| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Suvretta Capital Management LLC | 11,548,351 | 1,671,845 | 145,624,706.11 | 3.0497 | 33.6154 | 12/31/2025 |
| 2 | Janus Henderson Investors US LLC | 2,911,688 | 0 | 36,716,385.68 | 0.0169 | 8.4755 | 12/31/2025 |
| 3 | Franklin Advisers, Inc. | 2,197,305 | -392,328 | 27,708,016.05 | 0.0118 | 6.396 | 12/31/2025 |
| 4 | Adage Capital Management LP | 2,120,672 | 148,148 | 26,741,673.92 | 0.0382 | 6.1729 | 12/31/2025 |
| 5 | RA Capital Management LP | 1,850,000 | 1,850,000 | 23,328,500 | 0.2397 | 5.3851 | 12/31/2025 |
| 6 | HBM Partners AG (Investment Management) | 1,041,669 | 0 | 13,135,446.09 | 1.2509 | 3.0321 | 12/31/2024 |
| 7 | Nantahala Capital Management LLC | 1,038,371 | 200,276 | 13,093,858.31 | 0.7658 | 3.0225 | 12/31/2025 |
| 8 | The Vanguard Group, Inc. | 1,008,593 | 168,494 | 12,718,357.73 | 0.0002 | 2.9359 | 12/31/2025 |
| 9 | Infinitum Asset Management LLC | 898,871 | 398,871 | 11,334,763.31 | 1.8991 | 2.6165 | 12/31/2025 |
| 10 | BlackRock Fund Advisors | 893,134 | 21,977 | 11,262,419.74 | 0.0002 | 2.5998 | 12/31/2025 |
| 11 | Alyeska Investment Group LP | 750,000 | 750,000 | 9,457,500 | 0.0255 | 2.1831 | 12/31/2025 |
| 12 | SilverArc Capital Management LLC | 731,717 | 455,450 | 9,226,951.37 | 1.1943 | 2.1299 | 12/31/2025 |
| 13 | Balyasny Asset Management LP | 651,558 | 651,558 | 8,216,146.38 | 0.0155 | 1.8966 | 12/31/2025 |
| 14 | Millennium Management LLC | 613,160 | 613,160 | 7,731,947.6 | 0.0054 | 1.7848 | 12/31/2025 |
| 15 | Simplify Asset Management, Inc. | 562,242 | 483,517 | 7,089,871.62 | 0.1073 | 1.6366 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | FTIF SICAV - Biotechnology Discovery Fund | 997,476 | -457,864 | 12,578,172.36 | 0.7152 | 2.9035 | 03/31/2026 |
| 2 | Franklin Biotechnology Discovery Fund | 995,152 | -133,671 | 12,548,866.72 | 1.1839 | 2.8967 | 03/31/2026 |
| 3 | Vanguard Total Stock Market ETF | 627,793 | 132,676 | 7,916,469.73 | 0.0004 | 1.8274 | 03/31/2026 |
| 4 | Simplify Health Care ETF | 568,353 | 489,628 | 7,166,931.33 | 3.0012 | 1.6544 | 03/31/2026 |
| 5 | iShares Russell 2000 ETF | 449,198 | 89,427 | 5,664,386.78 | 0.0071 | 1.3075 | 03/31/2026 |
| 6 | Janus Henderson Horizon Fund - Biotechnology Fund | 433,141 | 0 | 5,461,908.01 | 0.3891 | 1.2608 | 12/31/2025 |
| 7 | Franklin Small Cap Growth Fund | 328,330 | 328,330 | 4,140,241.3 | 0.1644 | 0.9557 | 03/31/2026 |
| 8 | Vanguard Extended Market Index Fund | 282,910 | 36,710 | 3,567,495.1 | 0.0039 | 0.8235 | 03/31/2026 |
| 9 | FCP Medical - BioHealth | 195,115 | 59,831 | 2,460,400.15 | 0.2385 | 0.5679 | 01/30/2026 |
| 10 | iShares Russell 2000 Growth ETF | 155,958 | 32,348 | 1,966,630.38 | 0.0142 | 0.454 | 03/31/2026 |
| 11 | Fidelity Small Cap Index Fund | 144,190 | -2,413 | 1,818,235.9 | 0.0058 | 0.4197 | 01/31/2026 |
| 12 | Fidelity Extended Market Index Fund | 130,425 | -601 | 1,644,659.25 | 0.0039 | 0.3796 | 02/28/2026 |
| 13 | Vanguard Russell 2000 Index Fund | 95,864 | 24,914 | 1,208,845.04 | 0.0073 | 0.279 | 03/31/2026 |
| 14 | RIM Global - Bioscience | 52,664 | 9,600 | 664,093.04 | 0.5644 | 0.1533 | 12/30/2025 |
| 15 | iShares Tr. - Micro Cap ETF | 48,791 | 13,954 | 615,254.51 | 0.0451 | 0.142 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | RA Capital Management LP | 1,850,000 | 1,850,000 | 23,328,500 | 0.2397 | 5.3851 | 12/31/2025 |
| 2 | Suvretta Capital Management LLC | 11,548,351 | 1,671,845 | 145,624,706.11 | 3.0497 | 33.6154 | 12/31/2025 |
| 3 | Alyeska Investment Group LP | 750,000 | 750,000 | 9,457,500 | 0.0255 | 2.1831 | 12/31/2025 |
| 4 | Balyasny Asset Management LP | 651,558 | 651,558 | 8,216,146.38 | 0.0155 | 1.8966 | 12/31/2025 |
| 5 | Millennium Management LLC | 613,160 | 613,160 | 7,731,947.6 | 0.0054 | 1.7848 | 12/31/2025 |
| 6 | Simplify Asset Management, Inc. | 562,242 | 483,517 | 7,089,871.62 | 0.1073 | 1.6366 | 03/31/2026 |
| 7 | SilverArc Capital Management LLC | 731,717 | 455,450 | 9,226,951.37 | 1.1943 | 2.1299 | 12/31/2025 |
| 8 | Infinitum Asset Management LLC | 898,871 | 398,871 | 11,334,763.31 | 1.8991 | 2.6165 | 12/31/2025 |
| 9 | Longaeva Partners LP | 290,000 | 252,463 | 3,656,900 | 0.4718 | 0.8441 | 12/31/2025 |
| 10 | Nantahala Capital Management LLC | 1,038,371 | 200,276 | 13,093,858.31 | 0.7658 | 3.0225 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Franklin Advisers, Inc. | 2,197,305 | -392,328 | 27,708,016.05 | 0.0118 | 6.396 | 12/31/2025 |
| 2 | ExodusPoint Capital Management LP | 0 | -77,912 | 0 | 0 | 0 | |
| 3 | Goldman Sachs & Co. LLC (Private Banking) | 157,655 | -20,340 | 1,988,029.55 | 0.0009 | 0.4589 | 12/31/2025 |
| 4 | DWS Investment Management Americas, Inc. | 838 | -5,290 | 10,567.18 | 0 | 0.0024 | 12/31/2025 |
| 5 | Northern Trust Investments, Inc.(Investment Management) | 126,160 | -4,455 | 1,590,877.6 | 0.0002 | 0.3672 | 12/31/2025 |
| 6 | RBC Dominion Securities, Inc. (Investment Management) | 0 | -3,600 | 0 | 0 | 0 | |
| 7 | RhumbLine Advisers LP | 17,668 | -2,856 | 222,793.48 | 0.0002 | 0.0514 | 12/31/2025 |
| 8 | The Bank of New York Mellon Corp. (Investment Management) | 24,181 | -2,389 | 304,922.41 | 0.0001 | 0.0704 | 12/31/2025 |
| 9 | UBS Securities LLC | 97,845 | -1,594 | 1,233,825.45 | 0.0005 | 0.2848 | 12/31/2025 |
| 10 | Tower Research Capital LLC | 723 | -357 | 9,117.03 | 0.0002 | 0.0021 | 12/31/2025 |
Data provided by FactSet Research Systems Inc.