# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Fidelity Management & Research Co. LLC 7,077,981 1,862,909 686,281,037.76 0.0325 2.9443 06/30/2026
2 PRIMECAP Management Co. 3,772,031 -21,680 365,736,125.76 0.2193 1.5691 06/30/2026
3 Dodge & Cox 3,677,591 800 356,579,223.36 0.1362 1.5298 06/30/2026
4 Flossbach von Storch SE 2,226,138 -1,454,177 215,846,340.48 0.523 0.926 06/30/2026
5 T. Rowe Price Investment Management, Inc. 2,065,456 -3,790,617 200,266,613.76 0.1296 0.8592 06/30/2026
6 Temasek Holdings Pte Ltd. (Investment Management) 1,506,027 0 146,024,377.92 0.2667 0.6265 06/30/2026
7 BNP Paribas Financial Markets SNC 1,319,517 -332,272 127,940,368.32 0.0654 0.5489 06/30/2026
8 Logos Global Management LP 1,015,000 1,015,000 98,414,400 5.0439 0.4222 06/30/2026
9 BlackRock Fund Advisors 803,924 91,084 77,948,471.04 0.0014 0.3344 06/30/2026
10 Fidelity Management & Research (Hong Kong) Ltd. 799,523 253,023 77,521,750.08 0.4279 0.3326 08/31/2026
11 First Trust Advisors LP 791,469 -48,522 76,740,834.24 0.0405 0.3292 06/30/2026
12 Davern Capital Partners LP 754,550 449,495 73,161,168 13.588 0.3139 06/30/2026
13 ACATIS Investment Kapitalverwaltungsgesellschaft mbH 668,282 28 64,796,622.72 1.1078 0.278 07/31/2026
14 Massachusetts Financial Services Co. 651,883 7,145 63,206,575.68 0.0202 0.2712 06/30/2026
15 BlackRock Investment Management (UK) Ltd. 626,135 24,736 60,710,049.6 0.0067 0.2605 06/30/2026
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Fidelity Contrafund 3,847,315 1,807,462 373,035,662.4 0.2037 1.6004 08/31/2026
2 Dodge & Cox International Stock Fund 2,517,713 0 244,117,452.48 0.3766 1.0473 06/30/2026
3 Flossbach von Storch - Multiple Opportunities 2,426,536 0 235,276,930.56 1.0182 1.0094 03/31/2026
4 Vanguard Capital Opportunity Fund 2,189,120 0 212,257,075.2 0.6723 0.9106 06/30/2026
5 Fidelity Contrafund Commingled Pool 1,432,130 701,967 138,859,324.8 0.2083 0.5957 08/31/2026
6 T Rowe Price Mid Cap Growth Fund 1,018,613 -687 98,764,716.48 0.4261 0.4237 06/30/2026
7 First Trust NYSE Arca Biotechnology Index Fund 989,580 181,869 95,949,676.8 3.3164 0.4117 09/30/2026
8 Flossbach von Storch - Multiple Opportunities II 975,000 0 94,536,000 0.9575 0.4056 03/31/2026
9 PRIMECAP Odyssey Aggressive Growth Fund 899,516 -19,630 87,217,071.36 1.0864 0.3742 06/30/2026
10 Fidelity Contrafund K6 820,937 376,333 79,598,051.52 0.2082 0.3415 08/31/2026
11 Fidelity Emerging Markets Fund 766,000 219,500 74,271,360 0.6575 0.3186 08/31/2026
12 iShares Biotechnology ETF 752,431 152,925 72,955,709.76 0.6647 0.313 09/30/2026
13 Dodge & Cox Global Stock Fund 525,778 0 50,979,434.88 0.3929 0.2187 06/30/2026
14 MFS Mid Cap Value Fund 497,120 4,129 48,200,755.2 0.2846 0.2068 07/31/2026
15 ProfitlichSchmidlin Fonds UI 368,633 15,250 35,742,655.68 7.0509 0.1533 05/29/2026
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Fidelity Management & Research Co. LLC 7,077,981 1,862,909 686,281,037.76 0.0325 2.9443 06/30/2026
2 Logos Global Management LP 1,015,000 1,015,000 98,414,400 5.0439 0.4222 06/30/2026
3 Goldman Sachs & Co. LLC (Private Banking) 568,107 492,992 55,083,654.72 0.014 0.2363 06/30/2026
4 Davern Capital Partners LP 754,550 449,495 73,161,168 13.588 0.3139 06/30/2026
5 Assenagon Asset Management SA (Germany) 423,263 423,263 41,039,580.48 0.0507 0.1761 06/30/2026
6 Balyasny Asset Management LP 463,163 369,708 44,908,284.48 0.0851 0.1927 06/30/2026
7 Point72 Asset Management LP 327,184 327,184 31,723,760.64 0.0497 0.1361 06/30/2026
8 Fidelity Management & Research (Hong Kong) Ltd. 799,523 253,023 77,521,750.08 0.4279 0.3326 08/31/2026
9 D. E. Shaw & Co. LP 417,421 217,653 40,473,140.16 0.025 0.1736 06/30/2026
10 Franklin Advisers, Inc. 205,822 199,833 19,956,501.12 0.0085 0.0856 06/30/2026
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 T. Rowe Price Investment Management, Inc. 2,065,456 -3,790,617 200,266,613.76 0.1296 0.8592 06/30/2026
2 Flossbach von Storch SE 2,226,138 -1,454,177 215,846,340.48 0.523 0.926 06/30/2026
3 Citadel Advisors LLC 219,872 -563,301 21,318,789.12 0.016 0.0915 06/30/2026
4 BNP Paribas Financial Markets SNC 1,319,517 -332,272 127,940,368.32 0.0654 0.5489 06/30/2026
5 Bank of America, NA (Private Banking) 462,323 -322,564 44,826,838.08 0.0115 0.1923 06/30/2026
6 Baillie Gifford & Co. 592,380 -290,192 57,437,164.8 0.0324 0.2464 06/30/2026
7 Jane Street Capital LLC 128,490 -208,267 12,458,390.4 0.0076 0.0535 06/30/2026
8 Longaeva Partners LP 0 -119,204 0 0 0
9 BofA Securities, Inc. 16,548 -88,267 1,604,494.08 0.0024 0.0069 06/30/2026
10 Group One Trading LLC 21,540 -82,408 2,088,518.4 0.0626 0.009 06/30/2026

Data provided by FactSet Research Systems Inc.