| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Ikarian Capital LLC | 211,538 | 0 | 904,324.95 | 0.1392 | 10.5326 | 03/31/2026 |
| 2 | Dauntless Investment Group LLC | 196,592 | 196,592 | 840,430.8 | 2.5536 | 9.7884 | 03/31/2026 |
| 3 | Millennium Management LLC | 110,011 | 35,194 | 470,297.02 | 0.0003 | 5.4775 | 05/26/2026 |
| 4 | Adar1 Capital Management LLC | 102,883 | 44,653 | 439,824.82 | 0.0238 | 5.1226 | 03/31/2026 |
| 5 | Summittx Capital LP | 100,300 | 35,505 | 428,782.5 | 0.0128 | 4.994 | 03/31/2026 |
| 6 | Velan Capital Investment Management LP | 84,849 | 84,849 | 362,729.48 | 0.2536 | 4.2247 | 03/31/2026 |
| 7 | Woodline Partners LP | 79,582 | 0 | 340,213.05 | 0.0011 | 3.9624 | 03/31/2026 |
| 8 | abrdn, Inc. | 75,000 | 0 | 320,625 | 0.0029 | 3.7343 | 04/01/2026 |
| 9 | Soleus Capital Management LP (Investment Management) | 72,730 | 47,730 | 310,920.75 | 0.01 | 3.6213 | 03/31/2026 |
| 10 | Centiva Capital LP | 60,000 | 47,947 | 256,500 | 0.0113 | 2.9874 | 03/31/2026 |
| 11 | Boothbay Fund Management LLC | 59,838 | 0 | 255,807.45 | 0.0056 | 2.9794 | 03/31/2026 |
| 12 | Stonepine Capital Management LLC | 53,460 | -24,729 | 228,541.5 | 0.0984 | 2.6618 | 03/31/2026 |
| 13 | AIGH Capital Management LLC | 51,000 | 1,677 | 218,025 | 0.0293 | 2.5393 | 03/31/2026 |
| 14 | Citadel Advisors LLC | 32,519 | 32,519 | 139,018.72 | 0.0001 | 1.6191 | 03/31/2026 |
| 15 | Birchview Capital LP | 20,000 | 20,000 | 85,500 | 0.0456 | 0.9958 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | abrdn World Healthcare Fund | 40,400 | 0 | 172,710 | 0.0273 | 2.0115 | 06/30/2026 |
| 2 | abrdn Life Sciences Investors | 34,600 | 0 | 147,915 | 0.0228 | 1.7227 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Dauntless Investment Group LLC | 196,592 | 196,592 | 840,430.8 | 2.5536 | 9.7884 | 03/31/2026 |
| 2 | Velan Capital Investment Management LP | 84,849 | 84,849 | 362,729.48 | 0.2536 | 4.2247 | 03/31/2026 |
| 3 | Centiva Capital LP | 60,000 | 47,947 | 256,500 | 0.0113 | 2.9874 | 03/31/2026 |
| 4 | Soleus Capital Management LP (Investment Management) | 72,730 | 47,730 | 310,920.75 | 0.01 | 3.6213 | 03/31/2026 |
| 5 | Adar1 Capital Management LLC | 102,883 | 44,653 | 439,824.82 | 0.0238 | 5.1226 | 03/31/2026 |
| 6 | Summittx Capital LP | 100,300 | 35,505 | 428,782.5 | 0.0128 | 4.994 | 03/31/2026 |
| 7 | Millennium Management LLC | 110,011 | 35,194 | 470,297.02 | 0.0003 | 5.4775 | 05/26/2026 |
| 8 | Citadel Advisors LLC | 32,519 | 32,519 | 139,018.72 | 0.0001 | 1.6191 | 03/31/2026 |
| 9 | Birchview Capital LP | 20,000 | 20,000 | 85,500 | 0.0456 | 0.9958 | 03/31/2026 |
| 10 | UBS Securities LLC | 2,512 | 2,495 | 10,738.8 | 0 | 0.1251 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Resolute Capital Asset Partners LLC | 0 | -30,000 | 0 | 0 | 0 | |
| 2 | Stonepine Capital Management LLC | 53,460 | -24,729 | 228,541.5 | 0.0984 | 2.6618 | 03/31/2026 |
| 3 | Simplify Asset Management, Inc. | 0 | -17,448 | 0 | 0 | 0 | |
| 4 | GAMMA Investing LLC | 439 | -1,645 | 1,876.72 | 0.0001 | 0.0219 | 06/30/2026 |
| 5 | RhumbLine Advisers LP | 1,521 | -145 | 6,502.28 | 0 | 0.0757 | 03/31/2026 |
Data provided by FactSet Research Systems Inc.