| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Baker Bros. Advisors LP | 10,885,357 | 0 | 74,020,427.6 | 0.3736 | 21.8013 | 09/30/2025 |
| 2 | Armistice Capital LLC | 2,978,000 | 306,000 | 20,250,400 | 0.5159 | 5.9644 | 09/30/2025 |
| 3 | Westfield Capital Management Co. LP | 2,952,543 | 295,238 | 20,077,292.4 | 0.0827 | 5.9134 | 09/30/2025 |
| 4 | Long Focus Capital Management LLC | 1,418,695 | 124,942 | 9,647,126 | 0.5576 | 2.8414 | 09/30/2025 |
| 5 | T. Rowe Price Associates, Inc. (IM) | 1,384,794 | -151,790 | 9,416,599.2 | 0.0011 | 2.7735 | 09/30/2025 |
| 6 | Acadian Asset Management LLC | 1,314,556 | 1,188,494 | 8,938,980.8 | 0.0131 | 2.6328 | 09/30/2025 |
| 7 | Candriam Belgium SA | 1,172,387 | -32,820 | 7,972,231.6 | 0.0211 | 2.3481 | 09/30/2025 |
| 8 | Principal Global Investors LLC | 1,148,402 | 517,142 | 7,809,133.6 | 0.0035 | 2.3 | 09/30/2025 |
| 9 | Millennium Management LLC | 1,054,746 | 601,318 | 7,172,272.8 | 0.0056 | 2.1125 | 09/30/2025 |
| 10 | Morgan Stanley & Co. LLC | 683,703 | -201,260 | 4,649,180.4 | 0.0016 | 1.3693 | 09/30/2025 |
| 11 | Bank of America, NA (Private Banking) | 589,430 | 26,455 | 4,008,124 | 0.0012 | 1.1805 | 09/30/2025 |
| 12 | Renaissance Technologies LLC | 518,700 | 217,200 | 3,527,160 | 0.0047 | 1.0389 | 09/30/2025 |
| 13 | Silvercrest Asset Management Group LLC | 476,976 | 211,283 | 3,243,436.8 | 0.0211 | 0.9553 | 09/30/2025 |
| 14 | Point72 Asset Management LP | 430,900 | -3,261,169 | 2,930,120 | 0.0053 | 0.863 | 09/30/2025 |
| 15 | Jefferies LLC | 401,926 | -6,963 | 2,733,096.8 | 0.0925 | 0.805 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | T Rowe Price Health Sciences Fund | 1,039,244 | -129,224 | 7,066,859.2 | 0.0563 | 2.0814 | 09/30/2025 |
| 2 | Harbor Small Cap Growth Fund | 1,022,222 | 21,402 | 6,951,109.6 | 0.322 | 2.0473 | 10/31/2025 |
| 3 | Candriam Equities L - Biotechnology | 643,676 | 0 | 4,376,996.8 | 0.2721 | 1.2892 | 04/30/2025 |
| 4 | Principal Funds, Inc. - Small Cap Fund | 572,500 | 282,600 | 3,893,000 | 0.1653 | 1.1466 | 10/31/2025 |
| 5 | BNP Paribas Funds - Health Care Innovators | 568,225 | 0 | 3,863,930 | 0.1832 | 1.138 | 11/28/2025 |
| 6 | Candriam Equities L - Oncology | 367,152 | 0 | 2,496,633.6 | 0.1319 | 0.7353 | 04/30/2025 |
| 7 | FCP Medical - BioHealth | 343,416 | 0 | 2,335,228.8 | 0.2535 | 0.6878 | 09/30/2025 |
| 8 | iShares Biotechnology ETF | 225,888 | 49,524 | 1,536,038.4 | 0.0179 | 0.4524 | 11/28/2025 |
| 9 | Old Westbury Small & Mid Cap Strategies Fund | 212,327 | 185,633 | 1,443,823.6 | 0.0156 | 0.4252 | 10/31/2025 |
| 10 | Westfield Small/Mid Cap Growth Equity | 204,292 | 29,383 | 1,389,185.6 | 0.0846 | 0.4092 | 10/31/2025 |
| 11 | State Board of Administration of Florida Retirement System | 140,680 | 56,939 | 956,624 | 0.0009 | 0.2818 | 09/30/2025 |
| 12 | Goldman Sachs Multi Manager US Small Cap Equity Fund | 99,181 | 621 | 674,430.8 | 0.1114 | 0.1986 | 10/31/2025 |
| 13 | TD Health Sciences Fund | 96,546 | -11,462 | 656,512.8 | 0.06 | 0.1934 | 06/30/2025 |
| 14 | BlueBox Funds - Precision Medicine Fund | 87,400 | 30,793 | 594,320 | 1.2442 | 0.175 | 11/28/2025 |
| 15 | GS Funds II - GMS US Small Cap Equity Portfolio | 67,390 | 0 | 458,252 | 0.105 | 0.135 | 05/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Acadian Asset Management LLC | 1,314,556 | 1,188,494 | 8,938,980.8 | 0.0131 | 2.6328 | 09/30/2025 |
| 2 | Millennium Management LLC | 1,054,746 | 601,318 | 7,172,272.8 | 0.0056 | 2.1125 | 09/30/2025 |
| 3 | Principal Global Investors LLC | 1,148,402 | 517,142 | 7,809,133.6 | 0.0035 | 2.3 | 09/30/2025 |
| 4 | Armistice Capital LLC | 2,978,000 | 306,000 | 20,250,400 | 0.5159 | 5.9644 | 09/30/2025 |
| 5 | Westfield Capital Management Co. LP | 2,952,543 | 295,238 | 20,077,292.4 | 0.0827 | 5.9134 | 09/30/2025 |
| 6 | Renaissance Technologies LLC | 518,700 | 217,200 | 3,527,160 | 0.0047 | 1.0389 | 09/30/2025 |
| 7 | Silvercrest Asset Management Group LLC | 476,976 | 211,283 | 3,243,436.8 | 0.0211 | 0.9553 | 09/30/2025 |
| 8 | Eversept Partners LP | 194,440 | 194,440 | 1,322,192 | 0.0845 | 0.3894 | 09/30/2025 |
| 9 | Two Sigma Investments LP | 184,537 | 184,537 | 1,254,851.6 | 0.0019 | 0.3696 | 09/30/2025 |
| 10 | Two Sigma Advisers LP | 156,700 | 156,700 | 1,065,560 | 0.0021 | 0.3138 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Point72 Asset Management LP | 430,900 | -3,261,169 | 2,930,120 | 0.0053 | 0.863 | 09/30/2025 |
| 2 | Deep Track Capital LP | 0 | -2,821,171 | 0 | 0 | 0 | |
| 3 | BNP Paribas Asset Management USA, Inc. | 0 | -1,219,688 | 0 | 0 | 0 | |
| 4 | RA Capital Management LP | 0 | -1,093,477 | 0 | 0 | 0 | |
| 5 | EcoR1 Capital, LLC | 0 | -910,000 | 0 | 0 | 0 | |
| 6 | Tybourne Capital Management (HK) Ltd. | 0 | -576,343 | 0 | 0 | 0 | |
| 7 | AXA Investment Managers UK Ltd. | 0 | -553,682 | 0 | 0 | 0 | |
| 8 | Woodline Partners LP | 0 | -363,751 | 0 | 0 | 0 | |
| 9 | Morgan Stanley & Co. LLC | 683,703 | -201,260 | 4,649,180.4 | 0.0016 | 1.3693 | 09/30/2025 |
| 10 | Aquilo Capital Management LLC | 0 | -171,695 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.