| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Darwin Global Management Ltd. | 2,617,094 | 2,617,094 | 369,847,724.08 | 6.2304 | 6.9762 | 12/03/2025 |
| 2 | RA Capital Management LP | 875,000 | 875,000 | 123,655,000 | 1.2421 | 2.3324 | 09/30/2025 |
| 3 | RTW Investments LP | 312,500 | 312,500 | 44,162,500 | 0.4556 | 0.833 | 09/30/2025 |
| 4 | Vestal Point Capital LP | 312,500 | 312,500 | 44,162,500 | 1.5819 | 0.833 | 09/30/2025 |
| 5 | Soleus Capital Management LP (Investment Management) | 210,000 | 210,000 | 29,677,200 | 1.0287 | 0.5598 | 09/30/2025 |
| 6 | Eventide Asset Management LLC | 195,312 | 195,312 | 27,601,491.84 | 0.4225 | 0.5206 | 09/30/2025 |
| 7 | Marshall Wace LLP | 187,500 | 187,500 | 26,497,500 | 0.0284 | 0.4998 | 09/30/2025 |
| 8 | Fubon Asset Management Co., Ltd. | 140,888 | 80,494 | 19,910,292.16 | 0.0926 | 0.3756 | 09/30/2025 |
| 9 | Medical Strategy GmbH | 83,161 | 83,161 | 11,752,312.52 | 1.2759 | 0.2217 | 09/30/2025 |
| 10 | Perceptive Advisors LLC | 49,788 | 49,788 | 7,036,040.16 | 0.1376 | 0.1327 | 09/30/2025 |
| 11 | Uni-President Asset Management Corp. | 41,975 | 17,391 | 5,931,907 | 0.0772 | 0.1119 | 09/30/2025 |
| 12 | Millennium Management LLC | 20,741 | 20,741 | 2,931,118.12 | 0.0023 | 0.0553 | 09/30/2025 |
| 13 | Geode Capital Management LLC | 15,625 | 2,872 | 2,208,125 | 0.0001 | 0.0417 | 09/30/2025 |
| 14 | SSgA Funds Management, Inc. | 13,273 | -6,825 | 1,875,740.36 | 0.0001 | 0.0354 | 09/30/2025 |
| 15 | BNP Paribas Financial Markets | 11,549 | 11,549 | 1,632,104.68 | 0.0012 | 0.0308 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | FCP Medical - BioHealth | 83,161 | 83,161 | 11,752,312.52 | 1.2362 | 0.2217 | 09/30/2025 |
| 2 | Fubon Taiwan-US Double Star Multi Asset Fund | 77,475 | 77,475 | 10,948,767 | 3.6172 | 0.2065 | 09/30/2025 |
| 3 | Fubon AI New Trends Multi-Asset Fund | 63,413 | 3,019 | 8,961,525.16 | 6.8523 | 0.169 | 09/30/2025 |
| 4 | UPAMC Global AIoT Fund | 33,090 | 8,506 | 4,676,278.8 | 3.693 | 0.0882 | 09/30/2025 |
| 5 | SPDR Portfolio Emerging Markets ETF | 12,120 | 1,548 | 1,712,798.4 | 0.0111 | 0.0323 | 11/28/2025 |
| 6 | Fidelity Nasdaq Composite Index ETF | 8,958 | 2,833 | 1,265,944.56 | 0.0137 | 0.0239 | 11/28/2025 |
| 7 | UPAMC China Fund | 8,885 | 8,885 | 1,255,628.2 | 1.851 | 0.0237 | 09/30/2025 |
| 8 | Fidelity Nasdaq Composite Index Fund | 6,727 | 27 | 950,659.64 | 0.0041 | 0.0179 | 10/31/2025 |
| 9 | ActivePassive International Equity ETF | 3,051 | 2,641 | 431,167.32 | 0.0451 | 0.0081 | 11/28/2025 |
| 10 | Virtus LifeSci Biotech Clinical Trials ETF | 2,072 | 283 | 292,815.04 | 1.0467 | 0.0055 | 11/28/2025 |
| 11 | SPDR S&P China ETF | 1,377 | -30 | 194,597.64 | 0.0406 | 0.0037 | 11/28/2025 |
| 12 | John Hancock VIT - Total Stock Market Index Trust | 19 | -475 | 2,685.08 | 0.0002 | 0.0001 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Darwin Global Management Ltd. | 2,617,094 | 2,617,094 | 369,847,724.08 | 6.2304 | 6.9762 | 12/03/2025 |
| 2 | RA Capital Management LP | 875,000 | 875,000 | 123,655,000 | 1.2421 | 2.3324 | 09/30/2025 |
| 3 | RTW Investments LP | 312,500 | 312,500 | 44,162,500 | 0.4556 | 0.833 | 09/30/2025 |
| 4 | Vestal Point Capital LP | 312,500 | 312,500 | 44,162,500 | 1.5819 | 0.833 | 09/30/2025 |
| 5 | Soleus Capital Management LP (Investment Management) | 210,000 | 210,000 | 29,677,200 | 1.0287 | 0.5598 | 09/30/2025 |
| 6 | Eventide Asset Management LLC | 195,312 | 195,312 | 27,601,491.84 | 0.4225 | 0.5206 | 09/30/2025 |
| 7 | Marshall Wace LLP | 187,500 | 187,500 | 26,497,500 | 0.0284 | 0.4998 | 09/30/2025 |
| 8 | Medical Strategy GmbH | 83,161 | 83,161 | 11,752,312.52 | 1.2759 | 0.2217 | 09/30/2025 |
| 9 | Fubon Asset Management Co., Ltd. | 140,888 | 80,494 | 19,910,292.16 | 0.0926 | 0.3756 | 09/30/2025 |
| 10 | Perceptive Advisors LLC | 49,788 | 49,788 | 7,036,040.16 | 0.1376 | 0.1327 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Alyeska Investment Group LP | 0 | -83,623 | 0 | 0 | 0 | |
| 2 | SSgA Funds Management, Inc. | 13,273 | -6,825 | 1,875,740.36 | 0.0001 | 0.0354 | 09/30/2025 |
| 3 | HRT Financial LP (US) | 0 | -4,117 | 0 | 0 | 0 | |
| 4 | Bank of America, NA (Private Banking) | 1,171 | -4,053 | 165,485.72 | 0.0001 | 0.0031 | 09/30/2025 |
| 5 | RhumbLine Advisers LP | 0 | -1,435 | 0 | 0 | 0 | |
| 6 | Virtus Investment Advisers LLC | 1,831 | -758 | 258,756.92 | 0.0403 | 0.0049 | 09/30/2025 |
| 7 | GAMMA Investing LLC | 1,758 | -91 | 248,440.56 | 0.0135 | 0.0047 | 09/30/2025 |
| 8 | SBI Securities Co., Ltd. | 52 | -52 | 7,348.64 | 0.0002 | 0.0001 | 09/30/2025 |
| 9 | Caitong International Asset Management Co., Ltd. | 1 | -48 | 141.32 | 0.0001 | 0 | 09/30/2025 |
| 10 | Columbia Management Investment Advisers LLC | 3,031 | -44 | 428,340.92 | 0.0001 | 0.0081 | 09/30/2025 |
Data provided by FactSet Research Systems Inc.