# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Darwin Global Management Ltd. 3,027,704 3,027,704 563,607,099.6 11.3512 8.0707 12/31/2025
2 RTW Investments LP 715,332 715,332 133,159,051.8 1.3907 1.9068 12/31/2025
3 Millennium Management LLC 558,882 558,882 104,035,884.3 0.0733 1.4898 12/31/2025
4 RA Capital Management LP 432,484 432,484 80,506,896.6 0.7704 1.1528 12/31/2025
5 Perceptive Advisors LLC 414,239 414,239 77,110,589.85 1.3741 1.1042 12/31/2025
6 Eventide Asset Management LLC 383,091 383,091 71,312,389.65 1.0701 1.0212 12/31/2025
7 Point72 Asset Management LP 284,437 283,137 52,947,947.55 0.0793 0.7582 12/31/2025
8 Marshall Wace LLP 192,700 183,214 35,871,105 0.0338 0.5137 12/31/2025
9 UBS Securities LLC 94,300 91,942 17,553,945 0.007 0.2514 12/31/2025
10 HBM Partners AG (Investment Management) 90,000 90,000 16,753,500 1.6012 0.2399 12/31/2025
11 Holocene Advisors, LP 84,067 84,067 15,649,072.05 0.0325 0.2241 12/31/2025
12 Fubon Asset Management Co., Ltd. 79,974 -52,001 14,887,160.1 0.0514 0.2132 12/31/2025
13 Fred Alger Management LLC 79,394 79,394 14,779,193.1 0.0641 0.2116 12/31/2025
14 Western Standard LLC 60,026 60,026 11,173,839.9 5.3305 0.16 12/31/2025
15 Medical Strategy GmbH 57,543 57,543 10,711,629.45 1.2206 0.1534 11/28/2025
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 HBM Healthcare Investments AG 90,000 90,000 16,753,500 0.6526 0.2399 12/31/2025
2 FCP Medical - BioHealth 57,543 57,543 10,711,629.45 1.1644 0.1534 11/28/2025
3 Alger Small Cap Focus Fund 57,224 57,224 10,652,247.6 1.1996 0.1525 12/31/2025
4 Fubon AI New Trends Multi-Asset Fund 41,455 -23,475 7,716,848.25 3.8811 0.1105 12/31/2025
5 Fubon Taiwan-US Double Star Multi Asset Fund 38,519 -28,526 7,170,311.85 2.2576 0.1027 12/31/2025
6 UPAMC Global AIoT Fund 33,018 1,286 6,146,300.7 4.1468 0.088 12/31/2025
7 RIM Global - Bioscience 14,796 14,796 2,754,275.4 2.372 0.0394 10/31/2025
8 State Street SPDR Portfolio Emerging Markets ETF 12,456 1,720 2,318,684.4 0.0137 0.0332 01/30/2026
9 UPAMC China Fund 12,006 12,006 2,234,916.9 3.1301 0.032 12/31/2025
10 Morgan Stanley Instl. Fund - Global Endurance Portfolio 7,022 7,022 1,307,145.3 4.8506 0.0187 12/31/2025
11 Fidelity Nasdaq Composite Index Fund 6,727 0 1,252,231.05 0.0055 0.0179 12/31/2025
12 Alger Health Sciences Fund 4,535 4,535 844,190.25 1.2459 0.0121 12/31/2025
13 Fidelity Nasdaq Composite Index ETF 3,712 -2,425 690,988.8 0.0075 0.0099 01/30/2026
14 State Street SPDR S&P China ETF 3,068 1,661 571,108.2 0.1135 0.0082 01/30/2026
15 Alger SICAV - Small Cap Focus Fund 2,332 2,332 434,101.8 0.8251 0.0062 12/31/2025
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Darwin Global Management Ltd. 3,027,704 3,027,704 563,607,099.6 11.3512 8.0707 12/31/2025
2 RTW Investments LP 715,332 715,332 133,159,051.8 1.3907 1.9068 12/31/2025
3 Millennium Management LLC 558,882 558,882 104,035,884.3 0.0733 1.4898 12/31/2025
4 RA Capital Management LP 432,484 432,484 80,506,896.6 0.7704 1.1528 12/31/2025
5 Perceptive Advisors LLC 414,239 414,239 77,110,589.85 1.3741 1.1042 12/31/2025
6 Eventide Asset Management LLC 383,091 383,091 71,312,389.65 1.0701 1.0212 12/31/2025
7 Point72 Asset Management LP 284,437 283,137 52,947,947.55 0.0793 0.7582 12/31/2025
8 Marshall Wace LLP 192,700 183,214 35,871,105 0.0338 0.5137 12/31/2025
9 UBS Securities LLC 94,300 91,942 17,553,945 0.007 0.2514 12/31/2025
10 HBM Partners AG (Investment Management) 90,000 90,000 16,753,500 1.6012 0.2399 12/31/2025
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Fubon Asset Management Co., Ltd. 79,974 -52,001 14,887,160.1 0.0514 0.2132 12/31/2025
2 JPMorgan Securities LLC (Investment Management) 0 -6,757 0 0 0
3 SSgA Funds Management, Inc. 15,740 -4,463 2,930,001 0.0001 0.042 12/31/2025
4 Renaissance Technologies LLC 0 -4,300 0 0 0
5 Cubist Systematic Strategies LLC 0 -2,874 0 0 0
6 Geode Capital Management LLC 10,445 -2,419 1,944,336.75 0.0001 0.0278 12/31/2025
7 Citadel Securities LLC 5,055 -2,401 940,988.25 0.002 0.0135 12/31/2025
8 EverSource Wealth Advisors LLC 1,598 -952 297,467.7 0.0107 0.0043 12/31/2025
9 BNP Paribas Financial Markets 2,448 -843 455,695.2 0.0003 0.0065 12/31/2025
10 Osaic Institutions, Inc. 0 -6 0 0 0

Data provided by FactSet Research Systems Inc.