| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Baillie Gifford & Co. | 8,038,872 | -181,709 | 774,223,762.32 | 0.3757 | 3.3441 | 06/30/2025 |
| 2 | Fidelity Management & Research Co. LLC | 5,868,813 | 716,381 | 565,225,380.03 | 0.0316 | 2.4413 | 06/30/2025 |
| 3 | Flossbach von Storch SE | 4,230,098 | -176,745 | 407,400,738.38 | 0.942 | 1.7597 | 06/30/2025 |
| 4 | PRIMECAP Management Co. | 4,001,466 | -294,351 | 385,381,190.46 | 0.268 | 1.6646 | 06/30/2025 |
| 5 | T. Rowe Price Investment Management, Inc. | 3,598,472 | 3,545,136 | 346,568,838.32 | 0.2084 | 1.4969 | 06/30/2025 |
| 6 | Temasek Holdings Pte Ltd. (Investment Management) | 1,506,027 | -301,205 | 145,045,460.37 | 0.3299 | 0.6265 | 06/30/2025 |
| 7 | BNP Paribas Financial Markets | 1,275,475 | 661,178 | 122,840,997.25 | 0.087 | 0.5306 | 06/30/2025 |
| 8 | FIAM LLC | 1,180,469 | -71,535 | 113,690,969.39 | 0.0625 | 0.4911 | 06/30/2025 |
| 9 | Capital Research & Management Co. (International Investors) | 1,133,473 | -282,093 | 109,164,784.63 | 0.017 | 0.4715 | 06/30/2025 |
| 10 | Strategic Advisers LLC | 1,109,729 | -187,311 | 106,877,999.99 | 0.0355 | 0.4616 | 06/30/2025 |
| 11 | BlackRock Fund Advisors | 964,535 | -295,559 | 92,894,365.85 | 0.0021 | 0.4012 | 06/30/2025 |
| 12 | Dodge & Cox | 877,437 | 877,437 | 84,505,957.47 | 0.0345 | 0.365 | 06/30/2025 |
| 13 | Newton Investment Management North America LLC | 778,188 | 778,147 | 74,947,286.28 | 0.1586 | 0.3237 | 06/30/2025 |
| 14 | Franklin Templeton Institutional LLC | 679,825 | 679,825 | 65,473,945.75 | 1.5128 | 0.2828 | 06/30/2025 |
| 15 | Gilder, Gagnon, Howe & Co. LLC | 667,635 | 386,223 | 64,299,926.85 | 0.6416 | 0.2777 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Flossbach von Storch - Multiple Opportunities | 2,726,536 | -123,464 | 262,592,682.16 | 0.9728 | 1.1342 | 03/31/2025 |
| 2 | Vanguard Capital Opportunity Fund | 2,216,440 | -54,476 | 213,465,336.4 | 0.8588 | 0.922 | 06/30/2025 |
| 3 | Flossbach von Storch - Multiple Opportunities II | 1,261,959 | -69,141 | 121,539,271.29 | 0.9931 | 0.525 | 03/31/2025 |
| 4 | T Rowe Price Mid Cap Growth Fund | 1,025,000 | 1,025,000 | 98,717,750 | 0.3476 | 0.4264 | 06/30/2025 |
| 5 | PRIMECAP Odyssey Aggressive Growth Fund | 975,656 | -161,610 | 93,965,429.36 | 1.3959 | 0.4059 | 06/30/2025 |
| 6 | iShares Biotechnology ETF | 904,249 | -248,176 | 87,088,221.19 | 1.5117 | 0.3762 | 08/29/2025 |
| 7 | Fidelity Growth Company Commingled Pool | 661,078 | 390,769 | 63,668,422.18 | 0.0611 | 0.275 | 07/31/2025 |
| 8 | Baillie Gifford Worldwide Funds Plc - Long Term Global Growth | 611,249 | -38,076 | 58,869,391.19 | 1.0906 | 0.2543 | 08/31/2025 |
| 9 | Deka - GlobalChampions | 600,000 | 130,000 | 57,786,000 | 0.4233 | 0.2496 | 05/31/2025 |
| 10 | American Funds Insurance Series - Growth Fund | 562,734 | 0 | 54,196,911.54 | 0.1 | 0.2341 | 06/30/2025 |
| 11 | Fidelity Growth Company Fund | 517,500 | 335,807 | 49,840,425 | 0.0646 | 0.2153 | 07/31/2025 |
| 12 | American Funds EuroPacific Growth Fund | 478,902 | -262,406 | 46,123,051.62 | 0.0343 | 0.1992 | 06/30/2025 |
| 13 | Fidelity Advisor Series I - Equity Growth Fund | 466,267 | 48,700 | 44,906,174.77 | 0.3414 | 0.194 | 07/31/2025 |
| 14 | Fidelity Emerging Markets Fund | 461,500 | 67,200 | 44,447,065 | 0.4962 | 0.192 | 07/31/2025 |
| 15 | Fidelity VIP - Growth Portfolio | 413,400 | 22,200 | 39,814,554 | 0.3327 | 0.172 | 07/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | T. Rowe Price Investment Management, Inc. | 3,598,472 | 3,545,136 | 346,568,838.32 | 0.2084 | 1.4969 | 06/30/2025 |
| 2 | Dodge & Cox | 877,437 | 877,437 | 84,505,957.47 | 0.0345 | 0.365 | 06/30/2025 |
| 3 | Newton Investment Management North America LLC | 778,188 | 778,147 | 74,947,286.28 | 0.1586 | 0.3237 | 06/30/2025 |
| 4 | Fidelity Management & Research Co. LLC | 5,868,813 | 716,381 | 565,225,380.03 | 0.0316 | 2.4413 | 06/30/2025 |
| 5 | Franklin Templeton Institutional LLC | 679,825 | 679,825 | 65,473,945.75 | 1.5128 | 0.2828 | 06/30/2025 |
| 6 | BNP Paribas Financial Markets | 1,275,475 | 661,178 | 122,840,997.25 | 0.087 | 0.5306 | 06/30/2025 |
| 7 | Invesco Asset Management Ltd. | 586,170 | 586,170 | 56,454,032.7 | 0.0645 | 0.2438 | 06/30/2025 |
| 8 | Gilder, Gagnon, Howe & Co. LLC | 667,635 | 386,223 | 64,299,926.85 | 0.6416 | 0.2777 | 06/30/2025 |
| 9 | abrdn Investment Management Ltd. | 336,260 | 336,260 | 32,385,200.6 | 0.0397 | 0.1399 | 06/30/2025 |
| 10 | Baker Bros. Advisors LP | 368,923 | 323,892 | 35,530,974.13 | 0.2209 | 0.1535 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Viking Global Investors LP | 0 | -940,850 | 0 | 0 | 0 | |
| 2 | Fred Alger Management LLC | 13,839 | -451,538 | 1,332,834.09 | 0.0056 | 0.0058 | 06/30/2025 |
| 3 | UBS Securities LLC | 78,180 | -333,668 | 7,529,515.8 | 0.0031 | 0.0325 | 06/30/2025 |
| 4 | Quinn Opportunity Partners LLC | 25,075 | -331,119 | 2,414,973.25 | 0.1853 | 0.0104 | 06/30/2025 |
| 5 | T. Rowe Price Associates, Inc. (IM) | 0 | -313,789 | 0 | 0 | 0 | |
| 6 | Braidwell LP | 0 | -309,865 | 0 | 0 | 0 | |
| 7 | Temasek Holdings Pte Ltd. (Investment Management) | 1,506,027 | -301,205 | 145,045,460.37 | 0.3299 | 0.6265 | 06/30/2025 |
| 8 | Logos Global Management LP | 0 | -300,000 | 0 | 0 | 0 | |
| 9 | BlackRock Fund Advisors | 964,535 | -295,559 | 92,894,365.85 | 0.0021 | 0.4012 | 06/30/2025 |
| 10 | PRIMECAP Management Co. | 4,001,466 | -294,351 | 385,381,190.46 | 0.268 | 1.6646 | 06/30/2025 |
Data provided by FactSet Research Systems Inc.