| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Baker Bros. Advisors LP | 8,799,053 | 0 | 2,722,954,941.38 | 11.6498 | 8.0195 | 06/11/2026 |
| 2 | PRIMECAP Management Co. | 4,975,181 | -5,400 | 1,539,619,512.26 | 0.9015 | 4.5344 | 03/31/2026 |
| 3 | Capital Research & Management Co. (International Investors) | 4,158,726 | -955,140 | 1,286,959,347.96 | 0.2293 | 3.7903 | 03/31/2026 |
| 4 | Fidelity Management & Research Co. LLC | 3,644,209 | -291,897 | 1,127,736,917.14 | 0.0553 | 3.3214 | 03/31/2026 |
| 5 | Capital Research & Management Co. (World Investors) | 1,622,687 | 1,622,687 | 502,156,719.02 | 0.0439 | 1.4789 | 03/31/2026 |
| 6 | HHLR Advisors Ltd. | 1,034,306 | 0 | 320,076,334.76 | 2.3848 | 0.9427 | 03/31/2026 |
| 7 | Citadel Advisors LLC | 980,901 | 507,796 | 303,549,623.46 | 0.2685 | 0.894 | 03/31/2026 |
| 8 | Temasek Holdings Pte Ltd. (Investment Management) | 862,643 | -56,944 | 266,953,502.78 | 0.5522 | 0.7862 | 03/31/2026 |
| 9 | BlackRock Fund Advisors | 563,766 | 16,048 | 174,463,026.36 | 0.0033 | 0.5138 | 03/31/2026 |
| 10 | T. Rowe Price International Ltd. | 402,903 | -403,061 | 124,682,362.38 | 0.0684 | 0.3672 | 03/31/2026 |
| 11 | UBS Securities LLC | 395,071 | 247,625 | 122,258,671.66 | 0.0429 | 0.3601 | 03/31/2026 |
| 12 | Robert W. Baird & Co., Inc. (Private Banking) | 349,651 | 45,312 | 108,202,998.46 | 0.1524 | 0.3187 | 03/31/2026 |
| 13 | Capital International, Inc. | 302,243 | -5,417 | 93,532,118.78 | 0.5197 | 0.2755 | 03/31/2026 |
| 14 | Candriam Belgium SA | 259,731 | 62,470 | 80,376,355.26 | 0.1906 | 0.2367 | 03/31/2026 |
| 15 | Numeric Investors LLC | 241,922 | -6,592 | 74,865,182.12 | 0.174 | 0.2205 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | American Funds New Perspective Fund | 2,663,960 | 291,193 | 824,389,061.6 | 0.493 | 2.428 | 03/31/2026 |
| 2 | Vanguard PRIMECAP Fund | 2,319,622 | -1,300 | 717,830,224.12 | 0.7682 | 2.1141 | 03/31/2026 |
| 3 | Vanguard Capital Opportunity Fund | 1,169,571 | -1,600 | 361,935,441.66 | 1.1356 | 1.066 | 03/31/2026 |
| 4 | Fidelity Growth Company Commingled Pool | 828,163 | -25,508 | 256,283,321.98 | 0.2029 | 0.7548 | 05/31/2026 |
| 5 | American Funds EUPAC Fund | 730,386 | 133,283 | 226,025,251.56 | 0.1612 | 0.6657 | 03/31/2026 |
| 6 | American Funds New World Fund | 662,549 | 94,261 | 205,032,413.54 | 0.2459 | 0.6039 | 03/31/2026 |
| 7 | PRIMECAP Odyssey Aggressive Growth Fund | 660,957 | 0 | 204,539,753.22 | 2.5368 | 0.6024 | 03/31/2026 |
| 8 | Fidelity Growth Company Fund | 624,896 | 0 | 193,380,316.16 | 0.2007 | 0.5695 | 05/31/2026 |
| 9 | PRIMECAP Odyssey Growth Fund | 595,347 | -2,200 | 184,236,082.62 | 2.8686 | 0.5426 | 03/31/2026 |
| 10 | iShares Biotechnology ETF | 564,180 | 31,188 | 174,591,142.8 | 1.8703 | 0.5142 | 06/30/2026 |
| 11 | American Funds Global Insight Fund | 374,007 | 1,402 | 115,740,206.22 | 0.5545 | 0.3409 | 03/31/2026 |
| 12 | CIF - Capital Group New Perspective Fund (Lux) | 333,303 | 39,372 | 103,143,946.38 | 0.4832 | 0.3038 | 03/31/2026 |
| 13 | First Trust NYSE Arca Biotechnology Index Fund | 245,095 | 122,438 | 75,847,098.7 | 2.6135 | 0.2234 | 06/30/2026 |
| 14 | Fidelity Contrafund | 242,273 | -590,753 | 74,973,802.58 | 0.0423 | 0.2208 | 05/31/2026 |
| 15 | CIF - Capital Group Global New Perspective Fund (LUX) | 227,356 | 32,413 | 70,357,587.76 | 0.4816 | 0.2072 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Capital Research & Management Co. (World Investors) | 1,622,687 | 1,622,687 | 502,156,719.02 | 0.0439 | 1.4789 | 03/31/2026 |
| 2 | Citadel Advisors LLC | 980,901 | 507,796 | 303,549,623.46 | 0.2685 | 0.894 | 03/31/2026 |
| 3 | UBS Securities LLC | 395,071 | 247,625 | 122,258,671.66 | 0.0429 | 0.3601 | 03/31/2026 |
| 4 | Millennium Management LLC | 204,846 | 173,395 | 63,391,643.16 | 0.0431 | 0.1867 | 03/31/2026 |
| 5 | Driehaus Capital Management LLC | 155,002 | 131,789 | 47,966,918.92 | 0.2128 | 0.1413 | 03/31/2026 |
| 6 | First Trust Advisors LP | 241,426 | 115,601 | 74,711,689.96 | 0.0415 | 0.22 | 03/31/2026 |
| 7 | Franklin Advisers, Inc. | 200,938 | 107,012 | 62,182,273.48 | 0.0267 | 0.1831 | 03/31/2026 |
| 8 | Jennison Associates LLC | 154,465 | 78,027 | 47,800,738.9 | 0.0257 | 0.1408 | 03/31/2026 |
| 9 | Jane Street Capital LLC | 75,953 | 75,953 | 23,504,415.38 | 0.0205 | 0.0692 | 03/31/2026 |
| 10 | JPMorgan Securities LLC (Investment Management) | 73,895 | 69,616 | 22,867,546.7 | 0.0106 | 0.0673 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Capital Research & Management Co. (International Investors) | 4,158,726 | -955,140 | 1,286,959,347.96 | 0.2293 | 3.7903 | 03/31/2026 |
| 2 | T. Rowe Price Associates, Inc. (IM) | 136,866 | -429,849 | 42,354,552.36 | 0.0047 | 0.1247 | 03/31/2026 |
| 3 | T. Rowe Price International Ltd. | 402,903 | -403,061 | 124,682,362.38 | 0.0684 | 0.3672 | 03/31/2026 |
| 4 | Fidelity Management & Research Co. LLC | 3,644,209 | -291,897 | 1,127,736,917.14 | 0.0553 | 3.3214 | 03/31/2026 |
| 5 | Jain Global LLC | 1,668 | -95,667 | 516,179.28 | 0.0057 | 0.0015 | 03/31/2026 |
| 6 | Qube Research & Technologies Ltd. | 0 | -94,848 | 0 | 0 | 0 | |
| 7 | Woodline Partners LP | 0 | -66,985 | 0 | 0 | 0 | |
| 8 | Temasek Holdings Pte Ltd. (Investment Management) | 862,643 | -56,944 | 266,953,502.78 | 0.5522 | 0.7862 | 03/31/2026 |
| 9 | Goldman Sachs & Co. LLC (Private Banking) | 87,722 | -51,176 | 27,146,450.12 | 0.0083 | 0.08 | 03/31/2026 |
| 10 | Engineers Gate Manager LP | 0 | -47,864 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.