| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Baker Bros. Advisors LP | 10,885,357 | 0 | 38,643,017.35 | 0.143 | 21.5317 | 06/30/2026 |
| 2 | Armistice Capital LLC | 3,398,000 | 0 | 12,062,900 | 0.3328 | 6.7214 | 06/30/2026 |
| 3 | Long Focus Capital Management LLC | 3,310,687 | 0 | 11,752,938.85 | 0.5145 | 6.5487 | 06/30/2026 |
| 4 | Acadian Asset Management LLC | 1,968,025 | 0 | 6,986,488.75 | 0.007 | 3.8928 | 06/30/2026 |
| 5 | Renaissance Technologies LLC | 1,533,400 | 554,100 | 5,443,570 | 0.0075 | 3.0331 | 06/30/2026 |
| 6 | T. Rowe Price Associates, Inc. (IM) | 902,150 | -126,093 | 3,202,632.5 | 0.0004 | 1.7845 | 06/30/2026 |
| 7 | Marshall Wace LLP | 797,940 | 420,605 | 2,832,687 | 0.0024 | 1.5784 | 06/30/2026 |
| 8 | Qube Research & Technologies Ltd. | 775,567 | 466,950 | 2,753,262.85 | 0.0031 | 1.5341 | 06/30/2026 |
| 9 | Schroder Investment Management Ltd. | 615,833 | 0 | 2,186,207.15 | 0.0008 | 1.2181 | 06/30/2026 |
| 10 | Millennium Management LLC | 553,967 | 269,981 | 1,966,582.85 | 0.0014 | 1.0958 | 06/30/2026 |
| 11 | Peapod Lane Capital LLC | 501,708 | 380,602 | 1,781,063.4 | 1.3542 | 0.9924 | 09/30/2026 |
| 12 | Diadema Partners LP | 462,724 | -13,700 | 1,642,670.2 | 0.5842 | 0.9153 | 06/30/2026 |
| 13 | Morgan Stanley & Co. LLC | 457,009 | 50,526 | 1,622,381.95 | 0.0005 | 0.904 | 06/30/2026 |
| 14 | Two Sigma Investments LP | 434,577 | 269,777 | 1,542,748.35 | 0.0012 | 0.8596 | 06/30/2026 |
| 15 | Jane Street Capital LLC | 392,163 | 174,048 | 1,392,178.65 | 0.0009 | 0.7757 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | iShares Biotechnology ETF | 293,801 | 49,700 | 1,042,993.55 | 0.0094 | 0.5812 | 09/30/2026 |
| 2 | Old Westbury Small & Mid Cap Strategies Fund | 265,973 | 0 | 944,204.15 | 0.0106 | 0.5261 | 07/31/2026 |
| 3 | Westfield Small/Mid Cap Growth Equity | 204,292 | 0 | 725,236.6 | 0.0411 | 0.4041 | 11/30/2025 |
| 4 | Virtus Biotech Clinical Trials ETF | 78,354 | 41,753 | 278,156.7 | 0.7101 | 0.155 | 09/30/2026 |
| 5 | TD Health Sciences Fund | 73,996 | 0 | 262,685.8 | 0.026 | 0.1464 | 12/31/2025 |
| 6 | ALPS Medical Breakthroughs ETF | 66,501 | 25,850 | 236,078.55 | 0.1221 | 0.1315 | 09/30/2026 |
| 7 | PPF (PMG Partners Funds) - PMG Global Biotech Fund | 58,300 | 0 | 206,965 | 0.6066 | 0.1153 | 12/31/2025 |
| 8 | iShares IV Plc - NASDAQ US Biotechnology UCITS ETF | 37,683 | 3,300 | 133,774.65 | 0.011 | 0.0745 | 09/30/2026 |
| 9 | State Street SPDR S&P International Small Cap ETF | 37,225 | 6,713 | 132,148.75 | 0.0148 | 0.0736 | 09/30/2026 |
| 10 | Voya Multi Manager International Small Cap Fund | 30,052 | 0 | 106,684.6 | 0.0212 | 0.0594 | 06/30/2026 |
| 11 | Invesco NASDAQ Future Gen 200 ETF | 29,023 | 16,681 | 103,031.65 | 0.489 | 0.0574 | 09/30/2026 |
| 12 | John Hancock VIT - Health Sciences Trust | 25,602 | 0 | 90,887.1 | 0.0343 | 0.0506 | 06/30/2026 |
| 13 | ActivePassive International Equity ETF | 20,439 | 20,439 | 72,558.45 | 0.0065 | 0.0404 | 09/30/2026 |
| 14 | Invesco Markets Plc - NASDAQ Biotech UCITS ETF | 15,253 | -437 | 54,148.15 | 0.0111 | 0.0302 | 09/30/2026 |
| 15 | AtonRa SICAV - AtonRa Fund (The) | 14,707 | 0 | 52,209.85 | 0.1377 | 0.0291 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Renaissance Technologies LLC | 1,533,400 | 554,100 | 5,443,570 | 0.0075 | 3.0331 | 06/30/2026 |
| 2 | Qube Research & Technologies Ltd. | 775,567 | 466,950 | 2,753,262.85 | 0.0031 | 1.5341 | 06/30/2026 |
| 3 | Marshall Wace LLP | 797,940 | 420,605 | 2,832,687 | 0.0024 | 1.5784 | 06/30/2026 |
| 4 | Peapod Lane Capital LLC | 501,708 | 380,602 | 1,781,063.4 | 1.3542 | 0.9924 | 09/30/2026 |
| 5 | Millennium Management LLC | 553,967 | 269,981 | 1,966,582.85 | 0.0014 | 1.0958 | 06/30/2026 |
| 6 | Two Sigma Investments LP | 434,577 | 269,777 | 1,542,748.35 | 0.0012 | 0.8596 | 06/30/2026 |
| 7 | Sculptor Capital LP | 197,904 | 197,904 | 702,559.2 | 0.0083 | 0.3915 | 06/30/2026 |
| 8 | Citadel Advisors LLC | 266,339 | 179,220 | 945,503.45 | 0.0007 | 0.5268 | 06/30/2026 |
| 9 | Jane Street Capital LLC | 392,163 | 174,048 | 1,392,178.65 | 0.0009 | 0.7757 | 06/30/2026 |
| 10 | Leap Investments LP | 167,100 | 114,556 | 593,205 | 0.0103 | 0.3305 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Principal Global Investors LLC | 0 | -1,174,625 | 0 | 0 | 0 | |
| 2 | Silvercrest Asset Management Group LLC | 0 | -428,684 | 0 | 0 | 0 | |
| 3 | Platinum Investment Management Ltd. | 0 | -184,603 | 0 | 0 | 0 | |
| 4 | Birchview Capital LP | 313,616 | -149,983 | 1,113,336.8 | 0.7125 | 0.6203 | 06/30/2026 |
| 5 | T. Rowe Price Associates, Inc. (IM) | 902,150 | -126,093 | 3,202,632.5 | 0.0004 | 1.7845 | 06/30/2026 |
| 6 | Marex Financial | 0 | -115,000 | 0 | 0 | 0 | |
| 7 | Bluebox Asset Management Uk Ltd. | 0 | -93,414 | 0 | 0 | 0 | |
| 8 | Goldman Sachs Asset Management International | 1,153 | -67,994 | 4,093.15 | 0 | 0.0023 | 08/28/2026 |
| 9 | Numeric Investors LLC | 0 | -63,305 | 0 | 0 | 0 | |
| 10 | AXQ Capital LP | 27,368 | -35,766 | 97,156.4 | 0.0106 | 0.0541 | 06/30/2026 |
Data provided by FactSet Research Systems Inc.