| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Darwin Global Management Ltd. | 3,077,219 | 19,807 | 469,337,441.88 | 8.7794 | 7.6411 | 06/30/2026 |
| 2 | Paradigm BioCapital Advisors LP | 1,232,877 | 118,093 | 188,038,400.04 | 4.1519 | 3.0614 | 06/30/2026 |
| 3 | RTW Investments LP | 715,332 | 0 | 109,102,436.64 | 1.0323 | 1.7762 | 06/30/2026 |
| 4 | Millennium Management LLC | 494,564 | -75,524 | 75,430,901.28 | 0.0521 | 1.2281 | 06/30/2026 |
| 5 | Maverick Capital Ltd. | 396,311 | 396,311 | 60,445,353.72 | 0.537 | 0.9841 | 06/30/2026 |
| 6 | Eventide Asset Management LLC | 390,829 | 33,179 | 59,609,239.08 | 0.863 | 0.9705 | 06/30/2026 |
| 7 | Holocene Advisors, LP | 251,035 | -243,460 | 38,287,858.2 | 0.0877 | 0.6233 | 06/30/2026 |
| 8 | Logos Global Management LP | 250,000 | 250,000 | 38,130,000 | 1.994 | 0.6208 | 06/30/2026 |
| 9 | Morgan Stanley & Co. LLC | 231,121 | 75,578 | 35,250,574.92 | 0.0103 | 0.5739 | 06/30/2026 |
| 10 | UBS Securities LLC | 224,876 | -491,777 | 34,298,087.52 | 0.0129 | 0.5584 | 06/30/2026 |
| 11 | Citadel Advisors LLC | 176,210 | 174,202 | 26,875,549.2 | 0.0204 | 0.4375 | 06/30/2026 |
| 12 | Goldman Sachs & Co. LLC (Private Banking) | 166,188 | 60,679 | 25,346,993.76 | 0.0065 | 0.4127 | 06/30/2026 |
| 13 | Affinity Asset Advisors LLC | 165,000 | 100,000 | 25,165,800 | 1.482 | 0.4097 | 06/30/2026 |
| 14 | Medical Strategy GmbH | 112,479 | -17,671 | 17,155,297.08 | 1.8317 | 0.2793 | 06/30/2026 |
| 15 | T. Rowe Price Associates, Inc. (IM) | 105,859 | -175,946 | 16,145,614.68 | 0.0018 | 0.2629 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | FCP Medical - BioHealth | 112,479 | -17,671 | 17,155,297.08 | 1.731 | 0.2793 | 06/30/2026 |
| 2 | Eventide Healthcare & Life Sciences Fund | 62,205 | 33,179 | 9,487,506.6 | 0.5999 | 0.1545 | 06/30/2026 |
| 3 | UPAMC Global AIoT Fund | 48,010 | 1,426 | 7,322,485.2 | 3.4428 | 0.1192 | 06/30/2026 |
| 4 | State Street SPDR Portfolio Emerging Markets ETF | 30,060 | 17,604 | 4,584,751.2 | 0.0261 | 0.0746 | 09/30/2026 |
| 5 | APO Medical Opportunities | 23,156 | 0 | 3,531,753.12 | 0.5007 | 0.0575 | 03/31/2026 |
| 6 | UPAMC China Fund | 19,987 | 770 | 3,048,417.24 | 4.0829 | 0.0496 | 06/30/2026 |
| 7 | Biotech Growth Trust Plc (The) | 13,300 | 13,300 | 2,028,516 | 0.5379 | 0.033 | 08/31/2026 |
| 8 | RIM Global - Bioscience | 12,806 | 0 | 1,953,171.12 | 1.7531 | 0.0318 | 05/29/2026 |
| 9 | Fidelity Nasdaq Composite Index Fund | 6,727 | 0 | 1,026,002.04 | 0.0036 | 0.0167 | 08/31/2026 |
| 10 | Fidelity ZERO International Index Fund | 5,934 | 5,934 | 905,053.68 | 0.0073 | 0.0147 | 08/31/2026 |
| 11 | FSITC AI Global Precision Medicine Fund | 4,697 | -604 | 716,386.44 | 1.0974 | 0.0117 | 06/30/2026 |
| 12 | ActivePassive International Equity ETF | 4,286 | 2,969 | 653,700.72 | 0.0576 | 0.0106 | 09/30/2026 |
| 13 | Fidelity Nasdaq Composite Index ETF | 3,745 | 45 | 571,187.4 | 0.0052 | 0.0093 | 09/30/2026 |
| 14 | State Street SPDR S&P China ETF | 3,192 | 0 | 486,843.84 | 0.1091 | 0.0079 | 09/30/2026 |
| 15 | Fidelity Select Port. - Biotechnology Portfolio | 3,100 | 3,100 | 472,812 | 0.0082 | 0.0077 | 08/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Maverick Capital Ltd. | 396,311 | 396,311 | 60,445,353.72 | 0.537 | 0.9841 | 06/30/2026 |
| 2 | Logos Global Management LP | 250,000 | 250,000 | 38,130,000 | 1.994 | 0.6208 | 06/30/2026 |
| 3 | Citadel Advisors LLC | 176,210 | 174,202 | 26,875,549.2 | 0.0204 | 0.4375 | 06/30/2026 |
| 4 | Paradigm BioCapital Advisors LP | 1,232,877 | 118,093 | 188,038,400.04 | 4.1519 | 3.0614 | 06/30/2026 |
| 5 | Affinity Asset Advisors LLC | 165,000 | 100,000 | 25,165,800 | 1.482 | 0.4097 | 06/30/2026 |
| 6 | Bank of America, NA (Private Banking) | 99,492 | 97,246 | 15,174,519.84 | 0.0039 | 0.247 | 06/30/2026 |
| 7 | Morgan Stanley & Co. LLC | 231,121 | 75,578 | 35,250,574.92 | 0.0103 | 0.5739 | 06/30/2026 |
| 8 | Goldman Sachs & Co. LLC (Private Banking) | 166,188 | 60,679 | 25,346,993.76 | 0.0065 | 0.4127 | 06/30/2026 |
| 9 | Jane Street Capital LLC | 65,801 | 53,579 | 10,035,968.52 | 0.0062 | 0.1634 | 06/30/2026 |
| 10 | Point72 Asset Management LP | 51,186 | 51,186 | 7,806,888.72 | 0.0123 | 0.1271 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | UBS Securities LLC | 224,876 | -491,777 | 34,298,087.52 | 0.0129 | 0.5584 | 06/30/2026 |
| 2 | Holocene Advisors, LP | 251,035 | -243,460 | 38,287,858.2 | 0.0877 | 0.6233 | 06/30/2026 |
| 3 | T. Rowe Price Associates, Inc. (IM) | 105,859 | -175,946 | 16,145,614.68 | 0.0018 | 0.2629 | 06/30/2026 |
| 4 | Perceptive Advisors LLC | 0 | -151,979 | 0 | 0 | 0 | |
| 5 | HBM Partners AG (Investment Management) | 0 | -90,000 | 0 | 0 | 0 | |
| 6 | Fubon Asset Management Co., Ltd. | 0 | -79,954 | 0 | 0 | 0 | |
| 7 | Millennium Management LLC | 494,564 | -75,524 | 75,430,901.28 | 0.0521 | 1.2281 | 06/30/2026 |
| 8 | Fred Alger Management LLC | 2,119 | -60,455 | 323,189.88 | 0.0011 | 0.0053 | 06/30/2026 |
| 9 | UBS Europe SE | 113 | -51,593 | 17,234.76 | 0.0002 | 0.0003 | 06/30/2026 |
| 10 | Morgan Stanley Investment Management, Inc. | 0 | -42,036 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.