| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Baker Bros. Advisors LP | 10,956,157 | 70,800 | 55,438,154.42 | 0.264 | 21.795 | 01/02/2026 |
| 2 | Armistice Capital LLC | 3,236,000 | 258,000 | 16,374,160 | 0.3787 | 6.4374 | 12/31/2025 |
| 3 | Westfield Capital Management Co. LP | 3,016,026 | 63,483 | 15,261,091.56 | 0.0599 | 5.9998 | 12/31/2025 |
| 4 | Acadian Asset Management LLC | 1,671,258 | 356,702 | 8,456,565.48 | 0.0114 | 3.3246 | 12/31/2025 |
| 5 | Long Focus Capital Management LLC | 1,633,091 | 214,396 | 8,263,440.46 | 0.4239 | 3.2487 | 12/31/2025 |
| 6 | Candriam Belgium SA | 1,192,279 | 19,892 | 6,032,931.74 | 0.0153 | 2.3718 | 12/31/2025 |
| 7 | T. Rowe Price Associates, Inc. (IM) | 1,171,787 | -213,007 | 5,929,242.22 | 0.0007 | 2.331 | 12/31/2025 |
| 8 | Principal Global Investors LLC | 1,148,272 | -130 | 5,810,256.32 | 0.0026 | 2.2843 | 12/31/2025 |
| 9 | Schroder Investment Management Ltd. | 584,770 | 584,770 | 2,958,936.2 | 0.0011 | 1.1633 | 12/31/2025 |
| 10 | BNP Paribas Asset Management USA, Inc. | 568,225 | 568,225 | 2,875,218.5 | 0.0221 | 1.1304 | 12/31/2025 |
| 11 | Renaissance Technologies LLC | 566,600 | 47,900 | 2,866,996 | 0.0043 | 1.1271 | 12/31/2025 |
| 12 | Silvercrest Asset Management Group LLC | 476,976 | 0 | 2,413,498.56 | 0.0157 | 0.9488 | 12/31/2025 |
| 13 | Birchview Capital LP | 462,700 | 308,700 | 2,341,262 | 1.228 | 0.9204 | 12/31/2025 |
| 14 | Candriam SCA | 367,152 | 0 | 1,857,789.12 | 0.0524 | 0.7304 | 08/29/2025 |
| 15 | Morgan Stanley & Co. LLC | 336,520 | -347,183 | 1,702,791.2 | 0.0006 | 0.6694 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Harbor Small Cap Growth Fund | 965,187 | -4,813 | 4,883,846.22 | 0.2025 | 1.92 | 01/31/2026 |
| 2 | T Rowe Price Health Sciences Fund | 854,795 | -184,449 | 4,325,262.7 | 0.0375 | 1.7004 | 12/31/2025 |
| 3 | Candriam Equities L - Biotechnology | 805,235 | 0 | 4,074,489.1 | 0.242 | 1.6018 | 08/29/2025 |
| 4 | Principal Funds, Inc. - Small Cap Fund | 542,800 | -25,500 | 2,746,568 | 0.1261 | 1.0798 | 02/28/2026 |
| 5 | Candriam Equities L - Oncology | 367,152 | 0 | 1,857,789.12 | 0.105 | 0.7304 | 08/29/2025 |
| 6 | Old Westbury Small & Mid Cap Strategies Fund | 265,973 | 138,928 | 1,345,823.38 | 0.0143 | 0.5291 | 01/30/2026 |
| 7 | iShares Biotechnology ETF | 244,101 | 60,583 | 1,235,151.06 | 0.0146 | 0.4856 | 03/31/2026 |
| 8 | Westfield Small/Mid Cap Growth Equity | 204,292 | 5,460 | 1,033,717.52 | 0.0571 | 0.4064 | 11/30/2025 |
| 9 | Belfius Equities - Cure | 154,957 | 0 | 784,082.42 | 0.105 | 0.3083 | 08/29/2025 |
| 10 | State Board of Administration of Florida Retirement System | 140,680 | 0 | 711,840.8 | 0.0006 | 0.2799 | 12/31/2025 |
| 11 | BlueBox Funds - Precision Medicine Fund | 93,414 | 23,514 | 472,674.84 | 0.6697 | 0.1858 | 03/31/2026 |
| 12 | Goldman Sachs Multi Manager US Small Cap Equity Fund | 91,488 | -11,582 | 462,929.28 | 0.0775 | 0.182 | 01/31/2026 |
| 13 | TD Health Sciences Fund | 73,996 | -22,550 | 374,419.76 | 0.0398 | 0.1472 | 12/31/2025 |
| 14 | GS Funds II - GMS US Small Cap Equity Portfolio | 67,390 | 0 | 340,993.4 | 0.0707 | 0.1341 | 05/31/2025 |
| 15 | T Rowe Price Health Sciences Portfolio | 62,846 | 0 | 318,000.76 | 0.0456 | 0.125 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Schroder Investment Management Ltd. | 584,770 | 584,770 | 2,958,936.2 | 0.0011 | 1.1633 | 12/31/2025 |
| 2 | BNP Paribas Asset Management USA, Inc. | 568,225 | 568,225 | 2,875,218.5 | 0.0221 | 1.1304 | 12/31/2025 |
| 3 | Acadian Asset Management LLC | 1,671,258 | 356,702 | 8,456,565.48 | 0.0114 | 3.3246 | 12/31/2025 |
| 4 | Birchview Capital LP | 462,700 | 308,700 | 2,341,262 | 1.228 | 0.9204 | 12/31/2025 |
| 5 | Armistice Capital LLC | 3,236,000 | 258,000 | 16,374,160 | 0.3787 | 6.4374 | 12/31/2025 |
| 6 | Long Focus Capital Management LLC | 1,633,091 | 214,396 | 8,263,440.46 | 0.4239 | 3.2487 | 12/31/2025 |
| 7 | Flax Pond Capital LLC | 173,633 | 173,633 | 878,582.98 | 0.6355 | 0.3454 | 12/31/2025 |
| 8 | Moore Capital Management LP | 275,000 | 150,000 | 1,391,500 | 0.0278 | 0.5471 | 12/31/2025 |
| 9 | Fideuram Asset Management SGR SpA | 134,689 | 134,689 | 681,526.34 | 0.0093 | 0.2679 | 12/31/2025 |
| 10 | Walleye Capital LLC | 111,659 | 111,029 | 564,994.54 | 0.0023 | 0.2221 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Millennium Management LLC | 326,626 | -728,120 | 1,652,727.56 | 0.0012 | 0.6498 | 12/31/2025 |
| 2 | Bank of America, NA (Private Banking) | 92,484 | -496,946 | 467,969.04 | 0.0001 | 0.184 | 12/31/2025 |
| 3 | Point72 Asset Management LP | 76,779 | -354,121 | 388,501.74 | 0.0006 | 0.1527 | 12/31/2025 |
| 4 | Morgan Stanley & Co. LLC | 336,520 | -347,183 | 1,702,791.2 | 0.0006 | 0.6694 | 12/31/2025 |
| 5 | Medical Strategy GmbH | 0 | -343,416 | 0 | 0 | 0 | |
| 6 | T. Rowe Price Associates, Inc. (IM) | 1,171,787 | -213,007 | 5,929,242.22 | 0.0007 | 2.331 | 12/31/2025 |
| 7 | Legal & General Investment Management Ltd. | 9,054 | -188,863 | 45,813.24 | 0 | 0.018 | 12/31/2025 |
| 8 | Handelsbanken Fonder AB | 0 | -150,000 | 0 | 0 | 0 | |
| 9 | Jefferies LLC | 297,247 | -104,679 | 1,504,069.82 | 0.1261 | 0.5913 | 12/31/2025 |
| 10 | Cubist Systematic Strategies LLC | 0 | -103,410 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.