| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Baker Bros. Advisors LP | 10,956,157 | 70,800 | 59,601,494.08 | 0.2966 | 21.9431 | 01/02/2026 |
| 2 | Armistice Capital LLC | 3,236,000 | 436,000 | 17,603,840 | 0.4162 | 6.4811 | 12/31/2025 |
| 3 | Westfield Capital Management Co. LP | 3,016,026 | 235,535 | 16,407,181.44 | 0.0668 | 6.0405 | 12/31/2025 |
| 4 | Acadian Asset Management LLC | 1,671,258 | 972,757 | 9,091,643.52 | 0.0125 | 3.3472 | 12/31/2025 |
| 5 | Long Focus Capital Management LLC | 1,633,091 | 315,798 | 8,884,015.04 | 0.4558 | 3.2708 | 12/31/2025 |
| 6 | Candriam Belgium SA | 1,192,279 | 19,892 | 6,485,997.76 | 0.0166 | 2.3879 | 12/31/2025 |
| 7 | T. Rowe Price Associates, Inc. (IM) | 1,171,787 | -296,606 | 6,374,521.28 | 0.0008 | 2.3469 | 12/31/2025 |
| 8 | Principal Global Investors LLC | 1,148,272 | 451,005 | 6,246,599.68 | 0.0028 | 2.2998 | 12/31/2025 |
| 9 | Schroder Investment Management Ltd. | 584,770 | 584,770 | 3,181,148.8 | 0.0012 | 1.1712 | 12/31/2025 |
| 10 | BNP Paribas Asset Management USA, Inc. | 568,225 | -473,231 | 3,091,144 | 0.0245 | 1.138 | 12/31/2025 |
| 11 | Renaissance Technologies LLC | 566,600 | 248,200 | 3,082,304 | 0.0047 | 1.1348 | 12/31/2025 |
| 12 | Silvercrest Asset Management Group LLC | 476,976 | 211,283 | 2,594,749.44 | 0.0169 | 0.9553 | 12/31/2025 |
| 13 | Birchview Capital LP | 462,700 | 462,700 | 2,517,088 | 1.3658 | 0.9267 | 12/31/2025 |
| 14 | Candriam SCA | 367,152 | 0 | 1,997,306.88 | 0.0552 | 0.7353 | 07/31/2025 |
| 15 | Morgan Stanley & Co. LLC | 336,520 | -567,165 | 1,830,668.8 | 0.0006 | 0.674 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Harbor Small Cap Growth Fund | 1,022,222 | 52,222 | 5,560,887.68 | 0.2418 | 2.0473 | 10/31/2025 |
| 2 | T Rowe Price Health Sciences Fund | 854,795 | -240,204 | 4,650,084.8 | 0.0385 | 1.712 | 12/31/2025 |
| 3 | Candriam Equities L - Biotechnology | 805,235 | 0 | 4,380,478.4 | 0.2618 | 1.6127 | 07/31/2025 |
| 4 | BNP Paribas Funds - Health Care Innovators | 568,225 | 0 | 3,091,144 | 0.1514 | 1.138 | 01/30/2026 |
| 5 | Principal Funds, Inc. - Small Cap Fund | 567,800 | 28,807 | 3,088,832 | 0.1307 | 1.1372 | 12/31/2025 |
| 6 | Candriam Equities L - Oncology | 367,152 | 0 | 1,997,306.88 | 0.1078 | 0.7353 | 07/31/2025 |
| 7 | iShares Biotechnology ETF | 251,213 | 89,323 | 1,366,598.72 | 0.0158 | 0.5031 | 01/30/2026 |
| 8 | Old Westbury Small & Mid Cap Strategies Fund | 212,327 | 85,282 | 1,155,058.88 | 0.0116 | 0.4252 | 10/31/2025 |
| 9 | Westfield Small/Mid Cap Growth Equity | 204,292 | 18,600 | 1,111,348.48 | 0.0635 | 0.4092 | 11/30/2025 |
| 10 | Belfius Equities - Cure | 154,225 | 0 | 838,984 | 0.1087 | 0.3089 | 07/31/2025 |
| 11 | State Board of Administration of Florida Retirement System | 140,680 | 56,939 | 765,299.2 | 0.0007 | 0.2818 | 09/30/2025 |
| 12 | BlueBox Funds - Precision Medicine Fund | 134,830 | 84,673 | 733,475.2 | 1.2704 | 0.27 | 01/31/2026 |
| 13 | Goldman Sachs Multi Manager US Small Cap Equity Fund | 99,181 | -3,889 | 539,544.64 | 0.0851 | 0.1986 | 10/31/2025 |
| 14 | TD Health Sciences Fund | 96,546 | 0 | 525,210.24 | 0.0489 | 0.1934 | 06/30/2025 |
| 15 | GS Funds II - GMS US Small Cap Equity Portfolio | 67,390 | 0 | 366,601.6 | 0.0789 | 0.135 | 05/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Acadian Asset Management LLC | 1,671,258 | 972,757 | 9,091,643.52 | 0.0125 | 3.3472 | 12/31/2025 |
| 2 | Schroder Investment Management Ltd. | 584,770 | 584,770 | 3,181,148.8 | 0.0012 | 1.1712 | 12/31/2025 |
| 3 | Birchview Capital LP | 462,700 | 462,700 | 2,517,088 | 1.3658 | 0.9267 | 12/31/2025 |
| 4 | Principal Global Investors LLC | 1,148,272 | 451,005 | 6,246,599.68 | 0.0028 | 2.2998 | 12/31/2025 |
| 5 | Armistice Capital LLC | 3,236,000 | 436,000 | 17,603,840 | 0.4162 | 6.4811 | 12/31/2025 |
| 6 | Long Focus Capital Management LLC | 1,633,091 | 315,798 | 8,884,015.04 | 0.4558 | 3.2708 | 12/31/2025 |
| 7 | Renaissance Technologies LLC | 566,600 | 248,200 | 3,082,304 | 0.0047 | 1.1348 | 12/31/2025 |
| 8 | Westfield Capital Management Co. LP | 3,016,026 | 235,535 | 16,407,181.44 | 0.0668 | 6.0405 | 12/31/2025 |
| 9 | Silvercrest Asset Management Group LLC | 476,976 | 211,283 | 2,594,749.44 | 0.0169 | 0.9553 | 12/31/2025 |
| 10 | Moore Capital Management LP | 275,000 | 200,000 | 1,496,000 | 0.0301 | 0.5508 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Point72 Asset Management LP | 76,779 | -1,695,821 | 417,677.76 | 0.0006 | 0.1538 | 12/31/2025 |
| 2 | Deep Track Capital LP | 0 | -1,203,244 | 0 | 0 | 0 | |
| 3 | Millennium Management LLC | 326,626 | -1,116,993 | 1,776,845.44 | 0.0013 | 0.6542 | 12/31/2025 |
| 4 | Tybourne Capital Management (HK) Ltd. | 0 | -993,743 | 0 | 0 | 0 | |
| 5 | Morgan Stanley & Co. LLC | 336,520 | -567,165 | 1,830,668.8 | 0.0006 | 0.674 | 12/31/2025 |
| 6 | BNP Paribas Asset Management USA, Inc. | 568,225 | -473,231 | 3,091,144 | 0.0245 | 1.138 | 12/31/2025 |
| 7 | Bank of America, NA (Private Banking) | 92,484 | -468,054 | 503,112.96 | 0.0001 | 0.1852 | 12/31/2025 |
| 8 | Woodline Partners LP | 0 | -362,325 | 0 | 0 | 0 | |
| 9 | Medical Strategy GmbH | 0 | -343,416 | 0 | 0 | 0 | |
| 10 | T. Rowe Price Associates, Inc. (IM) | 1,171,787 | -296,606 | 6,374,521.28 | 0.0008 | 2.3469 | 12/31/2025 |
Data provided by FactSet Research Systems Inc.