| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Baker Bros. Advisors LP | 10,885,357 | 0 | 47,351,302.95 | 0.2063 | 21.6094 | 03/31/2026 |
| 2 | Armistice Capital LLC | 3,398,000 | 162,000 | 14,781,300 | 0.3746 | 6.7456 | 03/31/2026 |
| 3 | Long Focus Capital Management LLC | 3,310,687 | 1,677,596 | 14,401,488.45 | 0.5632 | 6.5723 | 03/31/2026 |
| 4 | Acadian Asset Management LLC | 1,968,025 | 296,767 | 8,560,908.75 | 0.0091 | 3.9069 | 03/31/2026 |
| 5 | Principal Global Investors LLC | 1,174,625 | 26,353 | 5,109,618.75 | 0.0022 | 2.3318 | 03/31/2026 |
| 6 | T. Rowe Price Associates, Inc. (IM) | 1,028,243 | -143,544 | 4,472,857.05 | 0.0005 | 2.0412 | 03/31/2026 |
| 7 | Renaissance Technologies LLC | 979,300 | 412,700 | 4,259,955 | 0.0058 | 1.9441 | 03/31/2026 |
| 8 | Schroder Investment Management Ltd. | 615,833 | 31,063 | 2,678,873.55 | 0.001 | 1.2225 | 03/31/2026 |
| 9 | Diadema Partners LP | 476,424 | 476,424 | 2,072,444.4 | 0.8333 | 0.9458 | 03/31/2026 |
| 10 | Birchview Capital LP | 463,599 | 899 | 2,016,655.65 | 0.9781 | 0.9203 | 03/31/2026 |
| 11 | Silvercrest Asset Management Group LLC | 428,684 | -48,292 | 1,864,775.4 | 0.0119 | 0.851 | 03/31/2026 |
| 12 | Morgan Stanley & Co. LLC | 406,483 | 69,963 | 1,768,201.05 | 0.0005 | 0.8069 | 03/31/2026 |
| 13 | Marshall Wace LLP | 377,335 | 338,540 | 1,641,407.25 | 0.0015 | 0.7491 | 03/31/2026 |
| 14 | Qube Research & Technologies Ltd. | 308,617 | 266,769 | 1,342,483.95 | 0.0017 | 0.6127 | 03/31/2026 |
| 15 | Citadel Securities LLC | 289,966 | 23,812 | 1,261,352.1 | 0.0026 | 0.5756 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Candriam Equities L - Biotechnology | 825,127 | 0 | 3,589,302.45 | 0.1772 | 1.638 | 12/31/2025 |
| 2 | T Rowe Price Health Sciences Fund | 739,251 | -115,544 | 3,215,741.85 | 0.0263 | 1.4675 | 03/31/2026 |
| 3 | Principal Funds, Inc. - Small Cap Fund | 511,200 | -56,600 | 2,223,720 | 0.1032 | 1.0148 | 05/31/2026 |
| 4 | Candriam Equities L - Oncology | 367,152 | 0 | 1,597,111.2 | 0.092 | 0.7289 | 12/31/2025 |
| 5 | Old Westbury Small & Mid Cap Strategies Fund | 265,973 | 53,646 | 1,156,982.55 | 0.0123 | 0.528 | 04/30/2026 |
| 6 | iShares Biotechnology ETF | 242,577 | -8,128 | 1,055,209.95 | 0.0116 | 0.4816 | 06/30/2026 |
| 7 | Westfield Small/Mid Cap Growth Equity | 204,292 | 0 | 888,670.2 | 0.0459 | 0.4056 | 11/30/2025 |
| 8 | State Board of Administration of Florida Retirement System | 140,680 | 0 | 611,958 | 0.0005 | 0.2793 | 12/31/2025 |
| 9 | Virtus Biotech Clinical Trials ETF | 76,743 | 41,034 | 333,832.05 | 0.6843 | 0.1523 | 06/30/2026 |
| 10 | TD Health Sciences Fund | 73,996 | 0 | 321,882.6 | 0.0319 | 0.1469 | 12/31/2025 |
| 11 | GS Funds II - GMS US Small Cap Equity Portfolio | 67,390 | 0 | 293,146.5 | 0.0567 | 0.1338 | 05/31/2025 |
| 12 | T Rowe Price Health Sciences Portfolio | 62,846 | 0 | 273,380.1 | 0.0367 | 0.1248 | 03/31/2026 |
| 13 | PPF (PMG Partners Funds) - PMG Global Biotech Fund | 58,300 | 0 | 253,605 | 0.6542 | 0.1157 | 12/31/2025 |
| 14 | ALPS Medical Breakthroughs ETF | 51,122 | 10,127 | 222,380.7 | 0.1154 | 0.1015 | 06/30/2026 |
| 15 | Principal Variable Contract - SmallCap Account | 45,500 | 0 | 197,925 | 0.1005 | 0.0903 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Long Focus Capital Management LLC | 3,310,687 | 1,677,596 | 14,401,488.45 | 0.5632 | 6.5723 | 03/31/2026 |
| 2 | Diadema Partners LP | 476,424 | 476,424 | 2,072,444.4 | 0.8333 | 0.9458 | 03/31/2026 |
| 3 | Renaissance Technologies LLC | 979,300 | 412,700 | 4,259,955 | 0.0058 | 1.9441 | 03/31/2026 |
| 4 | Marshall Wace LLP | 377,335 | 338,540 | 1,641,407.25 | 0.0015 | 0.7491 | 03/31/2026 |
| 5 | Acadian Asset Management LLC | 1,968,025 | 296,767 | 8,560,908.75 | 0.0091 | 3.9069 | 03/31/2026 |
| 6 | Qube Research & Technologies Ltd. | 308,617 | 266,769 | 1,342,483.95 | 0.0017 | 0.6127 | 03/31/2026 |
| 7 | Armistice Capital LLC | 3,398,000 | 162,000 | 14,781,300 | 0.3746 | 6.7456 | 03/31/2026 |
| 8 | Jane Street Capital LLC | 218,115 | 154,925 | 948,800.25 | 0.0008 | 0.433 | 03/31/2026 |
| 9 | Peapod Lane Capital LLC | 121,106 | 121,106 | 526,811.1 | 0.366 | 0.2404 | 03/31/2026 |
| 10 | Persistent Asset Partners Ltd. | 120,437 | 120,437 | 523,900.95 | 0.1541 | 0.2391 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Westfield Capital Management Co. LP | 0 | -3,016,026 | 0 | 0 | 0 | |
| 2 | Candriam Belgium SA | 0 | -1,192,279 | 0 | 0 | 0 | |
| 3 | BNP Paribas Asset Management USA, Inc. | 0 | -568,225 | 0 | 0 | 0 | |
| 4 | Jefferies LLC | 0 | -297,247 | 0 | 0 | 0 | |
| 5 | Two Sigma Advisers LP | 0 | -146,100 | 0 | 0 | 0 | |
| 6 | T. Rowe Price Associates, Inc. (IM) | 1,028,243 | -143,544 | 4,472,857.05 | 0.0005 | 2.0412 | 03/31/2026 |
| 7 | Bluebox Asset Management Uk Ltd. | 0 | -134,830 | 0 | 0 | 0 | |
| 8 | Fideuram Intesa Sanpaolo Private Banking SpA | 9 | -134,680 | 39.15 | 0 | 0 | 03/31/2026 |
| 9 | Walleye Capital LLC | 0 | -111,659 | 0 | 0 | 0 | |
| 10 | Monimus Capital Management LP | 0 | -93,840 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.