# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Fidelity Management & Research Co. LLC 7,077,981 1,682,858 807,243,733.05 0.0387 2.9443 06/30/2026
2 PRIMECAP Management Co. 3,772,031 -27,980 430,200,135.55 0.2594 1.5691 06/30/2026
3 Dodge & Cox 3,677,591 63,100 419,429,253.55 0.1529 1.5298 06/30/2026
4 Flossbach von Storch SE 2,226,138 -1,969,910 253,891,038.9 0.5901 0.926 06/30/2026
5 T. Rowe Price Investment Management, Inc. 2,065,456 -2,419,143 235,565,256.8 0.151 0.8592 06/30/2026
6 Temasek Holdings Pte Ltd. (Investment Management) 1,506,027 0 171,762,379.35 0.31 0.6265 06/30/2026
7 BNP Paribas Financial Markets SNC 1,319,517 -258,577 150,490,913.85 0.0758 0.5489 06/30/2026
8 Logos Global Management LP 1,015,000 1,015,000 115,760,750 4.7259 0.4222 06/30/2026
9 BlackRock Fund Advisors 803,924 200,732 91,687,532.2 0.0017 0.3344 06/30/2026
10 First Trust Advisors LP 791,469 402,602 90,267,039.45 0.0477 0.3292 06/30/2026
11 Davern Capital Partners LP 754,550 383,334 86,056,427.5 13.9517 0.3139 06/30/2026
12 ACATIS Investment Kapitalverwaltungsgesellschaft mbH 668,254 171,950 76,214,368.7 1.1971 0.278 06/30/2026
13 Fidelity Management & Research (Hong Kong) Ltd. 660,800 280,900 75,364,240 0.43 0.2749 06/30/2026
14 Massachusetts Financial Services Co. 651,883 651,883 74,347,256.15 0.0231 0.2712 06/30/2026
15 BlackRock Investment Management (UK) Ltd. 626,135 414,348 71,410,696.75 0.0077 0.2605 06/30/2026
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Fidelity Contrafund 3,278,252 2,050,651 373,884,640.6 0.2043 1.3637 06/30/2026
2 Dodge & Cox International Stock Fund 2,517,713 0 287,145,167.65 0.4218 1.0473 06/30/2026
3 Flossbach von Storch - Multiple Opportunities 2,426,536 -300,000 276,746,430.8 1.156 1.0094 03/31/2026
4 Vanguard Capital Opportunity Fund 2,189,120 -2,600 249,669,136 0.7904 0.9106 03/31/2026
5 Fidelity Contrafund Commingled Pool 1,269,021 800,967 144,731,845.05 0.2171 0.5279 06/30/2026
6 T Rowe Price Mid Cap Growth Fund 1,018,613 -1,587 116,172,812.65 0.5036 0.4237 06/30/2026
7 First Trust NYSE Arca Biotechnology Index Fund 985,041 177,331 112,343,926.05 3.7971 0.4098 07/31/2026
8 Flossbach von Storch - Multiple Opportunities II 975,000 -231,959 111,198,750 1.0756 0.4056 03/31/2026
9 PRIMECAP Odyssey Aggressive Growth Fund 899,516 -19,630 102,589,799.8 1.2848 0.3742 06/30/2026
10 Fidelity Contrafund K6 704,487 387,271 80,346,742.35 0.2107 0.2931 06/30/2026
11 iShares Biotechnology ETF 671,498 166,035 76,584,346.9 0.7167 0.2793 07/31/2026
12 Fidelity Emerging Markets Fund 660,800 280,900 75,364,240 0.6662 0.2749 06/30/2026
13 Dodge & Cox Global Stock Fund 525,778 0 59,964,980.9 0.4448 0.2187 06/30/2026
14 MFS Mid Cap Value Fund 497,120 497,120 56,696,536 0.3171 0.2068 07/31/2026
15 PRIMECAP Odyssey Growth Fund 354,600 -6,000 40,442,130 0.6441 0.1475 06/30/2026
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Fidelity Management & Research Co. LLC 7,077,981 1,682,858 807,243,733.05 0.0387 2.9443 06/30/2026
2 Logos Global Management LP 1,015,000 1,015,000 115,760,750 4.7259 0.4222 06/30/2026
3 Massachusetts Financial Services Co. 651,883 651,883 74,347,256.15 0.0231 0.2712 06/30/2026
4 Goldman Sachs & Co. LLC (Private Banking) 568,107 478,385 64,792,603.35 0.0162 0.2363 06/30/2026
5 Balyasny Asset Management LP 463,163 459,751 52,823,740.15 0.0965 0.1927 06/30/2026
6 Assenagon Asset Management SA (Germany) 423,263 423,263 48,273,145.15 0.0609 0.1761 06/30/2026
7 BlackRock Investment Management (UK) Ltd. 626,135 414,348 71,410,696.75 0.0077 0.2605 06/30/2026
8 First Trust Advisors LP 791,469 402,602 90,267,039.45 0.0477 0.3292 06/30/2026
9 Davern Capital Partners LP 754,550 383,334 86,056,427.5 13.9517 0.3139 06/30/2026
10 Point72 Asset Management LP 327,184 327,184 37,315,335.2 0.0571 0.1361 06/30/2026
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 T. Rowe Price Investment Management, Inc. 2,065,456 -2,419,143 235,565,256.8 0.151 0.8592 06/30/2026
2 Flossbach von Storch SE 2,226,138 -1,969,910 253,891,038.9 0.5901 0.926 06/30/2026
3 Jane Street Capital LLC 128,490 -1,232,731 14,654,284.5 0.0086 0.0535 06/30/2026
4 Capital Research & Management Co. (International Investors) 0 -1,134,941 0 0 0
5 Baillie Gifford & Co. 592,380 -652,487 67,560,939 0.0379 0.2464 06/30/2026
6 BofA Securities, Inc. 16,548 -475,141 1,887,299.4 0.0027 0.0069 06/30/2026
7 Capital International, Inc. 0 -273,073 0 0 0
8 Millennium Management LLC 0 -272,365 0 0 0
9 BNP Paribas Financial Markets SNC 1,319,517 -258,577 150,490,913.85 0.0758 0.5489 06/30/2026
10 Franklin Templeton Institutional LLC 317,380 -252,630 36,197,189 1.9485 0.132 06/30/2026

Data provided by FactSet Research Systems Inc.