| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Suvretta Capital Management LLC | 11,548,351 | 1,671,845 | 128,417,663.12 | 3.0312 | 34.1039 | 12/31/2025 |
| 2 | Janus Henderson Investors US LLC | 2,911,688 | 8,894 | 32,377,970.56 | 0.0154 | 8.5986 | 12/31/2025 |
| 3 | Franklin Advisers, Inc. | 2,197,305 | -504,138 | 24,434,031.6 | 0.0108 | 6.489 | 12/31/2025 |
| 4 | Adage Capital Management LP | 2,120,672 | 148,148 | 23,581,872.64 | 0.0348 | 6.2626 | 12/31/2025 |
| 5 | RA Capital Management LP | 1,850,000 | 1,850,000 | 20,572,000 | 0.1969 | 5.4633 | 12/31/2025 |
| 6 | HBM Partners AG (Investment Management) | 1,041,669 | 0 | 11,583,359.28 | 1.1071 | 3.0762 | 12/31/2024 |
| 7 | Nantahala Capital Management LLC | 1,038,371 | 200,276 | 11,546,685.52 | 0.6845 | 3.0665 | 12/31/2025 |
| 8 | The Vanguard Group, Inc. | 1,008,593 | 62,181 | 11,215,554.16 | 0.0001 | 2.9785 | 12/31/2025 |
| 9 | Infinitum Asset Management LLC | 898,871 | 398,871 | 9,995,445.52 | 1.6342 | 2.6545 | 12/31/2025 |
| 10 | BlackRock Fund Advisors | 893,134 | 231,492 | 9,931,650.08 | 0.0002 | 2.6376 | 12/31/2025 |
| 11 | Alyeska Investment Group LP | 750,000 | 750,000 | 8,340,000 | 0.0231 | 2.2149 | 12/31/2025 |
| 12 | SilverArc Capital Management LLC | 731,717 | 478,483 | 8,136,693.04 | 1.143 | 2.1609 | 12/31/2025 |
| 13 | Balyasny Asset Management LP | 651,558 | 651,558 | 7,245,324.96 | 0.0133 | 1.9241 | 12/31/2025 |
| 14 | Millennium Management LLC | 613,160 | 613,160 | 6,818,339.2 | 0.0048 | 1.8107 | 12/31/2025 |
| 15 | Geode Capital Management LLC | 453,375 | 38,164 | 5,041,530 | 0.0002 | 1.3389 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | FTIF SICAV - Biotechnology Discovery Fund | 1,202,062 | -293,807 | 13,366,929.44 | 0.7192 | 3.5499 | 11/30/2025 |
| 2 | Franklin Biotechnology Discovery Fund | 995,152 | -155,062 | 11,066,090.24 | 1.0211 | 2.9388 | 11/30/2025 |
| 3 | Vanguard Total Stock Market ETF | 627,793 | 132,676 | 6,981,058.16 | 0.0003 | 1.854 | 01/31/2026 |
| 4 | Janus Henderson Horizon Fund - Biotechnology Fund | 433,141 | 8,894 | 4,816,527.92 | 0.3301 | 1.2791 | 12/31/2025 |
| 5 | iShares Russell 2000 ETF | 346,653 | 23,483 | 3,854,781.36 | 0.0051 | 1.0237 | 01/30/2026 |
| 6 | Vanguard Extended Market Index Fund | 272,513 | 38,604 | 3,030,344.56 | 0.0035 | 0.8048 | 01/31/2026 |
| 7 | FCP Medical - BioHealth | 195,115 | 78,312 | 2,169,678.8 | 0.2358 | 0.5762 | 11/28/2025 |
| 8 | Simplify Health Care ETF | 153,545 | 85,964 | 1,707,420.4 | 0.5077 | 0.4534 | 01/30/2026 |
| 9 | Fidelity Small Cap Index Fund | 149,545 | 2,942 | 1,662,940.4 | 0.0054 | 0.4416 | 11/30/2025 |
| 10 | Fidelity Extended Market Index Fund | 131,441 | 15,941 | 1,461,623.92 | 0.0035 | 0.3882 | 12/31/2025 |
| 11 | iShares Russell 2000 Growth ETF | 130,243 | 7,245 | 1,448,302.16 | 0.0108 | 0.3846 | 01/30/2026 |
| 12 | Franklin Small Cap Growth Fund | 75,967 | 75,967 | 844,753.04 | 0.034 | 0.2243 | 01/31/2026 |
| 13 | Vanguard Russell 2000 Index Fund | 70,768 | 1,572 | 786,940.16 | 0.0052 | 0.209 | 01/31/2026 |
| 14 | RIM Global - Bioscience | 43,064 | 0 | 478,871.68 | 0.4124 | 0.1272 | 10/31/2025 |
| 15 | Fidelity Total Market Index Fund | 42,298 | 2,566 | 470,353.76 | 0.0004 | 0.1249 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | RA Capital Management LP | 1,850,000 | 1,850,000 | 20,572,000 | 0.1969 | 5.4633 | 12/31/2025 |
| 2 | Suvretta Capital Management LLC | 11,548,351 | 1,671,845 | 128,417,663.12 | 3.0312 | 34.1039 | 12/31/2025 |
| 3 | Alyeska Investment Group LP | 750,000 | 750,000 | 8,340,000 | 0.0231 | 2.2149 | 12/31/2025 |
| 4 | Balyasny Asset Management LP | 651,558 | 651,558 | 7,245,324.96 | 0.0133 | 1.9241 | 12/31/2025 |
| 5 | Millennium Management LLC | 613,160 | 613,160 | 6,818,339.2 | 0.0048 | 1.8107 | 12/31/2025 |
| 6 | SilverArc Capital Management LLC | 731,717 | 478,483 | 8,136,693.04 | 1.143 | 2.1609 | 12/31/2025 |
| 7 | Infinitum Asset Management LLC | 898,871 | 398,871 | 9,995,445.52 | 1.6342 | 2.6545 | 12/31/2025 |
| 8 | Longaeva Partners LP | 290,000 | 238,003 | 3,224,800 | 0.4277 | 0.8564 | 12/31/2025 |
| 9 | BlackRock Fund Advisors | 893,134 | 231,492 | 9,931,650.08 | 0.0002 | 2.6376 | 12/31/2025 |
| 10 | Nantahala Capital Management LLC | 1,038,371 | 200,276 | 11,546,685.52 | 0.6845 | 3.0665 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Franklin Advisers, Inc. | 2,197,305 | -504,138 | 24,434,031.6 | 0.0108 | 6.489 | 12/31/2025 |
| 2 | ExodusPoint Capital Management LP | 0 | -76,379 | 0 | 0 | 0 | |
| 3 | The Informed Momentum Co. LLC | 0 | -37,809 | 0 | 0 | 0 | |
| 4 | Susquehanna Financial Group LLLP | 0 | -17,728 | 0 | 0 | 0 | |
| 5 | Anson Funds Management LP | 0 | -11,710 | 0 | 0 | 0 | |
| 6 | XTX Markets LLC | 0 | -10,845 | 0 | 0 | 0 | |
| 7 | Marshall Wace LLP | 35,688 | -7,315 | 396,850.56 | 0.0004 | 0.1054 | 12/31/2025 |
| 8 | Citigroup Global Markets, Inc. (Investment Management) | 544 | -4,595 | 6,049.28 | 0 | 0.0016 | 12/31/2025 |
| 9 | New York State Common Retirement Fund | 4,327 | -3,773 | 48,116.24 | 0.0001 | 0.0128 | 12/31/2025 |
| 10 | Barclays Bank Plc (Private Banking) | 23,211 | -3,729 | 258,106.32 | 0.0001 | 0.0685 | 12/31/2025 |
Data provided by FactSet Research Systems Inc.