| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Avoro Capital Advisor LLC | 11,430,455 | 622,375 | 454,360,586.25 | 4.207 | 8.5545 | 03/31/2026 |
| 2 | Adage Capital Management LP | 8,925,010 | -1,109,990 | 354,769,147.5 | 0.4834 | 6.6795 | 03/31/2026 |
| 3 | Pentwater Capital Management LP | 8,170,000 | 8,170,000 | 324,757,500 | 2.4509 | 6.1144 | 03/31/2026 |
| 4 | EcoR1 Capital, LLC | 6,000,000 | 5,450,000 | 238,500,000 | 8.6236 | 4.4904 | 03/31/2026 |
| 5 | Fidelity Management & Research Co. LLC | 5,825,876 | -413,967 | 231,578,571 | 0.0116 | 4.3601 | 03/31/2026 |
| 6 | Perceptive Advisors LLC | 5,258,903 | 2,158,001 | 209,041,394.25 | 3.776 | 3.9358 | 03/31/2026 |
| 7 | Capital Research & Management Co. (World Investors) | 4,832,548 | 4,147,743 | 192,093,783 | 0.0174 | 3.6167 | 03/31/2026 |
| 8 | Farallon Capital Management LLC | 4,809,000 | 477,682 | 191,157,750 | 1.0191 | 3.599 | 03/31/2026 |
| 9 | Morgan Stanley & Co. LLC | 4,242,768 | 3,219,163 | 168,650,028 | 0.0502 | 3.1753 | 03/31/2026 |
| 10 | Paradigm BioCapital Advisors LP | 3,574,048 | 3,574,048 | 142,068,408 | 3.1899 | 2.6748 | 03/31/2026 |
| 11 | Janus Henderson Investors US LLC | 3,352,143 | -1,930,867 | 133,247,684.25 | 0.0595 | 2.5087 | 03/31/2026 |
| 12 | Deep Track Capital LP | 3,158,041 | 3,158,041 | 125,532,129.75 | 2.1422 | 2.3635 | 03/31/2026 |
| 13 | Logos Global Management LP | 2,125,000 | 1,600,000 | 84,468,750 | 4.2402 | 1.5903 | 03/31/2026 |
| 14 | RTW Investments LP | 2,054,175 | -237,572 | 81,653,456.25 | 0.7848 | 1.5373 | 03/31/2026 |
| 15 | Federated Global Investment Management Corp. | 2,049,439 | 299,789 | 81,465,200.25 | 0.7064 | 1.5338 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | American Funds Small Cap World Fund | 4,422,431 | 3,737,626 | 175,791,632.25 | 0.1997 | 3.3097 | 03/31/2026 |
| 2 | Fidelity Select Port. - Biotechnology Portfolio | 2,147,694 | -254,600 | 85,370,836.5 | 1.6228 | 1.6073 | 03/31/2026 |
| 3 | Fidelity Select Port. - Health Care Portfolio | 1,650,000 | 370,000 | 65,587,500 | 1.1149 | 1.2349 | 03/31/2026 |
| 4 | Fidelity Contrafund | 1,321,353 | 1,321,353 | 52,523,781.75 | 0.0298 | 0.9889 | 03/31/2026 |
| 5 | Federated Hermes Kaufmann Fund | 1,236,100 | 350,700 | 49,134,975 | 1.0045 | 0.9251 | 03/31/2026 |
| 6 | Janus Henderson Triton Fund | 853,852 | -74,756 | 33,940,617 | 0.5844 | 0.639 | 03/31/2026 |
| 7 | Fidelity Advisor Health Care Fund | 850,000 | 180,000 | 33,787,500 | 1.1375 | 0.6361 | 03/31/2026 |
| 8 | Strategic Advisers Fidelity US Total Stock Fund | 800,000 | 300,000 | 31,800,000 | 0.0131 | 0.5987 | 03/31/2026 |
| 9 | Federated Hermes Kaufmann Small Cap Fund | 787,000 | -53,000 | 31,283,250 | 1.0278 | 0.589 | 03/31/2026 |
| 10 | Fidelity VIP - Mid Cap Portfolio | 702,200 | 0 | 27,912,450 | 0.3093 | 0.5255 | 03/31/2026 |
| 11 | Fidelity Small Cap Growth Fund | 525,560 | 28,300 | 20,891,010 | 0.2423 | 0.3933 | 02/28/2026 |
| 12 | American Century Small Cap Growth Fund | 520,609 | -343,550 | 20,694,207.75 | 0.394 | 0.3896 | 03/31/2026 |
| 13 | iShares Biotechnology ETF | 509,942 | 151,551 | 20,270,194.5 | 0.255 | 0.3816 | 04/30/2026 |
| 14 | Fidelity Contrafund Commingled Pool | 485,786 | 485,786 | 19,309,993.5 | 0.0296 | 0.3636 | 03/31/2026 |
| 15 | Fidelity US Equity Central Fund | 480,000 | 480,000 | 19,080,000 | 0.0847 | 0.3592 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Pentwater Capital Management LP | 8,170,000 | 8,170,000 | 324,757,500 | 2.4509 | 6.1144 | 03/31/2026 |
| 2 | EcoR1 Capital, LLC | 6,000,000 | 5,450,000 | 238,500,000 | 8.6236 | 4.4904 | 03/31/2026 |
| 3 | Capital Research & Management Co. (World Investors) | 4,832,548 | 4,147,743 | 192,093,783 | 0.0174 | 3.6167 | 03/31/2026 |
| 4 | Paradigm BioCapital Advisors LP | 3,574,048 | 3,574,048 | 142,068,408 | 3.1899 | 2.6748 | 03/31/2026 |
| 5 | Morgan Stanley & Co. LLC | 4,242,768 | 3,219,163 | 168,650,028 | 0.0502 | 3.1753 | 03/31/2026 |
| 6 | Deep Track Capital LP | 3,158,041 | 3,158,041 | 125,532,129.75 | 2.1422 | 2.3635 | 03/31/2026 |
| 7 | Perceptive Advisors LLC | 5,258,903 | 2,158,001 | 209,041,394.25 | 3.776 | 3.9358 | 03/31/2026 |
| 8 | Braidwell LP | 1,986,768 | 1,986,768 | 78,974,028 | 2.4883 | 1.4869 | 03/31/2026 |
| 9 | Maverick Capital Ltd. | 1,854,488 | 1,854,488 | 73,715,898 | 0.7314 | 1.3879 | 03/31/2026 |
| 10 | BofA Securities, Inc. | 1,788,438 | 1,783,759 | 71,090,410.5 | 0.0968 | 1.3385 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | T. Rowe Price Associates, Inc. (IM) | 0 | -4,804,056 | 0 | 0 | 0 | |
| 2 | Commodore Capital LP | 0 | -2,850,000 | 0 | 0 | 0 | |
| 3 | First Light Asset Management LLC | 1,560,991 | -2,074,825 | 62,049,392.25 | 4.9582 | 1.1682 | 03/31/2026 |
| 4 | Janus Henderson Investors US LLC | 3,352,143 | -1,930,867 | 133,247,684.25 | 0.0595 | 2.5087 | 03/31/2026 |
| 5 | Franklin Advisers, Inc. | 684,482 | -1,873,932 | 27,208,159.5 | 0.0118 | 0.5123 | 03/31/2026 |
| 6 | Adage Capital Management LP | 8,925,010 | -1,109,990 | 354,769,147.5 | 0.4834 | 6.6795 | 03/31/2026 |
| 7 | Cormorant Asset Management LP | 1,050,000 | -875,000 | 41,737,500 | 2.0451 | 0.7858 | 03/31/2026 |
| 8 | Point72 Asset Management LP | 307,355 | -772,000 | 12,217,361.25 | 0.0185 | 0.23 | 03/31/2026 |
| 9 | Saturn V Capital Management LP | 0 | -734,539 | 0 | 0 | 0 | |
| 10 | StemPoint Capital LP | 0 | -655,385 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.