# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Baker Bros. Advisors LP 10,885,357 0 95,355,727.32 0.5413 22.8155 06/30/2025
2 Armistice Capital LLC 2,800,000 128,000 24,528,000 0.6628 5.8688 06/30/2025
3 Westfield Capital Management Co. LP 2,780,491 123,186 24,357,101.16 0.0944 5.8279 06/30/2025
4 Point72 Asset Management LP 1,772,600 -1,919,469 15,527,976 0.0286 3.7153 06/30/2025
5 T. Rowe Price Associates, Inc. (IM) 1,468,393 -68,191 12,863,122.68 0.0015 3.0777 06/30/2025
6 Millennium Management LLC 1,443,619 990,191 12,646,102.44 0.0105 3.0258 06/30/2025
7 Long Focus Capital Management LLC 1,317,293 23,540 11,539,486.68 0.6475 2.761 06/30/2025
8 Deep Track Capital LP 1,203,244 436,228 10,540,417.44 0.1881 2.522 06/30/2025
9 Candriam Belgium SA 1,172,387 -32,820 10,270,110.12 0.0273 2.4573 06/30/2025
10 BNP Paribas Asset Management USA, Inc. 1,041,456 -178,232 9,123,154.56 0.0698 2.1829 06/30/2025
11 Tybourne Capital Management (HK) Ltd. 993,743 417,400 8,705,188.68 17.4569 2.0829 06/30/2025
12 Morgan Stanley & Co. LLC 903,685 18,722 7,916,280.6 0.0026 1.8941 06/30/2025
13 Acadian Asset Management LLC 698,501 572,439 6,118,868.76 0.01 1.464 06/30/2025
14 Principal Global Investors LLC 697,267 66,007 6,108,058.92 0.0028 1.4615 06/30/2025
15 Bank of America, NA (Private Banking) 560,538 -2,437 4,910,312.88 0.0015 1.1749 06/30/2025
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 T Rowe Price Health Sciences Fund 1,039,244 -129,224 9,103,777.44 0.0769 2.1782 09/30/2025
2 Harbor Small Cap Growth Fund 970,000 -30,820 8,497,200 0.3921 2.0331 07/31/2025
3 Candriam Equities L - Biotechnology 648,865 0 5,684,057.4 0.3557 1.36 03/31/2025
4 Principal Funds, Inc. - Small Cap Fund 568,300 279,400 4,978,308 0.2271 1.1911 08/31/2025
5 BNP Paribas Funds - Health Care Innovators 568,225 -108,808 4,977,651 0.2465 1.191 09/30/2025
6 Candriam Equities L - Oncology 556,312 0 4,873,293.12 0.2847 1.166 03/31/2025
7 FCP Medical - BioHealth 343,416 0 3,008,324.16 0.3392 0.7198 08/29/2025
8 Belfius Equities - Cure 220,057 0 1,927,699.32 0.2853 0.4612 03/31/2025
9 Westfield Small/Mid Cap Growth Equity 197,832 31,803 1,733,008.32 0.1099 0.4147 08/31/2025
10 iShares Biotechnology ETF 183,518 -7,126 1,607,617.68 0.0248 0.3847 09/30/2025
11 Handelsbanken Haelsovard Tema 150,000 -50,000 1,314,000 0.0571 0.3144 09/30/2025
12 Old Westbury Small & Mid Cap Strategies Fund 127,045 127,045 1,112,914.2 0.0123 0.2663 07/31/2025
13 Goldman Sachs Multi Manager US Small Cap Equity Fund 103,070 9,020 902,893.2 0.1405 0.216 07/31/2025
14 TD Health Sciences Fund 96,546 -11,462 845,742.96 0.0814 0.2024 06/30/2025
15 State Board of Administration of Florida Retirement System 83,741 0 733,571.16 0.0006 0.1755 06/30/2025
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Millennium Management LLC 1,443,619 990,191 12,646,102.44 0.0105 3.0258 06/30/2025
2 Acadian Asset Management LLC 698,501 572,439 6,118,868.76 0.01 1.464 06/30/2025
3 Deep Track Capital LP 1,203,244 436,228 10,540,417.44 0.1881 2.522 06/30/2025
4 Tybourne Capital Management (HK) Ltd. 993,743 417,400 8,705,188.68 17.4569 2.0829 06/30/2025
5 BofA Securities, Inc. 270,096 269,512 2,366,040.96 0.004 0.5661 06/30/2025
6 Eversept Partners LP 211,469 211,469 1,852,468.44 0.1518 0.4432 06/30/2025
7 Armistice Capital LLC 2,800,000 128,000 24,528,000 0.6628 5.8688 06/30/2025
8 Westfield Capital Management Co. LP 2,780,491 123,186 24,357,101.16 0.0944 5.8279 06/30/2025
9 Soleus Capital Management LP (Investment Management) 100,000 100,000 876,000 0.0411 0.2096 06/30/2025
10 Monimus Capital Management LP 85,224 85,224 746,562.24 0.5511 0.1786 06/30/2025
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Point72 Asset Management LP 1,772,600 -1,919,469 15,527,976 0.0286 3.7153 06/30/2025
2 RA Capital Management LP 0 -1,093,477 0 0 0
3 EcoR1 Capital, LLC 0 -910,000 0 0 0
4 AXA Investment Managers UK Ltd. 280,152 -273,530 2,454,131.52 0.0078 0.5872 06/30/2025
5 BNP Paribas Asset Management USA, Inc. 1,041,456 -178,232 9,123,154.56 0.0698 2.1829 06/30/2025
6 Aquilo Capital Management LLC 0 -171,695 0 0 0
7 Harbor Capital Advisors, Inc. 41,368 -106,761 362,383.68 0.0281 0.0867 09/30/2025
8 Caption Management LLC 0 -81,559 0 0 0
9 T. Rowe Price Associates, Inc. (IM) 1,468,393 -68,191 12,863,122.68 0.0015 3.0777 06/30/2025
10 Shay Capital LLC 0 -60,000 0 0 0

Data provided by FactSet Research Systems Inc.