| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Darwin Global Management Ltd. | 3,077,219 | 49,515 | 488,877,782.53 | 10.4265 | 7.6997 | 06/30/2026 |
| 2 | Paradigm BioCapital Advisors LP | 1,232,877 | 1,232,877 | 195,867,168.99 | 3.9392 | 3.0849 | 06/30/2026 |
| 3 | RTW Investments LP | 715,332 | 0 | 113,644,794.84 | 0.9204 | 1.7899 | 06/30/2026 |
| 4 | Millennium Management LLC | 494,564 | -64,318 | 78,571,382.68 | 0.0529 | 1.2375 | 06/30/2026 |
| 5 | Maverick Capital Ltd. | 396,311 | 396,311 | 62,961,928.57 | 0.5696 | 0.9916 | 06/30/2026 |
| 6 | Eventide Asset Management LLC | 390,829 | 7,738 | 62,091,003.23 | 0.8528 | 0.9779 | 06/30/2026 |
| 7 | Holocene Advisors, LP | 251,035 | 166,968 | 39,881,930.45 | 0.0894 | 0.6281 | 06/30/2026 |
| 8 | Logos Global Management LP | 250,000 | 250,000 | 39,717,500 | 1.6557 | 0.6255 | 06/30/2026 |
| 9 | Morgan Stanley & Co. LLC | 231,121 | 223,885 | 36,718,193.27 | 0.0107 | 0.5783 | 06/30/2026 |
| 10 | UBS Securities LLC | 224,876 | 130,576 | 35,726,050.12 | 0.0131 | 0.5627 | 06/30/2026 |
| 11 | Citadel Advisors LLC | 176,210 | 176,210 | 27,994,482.7 | 0.0205 | 0.4409 | 06/30/2026 |
| 12 | Goldman Sachs & Co. LLC (Private Banking) | 166,188 | 121,589 | 26,402,287.56 | 0.0067 | 0.4158 | 06/30/2026 |
| 13 | Affinity Asset Advisors LLC | 165,000 | 145,000 | 26,213,550 | 1.1923 | 0.4129 | 06/30/2026 |
| 14 | Medical Strategy GmbH | 112,479 | -31,077 | 17,869,538.73 | 1.6029 | 0.2814 | 05/29/2026 |
| 15 | T. Rowe Price Associates, Inc. (IM) | 105,859 | 105,859 | 16,817,819.33 | 0.0018 | 0.2649 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | FCP Medical - BioHealth | 112,479 | -31,077 | 17,869,538.73 | 1.5552 | 0.2814 | 05/29/2026 |
| 2 | HBM Healthcare Investments AG | 90,000 | 0 | 14,298,300 | 0.5472 | 0.2252 | 12/31/2025 |
| 3 | UPAMC Global AIoT Fund | 48,010 | 14,992 | 7,627,348.7 | 4.1563 | 0.1201 | 06/30/2026 |
| 4 | Eventide Healthcare & Life Sciences Fund | 29,026 | -25,441 | 4,611,360.62 | 0.242 | 0.0726 | 03/31/2026 |
| 5 | UPAMC China Fund | 19,987 | 7,981 | 3,175,334.69 | 4.623 | 0.05 | 06/30/2026 |
| 6 | Brighthouse Funds Trust I - Morgan Stanley Discovery Port. | 15,913 | 15,913 | 2,528,098.31 | 0.1962 | 0.0398 | 03/31/2026 |
| 7 | Biotech Growth Trust Plc (The) | 13,300 | 13,300 | 2,112,971 | 0.4532 | 0.0333 | 07/31/2026 |
| 8 | RIM Global - Bioscience | 12,806 | -1,794 | 2,034,489.22 | 1.5301 | 0.032 | 04/30/2026 |
| 9 | State Street SPDR Portfolio Emerging Markets ETF | 12,496 | 40 | 1,985,239.52 | 0.0112 | 0.0313 | 07/31/2026 |
| 10 | Fidelity Nasdaq Composite Index Fund | 6,727 | 0 | 1,068,718.49 | 0.004 | 0.0168 | 06/30/2026 |
| 11 | Fidelity ZERO International Index Fund | 5,488 | 5,488 | 871,878.56 | 0.0072 | 0.0137 | 06/30/2026 |
| 12 | Morgan Stanley Invt. Fds. - Global Endurance Fund | 4,802 | -4,407 | 762,893.74 | 1.9526 | 0.012 | 03/31/2026 |
| 13 | John Hancock VIT - Health Sciences Trust | 4,800 | 4,800 | 762,576 | 0.2834 | 0.012 | 03/31/2026 |
| 14 | FSITC AI Global Precision Medicine Fund | 4,697 | 4,697 | 746,212.39 | 1.0884 | 0.0118 | 06/30/2026 |
| 15 | ActivePassive International Equity ETF | 4,131 | 3,140 | 656,291.97 | 0.0571 | 0.0103 | 07/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Paradigm BioCapital Advisors LP | 1,232,877 | 1,232,877 | 195,867,168.99 | 3.9392 | 3.0849 | 06/30/2026 |
| 2 | Maverick Capital Ltd. | 396,311 | 396,311 | 62,961,928.57 | 0.5696 | 0.9916 | 06/30/2026 |
| 3 | Logos Global Management LP | 250,000 | 250,000 | 39,717,500 | 1.6557 | 0.6255 | 06/30/2026 |
| 4 | Morgan Stanley & Co. LLC | 231,121 | 223,885 | 36,718,193.27 | 0.0107 | 0.5783 | 06/30/2026 |
| 5 | Citadel Advisors LLC | 176,210 | 176,210 | 27,994,482.7 | 0.0205 | 0.4409 | 06/30/2026 |
| 6 | Holocene Advisors, LP | 251,035 | 166,968 | 39,881,930.45 | 0.0894 | 0.6281 | 06/30/2026 |
| 7 | Affinity Asset Advisors LLC | 165,000 | 145,000 | 26,213,550 | 1.1923 | 0.4129 | 06/30/2026 |
| 8 | UBS Securities LLC | 224,876 | 130,576 | 35,726,050.12 | 0.0131 | 0.5627 | 06/30/2026 |
| 9 | Goldman Sachs & Co. LLC (Private Banking) | 166,188 | 121,589 | 26,402,287.56 | 0.0067 | 0.4158 | 06/30/2026 |
| 10 | T. Rowe Price Associates, Inc. (IM) | 105,859 | 105,859 | 16,817,819.33 | 0.0018 | 0.2649 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | RA Capital Management LP | 0 | -432,484 | 0 | 0 | 0 | |
| 2 | Perceptive Advisors LLC | 0 | -414,239 | 0 | 0 | 0 | |
| 3 | Point72 Asset Management LP | 51,186 | -233,251 | 8,131,919.82 | 0.0125 | 0.1281 | 06/30/2026 |
| 4 | Marshall Wace LLP | 0 | -192,700 | 0 | 0 | 0 | |
| 5 | Fubon Asset Management Co., Ltd. | 0 | -79,974 | 0 | 0 | 0 | |
| 6 | Fred Alger Management LLC | 2,119 | -77,275 | 336,645.53 | 0.0012 | 0.0053 | 06/30/2026 |
| 7 | Millennium Management LLC | 494,564 | -64,318 | 78,571,382.68 | 0.0529 | 1.2375 | 06/30/2026 |
| 8 | Western Standard LLC | 0 | -60,026 | 0 | 0 | 0 | |
| 9 | Adar1 Capital Management LLC | 0 | -39,839 | 0 | 0 | 0 | |
| 10 | UBS Switzerland AG (Investment Management) | 0 | -34,452 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.