| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Suvretta Capital Management LLC | 11,548,351 | 190,364 | 127,609,278.55 | 3.0581 | 33.6154 | 03/31/2026 |
| 2 | Janus Henderson Investors US LLC | 2,876,380 | -506,456 | 31,783,999 | 0.0143 | 8.3727 | 03/31/2026 |
| 3 | Franklin Advisers, Inc. | 2,377,721 | -211,912 | 26,273,817.05 | 0.0115 | 6.9212 | 03/31/2026 |
| 4 | Adage Capital Management LP | 2,120,672 | 148,148 | 23,433,425.6 | 0.0324 | 6.1729 | 03/31/2026 |
| 5 | RA Capital Management LP | 1,850,000 | 0 | 20,442,500 | 0.2012 | 5.3851 | 03/31/2026 |
| 6 | Nantahala Capital Management LLC | 1,438,371 | 600,276 | 15,893,999.55 | 0.9468 | 4.1869 | 03/31/2026 |
| 7 | BlackRock Fund Advisors | 1,051,290 | 180,133 | 11,616,754.5 | 0.0002 | 3.0601 | 03/31/2026 |
| 8 | HBM Partners AG (Investment Management) | 1,041,669 | 0 | 11,510,442.45 | 1.2623 | 3.0321 | 12/31/2024 |
| 9 | Vanguard Capital Management LLC | 931,556 | 931,556 | 10,293,693.8 | 0.0002 | 2.7116 | 03/31/2026 |
| 10 | Infinitum Asset Management LLC | 923,006 | 423,006 | 10,199,216.3 | 1.0741 | 2.6867 | 03/31/2026 |
| 11 | Alyeska Investment Group LP | 750,000 | 750,000 | 8,287,500 | 0.0204 | 2.1831 | 03/31/2026 |
| 12 | SilverArc Capital Management LLC | 717,725 | 441,458 | 7,930,861.25 | 0.9275 | 2.0892 | 03/31/2026 |
| 13 | Balyasny Asset Management LP | 653,835 | 653,835 | 7,224,876.75 | 0.0134 | 1.9032 | 03/31/2026 |
| 14 | Millennium Management LLC | 652,064 | 652,064 | 7,205,307.2 | 0.005 | 1.8981 | 03/31/2026 |
| 15 | Simplify Asset Management, Inc. | 562,242 | 483,517 | 6,212,774.1 | 0.0936 | 1.6366 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | FTIF SICAV - Biotechnology Discovery Fund | 997,476 | -204,586 | 11,022,109.8 | 0.6319 | 2.9035 | 04/30/2026 |
| 2 | Franklin Biotechnology Discovery Fund | 995,152 | 0 | 10,996,429.6 | 1.0611 | 2.8967 | 04/30/2026 |
| 3 | Simplify Health Care ETF | 666,828 | 533,179 | 7,368,449.4 | 2.8062 | 1.941 | 05/29/2026 |
| 4 | Vanguard Total Stock Market ETF | 627,793 | 0 | 6,937,112.65 | 0.0003 | 1.8274 | 04/30/2026 |
| 5 | iShares Russell 2000 ETF | 431,796 | 74,160 | 4,771,345.8 | 0.0059 | 1.2569 | 05/29/2026 |
| 6 | Janus Henderson Horizon Fund - Biotechnology Fund | 397,833 | -35,308 | 4,396,054.65 | 0.2806 | 1.158 | 03/31/2026 |
| 7 | Franklin Small Cap Growth Fund | 357,531 | 357,531 | 3,950,717.55 | 0.1557 | 1.0407 | 04/30/2026 |
| 8 | Vanguard Extended Market Index Fund | 282,910 | 22,502 | 3,126,155.5 | 0.0033 | 0.8235 | 04/30/2026 |
| 9 | FCP Medical - BioHealth | 195,115 | 0 | 2,156,020.75 | 0.2242 | 0.5679 | 03/31/2026 |
| 10 | Fidelity Small Cap Index Fund | 190,101 | 40,556 | 2,100,616.05 | 0.0063 | 0.5534 | 03/31/2026 |
| 11 | iShares Russell 2000 Growth ETF | 155,556 | 23,181 | 1,718,893.8 | 0.0118 | 0.4528 | 05/29/2026 |
| 12 | Fidelity Extended Market Index Fund | 134,313 | 4,046 | 1,484,158.65 | 0.0034 | 0.391 | 04/30/2026 |
| 13 | Vanguard Russell 2000 Index Fund | 97,955 | 24,703 | 1,082,402.75 | 0.0061 | 0.2851 | 04/30/2026 |
| 14 | RIM Global - Bioscience | 52,664 | 0 | 581,937.2 | 0.5331 | 0.1533 | 02/27/2026 |
| 15 | iShares Tr. - Micro Cap ETF | 49,561 | 14,196 | 547,649.05 | 0.0388 | 0.1443 | 05/29/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Vanguard Capital Management LLC | 931,556 | 931,556 | 10,293,693.8 | 0.0002 | 2.7116 | 03/31/2026 |
| 2 | Alyeska Investment Group LP | 750,000 | 750,000 | 8,287,500 | 0.0204 | 2.1831 | 03/31/2026 |
| 3 | Balyasny Asset Management LP | 653,835 | 653,835 | 7,224,876.75 | 0.0134 | 1.9032 | 03/31/2026 |
| 4 | Millennium Management LLC | 652,064 | 652,064 | 7,205,307.2 | 0.005 | 1.8981 | 03/31/2026 |
| 5 | Nantahala Capital Management LLC | 1,438,371 | 600,276 | 15,893,999.55 | 0.9468 | 4.1869 | 03/31/2026 |
| 6 | Simplify Asset Management, Inc. | 562,242 | 483,517 | 6,212,774.1 | 0.0936 | 1.6366 | 03/31/2026 |
| 7 | SilverArc Capital Management LLC | 717,725 | 441,458 | 7,930,861.25 | 0.9275 | 2.0892 | 03/31/2026 |
| 8 | Infinitum Asset Management LLC | 923,006 | 423,006 | 10,199,216.3 | 1.0741 | 2.6867 | 03/31/2026 |
| 9 | Suvretta Capital Management LLC | 11,548,351 | 190,364 | 127,609,278.55 | 3.0581 | 33.6154 | 03/31/2026 |
| 10 | BlackRock Fund Advisors | 1,051,290 | 180,133 | 11,616,754.5 | 0.0002 | 3.0601 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | The Vanguard Group, Inc. | 0 | -840,099 | 0 | 0 | 0 | |
| 2 | Janus Henderson Investors US LLC | 2,876,380 | -506,456 | 31,783,999 | 0.0143 | 8.3727 | 03/31/2026 |
| 3 | Franklin Advisers, Inc. | 2,377,721 | -211,912 | 26,273,817.05 | 0.0115 | 6.9212 | 03/31/2026 |
| 4 | Schonfeld Strategic Advisors LLC | 153,179 | -107,240 | 1,692,627.95 | 0.0121 | 0.4459 | 03/31/2026 |
| 5 | ExodusPoint Capital Management LP | 0 | -77,912 | 0 | 0 | 0 | |
| 6 | Barclays Bank Plc (Private Banking) | 3,589 | -17,694 | 39,658.45 | 0 | 0.0104 | 03/31/2026 |
| 7 | RBC Dominion Securities, Inc. (Investment Management) | 0 | -3,600 | 0 | 0 | 0 | |
| 8 | DWS Investment Management Americas, Inc. | 3,285 | -2,843 | 36,299.25 | 0.0001 | 0.0096 | 03/31/2026 |
| 9 | Wells Fargo Bank, NA (Private Banking) | 6,634 | -2,088 | 73,305.7 | 0.0001 | 0.0193 | 03/31/2026 |
| 10 | BofA Securities, Inc. | 0 | -528 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.