# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Ikarian Capital LLC 211,538 211,538 1,347,497.06 0.1806 25.2138 01/31/2026
2 Stonepine Capital Management LLC 93,460 93,460 595,340.2 0.244 11.1398 01/29/2026
3 Woodline Partners LP 79,582 79,582 506,937.34 0.0018 9.4856 12/31/2025
4 abrdn, Inc. 75,000 75,000 477,750 0.0042 8.9395 04/01/2026
5 Millennium Management LLC 74,817 20,486 476,584.29 0.0003 8.9177 12/31/2025
6 Summittx Capital LP 64,795 64,795 412,744.15 0.0115 7.7231 12/31/2025
7 Boothbay Fund Management LLC 59,838 59,838 381,168.06 0.0089 7.1323 12/31/2025
8 Adar1 Capital Management LLC 58,230 58,230 370,925.1 0.0276 6.9406 12/31/2025
9 AIGH Capital Management LLC 51,000 51,000 324,870 0.0453 6.0788 03/31/2026
10 Resolute Capital Asset Partners LLC 30,000 -20,000 191,100 0.084 3.5758 12/31/2025
11 Soleus Capital Management LP (Investment Management) 25,000 25,000 159,250 0.0059 2.9798 12/31/2025
12 Centiva Capital LP 12,053 12,053 76,777.61 0.0047 1.4366 12/31/2025
13 Morgan Stanley Smith Barney LLC (Investment Management) 3,000 3,000 19,110 0 0.3576 12/31/2025
14 UBS Securities LLC 2,512 2,511 16,001.44 0 0.2994 03/31/2026
15 GAMMA Investing LLC 1,720 1,442 10,956.4 0.0005 0.205 03/31/2026
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 abrdn World Healthcare Fund 40,400 40,400 257,348 0.0451 4.8154 03/31/2026
2 abrdn Life Sciences Investors 34,600 34,600 220,402 0.0385 4.1241 12/31/2025
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Ikarian Capital LLC 211,538 211,538 1,347,497.06 0.1806 25.2138 01/31/2026
2 Stonepine Capital Management LLC 93,460 93,460 595,340.2 0.244 11.1398 01/29/2026
3 Woodline Partners LP 79,582 79,582 506,937.34 0.0018 9.4856 12/31/2025
4 abrdn, Inc. 75,000 75,000 477,750 0.0042 8.9395 04/01/2026
5 Summittx Capital LP 64,795 64,795 412,744.15 0.0115 7.7231 12/31/2025
6 Boothbay Fund Management LLC 59,838 59,838 381,168.06 0.0089 7.1323 12/31/2025
7 Adar1 Capital Management LLC 58,230 58,230 370,925.1 0.0276 6.9406 12/31/2025
8 AIGH Capital Management LLC 51,000 51,000 324,870 0.0453 6.0788 03/31/2026
9 Soleus Capital Management LP (Investment Management) 25,000 25,000 159,250 0.0059 2.9798 12/31/2025
10 Millennium Management LLC 74,817 20,486 476,584.29 0.0003 8.9177 12/31/2025
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Resolute Capital Asset Partners LLC 30,000 -20,000 191,100 0.084 3.5758 12/31/2025

Data provided by FactSet Research Systems Inc.