# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Fidelity Management & Research Co. LLC 5,395,123 -473,690 459,934,235.75 0.0276 2.2443 12/31/2025
2 T. Rowe Price Investment Management, Inc. 4,484,599 886,127 382,312,064.75 0.2597 1.8655 12/31/2025
3 Flossbach von Storch SE 4,196,048 -34,050 357,713,092 0.8864 1.7455 12/31/2025
4 PRIMECAP Management Co. 3,800,011 -201,455 323,950,937.75 0.2599 1.5808 12/31/2025
5 Dodge & Cox 3,614,491 2,737,054 308,135,357.75 0.1294 1.5036 12/31/2025
6 BNP Paribas Financial Markets 1,578,094 302,619 134,532,513.5 0.0892 0.6565 12/31/2025
7 Temasek Holdings Pte Ltd. (Investment Management) 1,506,027 0 128,388,801.75 0.325 0.6265 12/31/2025
8 Jane Street Capital LLC 1,361,221 1,361,221 116,044,090.25 0.1459 0.5662 12/31/2025
9 Baillie Gifford & Co. 1,244,867 -6,794,005 106,124,911.75 0.0698 0.5178 12/31/2025
10 Capital Research & Management Co. (International Investors) 1,134,941 1,468 96,753,720.25 0.0151 0.4721 12/31/2025
11 Candriam Belgium SA 604,916 18,180 51,569,089 0.1455 0.2516 12/31/2025
12 BlackRock Fund Advisors 603,192 -361,343 51,422,118 0.0012 0.2509 12/31/2025
13 Franklin Templeton Institutional LLC 570,010 -109,815 48,593,352.5 1.7419 0.2371 12/31/2025
14 Morgan Stanley & Co. LLC 563,560 62,634 48,043,490 0.0183 0.2344 12/31/2025
15 Long Focus Capital Management LLC 507,655 299,752 43,277,588.75 2.3941 0.2112 12/31/2025
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Flossbach von Storch - Multiple Opportunities 2,726,536 0 232,437,194 0.923 1.1342 09/30/2025
2 Dodge & Cox International Stock Fund 2,517,713 2,517,713 214,635,033.25 0.3616 1.0473 12/31/2025
3 Vanguard Capital Opportunity Fund 2,191,720 -24,720 186,844,130 0.7836 0.9117 12/31/2025
4 T. Rowe Price Capital Appreciation Fund 1,443,737 1,443,737 123,078,579.25 0.2772 0.6006 12/31/2025
5 Fidelity Contrafund 1,227,601 849,559 104,652,985.25 0.0673 0.5107 01/31/2026
6 Flossbach von Storch - Multiple Opportunities II 1,206,959 -55,000 102,893,254.75 0.9389 0.5021 09/30/2025
7 T Rowe Price Mid Cap Growth Fund 1,020,200 -4,800 86,972,050 0.3682 0.4244 12/31/2025
8 PRIMECAP Odyssey Aggressive Growth Fund 919,146 -56,510 78,357,196.5 1.3358 0.3824 12/31/2025
9 First Trust NYSE Arca Biotechnology Index Fund 814,858 513,202 69,466,644.5 3.155 0.339 02/27/2026
10 Fidelity Growth Company Commingled Pool 747,190 86,112 63,697,947.5 0.0638 0.3108 02/28/2026
11 Deka - GlobalChampions 600,000 0 51,150,000 0.3581 0.2496 11/30/2025
12 American Funds Insurance Series - Growth Fund 562,734 0 47,973,073.5 0.1027 0.2341 12/31/2025
13 Fidelity Contrafund Commingled Pool 558,944 418,471 47,649,976 0.0841 0.2325 02/28/2026
14 Fidelity Growth Company Fund 537,001 19,501 45,779,335.25 0.061 0.2234 01/31/2026
15 Dodge & Cox Global Stock Fund 525,778 525,778 44,822,574.5 0.3785 0.2187 12/31/2025
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Dodge & Cox 3,614,491 2,737,054 308,135,357.75 0.1294 1.5036 12/31/2025
2 Jane Street Capital LLC 1,361,221 1,361,221 116,044,090.25 0.1459 0.5662 12/31/2025
3 T. Rowe Price Investment Management, Inc. 4,484,599 886,127 382,312,064.75 0.2597 1.8655 12/31/2025
4 D. E. Shaw & Co. LP 488,552 488,552 41,649,058 0.0343 0.2032 12/31/2025
5 BofA Securities, Inc. 491,689 460,457 41,916,487.25 0.0688 0.2045 12/31/2025
6 Davern Capital Partners LP 371,216 371,216 31,646,164 10.4914 0.1544 12/31/2025
7 Citadel Advisors LLC 363,792 363,792 31,013,268 0.0326 0.1513 12/31/2025
8 Citadel Securities LLC 314,383 311,671 26,801,150.75 0.0613 0.1308 12/31/2025
9 BNP Paribas Financial Markets 1,578,094 302,619 134,532,513.5 0.0892 0.6565 12/31/2025
10 Long Focus Capital Management LLC 507,655 299,752 43,277,588.75 2.3941 0.2112 12/31/2025
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Baillie Gifford & Co. 1,244,867 -6,794,005 106,124,911.75 0.0698 0.5178 12/31/2025
2 Strategic Advisers LLC 49,466 -1,060,263 4,216,976.5 0.0014 0.0206 12/31/2025
3 Newton Investment Management North America LLC 67,008 -711,180 5,712,432 0.012 0.0279 12/31/2025
4 FIAM LLC 489,005 -691,464 41,687,676.25 0.0217 0.2034 12/31/2025
5 Gilder, Gagnon, Howe & Co. LLC 32,287 -635,348 2,752,466.75 0.0333 0.0134 12/31/2025
6 Invesco Asset Management Ltd. 0 -586,170 0 0 0
7 Altrinsic Global Advisors LLC 0 -496,771 0 0 0
8 Fidelity Management & Research Co. LLC 5,395,123 -473,690 459,934,235.75 0.0276 2.2443 12/31/2025
9 BlackRock Fund Advisors 603,192 -361,343 51,422,118 0.0012 0.2509 12/31/2025
10 abrdn, Inc. 44,060 -341,608 3,756,115 0.0372 0.0183 12/31/2025

Data provided by FactSet Research Systems Inc.