| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Long Focus Capital Management LLC | 4,123,262 | -594,031 | 15,379,767.26 | 0.9052 | 4.099 | 09/30/2025 |
| 2 | The B Group, Inc. | 3,281,501 | 25,000 | 12,239,998.73 | 11.0475 | 3.2622 | 09/30/2025 |
| 3 | UBS Asset Management (Americas) LLC | 1,874,033 | 0 | 6,990,143.09 | 0.0043 | 1.863 | 12/31/2025 |
| 4 | UBS Asset Management Switzerland AG | 1,304,587 | 0 | 4,866,109.51 | 0.0013 | 1.2969 | 12/31/2025 |
| 5 | BlackRock Fund Advisors | 345,874 | 345,874 | 1,290,110.02 | 0 | 0.3438 | 12/31/2025 |
| 6 | Nomura Investment Management Business Trust | 226,875 | 0 | 846,243.75 | 0.0008 | 0.2255 | 09/30/2025 |
| 7 | Citadel Securities LLC | 221,959 | 221,959 | 827,907.07 | 0.0022 | 0.2207 | 09/30/2025 |
| 8 | Marshall Wace LLP | 178,473 | 178,473 | 665,704.29 | 0.0006 | 0.1774 | 12/31/2025 |
| 9 | Morgan Stanley & Co. International Plc | 84,837 | 11,643 | 316,442.01 | 0.0029 | 0.0843 | 12/31/2025 |
| 10 | LPL Financial LLC | 84,792 | -870 | 316,274.16 | 0.0001 | 0.0843 | 12/31/2025 |
| 11 | Millennium Management LLC | 57,740 | 22,080 | 215,370.2 | 0.0002 | 0.0574 | 09/30/2025 |
| 12 | UBS Securities LLC | 47,471 | 24,471 | 177,066.83 | 0.0001 | 0.0472 | 12/31/2025 |
| 13 | BNP Paribas Financial Markets | 41,300 | 0 | 154,049 | 0.0001 | 0.0411 | 12/31/2025 |
| 14 | Aperio Group LLC | 38,425 | 38,425 | 143,325.25 | 0.0001 | 0.0382 | 12/31/2025 |
| 15 | Susquehanna Financial Group LLLP | 33,780 | -653 | 125,999.4 | 0.0002 | 0.0336 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | CS Invt. Fds. 2 - (Lux) Digital Health Equity Fund | 1,304,587 | 0 | 4,866,109.51 | 0.719 | 1.2969 | 10/31/2025 |
| 2 | iShares Biotechnology ETF | 349,757 | 349,757 | 1,304,593.61 | 0.0153 | 0.3477 | 01/30/2026 |
| 3 | Nomura Healthcare Fund | 226,875 | 0 | 846,243.75 | 0.1188 | 0.2255 | 12/31/2025 |
| 4 | Galileo - Biotech Innovation Fund | 226,071 | 0 | 843,244.83 | 2.3859 | 0.2247 | 06/30/2025 |
| 5 | P & S Renditefonds | 15,000 | -15,000 | 55,950 | 0.1665 | 0.0149 | 11/28/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | BlackRock Fund Advisors | 345,874 | 345,874 | 1,290,110.02 | 0 | 0.3438 | 12/31/2025 |
| 2 | Citadel Securities LLC | 221,959 | 221,959 | 827,907.07 | 0.0022 | 0.2207 | 09/30/2025 |
| 3 | Marshall Wace LLP | 178,473 | 178,473 | 665,704.29 | 0.0006 | 0.1774 | 12/31/2025 |
| 4 | Aperio Group LLC | 38,425 | 38,425 | 143,325.25 | 0.0001 | 0.0382 | 12/31/2025 |
| 5 | Virtu Americas LLC | 25,211 | 25,211 | 94,037.03 | 0.0056 | 0.0251 | 09/30/2025 |
| 6 | The B Group, Inc. | 3,281,501 | 25,000 | 12,239,998.73 | 11.0475 | 3.2622 | 09/30/2025 |
| 7 | UBS Securities LLC | 47,471 | 24,471 | 177,066.83 | 0.0001 | 0.0472 | 12/31/2025 |
| 8 | Hemenway Trust Co. LLC | 24,000 | 24,000 | 89,520 | 0.0023 | 0.0239 | 09/30/2025 |
| 9 | Millennium Management LLC | 57,740 | 22,080 | 215,370.2 | 0.0002 | 0.0574 | 09/30/2025 |
| 10 | G1 Execution Services LLC | 20,085 | 20,085 | 74,917.05 | 0.0032 | 0.02 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Long Focus Capital Management LLC | 4,123,262 | -594,031 | 15,379,767.26 | 0.9052 | 4.099 | 09/30/2025 |
| 2 | Morgan Stanley Smith Barney LLC (Investment Management) | 2,336 | -17,265 | 8,713.28 | 0 | 0.0023 | 12/31/2025 |
| 3 | P&S Vermogensberatungs AG Performance & Sicherheit | 15,000 | -15,000 | 55,950 | 0.1845 | 0.0149 | 11/28/2025 |
| 4 | Wells Fargo Clearing Services LLC | 3,150 | -14,000 | 11,749.5 | 0 | 0.0031 | 12/31/2025 |
| 5 | Acadian Asset Management LLC | 0 | -11,747 | 0 | 0 | 0 | |
| 6 | First Affirmative Financial Network LLC | 10,149 | -9,636 | 37,855.77 | 0.017 | 0.0101 | 09/30/2025 |
| 7 | JPMorgan Securities LLC (Investment Management) | 0 | -1,777 | 0 | 0 | 0 | |
| 8 | Raymond James & Associates, Inc. (Invt Mgmt) | 0 | -1,132 | 0 | 0 | 0 | |
| 9 | LPL Financial LLC | 84,792 | -870 | 316,274.16 | 0.0001 | 0.0843 | 12/31/2025 |
| 10 | Susquehanna Financial Group LLLP | 33,780 | -653 | 125,999.4 | 0.0002 | 0.0336 | 09/30/2025 |
Data provided by FactSet Research Systems Inc.