| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Darwin Global Management Ltd. | 3,027,704 | 3,027,704 | 573,023,259.04 | 11.4627 | 8.0707 | 12/31/2025 |
| 2 | RTW Investments LP | 715,332 | 715,332 | 135,383,734.32 | 1.4245 | 1.9068 | 12/31/2025 |
| 3 | Millennium Management LLC | 558,882 | 558,882 | 105,774,007.32 | 0.0751 | 1.4898 | 12/31/2025 |
| 4 | RA Capital Management LP | 432,484 | 432,484 | 81,851,921.84 | 0.7936 | 1.1528 | 12/31/2025 |
| 5 | Perceptive Advisors LLC | 414,239 | 414,239 | 78,398,873.14 | 1.4173 | 1.1042 | 12/31/2025 |
| 6 | Eventide Asset Management LLC | 383,091 | 383,091 | 72,503,802.66 | 1.0935 | 1.0212 | 12/31/2025 |
| 7 | Point72 Asset Management LP | 284,437 | 283,137 | 53,832,546.62 | 0.0815 | 0.7582 | 12/31/2025 |
| 8 | Marshall Wace LLP | 192,700 | 183,214 | 36,470,402 | 0.0347 | 0.5137 | 12/31/2025 |
| 9 | UBS Securities LLC | 94,300 | 91,942 | 17,847,218 | 0.0072 | 0.2514 | 12/31/2025 |
| 10 | HBM Partners AG (Investment Management) | 90,000 | 90,000 | 17,033,400 | 1.6509 | 0.2399 | 12/31/2025 |
| 11 | Holocene Advisors, LP | 84,067 | 84,067 | 15,910,520.42 | 0.0334 | 0.2241 | 12/31/2025 |
| 12 | Fubon Asset Management Co., Ltd. | 79,974 | -52,001 | 15,135,879.24 | 0.0536 | 0.2132 | 12/31/2025 |
| 13 | Fred Alger Management LLC | 79,394 | 79,394 | 15,026,108.44 | 0.0658 | 0.2116 | 12/31/2025 |
| 14 | Western Standard LLC | 60,026 | 60,026 | 11,360,520.76 | 5.4288 | 0.16 | 12/31/2025 |
| 15 | Medical Strategy GmbH | 57,543 | 57,543 | 10,890,588.18 | 1.2611 | 0.1534 | 11/28/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | HBM Healthcare Investments AG | 90,000 | 90,000 | 17,033,400 | 0.6669 | 0.2399 | 12/31/2025 |
| 2 | FCP Medical - BioHealth | 57,543 | 57,543 | 10,890,588.18 | 1.2021 | 0.1534 | 11/28/2025 |
| 3 | Alger Small Cap Focus Fund | 57,224 | 57,224 | 10,830,214.24 | 1.2315 | 0.1525 | 12/31/2025 |
| 4 | Fubon AI New Trends Multi-Asset Fund | 41,455 | -23,475 | 7,845,773.3 | 3.9473 | 0.1105 | 12/31/2025 |
| 5 | Fubon Taiwan-US Double Star Multi Asset Fund | 38,519 | -28,526 | 7,290,105.94 | 2.3 | 0.1027 | 12/31/2025 |
| 6 | UPAMC Global AIoT Fund | 33,018 | 1,286 | 6,248,986.68 | 4.2639 | 0.088 | 12/31/2025 |
| 7 | RIM Global - Bioscience | 14,796 | 14,796 | 2,800,290.96 | 2.4507 | 0.0394 | 10/31/2025 |
| 8 | State Street SPDR Portfolio Emerging Markets ETF | 12,456 | 1,720 | 2,357,422.56 | 0.0139 | 0.0332 | 01/30/2026 |
| 9 | UPAMC China Fund | 12,006 | 12,006 | 2,272,255.56 | 3.2253 | 0.032 | 12/31/2025 |
| 10 | Morgan Stanley Instl. Fund - Global Endurance Portfolio | 7,022 | 7,022 | 1,328,983.72 | 4.9648 | 0.0187 | 12/31/2025 |
| 11 | Fidelity Nasdaq Composite Index Fund | 6,727 | 0 | 1,273,152.02 | 0.0057 | 0.0179 | 12/31/2025 |
| 12 | Alger Health Sciences Fund | 4,535 | 4,535 | 858,294.1 | 1.2654 | 0.0121 | 12/31/2025 |
| 13 | Fidelity Nasdaq Composite Index ETF | 3,712 | -2,425 | 702,533.12 | 0.0078 | 0.0099 | 01/30/2026 |
| 14 | State Street SPDR S&P China ETF | 3,068 | 1,661 | 580,649.68 | 0.1138 | 0.0082 | 01/30/2026 |
| 15 | Alger SICAV - Small Cap Focus Fund | 2,332 | 2,332 | 441,354.32 | 0.8468 | 0.0062 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Darwin Global Management Ltd. | 3,027,704 | 3,027,704 | 573,023,259.04 | 11.4627 | 8.0707 | 12/31/2025 |
| 2 | RTW Investments LP | 715,332 | 715,332 | 135,383,734.32 | 1.4245 | 1.9068 | 12/31/2025 |
| 3 | Millennium Management LLC | 558,882 | 558,882 | 105,774,007.32 | 0.0751 | 1.4898 | 12/31/2025 |
| 4 | RA Capital Management LP | 432,484 | 432,484 | 81,851,921.84 | 0.7936 | 1.1528 | 12/31/2025 |
| 5 | Perceptive Advisors LLC | 414,239 | 414,239 | 78,398,873.14 | 1.4173 | 1.1042 | 12/31/2025 |
| 6 | Eventide Asset Management LLC | 383,091 | 383,091 | 72,503,802.66 | 1.0935 | 1.0212 | 12/31/2025 |
| 7 | Point72 Asset Management LP | 284,437 | 283,137 | 53,832,546.62 | 0.0815 | 0.7582 | 12/31/2025 |
| 8 | Marshall Wace LLP | 192,700 | 183,214 | 36,470,402 | 0.0347 | 0.5137 | 12/31/2025 |
| 9 | UBS Securities LLC | 94,300 | 91,942 | 17,847,218 | 0.0072 | 0.2514 | 12/31/2025 |
| 10 | HBM Partners AG (Investment Management) | 90,000 | 90,000 | 17,033,400 | 1.6509 | 0.2399 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Fubon Asset Management Co., Ltd. | 79,974 | -52,001 | 15,135,879.24 | 0.0536 | 0.2132 | 12/31/2025 |
| 2 | JPMorgan Securities LLC (Investment Management) | 0 | -6,757 | 0 | 0 | 0 | |
| 3 | SSgA Funds Management, Inc. | 15,740 | -4,463 | 2,978,952.4 | 0.0001 | 0.042 | 12/31/2025 |
| 4 | Renaissance Technologies LLC | 0 | -4,300 | 0 | 0 | 0 | |
| 5 | Cubist Systematic Strategies LLC | 0 | -2,874 | 0 | 0 | 0 | |
| 6 | Geode Capital Management LLC | 10,445 | -2,419 | 1,976,820.7 | 0.0001 | 0.0278 | 12/31/2025 |
| 7 | Citadel Securities LLC | 5,055 | -2,401 | 956,709.3 | 0.002 | 0.0135 | 12/31/2025 |
| 8 | EverSource Wealth Advisors LLC | 1,598 | -952 | 302,437.48 | 0.0109 | 0.0043 | 12/31/2025 |
| 9 | BNP Paribas Financial Markets | 2,448 | -843 | 463,308.48 | 0.0003 | 0.0065 | 12/31/2025 |
| 10 | Osaic Institutions, Inc. | 0 | -6 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.