| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Darwin Global Management Ltd. | 3,057,412 | 3,057,412 | 419,782,667.6 | 11.3707 | 7.6502 | 03/31/2026 |
| 2 | Paradigm BioCapital Advisors LP | 1,114,784 | 1,114,784 | 153,059,843.2 | 3.4367 | 2.7894 | 03/31/2026 |
| 3 | UBS Securities LLC | 716,653 | 712,558 | 98,396,456.9 | 0.0354 | 1.7932 | 03/31/2026 |
| 4 | RTW Investments LP | 715,332 | 402,832 | 98,215,083.6 | 0.9439 | 1.7899 | 03/31/2026 |
| 5 | Millennium Management LLC | 570,088 | 549,347 | 78,273,082.4 | 0.0545 | 1.4265 | 03/31/2026 |
| 6 | Holocene Advisors, LP | 494,495 | 494,495 | 67,894,163.5 | 0.149 | 1.2373 | 03/31/2026 |
| 7 | Eventide Asset Management LLC | 357,650 | 162,338 | 49,105,345 | 0.7111 | 0.8949 | 03/31/2026 |
| 8 | T. Rowe Price Associates, Inc. (IM) | 281,805 | 281,805 | 38,691,826.5 | 0.0043 | 0.7051 | 03/31/2026 |
| 9 | Morgan Stanley & Co. LLC | 155,543 | 152,890 | 21,356,053.9 | 0.0064 | 0.3892 | 03/31/2026 |
| 10 | Perceptive Advisors LLC | 151,979 | 102,191 | 20,866,716.7 | 0.3769 | 0.3803 | 03/31/2026 |
| 11 | Medical Strategy GmbH | 130,150 | 26,147 | 17,869,595 | 1.7843 | 0.3257 | 02/27/2026 |
| 12 | Duquesne Family Office LLC | 106,100 | 106,100 | 14,567,530 | 0.4317 | 0.2655 | 03/31/2026 |
| 13 | Goldman Sachs & Co. LLC (Private Banking) | 105,509 | 101,803 | 14,486,385.7 | 0.0045 | 0.264 | 03/31/2026 |
| 14 | HBM Partners AG (Investment Management) | 90,000 | 90,000 | 12,357,000 | 1.2087 | 0.2252 | 12/31/2025 |
| 15 | Fubon Asset Management Co., Ltd. | 79,954 | -60,934 | 10,977,684.2 | 0.0291 | 0.2001 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | FCP Medical - BioHealth | 130,150 | 26,147 | 17,869,595 | 1.7395 | 0.3257 | 02/27/2026 |
| 2 | HBM Healthcare Investments AG | 90,000 | 90,000 | 12,357,000 | 0.4779 | 0.2252 | 12/31/2025 |
| 3 | Eventide Healthcare & Life Sciences Fund | 54,467 | 54,467 | 7,478,319.1 | 0.4549 | 0.1363 | 12/31/2025 |
| 4 | Alger Small Cap Focus Fund | 51,649 | 51,649 | 7,091,407.7 | 0.7732 | 0.1292 | 01/31/2026 |
| 5 | UPAMC Global AIoT Fund | 46,584 | 13,494 | 6,395,983.2 | 3.3087 | 0.1166 | 03/31/2026 |
| 6 | Fubon AI New Trends Multi-Asset Fund | 41,444 | -21,969 | 5,690,261.2 | 1.7674 | 0.1037 | 03/31/2026 |
| 7 | Fubon Taiwan-US Double Star Multi Asset Fund | 38,510 | -38,965 | 5,287,423 | 1.3495 | 0.0964 | 03/31/2026 |
| 8 | UPAMC China Fund | 19,217 | 10,332 | 2,638,494.1 | 3.3542 | 0.0481 | 03/31/2026 |
| 9 | RIM Global - Bioscience | 14,600 | -196 | 2,004,580 | 1.7127 | 0.0365 | 01/30/2026 |
| 10 | State Street SPDR Portfolio Emerging Markets ETF | 12,456 | 984 | 1,710,208.8 | 0.0097 | 0.0312 | 04/30/2026 |
| 11 | Morgan Stanley Instl. Fund Tr. - Discovery Portfolio | 10,859 | 10,859 | 1,490,940.7 | 0.174 | 0.0272 | 03/31/2026 |
| 12 | Morgan Stanley Invt. Fds. - Global Endurance Fund | 9,209 | 9,209 | 1,264,395.7 | 3.4492 | 0.023 | 12/31/2025 |
| 13 | Fidelity Nasdaq Composite Index Fund | 6,727 | 0 | 923,617.1 | 0.0034 | 0.0168 | 03/31/2026 |
| 14 | FSITC AI Global Precision Medicine Fund | 5,301 | 5,301 | 727,827.3 | 1.0381 | 0.0133 | 03/31/2026 |
| 15 | Alger Health Sciences Fund | 4,535 | 4,535 | 622,655.5 | 0.9322 | 0.0113 | 01/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Darwin Global Management Ltd. | 3,057,412 | 3,057,412 | 419,782,667.6 | 11.3707 | 7.6502 | 03/31/2026 |
| 2 | Paradigm BioCapital Advisors LP | 1,114,784 | 1,114,784 | 153,059,843.2 | 3.4367 | 2.7894 | 03/31/2026 |
| 3 | UBS Securities LLC | 716,653 | 712,558 | 98,396,456.9 | 0.0354 | 1.7932 | 03/31/2026 |
| 4 | Millennium Management LLC | 570,088 | 549,347 | 78,273,082.4 | 0.0545 | 1.4265 | 03/31/2026 |
| 5 | Holocene Advisors, LP | 494,495 | 494,495 | 67,894,163.5 | 0.149 | 1.2373 | 03/31/2026 |
| 6 | RTW Investments LP | 715,332 | 402,832 | 98,215,083.6 | 0.9439 | 1.7899 | 03/31/2026 |
| 7 | T. Rowe Price Associates, Inc. (IM) | 281,805 | 281,805 | 38,691,826.5 | 0.0043 | 0.7051 | 03/31/2026 |
| 8 | Eventide Asset Management LLC | 357,650 | 162,338 | 49,105,345 | 0.7111 | 0.8949 | 03/31/2026 |
| 9 | Morgan Stanley & Co. LLC | 155,543 | 152,890 | 21,356,053.9 | 0.0064 | 0.3892 | 03/31/2026 |
| 10 | Duquesne Family Office LLC | 106,100 | 106,100 | 14,567,530 | 0.4317 | 0.2655 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | RA Capital Management LP | 0 | -875,000 | 0 | 0 | 0 | |
| 2 | Vestal Point Capital LP | 0 | -312,500 | 0 | 0 | 0 | |
| 3 | Soleus Capital Management LP (Investment Management) | 0 | -210,000 | 0 | 0 | 0 | |
| 4 | Marshall Wace LLP | 0 | -187,500 | 0 | 0 | 0 | |
| 5 | Fubon Asset Management Co., Ltd. | 79,954 | -60,934 | 10,977,684.2 | 0.0291 | 0.2001 | 03/31/2026 |
| 6 | Citadel Securities LLC | 0 | -10,827 | 0 | 0 | 0 | |
| 7 | JPMorgan Securities LLC (Investment Management) | 0 | -9,809 | 0 | 0 | 0 | |
| 8 | Polymer Capital Management (HK) Ltd. | 0 | -7,266 | 0 | 0 | 0 | |
| 9 | UBS Switzerland AG (Investment Management) | 0 | -7,239 | 0 | 0 | 0 | |
| 10 | Geode Capital Management LLC | 10,427 | -5,198 | 1,431,627.1 | 0.0001 | 0.0261 | 03/31/2026 |
Data provided by FactSet Research Systems Inc.