| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Darwin Global Management Ltd. | 3,027,704 | 3,027,704 | 563,607,099.6 | 11.3512 | 8.0707 | 12/31/2025 |
| 2 | RTW Investments LP | 715,332 | 715,332 | 133,159,051.8 | 1.3907 | 1.9068 | 12/31/2025 |
| 3 | Millennium Management LLC | 558,882 | 558,882 | 104,035,884.3 | 0.0733 | 1.4898 | 12/31/2025 |
| 4 | RA Capital Management LP | 432,484 | 432,484 | 80,506,896.6 | 0.7704 | 1.1528 | 12/31/2025 |
| 5 | Perceptive Advisors LLC | 414,239 | 414,239 | 77,110,589.85 | 1.3741 | 1.1042 | 12/31/2025 |
| 6 | Eventide Asset Management LLC | 383,091 | 383,091 | 71,312,389.65 | 1.0701 | 1.0212 | 12/31/2025 |
| 7 | Point72 Asset Management LP | 284,437 | 283,137 | 52,947,947.55 | 0.0793 | 0.7582 | 12/31/2025 |
| 8 | Marshall Wace LLP | 192,700 | 183,214 | 35,871,105 | 0.0338 | 0.5137 | 12/31/2025 |
| 9 | UBS Securities LLC | 94,300 | 91,942 | 17,553,945 | 0.007 | 0.2514 | 12/31/2025 |
| 10 | HBM Partners AG (Investment Management) | 90,000 | 90,000 | 16,753,500 | 1.6012 | 0.2399 | 12/31/2025 |
| 11 | Holocene Advisors, LP | 84,067 | 84,067 | 15,649,072.05 | 0.0325 | 0.2241 | 12/31/2025 |
| 12 | Fubon Asset Management Co., Ltd. | 79,974 | -52,001 | 14,887,160.1 | 0.0514 | 0.2132 | 12/31/2025 |
| 13 | Fred Alger Management LLC | 79,394 | 79,394 | 14,779,193.1 | 0.0641 | 0.2116 | 12/31/2025 |
| 14 | Western Standard LLC | 60,026 | 60,026 | 11,173,839.9 | 5.3305 | 0.16 | 12/31/2025 |
| 15 | Medical Strategy GmbH | 57,543 | 57,543 | 10,711,629.45 | 1.2206 | 0.1534 | 11/28/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | HBM Healthcare Investments AG | 90,000 | 90,000 | 16,753,500 | 0.6526 | 0.2399 | 12/31/2025 |
| 2 | FCP Medical - BioHealth | 57,543 | 57,543 | 10,711,629.45 | 1.1644 | 0.1534 | 11/28/2025 |
| 3 | Alger Small Cap Focus Fund | 57,224 | 57,224 | 10,652,247.6 | 1.1996 | 0.1525 | 12/31/2025 |
| 4 | Fubon AI New Trends Multi-Asset Fund | 41,455 | -23,475 | 7,716,848.25 | 3.8811 | 0.1105 | 12/31/2025 |
| 5 | Fubon Taiwan-US Double Star Multi Asset Fund | 38,519 | -28,526 | 7,170,311.85 | 2.2576 | 0.1027 | 12/31/2025 |
| 6 | UPAMC Global AIoT Fund | 33,018 | 1,286 | 6,146,300.7 | 4.1468 | 0.088 | 12/31/2025 |
| 7 | RIM Global - Bioscience | 14,796 | 14,796 | 2,754,275.4 | 2.372 | 0.0394 | 10/31/2025 |
| 8 | State Street SPDR Portfolio Emerging Markets ETF | 12,456 | 1,720 | 2,318,684.4 | 0.0137 | 0.0332 | 01/30/2026 |
| 9 | UPAMC China Fund | 12,006 | 12,006 | 2,234,916.9 | 3.1301 | 0.032 | 12/31/2025 |
| 10 | Morgan Stanley Instl. Fund - Global Endurance Portfolio | 7,022 | 7,022 | 1,307,145.3 | 4.8506 | 0.0187 | 12/31/2025 |
| 11 | Fidelity Nasdaq Composite Index Fund | 6,727 | 0 | 1,252,231.05 | 0.0055 | 0.0179 | 12/31/2025 |
| 12 | Alger Health Sciences Fund | 4,535 | 4,535 | 844,190.25 | 1.2459 | 0.0121 | 12/31/2025 |
| 13 | Fidelity Nasdaq Composite Index ETF | 3,712 | -2,425 | 690,988.8 | 0.0075 | 0.0099 | 01/30/2026 |
| 14 | State Street SPDR S&P China ETF | 3,068 | 1,661 | 571,108.2 | 0.1135 | 0.0082 | 01/30/2026 |
| 15 | Alger SICAV - Small Cap Focus Fund | 2,332 | 2,332 | 434,101.8 | 0.8251 | 0.0062 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Darwin Global Management Ltd. | 3,027,704 | 3,027,704 | 563,607,099.6 | 11.3512 | 8.0707 | 12/31/2025 |
| 2 | RTW Investments LP | 715,332 | 715,332 | 133,159,051.8 | 1.3907 | 1.9068 | 12/31/2025 |
| 3 | Millennium Management LLC | 558,882 | 558,882 | 104,035,884.3 | 0.0733 | 1.4898 | 12/31/2025 |
| 4 | RA Capital Management LP | 432,484 | 432,484 | 80,506,896.6 | 0.7704 | 1.1528 | 12/31/2025 |
| 5 | Perceptive Advisors LLC | 414,239 | 414,239 | 77,110,589.85 | 1.3741 | 1.1042 | 12/31/2025 |
| 6 | Eventide Asset Management LLC | 383,091 | 383,091 | 71,312,389.65 | 1.0701 | 1.0212 | 12/31/2025 |
| 7 | Point72 Asset Management LP | 284,437 | 283,137 | 52,947,947.55 | 0.0793 | 0.7582 | 12/31/2025 |
| 8 | Marshall Wace LLP | 192,700 | 183,214 | 35,871,105 | 0.0338 | 0.5137 | 12/31/2025 |
| 9 | UBS Securities LLC | 94,300 | 91,942 | 17,553,945 | 0.007 | 0.2514 | 12/31/2025 |
| 10 | HBM Partners AG (Investment Management) | 90,000 | 90,000 | 16,753,500 | 1.6012 | 0.2399 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Fubon Asset Management Co., Ltd. | 79,974 | -52,001 | 14,887,160.1 | 0.0514 | 0.2132 | 12/31/2025 |
| 2 | JPMorgan Securities LLC (Investment Management) | 0 | -6,757 | 0 | 0 | 0 | |
| 3 | SSgA Funds Management, Inc. | 15,740 | -4,463 | 2,930,001 | 0.0001 | 0.042 | 12/31/2025 |
| 4 | Renaissance Technologies LLC | 0 | -4,300 | 0 | 0 | 0 | |
| 5 | Cubist Systematic Strategies LLC | 0 | -2,874 | 0 | 0 | 0 | |
| 6 | Geode Capital Management LLC | 10,445 | -2,419 | 1,944,336.75 | 0.0001 | 0.0278 | 12/31/2025 |
| 7 | Citadel Securities LLC | 5,055 | -2,401 | 940,988.25 | 0.002 | 0.0135 | 12/31/2025 |
| 8 | EverSource Wealth Advisors LLC | 1,598 | -952 | 297,467.7 | 0.0107 | 0.0043 | 12/31/2025 |
| 9 | BNP Paribas Financial Markets | 2,448 | -843 | 455,695.2 | 0.0003 | 0.0065 | 12/31/2025 |
| 10 | Osaic Institutions, Inc. | 0 | -6 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.