| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Baker Bros. Advisors LP | 8,799,053 | 0 | 2,729,906,193.25 | 13.0844 | 8.0195 | 04/16/2026 |
| 2 | PRIMECAP Management Co. | 4,975,181 | -105,280 | 1,543,549,905.25 | 0.9587 | 4.5344 | 03/31/2026 |
| 3 | Capital Research & Management Co. (International Investors) | 4,158,726 | -887,332 | 1,290,244,741.5 | 0.2386 | 3.7903 | 03/31/2026 |
| 4 | Fidelity Management & Research Co. LLC | 3,644,209 | -87,568 | 1,130,615,842.25 | 0.0565 | 3.3214 | 03/31/2026 |
| 5 | Capital Research & Management Co. (World Investors) | 1,622,687 | 1,622,687 | 503,438,641.75 | 0.0457 | 1.4789 | 03/31/2026 |
| 6 | HHLR Advisors Ltd. | 1,034,306 | 0 | 320,893,436.5 | 2.353 | 0.9427 | 03/31/2026 |
| 7 | Citadel Advisors LLC | 980,901 | 959,058 | 304,324,535.25 | 0.2788 | 0.894 | 03/31/2026 |
| 8 | Temasek Holdings Pte Ltd. (Investment Management) | 862,643 | -148,821 | 267,634,990.75 | 0.5742 | 0.7862 | 03/31/2026 |
| 9 | BlackRock Fund Advisors | 563,766 | 173,185 | 174,908,401.5 | 0.0034 | 0.5138 | 03/31/2026 |
| 10 | T. Rowe Price International Ltd. | 402,903 | -538,955 | 125,000,655.75 | 0.0705 | 0.3672 | 03/31/2026 |
| 11 | UBS Securities LLC | 395,071 | 295,800 | 122,570,777.75 | 0.0441 | 0.3601 | 03/31/2026 |
| 12 | Robert W. Baird & Co., Inc. (Private Banking) | 349,651 | 6,729 | 108,479,222.75 | 0.1568 | 0.3187 | 03/31/2026 |
| 13 | Capital International, Inc. | 302,243 | -23,601 | 93,770,890.75 | 0.5409 | 0.2755 | 03/31/2026 |
| 14 | Candriam Belgium SA | 259,731 | 47,163 | 80,581,542.75 | 0.1937 | 0.2367 | 03/31/2026 |
| 15 | Numeric Investors LLC | 241,922 | 32,906 | 75,056,300.5 | 0.1781 | 0.2205 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | American Funds New Perspective Fund | 2,663,960 | 291,193 | 826,493,590 | 0.5089 | 2.428 | 03/31/2026 |
| 2 | Vanguard PRIMECAP Fund | 2,319,622 | 10,200 | 719,662,725.5 | 0.8065 | 2.1141 | 03/31/2026 |
| 3 | Vanguard Capital Opportunity Fund | 1,171,171 | -2,700 | 363,355,802.75 | 1.1891 | 1.0674 | 12/31/2025 |
| 4 | Fidelity Growth Company Commingled Pool | 827,027 | -19,844 | 256,585,126.75 | 0.2011 | 0.7538 | 03/31/2026 |
| 5 | Fidelity Contrafund | 735,295 | 180 | 228,125,273.75 | 0.1296 | 0.6702 | 03/31/2026 |
| 6 | American Funds EUPAC Fund | 730,386 | 133,283 | 226,602,256.5 | 0.1675 | 0.6657 | 03/31/2026 |
| 7 | American Funds New World Fund | 662,549 | 92,920 | 205,555,827.25 | 0.2568 | 0.6039 | 03/31/2026 |
| 8 | PRIMECAP Odyssey Aggressive Growth Fund | 660,957 | -44,630 | 205,061,909.25 | 2.7494 | 0.6024 | 03/31/2026 |
| 9 | Fidelity Growth Company Fund | 624,896 | 377 | 193,873,984 | 0.1996 | 0.5695 | 03/31/2026 |
| 10 | PRIMECAP Odyssey Growth Fund | 595,347 | -48,480 | 184,706,406.75 | 3.0709 | 0.5426 | 03/31/2026 |
| 11 | iShares Biotechnology ETF | 518,840 | 147,665 | 160,970,110 | 2.025 | 0.4729 | 04/30/2026 |
| 12 | American Funds Global Insight Fund | 374,007 | 1,402 | 116,035,671.75 | 0.5807 | 0.3409 | 03/31/2026 |
| 13 | CIF - Capital Group New Perspective Fund (Lux) | 333,303 | 53,479 | 103,407,255.75 | 0.499 | 0.3038 | 03/31/2026 |
| 14 | Fidelity Contrafund Commingled Pool | 288,757 | 12,590 | 89,586,859.25 | 0.1374 | 0.2632 | 03/31/2026 |
| 15 | First Trust NYSE Arca Biotechnology Index Fund | 242,979 | 127,930 | 75,384,234.75 | 3.1435 | 0.2215 | 04/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Capital Research & Management Co. (World Investors) | 1,622,687 | 1,622,687 | 503,438,641.75 | 0.0457 | 1.4789 | 03/31/2026 |
| 2 | Citadel Advisors LLC | 980,901 | 959,058 | 304,324,535.25 | 0.2788 | 0.894 | 03/31/2026 |
| 3 | UBS Securities LLC | 395,071 | 295,800 | 122,570,777.75 | 0.0441 | 0.3601 | 03/31/2026 |
| 4 | Millennium Management LLC | 204,846 | 186,997 | 63,553,471.5 | 0.0443 | 0.1867 | 03/31/2026 |
| 5 | BlackRock Fund Advisors | 563,766 | 173,185 | 174,908,401.5 | 0.0034 | 0.5138 | 03/31/2026 |
| 6 | Franklin Advisers, Inc. | 200,938 | 159,634 | 62,341,014.5 | 0.027 | 0.1831 | 03/31/2026 |
| 7 | Driehaus Capital Management LLC | 155,002 | 141,641 | 48,089,370.5 | 0.2191 | 0.1413 | 03/31/2026 |
| 8 | First Trust Advisors LP | 241,426 | 102,016 | 74,902,416.5 | 0.0432 | 0.22 | 03/31/2026 |
| 9 | BNP Paribas Financial Markets | 184,356 | 87,649 | 57,196,449 | 0.032 | 0.168 | 03/31/2026 |
| 10 | Jennison Associates LLC | 154,465 | 80,867 | 47,922,766.25 | 0.0263 | 0.1408 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Capital Research & Management Co. (International Investors) | 4,158,726 | -887,332 | 1,290,244,741.5 | 0.2386 | 3.7903 | 03/31/2026 |
| 2 | T. Rowe Price Associates, Inc. (IM) | 136,866 | -551,847 | 42,462,676.5 | 0.0048 | 0.1247 | 03/31/2026 |
| 3 | T. Rowe Price International Ltd. | 402,903 | -538,955 | 125,000,655.75 | 0.0705 | 0.3672 | 03/31/2026 |
| 4 | Temasek Holdings Pte Ltd. (Investment Management) | 862,643 | -148,821 | 267,634,990.75 | 0.5742 | 0.7862 | 03/31/2026 |
| 5 | Marshall Wace LLP | 172,643 | -139,794 | 53,562,490.75 | 0.0495 | 0.1573 | 03/31/2026 |
| 6 | Artisan Partners LP | 137,216 | -112,628 | 42,571,264 | 0.0322 | 0.1251 | 03/31/2026 |
| 7 | PRIMECAP Management Co. | 4,975,181 | -105,280 | 1,543,549,905.25 | 0.9587 | 4.5344 | 03/31/2026 |
| 8 | Fidelity Management & Research Co. LLC | 3,644,209 | -87,568 | 1,130,615,842.25 | 0.0565 | 3.3214 | 03/31/2026 |
| 9 | 1832 Asset Management LP | 0 | -80,000 | 0 | 0 | 0 | |
| 10 | TIAA-CREF Investment Management LLC | 196,320 | -72,619 | 60,908,280 | 0.0221 | 0.1789 | 03/31/2026 |
Data provided by FactSet Research Systems Inc.