| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Baker Bros. Advisors LP | 8,799,053 | 0 | 3,261,281,003.92 | 16.2299 | 7.4231 | 12/31/2025 |
| 2 | Capital Research & Management Co. (International Investors) | 5,113,866 | 228,860 | 1,895,403,294.24 | 0.2669 | 4.3142 | 12/31/2025 |
| 3 | PRIMECAP Management Co. | 4,980,581 | -107,698 | 1,846,002,541.84 | 1.2924 | 4.2017 | 12/31/2025 |
| 4 | Fidelity Management & Research Co. LLC | 3,936,106 | 547,174 | 1,458,878,327.84 | 0.0795 | 3.3206 | 12/31/2025 |
| 5 | HHLR Advisors Ltd. | 1,034,306 | 0 | 383,355,175.84 | 2.5624 | 0.8726 | 12/31/2025 |
| 6 | Temasek Holdings Pte Ltd. (Investment Management) | 919,587 | -90,878 | 340,835,725.68 | 0.7273 | 0.7758 | 12/31/2025 |
| 7 | T. Rowe Price International Ltd. | 805,964 | -125,933 | 298,722,496.96 | 0.1687 | 0.6799 | 12/31/2025 |
| 8 | T. Rowe Price Associates, Inc. (IM) | 566,715 | 478,485 | 210,047,247.6 | 0.0251 | 0.4781 | 12/31/2025 |
| 9 | BlackRock Fund Advisors | 547,718 | 153,582 | 203,006,199.52 | 0.0042 | 0.4621 | 12/31/2025 |
| 10 | Citadel Advisors LLC | 473,105 | 18,096 | 175,351,637.2 | 0.1716 | 0.3991 | 12/31/2025 |
| 11 | Capital International, Inc. | 307,660 | -37,899 | 114,031,102.4 | 0.6581 | 0.2595 | 12/31/2025 |
| 12 | Robert W. Baird & Co., Inc. (Private Banking) | 304,339 | -38,103 | 112,800,206.96 | 0.1735 | 0.2567 | 12/31/2025 |
| 13 | Numeric Investors LLC | 248,514 | 4,653 | 92,109,228.96 | 0.2257 | 0.2097 | 12/31/2025 |
| 14 | Managed Account Advisors LLC | 231,492 | 27,073 | 85,800,194.88 | 0.0126 | 0.1953 | 12/31/2025 |
| 15 | Morgan Stanley & Co. LLC | 198,434 | 60,598 | 73,547,577.76 | 0.0259 | 0.1674 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | American Funds New Perspective Fund | 2,372,767 | 0 | 879,442,360.88 | 0.5507 | 2.0017 | 12/31/2025 |
| 2 | Vanguard PRIMECAP Fund | 2,320,922 | 15,732 | 860,226,530.08 | 1.0847 | 1.958 | 12/31/2025 |
| 3 | Vanguard Capital Opportunity Fund | 1,173,871 | 36,850 | 435,083,547.44 | 1.5665 | 0.9903 | 09/30/2025 |
| 4 | Fidelity Growth Company Commingled Pool | 853,671 | 15,175 | 316,404,619.44 | 0.2896 | 0.7202 | 12/31/2025 |
| 5 | Fidelity Contrafund | 833,026 | 233,457 | 308,752,756.64 | 0.1769 | 0.7028 | 12/31/2025 |
| 6 | PRIMECAP Odyssey Aggressive Growth Fund | 660,957 | -37,390 | 244,977,102.48 | 3.6649 | 0.5576 | 12/31/2025 |
| 7 | Fidelity Growth Company Fund | 624,896 | 1,328 | 231,611,453.44 | 0.283 | 0.5272 | 12/31/2025 |
| 8 | PRIMECAP Odyssey Growth Fund | 597,547 | -52,990 | 221,474,820.08 | 4.1892 | 0.5041 | 12/31/2025 |
| 9 | American Funds EuroPacific Growth Fund | 597,103 | -49,953 | 221,310,255.92 | 0.1563 | 0.5037 | 12/31/2025 |
| 10 | American Funds New World Fund | 568,288 | -1,341 | 210,630,264.32 | 0.269 | 0.4794 | 12/31/2025 |
| 11 | iShares Biotechnology ETF | 533,150 | 192,088 | 197,606,716 | 2.28 | 0.4498 | 01/30/2026 |
| 12 | American Funds Global Insight Fund | 372,605 | 168,333 | 138,102,317.2 | 0.7237 | 0.3143 | 12/31/2025 |
| 13 | T. Rowe Price International Stock Fund | 335,647 | -65,700 | 124,404,204.08 | 0.8573 | 0.2832 | 12/31/2025 |
| 14 | Fidelity Contrafund Commingled Pool | 313,791 | 89,518 | 116,303,496.24 | 0.1836 | 0.2647 | 12/31/2025 |
| 15 | CIF - Capital Group New Perspective Fund (Lux) | 293,931 | 15,875 | 108,942,585.84 | 0.5396 | 0.248 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Fidelity Management & Research Co. LLC | 3,936,106 | 547,174 | 1,458,878,327.84 | 0.0795 | 3.3206 | 12/31/2025 |
| 2 | T. Rowe Price Associates, Inc. (IM) | 566,715 | 478,485 | 210,047,247.6 | 0.0251 | 0.4781 | 12/31/2025 |
| 3 | Capital Research & Management Co. (International Investors) | 5,113,866 | 228,860 | 1,895,403,294.24 | 0.2669 | 4.3142 | 12/31/2025 |
| 4 | BlackRock Fund Advisors | 547,718 | 153,582 | 203,006,199.52 | 0.0042 | 0.4621 | 12/31/2025 |
| 5 | Parametric Portfolio Associates LLC | 164,958 | 109,782 | 61,140,033.12 | 0.0155 | 0.1392 | 12/31/2025 |
| 6 | Franklin Advisers, Inc. | 93,926 | 78,324 | 34,812,732.64 | 0.0154 | 0.0792 | 12/31/2025 |
| 7 | Jennison Associates LLC | 76,438 | 76,438 | 28,330,980.32 | 0.0166 | 0.0645 | 12/31/2025 |
| 8 | Goldman Sachs & Co. LLC (Private Banking) | 138,898 | 73,471 | 51,481,154.72 | 0.0227 | 0.1172 | 12/31/2025 |
| 9 | Woodline Partners LP | 66,985 | 66,985 | 24,827,320.4 | 0.0945 | 0.0565 | 12/31/2025 |
| 10 | Morgan Stanley & Co. LLC | 198,434 | 60,598 | 73,547,577.76 | 0.0259 | 0.1674 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Paradigm BioCapital Advisors LP | 0 | -347,787 | 0 | 0 | 0 | |
| 2 | Marshall Wace LLP | 152,296 | -315,294 | 56,446,989.44 | 0.0537 | 0.1285 | 12/31/2025 |
| 3 | Connor, Clark & Lunn Investment Management Ltd. | 0 | -302,999 | 0 | 0 | 0 | |
| 4 | Driehaus Capital Management LLC | 23,213 | -174,990 | 8,603,666.32 | 0.0402 | 0.0196 | 12/31/2025 |
| 5 | Millennium Management LLC | 31,451 | -169,904 | 11,656,998.64 | 0.0083 | 0.0265 | 12/31/2025 |
| 6 | D. E. Shaw & Co. LP | 0 | -158,200 | 0 | 0 | 0 | |
| 7 | T. Rowe Price International Ltd. | 805,964 | -125,933 | 298,722,496.96 | 0.1687 | 0.6799 | 12/31/2025 |
| 8 | PRIMECAP Management Co. | 4,980,581 | -107,698 | 1,846,002,541.84 | 1.2924 | 4.2017 | 12/31/2025 |
| 9 | Capital Group Private Client Services, Inc. | 41,783 | -106,830 | 15,486,451.12 | 0.2396 | 0.0352 | 12/31/2025 |
| 10 | Artisan Partners LP | 165,241 | -104,912 | 61,244,924.24 | 0.0473 | 0.1394 | 12/31/2025 |
Data provided by FactSet Research Systems Inc.