| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Suvretta Capital Management LLC | 11,357,987 | 1,481,481 | 142,883,476.46 | 4.0353 | 43.2677 | 11/07/2025 |
| 2 | Janus Henderson Investors US LLC | 2,911,688 | -7,262 | 36,629,035.04 | 0.0172 | 11.0919 | 09/30/2025 |
| 3 | Franklin Advisers, Inc. | 2,589,633 | -271,093 | 32,577,583.14 | 0.0144 | 9.8651 | 09/30/2025 |
| 4 | Adage Capital Management LP | 1,972,524 | 0 | 24,814,351.92 | 0.0377 | 7.5142 | 09/30/2025 |
| 5 | HBM Partners AG (Investment Management) | 1,041,669 | 0 | 13,104,196.02 | 1.3304 | 3.9682 | 12/31/2024 |
| 6 | BlackRock Fund Advisors | 871,157 | 687,264 | 10,959,155.06 | 0.0002 | 3.3186 | 09/30/2025 |
| 7 | The Vanguard Group, Inc. | 840,099 | 521,725 | 10,568,445.42 | 0.0001 | 3.2003 | 09/30/2025 |
| 8 | Nantahala Capital Management LLC | 838,095 | 0 | 10,543,235.1 | 0.593 | 3.1927 | 09/30/2025 |
| 9 | Infinitum Asset Management LLC | 500,000 | -625,000 | 6,290,000 | 1.1733 | 1.9047 | 09/30/2025 |
| 10 | Geode Capital Management LLC | 438,505 | 204,685 | 5,516,392.9 | 0.0003 | 1.6705 | 09/30/2025 |
| 11 | SilverArc Capital Management LLC | 276,267 | 26,267 | 3,475,438.86 | 0.3897 | 1.0524 | 09/30/2025 |
| 12 | Schonfeld Strategic Advisors LLC | 260,419 | -1,345 | 3,276,071.02 | 0.0224 | 0.9921 | 09/30/2025 |
| 13 | SSgA Funds Management, Inc. | 218,398 | 197,208 | 2,747,446.84 | 0.0001 | 0.832 | 09/30/2025 |
| 14 | AWM Investment Co., Inc. | 182,977 | 45,000 | 2,301,850.66 | 0.2361 | 0.697 | 09/30/2025 |
| 15 | Goldman Sachs & Co. LLC (Private Banking) | 177,995 | 132,112 | 2,239,177.1 | 0.001 | 0.6781 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | FTIF SICAV - Biotechnology Discovery Fund | 1,202,062 | -313,137 | 15,121,939.96 | 0.8603 | 4.5792 | 10/31/2025 |
| 2 | Franklin Biotechnology Discovery Fund | 995,152 | -223,302 | 12,519,012.16 | 1.2184 | 3.791 | 10/31/2025 |
| 3 | Vanguard Total Stock Market ETF | 493,771 | 493,771 | 6,211,639.18 | 0.0003 | 1.881 | 10/31/2025 |
| 4 | Janus Henderson Horizon Fund - Biotechnology Fund | 433,141 | -7,262 | 5,448,913.78 | 0.5659 | 1.65 | 09/30/2025 |
| 5 | iShares Russell 2000 ETF | 339,458 | 339,458 | 4,270,381.64 | 0.0062 | 1.2932 | 10/31/2025 |
| 6 | Vanguard Extended Market Index Fund | 258,871 | -71,858 | 3,256,597.18 | 0.0038 | 0.9862 | 10/31/2025 |
| 7 | Fidelity Small Cap Index Fund | 146,603 | 146,603 | 1,844,265.74 | 0.0063 | 0.5585 | 09/30/2025 |
| 8 | FCP Medical - BioHealth | 135,284 | 81,426 | 1,701,872.72 | 0.1797 | 0.5154 | 09/30/2025 |
| 9 | Fidelity Extended Market Index Fund | 130,639 | 13,885 | 1,643,438.62 | 0.004 | 0.4977 | 10/31/2025 |
| 10 | iShares Russell 2000 Growth ETF | 122,845 | 122,845 | 1,545,390.1 | 0.0117 | 0.468 | 10/31/2025 |
| 11 | Simplify Health Care ETF | 103,401 | 30,248 | 1,300,784.58 | 0.545 | 0.3939 | 10/31/2025 |
| 12 | Vanguard Russell 2000 Index Fund | 71,854 | 71,854 | 903,923.32 | 0.0063 | 0.2737 | 10/31/2025 |
| 13 | RIM Global - Bioscience | 43,064 | 0 | 541,745.12 | 0.4641 | 0.1641 | 08/29/2025 |
| 14 | Fidelity Total Market Index Fund | 40,476 | 659 | 509,188.08 | 0.0004 | 0.1542 | 10/31/2025 |
| 15 | Schwab Small Cap Index Fund | 36,274 | 36,274 | 456,326.92 | 0.0063 | 0.1382 | 10/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Suvretta Capital Management LLC | 11,357,987 | 1,481,481 | 142,883,476.46 | 4.0353 | 43.2677 | 11/07/2025 |
| 2 | BlackRock Fund Advisors | 871,157 | 687,264 | 10,959,155.06 | 0.0002 | 3.3186 | 09/30/2025 |
| 3 | The Vanguard Group, Inc. | 840,099 | 521,725 | 10,568,445.42 | 0.0001 | 3.2003 | 09/30/2025 |
| 4 | Geode Capital Management LLC | 438,505 | 204,685 | 5,516,392.9 | 0.0003 | 1.6705 | 09/30/2025 |
| 5 | SSgA Funds Management, Inc. | 218,398 | 197,208 | 2,747,446.84 | 0.0001 | 0.832 | 09/30/2025 |
| 6 | Vanguard Fiduciary Trust Co. | 143,355 | 143,355 | 1,803,405.9 | 0.0004 | 0.5461 | 09/30/2025 |
| 7 | Goldman Sachs & Co. LLC (Private Banking) | 177,995 | 132,112 | 2,239,177.1 | 0.001 | 0.6781 | 09/30/2025 |
| 8 | Columbia Management Investment Advisers LLC | 154,414 | 119,996 | 1,942,528.12 | 0.0005 | 0.5882 | 09/30/2025 |
| 9 | UBS Securities LLC | 99,439 | 89,929 | 1,250,942.62 | 0.0005 | 0.3788 | 09/30/2025 |
| 10 | Northern Trust Investments, Inc.(Investment Management) | 130,615 | 84,738 | 1,643,136.7 | 0.0002 | 0.4976 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Infinitum Asset Management LLC | 500,000 | -625,000 | 6,290,000 | 1.1733 | 1.9047 | 09/30/2025 |
| 2 | Franklin Advisers, Inc. | 2,589,633 | -271,093 | 32,577,583.14 | 0.0144 | 9.8651 | 09/30/2025 |
| 3 | Susquehanna Financial Group LLLP | 0 | -226,096 | 0 | 0 | 0 | |
| 4 | Longaeva Partners LP | 37,537 | -42,463 | 472,215.46 | 0.0999 | 0.143 | 09/30/2025 |
| 5 | The Informed Momentum Co. LLC | 0 | -39,330 | 0 | 0 | 0 | |
| 6 | Millennium Management LLC | 0 | -32,046 | 0 | 0 | 0 | |
| 7 | HRT Financial LP (US) | 0 | -25,927 | 0 | 0 | 0 | |
| 8 | Qube Research & Technologies Ltd. | 0 | -19,003 | 0 | 0 | 0 | |
| 9 | Morgan Stanley & Co. LLC | 16,117 | -10,316 | 202,751.86 | 0.0001 | 0.0614 | 09/30/2025 |
| 10 | SG Americas Securities LLC | 0 | -8,458 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.