# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 T. Rowe Price Investment Management, Inc. 5,856,073 1,022,431 524,411,337.15 0.3284 2.436 03/31/2026
2 Fidelity Management & Research Co. LLC 5,215,072 328,477 467,009,697.6 0.0236 2.1694 03/31/2026
3 PRIMECAP Management Co. 3,793,711 -77,055 339,726,820.05 0.2167 1.5781 03/31/2026
4 Flossbach von Storch SE 3,680,315 -549,718 329,572,208.25 0.8057 1.531 03/31/2026
5 Dodge & Cox 3,676,791 29,700 329,256,634.05 0.1313 1.5295 03/31/2026
6 BNP Paribas Financial Markets 1,651,789 548,491 147,917,704.95 0.084 0.6871 03/31/2026
7 Temasek Holdings Pte Ltd. (Investment Management) 1,506,027 0 134,864,717.85 0.2909 0.6265 03/31/2026
8 Baillie Gifford & Co. 882,572 -6,996,787 79,034,322.6 0.0482 0.3671 03/31/2026
9 First Trust Advisors LP 839,991 534,369 75,221,194.05 0.0443 0.3494 03/31/2026
10 Citadel Advisors LLC 783,173 474,189 70,133,142.15 0.0656 0.3258 03/31/2026
11 BlackRock Fund Advisors 712,840 297,960 63,834,822 0.0012 0.2965 03/31/2026
12 Massachusetts Financial Services Co. 644,738 644,738 57,736,287.9 0.0185 0.2682 03/31/2026
13 Long Focus Capital Management LLC 624,000 226,345 55,879,200 2.2694 0.2596 03/31/2026
14 BlackRock Investment Management (UK) Ltd. 601,399 402,358 53,855,280.45 0.0062 0.2502 03/31/2026
15 Fidelity Management & Research (Hong Kong) Ltd. 546,500 166,600 48,939,075 0.2837 0.2273 03/31/2026
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Flossbach von Storch - Multiple Opportunities 2,726,536 0 244,161,298.8 0.9253 1.1342 09/30/2025
2 Dodge & Cox International Stock Fund 2,517,713 0 225,461,199.15 0.3506 1.0473 03/31/2026
3 T. Rowe Price Capital Appreciation Fund 2,272,437 555,465 203,496,733.35 0.4096 0.9453 03/31/2026
4 Vanguard Capital Opportunity Fund 2,191,720 -22,020 196,268,526 0.6571 0.9117 12/31/2025
5 Fidelity Contrafund 2,039,853 1,271,142 182,668,836.15 0.104 0.8486 03/31/2026
6 Flossbach von Storch - Multiple Opportunities II 1,206,959 0 108,083,178.45 0.9412 0.5021 09/30/2025
7 T Rowe Price Mid Cap Growth Fund 1,019,300 -2,300 91,278,315 0.3941 0.424 03/31/2026
8 PRIMECAP Odyssey Aggressive Growth Fund 919,146 -17,430 82,309,524.3 1.124 0.3824 03/31/2026
9 First Trust NYSE Arca Biotechnology Index Fund 787,861 427,023 70,552,952.55 3.0299 0.3277 04/30/2026
10 Fidelity Contrafund Commingled Pool 730,163 434,965 65,386,096.65 0.1005 0.3037 03/31/2026
11 Deka - GlobalChampions 600,000 0 53,730,000 0.3302 0.2496 11/30/2025
12 iShares Biotechnology ETF 587,026 209,887 52,568,178.3 0.6687 0.2442 04/30/2026
13 Fidelity Emerging Markets Fund 546,500 166,600 48,939,075 0.4442 0.2273 03/31/2026
14 Dodge & Cox Global Stock Fund 525,778 -13,500 47,083,419.9 0.3717 0.2187 03/31/2026
15 MFS Mid Cap Value Fund 492,991 492,991 44,147,344.05 0.2611 0.2051 03/31/2026
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 T. Rowe Price Investment Management, Inc. 5,856,073 1,022,431 524,411,337.15 0.3284 2.436 03/31/2026
2 Massachusetts Financial Services Co. 644,738 644,738 57,736,287.9 0.0185 0.2682 03/31/2026
3 BNP Paribas Financial Markets 1,651,789 548,491 147,917,704.95 0.084 0.6871 03/31/2026
4 First Trust Advisors LP 839,991 534,369 75,221,194.05 0.0443 0.3494 03/31/2026
5 BofA Securities, Inc. 491,689 477,868 44,030,749.95 0.0652 0.2045 12/31/2025
6 Citadel Advisors LLC 783,173 474,189 70,133,142.15 0.0656 0.3258 03/31/2026
7 BlackRock Investment Management (UK) Ltd. 601,399 402,358 53,855,280.45 0.0062 0.2502 03/31/2026
8 UBS Asset Management Switzerland AG 389,899 389,899 34,915,455.45 0.0093 0.1622 03/31/2026
9 UBS Asset Management (Americas) LLC 380,596 380,596 34,082,371.8 0.0168 0.1583 03/31/2026
10 Fidelity Management & Research Co. LLC 5,215,072 328,477 467,009,697.6 0.0236 2.1694 03/31/2026
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Baillie Gifford & Co. 882,572 -6,996,787 79,034,322.6 0.0482 0.3671 03/31/2026
2 Capital Research & Management Co. (International Investors) 0 -1,135,066 0 0 0
3 Flossbach von Storch SE 3,680,315 -549,718 329,572,208.25 0.8057 1.531 03/31/2026
4 UBS Securities LLC 111,172 -305,212 9,955,452.6 0.0037 0.0462 03/31/2026
5 Bank of America, NA (Private Banking) 229,185 -298,205 20,523,516.75 0.0057 0.0953 12/31/2025
6 Capital International, Inc. 0 -293,208 0 0 0
7 Franklin Templeton Institutional LLC 375,960 -292,270 33,667,218 1.7728 0.1564 03/31/2026
8 abrdn, Inc. 0 -291,907 0 0 0
9 Newton Investment Management North America LLC 0 -278,527 0 0 0
10 Baker Bros. Advisors LP 119,743 -249,180 10,722,985.65 0.0517 0.0498 03/31/2026

Data provided by FactSet Research Systems Inc.