| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Baker Bros. Advisors LP | 8,799,053 | 0 | 2,731,929,975.44 | 15.5822 | 8.0314 | 06/30/2025 |
| 2 | PRIMECAP Management Co. | 5,088,279 | 32,775 | 1,579,808,863.92 | 1.044 | 4.6444 | 06/30/2025 |
| 3 | Capital Research & Management Co. (International Investors) | 4,885,006 | -205,964 | 1,516,696,662.88 | 0.2339 | 4.4588 | 06/30/2025 |
| 4 | Fidelity Management & Research Co. LLC | 3,388,932 | 52,111 | 1,052,195,607.36 | 0.0576 | 3.0933 | 06/30/2025 |
| 5 | HHLR Advisors Ltd. | 1,034,306 | 0 | 321,131,326.88 | 2.5512 | 0.9441 | 06/30/2025 |
| 6 | Temasek Holdings Pte Ltd. (Investment Management) | 1,010,465 | 16,713 | 313,729,173.2 | 0.7286 | 0.9223 | 06/30/2025 |
| 7 | T. Rowe Price International Ltd. | 931,897 | -369,237 | 289,335,380.56 | 0.1717 | 0.8506 | 06/30/2025 |
| 8 | Marshall Wace LLP | 467,590 | -9,553 | 145,177,343.2 | 0.1563 | 0.4268 | 06/30/2025 |
| 9 | Citadel Advisors LLC | 455,009 | -381,731 | 141,271,194.32 | 0.156 | 0.4153 | 06/30/2025 |
| 10 | BlackRock Fund Advisors | 394,136 | -52,628 | 122,371,345.28 | 0.0027 | 0.3597 | 06/30/2025 |
| 11 | Paradigm BioCapital Advisors LP | 347,787 | -318,237 | 107,980,907.76 | 2.9947 | 0.3174 | 06/30/2025 |
| 12 | Capital International, Inc. | 345,559 | -91,823 | 107,289,158.32 | 0.7011 | 0.3154 | 06/30/2025 |
| 13 | Robert W. Baird & Co., Inc. (Private Banking) | 342,442 | 68,046 | 106,321,392.16 | 0.174 | 0.3126 | 06/30/2025 |
| 14 | Connor, Clark & Lunn Investment Management Ltd. | 302,999 | 11,393 | 94,075,129.52 | 0.2669 | 0.2766 | 06/30/2025 |
| 15 | TIAA-CREF Investment Management LLC | 298,881 | -1,700 | 92,796,572.88 | 0.0344 | 0.2728 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | American Funds New Perspective Fund | 2,372,767 | -146,186 | 736,696,698.16 | 0.4589 | 2.1658 | 09/30/2025 |
| 2 | Vanguard PRIMECAP Fund | 2,305,190 | 0 | 715,715,391.2 | 0.8452 | 2.1041 | 06/30/2025 |
| 3 | Vanguard Capital Opportunity Fund | 1,137,021 | 20,200 | 353,022,280.08 | 1.3584 | 1.0378 | 06/30/2025 |
| 4 | Fidelity Growth Company Commingled Pool | 841,496 | 5,563 | 261,267,678.08 | 0.2379 | 0.7681 | 09/30/2025 |
| 5 | PRIMECAP Odyssey Aggressive Growth Fund | 698,347 | 29,890 | 216,822,776.56 | 3.0222 | 0.6374 | 06/30/2025 |
| 6 | PRIMECAP Odyssey Growth Fund | 650,537 | -15,390 | 201,978,727.76 | 3.5734 | 0.5938 | 06/30/2025 |
| 7 | Fidelity Contrafund | 643,269 | 122,305 | 199,722,159.12 | 0.1128 | 0.5871 | 08/31/2025 |
| 8 | Fidelity Growth Company Fund | 624,168 | -1,625 | 193,791,680.64 | 0.2365 | 0.5697 | 08/31/2025 |
| 9 | American Funds EuroPacific Growth Fund | 597,103 | -52,233 | 185,388,539.44 | 0.1341 | 0.545 | 09/30/2025 |
| 10 | American Funds New World Fund | 569,629 | 0 | 176,858,411.92 | 0.2471 | 0.5199 | 09/30/2025 |
| 11 | T Rowe Price International Stock Fund | 398,776 | -170,439 | 123,811,972.48 | 0.8705 | 0.364 | 09/30/2025 |
| 12 | American Funds Global Insight Fund | 372,605 | 150,083 | 115,686,400.4 | 0.6377 | 0.3401 | 09/30/2025 |
| 13 | iShares Biotechnology ETF | 367,410 | 21,721 | 114,073,456.8 | 1.7384 | 0.3354 | 09/30/2025 |
| 14 | CIF - Capital Group New Perspective Fund (Lux) | 279,824 | -18,107 | 86,879,755.52 | 0.4474 | 0.2554 | 09/30/2025 |
| 15 | Fidelity Contrafund Commingled Pool | 273,880 | 78,967 | 85,034,262.4 | 0.1305 | 0.25 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | UBS Securities LLC | 173,561 | 111,252 | 53,887,219.28 | 0.022 | 0.1584 | 06/30/2025 |
| 2 | Numeric Investors LLC | 243,861 | 90,038 | 75,713,963.28 | 0.2113 | 0.2226 | 06/30/2025 |
| 3 | Jennison Associates LLC | 73,598 | 73,598 | 22,850,707.04 | 0.0121 | 0.0672 | 09/30/2025 |
| 4 | Qube Research & Technologies Ltd. | 107,546 | 72,317 | 33,390,882.08 | 0.0452 | 0.0982 | 06/30/2025 |
| 5 | Robert W. Baird & Co., Inc. (Private Banking) | 342,442 | 68,046 | 106,321,392.16 | 0.174 | 0.3126 | 06/30/2025 |
| 6 | Old Mission Capital LLC | 87,896 | 58,618 | 27,289,950.08 | 0.6906 | 0.0802 | 06/30/2025 |
| 7 | LMR Partners LLP | 78,369 | 53,711 | 24,332,007.12 | 0.3564 | 0.0715 | 06/30/2025 |
| 8 | Fidelity Management & Research Co. LLC | 3,388,932 | 52,111 | 1,052,195,607.36 | 0.0576 | 3.0933 | 06/30/2025 |
| 9 | PRIMECAP Management Co. | 5,088,279 | 32,775 | 1,579,808,863.92 | 1.044 | 4.6444 | 06/30/2025 |
| 10 | Schroder Investment Management North America, Inc. | 30,069 | 30,069 | 9,335,823.12 | 0.0095 | 0.0274 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Baillie Gifford & Co. | 8 | -3,630,702 | 2,483.84 | 0 | 0 | 09/30/2025 |
| 2 | T. Rowe Price Associates, Inc. (IM) | 88,230 | -1,324,054 | 27,393,650.4 | 0.0031 | 0.0805 | 06/30/2025 |
| 3 | Citadel Advisors LLC | 455,009 | -381,731 | 141,271,194.32 | 0.156 | 0.4153 | 06/30/2025 |
| 4 | T. Rowe Price International Ltd. | 931,897 | -369,237 | 289,335,380.56 | 0.1717 | 0.8506 | 06/30/2025 |
| 5 | Paradigm BioCapital Advisors LP | 347,787 | -318,237 | 107,980,907.76 | 2.9947 | 0.3174 | 06/30/2025 |
| 6 | Point72 Asset Management LP | 0 | -223,622 | 0 | 0 | 0 | |
| 7 | Capital Research & Management Co. (International Investors) | 4,885,006 | -205,964 | 1,516,696,662.88 | 0.2339 | 4.4588 | 06/30/2025 |
| 8 | Morgan Stanley & Co. International Plc | 31,352 | -182,423 | 9,734,168.96 | 0.0965 | 0.0286 | 06/30/2025 |
| 9 | TD Asset Management, Inc. | 0 | -114,094 | 0 | 0 | 0 | |
| 10 | Cubist Systematic Strategies LLC | 0 | -108,998 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.