| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Darwin Global Management Ltd. | 3,057,412 | 29,708 | 465,643,847.6 | 11.1814 | 7.6502 | 03/31/2026 |
| 2 | Paradigm BioCapital Advisors LP | 1,114,784 | 1,114,784 | 169,781,603.2 | 3.0662 | 2.7894 | 03/31/2026 |
| 3 | UBS Securities LLC | 716,653 | 622,353 | 109,146,251.9 | 0.0389 | 1.7932 | 03/31/2026 |
| 4 | RTW Investments LP | 715,332 | 0 | 108,945,063.6 | 0.8785 | 1.7899 | 03/31/2026 |
| 5 | Millennium Management LLC | 570,088 | 11,206 | 86,824,402.4 | 0.0599 | 1.4265 | 03/31/2026 |
| 6 | Holocene Advisors, LP | 494,495 | 410,428 | 75,311,588.5 | 0.1626 | 1.2373 | 03/31/2026 |
| 7 | Eventide Asset Management LLC | 357,650 | -25,441 | 54,470,095 | 0.7361 | 0.8949 | 03/31/2026 |
| 8 | T. Rowe Price Associates, Inc. (IM) | 281,805 | 281,805 | 42,918,901.5 | 0.0048 | 0.7051 | 03/31/2026 |
| 9 | Morgan Stanley & Co. LLC | 155,543 | 148,307 | 23,689,198.9 | 0.007 | 0.3892 | 03/31/2026 |
| 10 | Perceptive Advisors LLC | 151,979 | -262,260 | 23,146,401.7 | 0.3543 | 0.3803 | 03/31/2026 |
| 11 | Medical Strategy GmbH | 130,150 | -13,406 | 19,821,845 | 1.7122 | 0.3257 | 04/30/2026 |
| 12 | Duquesne Family Office LLC | 106,100 | 106,100 | 16,159,030 | 0.4413 | 0.2655 | 03/31/2026 |
| 13 | Goldman Sachs & Co. LLC (Private Banking) | 105,509 | 60,910 | 16,069,020.7 | 0.005 | 0.264 | 03/31/2026 |
| 14 | HBM Partners AG (Investment Management) | 90,000 | 0 | 13,707,000 | 1.358 | 0.2252 | 12/31/2025 |
| 15 | Fubon Asset Management Co., Ltd. | 79,954 | -20 | 12,176,994.2 | 0.0304 | 0.2001 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | FCP Medical - BioHealth | 130,150 | -13,406 | 19,821,845 | 1.6789 | 0.3257 | 04/30/2026 |
| 2 | HBM Healthcare Investments AG | 90,000 | 0 | 13,707,000 | 0.5255 | 0.2252 | 12/31/2025 |
| 3 | Alger Small Cap Focus Fund | 61,867 | 4,643 | 9,422,344.1 | 1.0558 | 0.1548 | 04/30/2026 |
| 4 | UPAMC Global AIoT Fund | 46,584 | 13,566 | 7,094,743.2 | 3.901 | 0.1166 | 03/31/2026 |
| 5 | Fubon AI New Trends Multi-Asset Fund | 41,444 | -11 | 6,311,921.2 | 2.0711 | 0.1037 | 03/31/2026 |
| 6 | Fubon Taiwan-US Double Star Multi Asset Fund | 38,510 | -9 | 5,865,073 | 1.5212 | 0.0964 | 03/31/2026 |
| 7 | Eventide Healthcare & Life Sciences Fund | 29,026 | -25,441 | 4,420,659.8 | 0.2316 | 0.0726 | 03/31/2026 |
| 8 | UPAMC China Fund | 19,217 | 7,211 | 2,926,749.1 | 3.9238 | 0.0481 | 03/31/2026 |
| 9 | Brighthouse Funds Trust I - Morgan Stanley Discovery Port. | 15,913 | 15,913 | 2,423,549.9 | 0.1873 | 0.0398 | 03/31/2026 |
| 10 | Biotech Growth Trust Plc (The) | 13,300 | 13,300 | 2,025,590 | 0.4542 | 0.0333 | 06/30/2026 |
| 11 | RIM Global - Bioscience | 12,806 | -3,794 | 1,950,353.8 | 1.4152 | 0.032 | 03/31/2026 |
| 12 | State Street SPDR Portfolio Emerging Markets ETF | 12,456 | 184 | 1,897,048.8 | 0.0109 | 0.0312 | 06/30/2026 |
| 13 | Morgan Stanley Instl. Fund Tr. - Discovery Portfolio | 10,859 | 10,859 | 1,653,825.7 | 0.1891 | 0.0272 | 03/31/2026 |
| 14 | Fidelity Nasdaq Composite Index Fund | 6,727 | 0 | 1,024,522.1 | 0.0038 | 0.0168 | 05/31/2026 |
| 15 | FSITC AI Global Precision Medicine Fund | 5,301 | 5,301 | 807,342.3 | 1.1145 | 0.0133 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Paradigm BioCapital Advisors LP | 1,114,784 | 1,114,784 | 169,781,603.2 | 3.0662 | 2.7894 | 03/31/2026 |
| 2 | UBS Securities LLC | 716,653 | 622,353 | 109,146,251.9 | 0.0389 | 1.7932 | 03/31/2026 |
| 3 | Holocene Advisors, LP | 494,495 | 410,428 | 75,311,588.5 | 0.1626 | 1.2373 | 03/31/2026 |
| 4 | T. Rowe Price Associates, Inc. (IM) | 281,805 | 281,805 | 42,918,901.5 | 0.0048 | 0.7051 | 03/31/2026 |
| 5 | Morgan Stanley & Co. LLC | 155,543 | 148,307 | 23,689,198.9 | 0.007 | 0.3892 | 03/31/2026 |
| 6 | Duquesne Family Office LLC | 106,100 | 106,100 | 16,159,030 | 0.4413 | 0.2655 | 03/31/2026 |
| 7 | Goldman Sachs & Co. LLC (Private Banking) | 105,509 | 60,910 | 16,069,020.7 | 0.005 | 0.264 | 03/31/2026 |
| 8 | Renaissance Technologies LLC | 52,000 | 52,000 | 7,919,600 | 0.0108 | 0.1301 | 03/31/2026 |
| 9 | UBS Europe SE | 51,706 | 51,706 | 7,874,823.8 | 0.1219 | 0.1294 | 03/31/2026 |
| 10 | Affinity Asset Advisors LLC | 65,000 | 45,000 | 9,899,500 | 0.4892 | 0.1626 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | RA Capital Management LP | 0 | -432,484 | 0 | 0 | 0 | |
| 2 | Point72 Asset Management LP | 0 | -284,437 | 0 | 0 | 0 | |
| 3 | Perceptive Advisors LLC | 151,979 | -262,260 | 23,146,401.7 | 0.3543 | 0.3803 | 03/31/2026 |
| 4 | Marshall Wace LLP | 0 | -192,700 | 0 | 0 | 0 | |
| 5 | Western Standard LLC | 0 | -60,026 | 0 | 0 | 0 | |
| 6 | Soleus Capital Management LP (Investment Management) | 0 | -40,354 | 0 | 0 | 0 | |
| 7 | UBS Switzerland AG (Investment Management) | 0 | -34,452 | 0 | 0 | 0 | |
| 8 | Squadron Capital Management LLC | 0 | -26,000 | 0 | 0 | 0 | |
| 9 | Eventide Asset Management LLC | 357,650 | -25,441 | 54,470,095 | 0.7361 | 0.8949 | 03/31/2026 |
| 10 | Superstring Capital Management LP | 0 | -24,703 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.