odyssey Growth Fund | 586,247 | -11,300 | 216,418,942.52 | 3.4524 | 0.5343 | 06/30/2026 |
| 10 | iShares Biotechnology ETF | 585,421 | 52,271 | 216,114,016.36 | 2.0752 | 0.5336 | 07/31/2026 |
| 11 | American Funds New Economy Fund | 491,760 | 491,760 | 181,538,121.6 | 0.3726 | 0.4482 | 06/30/2026 |
| 12 | American Funds Global Insight Fund | 374,007 | 1,402 | 138,068,424.12 | 0.657 | 0.3409 | 06/30/2026 |
| 13 | CIF - Capital Group New Perspective Fund (Lux) | 318,826 | 24,895 | 117,697,806.16 | 0.5758 | 0.2906 | 06/30/2026 |
| 14 | First Trust NYSE Arca Biotechnology Index Fund | 301,714 | 63,042 | 111,380,740.24 | 3.8278 | 0.275 | 07/31/2026 |
| 15 | T. Rowe Price International Stock Fund | 269,076 | -66,571 | 99,332,096.16 | 0.6858 | 0.2452 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Capital Research & Management Co. (World Investors) | 2,249,582 | 2,249,582 | 830,455,691.12 | 0.073 | 2.0503 | 06/30/2026 |
| 2 | Citadel Advisors LLC | 1,402,343 | 929,238 | 517,688,941.88 | 0.3799 | 1.2781 | 06/30/2026 |
| 3 | Millennium Management LLC | 543,323 | 511,872 | 200,573,118.68 | 0.1353 | 0.4952 | 06/30/2026 |
| 4 | Two Sigma Investments LP | 286,552 | 278,152 | 105,783,536.32 | 0.079 | 0.2612 | 06/30/2026 |
| 5 | Arrowstreet Capital LP | 249,758 | 193,432 | 92,200,663.28 | 0.0375 | 0.2276 | 06/30/2026 |
| 6 | JPMorgan Securities LLC (Investment Management) | 182,700 | 178,421 | 67,445,532 | 0.0311 | 0.1665 | 06/30/2026 |
| 7 | Lansforsakringar Fondforvaltning AB | 123,352 | 123,352 | 45,536,624.32 | 0.1114 | 0.1124 | 06/30/2026 |
| 8 | First Trust Advisors LP | 245,823 | 119,998 | 90,748,018.68 | 0.048 | 0.224 | 06/30/2026 |
| 9 | Renaissance Technologies LLC | 101,980 | 101,980 | 37,646,936.8 | 0.0505 | 0.0929 | 06/30/2026 |
| 10 | M&G Investment Management Ltd. | 223,445 | 93,654 | 82,486,956.2 | 0.0908 | 0.2036 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Fidelity Management & Research Co. LLC | 2,444,338 | -1,491,768 | 902,351,816.08 | 0.0434 | 2.2278 | 06/30/2026 |
| 2 | HHLR Advisors Ltd. | 0 | -1,034,306 | 0 | 0 | 0 | |
| 3 | Capital Research & Management Co. (International Investors) | 4,210,221 | -903,645 | 1,554,245,184.36 | 0.2709 | 3.8372 | 06/30/2026 |
| 4 | T. Rowe Price Associates, Inc. (IM) | 81,486 | -485,229 | 30,081,371.76 | 0.0033 | 0.0743 | 06/30/2026 |
| 5 | T. Rowe Price International Ltd. | 677,266 | -128,698 | 250,019,516.56 | 0.1341 | 0.6173 | 06/30/2026 |
| 6 | Jain Global LLC | 0 | -97,335 | 0 | 0 | 0 | |
| 7 | Temasek Holdings Pte Ltd. (Investment Management) | 845,729 | -73,858 | 312,209,317.64 | 0.572 | 0.7708 | 06/30/2026 |
| 8 | Artisan Partners LP | 115,374 | -49,867 | 42,591,465.84 | 0.0326 | 0.1052 | 06/30/2026 |
| 9 | Baring Asset Management (Asia) Ltd. | 0 | -42,815 | 0 | 0 | 0 | |
| 10 | Citadel Securities LLC | 23,174 | -37,238 | 8,554,913.84 | 0.0203 | 0.0211 | 06/30/2026 |
Data provided by FactSet Research Systems Inc.