| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Baker Bros. Advisors LP | 8,799,053 | -10,418 | 2,780,940,700.65 | 13.7729 | 8.0237 | 09/30/2025 |
| 2 | PRIMECAP Management Co. | 5,080,461 | 24,957 | 1,605,679,699.05 | 1.0838 | 4.6328 | 09/30/2025 |
| 3 | Capital Research & Management Co. (International Investors) | 5,046,058 | -44,912 | 1,594,806,630.9 | 0.2444 | 4.6014 | 09/30/2025 |
| 4 | Fidelity Management & Research Co. LLC | 3,731,777 | 394,956 | 1,179,428,120.85 | 0.0656 | 3.4029 | 09/30/2025 |
| 5 | HHLR Advisors Ltd. | 1,034,306 | 0 | 326,892,411.3 | 2.4131 | 0.9432 | 09/30/2025 |
| 6 | Temasek Holdings Pte Ltd. (Investment Management) | 1,011,464 | 17,712 | 319,673,197.2 | 0.7163 | 0.9223 | 09/30/2025 |
| 7 | T. Rowe Price International Ltd. | 941,858 | -359,276 | 297,674,220.9 | 0.1744 | 0.8589 | 09/30/2025 |
| 8 | T. Rowe Price Associates, Inc. (IM) | 688,713 | -723,571 | 217,667,743.65 | 0.0252 | 0.628 | 09/30/2025 |
| 9 | BlackRock Fund Advisors | 390,581 | -56,183 | 123,443,125.05 | 0.0027 | 0.3562 | 09/30/2025 |
| 10 | Robert W. Baird & Co., Inc. (Private Banking) | 342,922 | 68,526 | 108,380,498.1 | 0.1726 | 0.3127 | 09/30/2025 |
| 11 | Capital International, Inc. | 325,844 | -111,538 | 102,982,996.2 | 0.6008 | 0.2971 | 09/30/2025 |
| 12 | Marshall Wace LLP | 312,437 | -164,706 | 98,745,713.85 | 0.1058 | 0.2849 | 09/30/2025 |
| 13 | TIAA-CREF Investment Management LLC | 268,939 | -31,642 | 84,998,170.95 | 0.0325 | 0.2452 | 09/30/2025 |
| 14 | Artisan Partners LP | 249,844 | -37,556 | 78,963,196.2 | 0.0621 | 0.2278 | 09/30/2025 |
| 15 | Managed Account Advisors LLC | 218,139 | 34,497 | 68,942,830.95 | 0.0105 | 0.1989 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | American Funds New Perspective Fund | 2,372,767 | -146,186 | 749,913,010.35 | 0.4687 | 2.1637 | 09/30/2025 |
| 2 | Vanguard PRIMECAP Fund | 2,309,422 | 4,232 | 729,892,823.1 | 0.8719 | 2.1059 | 09/30/2025 |
| 3 | Vanguard Capital Opportunity Fund | 1,173,871 | 57,050 | 371,001,929.55 | 1.3925 | 1.0704 | 09/30/2025 |
| 4 | Fidelity Growth Company Commingled Pool | 846,871 | 10,354 | 267,653,579.55 | 0.2503 | 0.7722 | 10/31/2025 |
| 5 | Fidelity Contrafund | 735,115 | 214,151 | 232,333,095.75 | 0.1329 | 0.6703 | 10/31/2025 |
| 6 | PRIMECAP Odyssey Aggressive Growth Fund | 705,587 | 37,130 | 223,000,771.35 | 3.1712 | 0.6434 | 09/30/2025 |
| 7 | PRIMECAP Odyssey Growth Fund | 643,827 | -22,100 | 203,481,523.35 | 3.6285 | 0.5871 | 09/30/2025 |
| 8 | Fidelity Growth Company Fund | 624,519 | -2,782 | 197,379,229.95 | 0.2486 | 0.5695 | 10/31/2025 |
| 9 | American Funds EuroPacific Growth Fund | 597,103 | -52,233 | 188,714,403.15 | 0.1373 | 0.5445 | 09/30/2025 |
| 10 | American Funds New World Fund | 569,629 | 0 | 180,031,245.45 | 0.2539 | 0.5194 | 09/30/2025 |
| 11 | iShares Biotechnology ETF | 454,522 | 121,505 | 143,651,678.1 | 1.6649 | 0.4145 | 11/28/2025 |
| 12 | T Rowe Price International Stock Fund | 398,776 | -170,439 | 126,033,154.8 | 0.9098 | 0.3636 | 09/30/2025 |
| 13 | American Funds Global Insight Fund | 372,605 | 150,083 | 117,761,810.25 | 0.646 | 0.3398 | 09/30/2025 |
| 14 | CIF - Capital Group New Perspective Fund (Lux) | 279,824 | -18,107 | 88,438,375.2 | 0.4565 | 0.2552 | 09/30/2025 |
| 15 | Fidelity Contrafund Commingled Pool | 276,167 | 80,968 | 87,282,580.35 | 0.1356 | 0.2518 | 10/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Fidelity Management & Research Co. LLC | 3,731,777 | 394,956 | 1,179,428,120.85 | 0.0656 | 3.4029 | 09/30/2025 |
| 2 | Parametric Portfolio Associates LLC | 154,474 | 106,431 | 48,821,507.7 | 0.0127 | 0.1409 | 09/30/2025 |
| 3 | 1832 Asset Management LP | 80,000 | 80,000 | 25,284,000 | 0.0286 | 0.073 | 09/30/2025 |
| 4 | Jennison Associates LLC | 73,598 | 73,598 | 23,260,647.9 | 0.0126 | 0.0671 | 09/30/2025 |
| 5 | Robert W. Baird & Co., Inc. (Private Banking) | 342,922 | 68,526 | 108,380,498.1 | 0.1726 | 0.3127 | 09/30/2025 |
| 6 | Numeric Investors LLC | 209,016 | 55,193 | 66,059,506.8 | 0.165 | 0.1906 | 09/30/2025 |
| 7 | Franklin Advisers, Inc. | 41,304 | 41,104 | 13,054,129.2 | 0.0058 | 0.0377 | 09/30/2025 |
| 8 | Merrill Lynch, Pierce, Fenner & Smith, Inc. (Invt Mgmt) | 41,506 | 38,048 | 13,117,971.3 | 0.0045 | 0.0378 | 09/30/2025 |
| 9 | Nomura Global Financial Products, Inc. | 37,000 | 37,000 | 11,693,850 | 0.0784 | 0.0337 | 09/30/2025 |
| 10 | UBS Securities LLC | 99,271 | 36,962 | 31,374,599.55 | 0.0128 | 0.0905 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Baillie Gifford & Co. | 8 | -3,630,702 | 2,528.4 | 0 | 0 | 09/30/2025 |
| 2 | Citadel Advisors LLC | 21,843 | -814,897 | 6,903,480.15 | 0.0074 | 0.0199 | 09/30/2025 |
| 3 | T. Rowe Price Associates, Inc. (IM) | 688,713 | -723,571 | 217,667,743.65 | 0.0252 | 0.628 | 09/30/2025 |
| 4 | Paradigm BioCapital Advisors LP | 0 | -666,024 | 0 | 0 | 0 | |
| 5 | T. Rowe Price International Ltd. | 941,858 | -359,276 | 297,674,220.9 | 0.1744 | 0.8589 | 09/30/2025 |
| 6 | Connor, Clark & Lunn Investment Management Ltd. | 0 | -291,606 | 0 | 0 | 0 | |
| 7 | Point72 Asset Management LP | 0 | -223,622 | 0 | 0 | 0 | |
| 8 | Morgan Stanley & Co. International Plc | 9,455 | -204,320 | 2,988,252.75 | 0.0283 | 0.0086 | 09/30/2025 |
| 9 | Millennium Management LLC | 17,849 | -169,061 | 5,641,176.45 | 0.0044 | 0.0163 | 09/30/2025 |
| 10 | Driehaus Capital Management LLC | 13,361 | -167,595 | 4,222,744.05 | 0.0213 | 0.0122 | 09/30/2025 |
Data provided by FactSet Research Systems Inc.