| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Baker Bros. Advisors LP | 10,885,357 | -70,800 | 45,718,499.4 | 0.1607 | 21.6094 | 06/30/2026 |
| 2 | Armistice Capital LLC | 3,398,000 | 162,000 | 14,271,600 | 0.3578 | 6.7456 | 06/30/2026 |
| 3 | Long Focus Capital Management LLC | 3,310,687 | 1,677,596 | 13,904,885.4 | 0.5597 | 6.5723 | 06/30/2026 |
| 4 | Acadian Asset Management LLC | 1,968,025 | 296,767 | 8,265,705 | 0.0083 | 3.9069 | 06/30/2026 |
| 5 | Renaissance Technologies LLC | 1,533,400 | 966,800 | 6,440,280 | 0.0086 | 3.0441 | 06/30/2026 |
| 6 | T. Rowe Price Associates, Inc. (IM) | 902,150 | -269,637 | 3,789,030 | 0.0004 | 1.7909 | 06/30/2026 |
| 7 | Marshall Wace LLP | 797,940 | 759,145 | 3,351,348 | 0.0027 | 1.5841 | 06/30/2026 |
| 8 | Qube Research & Technologies Ltd. | 775,567 | 733,719 | 3,257,381.4 | 0.0035 | 1.5396 | 06/30/2026 |
| 9 | Schroder Investment Management Ltd. | 615,833 | 31,063 | 2,586,498.6 | 0.0009 | 1.2225 | 06/30/2026 |
| 10 | Millennium Management LLC | 553,967 | 227,341 | 2,326,661.4 | 0.0016 | 1.0997 | 06/30/2026 |
| 11 | Peapod Lane Capital LLC | 537,978 | 537,978 | 2,259,507.6 | 1.514 | 1.068 | 06/30/2026 |
| 12 | Diadema Partners LP | 462,724 | 462,724 | 1,943,440.8 | 0.6371 | 0.9186 | 06/30/2026 |
| 13 | Morgan Stanley & Co. LLC | 457,009 | 120,489 | 1,919,437.8 | 0.0006 | 0.9072 | 06/30/2026 |
| 14 | Two Sigma Investments LP | 434,577 | 302,545 | 1,825,223.4 | 0.0014 | 0.8627 | 06/30/2026 |
| 15 | Jane Street Capital LLC | 392,163 | 328,973 | 1,647,084.6 | 0.001 | 0.7785 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Candriam Equities L - Biotechnology | 825,127 | 0 | 3,465,533.4 | 0.1661 | 1.638 | 01/30/2026 |
| 2 | T Rowe Price Health Sciences Fund | 628,421 | -226,374 | 2,639,368.2 | 0.021 | 1.2475 | 06/30/2026 |
| 3 | Candriam Equities L - Oncology | 367,152 | 0 | 1,542,038.4 | 0.0855 | 0.7289 | 01/30/2026 |
| 4 | iShares Biotechnology ETF | 272,825 | 21,612 | 1,145,865 | 0.0111 | 0.5416 | 07/31/2026 |
| 5 | Old Westbury Small & Mid Cap Strategies Fund | 265,973 | 0 | 1,117,086.6 | 0.0116 | 0.528 | 04/30/2026 |
| 6 | Westfield Small/Mid Cap Growth Equity | 204,292 | 0 | 858,026.4 | 0.0454 | 0.4056 | 11/30/2025 |
| 7 | Belfius Equities - Cure | 158,994 | 0 | 667,774.8 | 0.0858 | 0.3156 | 01/30/2026 |
| 8 | State Board of Administration of Florida Retirement System | 140,680 | 0 | 590,856 | 0.0005 | 0.2793 | 12/31/2025 |
| 9 | Virtus Biotech Clinical Trials ETF | 76,743 | 38,927 | 322,320.6 | 0.6369 | 0.1523 | 07/31/2026 |
| 10 | TD Health Sciences Fund | 73,996 | 0 | 310,783.2 | 0.0301 | 0.1469 | 12/31/2025 |
| 11 | T Rowe Price Health Sciences Portfolio | 62,846 | 0 | 263,953.2 | 0.0335 | 0.1248 | 06/30/2026 |
| 12 | PPF (PMG Partners Funds) - PMG Global Biotech Fund | 58,300 | 0 | 244,860 | 0.6236 | 0.1157 | 12/31/2025 |
| 13 | ALPS Medical Breakthroughs ETF | 55,001 | 10,722 | 231,004.2 | 0.1085 | 0.1092 | 07/31/2026 |
| 14 | iShares IV Plc - NASDAQ US Biotechnology UCITS ETF | 38,505 | 3,539 | 161,721 | 0.0128 | 0.0764 | 07/31/2026 |
| 15 | State Street SPDR S&P International Small Cap ETF | 30,985 | 1,097 | 130,137 | 0.014 | 0.0615 | 07/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Long Focus Capital Management LLC | 3,310,687 | 1,677,596 | 13,904,885.4 | 0.5597 | 6.5723 | 06/30/2026 |
| 2 | Renaissance Technologies LLC | 1,533,400 | 966,800 | 6,440,280 | 0.0086 | 3.0441 | 06/30/2026 |
| 3 | Marshall Wace LLP | 797,940 | 759,145 | 3,351,348 | 0.0027 | 1.5841 | 06/30/2026 |
| 4 | Qube Research & Technologies Ltd. | 775,567 | 733,719 | 3,257,381.4 | 0.0035 | 1.5396 | 06/30/2026 |
| 5 | Peapod Lane Capital LLC | 537,978 | 537,978 | 2,259,507.6 | 1.514 | 1.068 | 06/30/2026 |
| 6 | Diadema Partners LP | 462,724 | 462,724 | 1,943,440.8 | 0.6371 | 0.9186 | 06/30/2026 |
| 7 | Jane Street Capital LLC | 392,163 | 328,973 | 1,647,084.6 | 0.001 | 0.7785 | 06/30/2026 |
| 8 | Two Sigma Investments LP | 434,577 | 302,545 | 1,825,223.4 | 0.0014 | 0.8627 | 06/30/2026 |
| 9 | Acadian Asset Management LLC | 1,968,025 | 296,767 | 8,265,705 | 0.0083 | 3.9069 | 06/30/2026 |
| 10 | Citadel Advisors LLC | 266,339 | 261,110 | 1,118,623.8 | 0.0008 | 0.5287 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Westfield Capital Management Co. LP | 0 | -3,016,026 | 0 | 0 | 0 | |
| 2 | Candriam Belgium SA | 0 | -1,192,279 | 0 | 0 | 0 | |
| 3 | Principal Global Investors LLC | 0 | -1,148,272 | 0 | 0 | 0 | |
| 4 | BNP Paribas Asset Management USA, Inc. | 0 | -568,225 | 0 | 0 | 0 | |
| 5 | Silvercrest Asset Management Group LLC | 0 | -476,976 | 0 | 0 | 0 | |
| 6 | Jefferies LLC | 0 | -297,247 | 0 | 0 | 0 | |
| 7 | T. Rowe Price Associates, Inc. (IM) | 902,150 | -269,637 | 3,789,030 | 0.0004 | 1.7909 | 06/30/2026 |
| 8 | Platinum Investment Management Ltd. | 0 | -184,603 | 0 | 0 | 0 | |
| 9 | Birchview Capital LP | 313,616 | -149,084 | 1,317,187.2 | 0.6921 | 0.6226 | 06/30/2026 |
| 10 | Two Sigma Advisers LP | 0 | -146,100 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.