| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Avoro Capital Advisor LLC | 14,555,555 | 9,555,555 | 371,021,096.95 | 3.7009 | 10.8933 | 12/31/2025 |
| 2 | Adage Capital Management LP | 11,281,741 | 2,878,741 | 287,571,578.09 | 0.4281 | 8.4432 | 12/31/2025 |
| 3 | Fidelity Management & Research Co. LLC | 8,059,493 | 4,233,299 | 205,436,476.57 | 0.0112 | 6.0317 | 12/31/2025 |
| 4 | Farallon Capital Management LLC | 5,377,068 | 847,750 | 137,061,463.32 | 0.8075 | 4.0242 | 12/31/2025 |
| 5 | Janus Henderson Investors US LLC | 3,964,005 | -2,453,461 | 101,042,487.45 | 0.0485 | 2.9667 | 12/31/2025 |
| 6 | T. Rowe Price Associates, Inc. (IM) | 3,927,343 | -1,980,649 | 100,107,973.07 | 0.0119 | 2.9392 | 12/31/2025 |
| 7 | EcoR1 Capital, LLC | 3,115,000 | 3,115,000 | 79,401,350 | 3.1524 | 2.3313 | 12/31/2025 |
| 8 | Perceptive Advisors LLC | 2,917,634 | 1,770,699 | 74,370,490.66 | 1.3445 | 2.1836 | 12/31/2025 |
| 9 | Franklin Advisers, Inc. | 2,368,381 | -175,158 | 60,370,031.69 | 0.0267 | 1.7725 | 12/31/2025 |
| 10 | Federated Global Investment Management Corp. | 2,342,139 | 2,342,139 | 59,701,123.11 | 0.5088 | 1.7529 | 12/31/2025 |
| 11 | First Light Asset Management LLC | 2,278,940 | -2,014,471 | 58,090,180.6 | 4.7084 | 1.7056 | 12/31/2025 |
| 12 | Braidwell LP | 2,188,320 | 2,188,320 | 55,780,276.8 | 1.8307 | 1.6377 | 12/31/2025 |
| 13 | Deep Track Capital LP | 2,000,000 | 1,500,000 | 50,980,000 | 1.0502 | 1.4968 | 12/31/2025 |
| 14 | Millennium Management LLC | 1,870,671 | 212,784 | 47,683,403.79 | 0.0339 | 1.4 | 12/31/2025 |
| 15 | RTW Investments LP | 1,790,837 | 261,001 | 45,648,435.13 | 0.4803 | 1.3403 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Fidelity Select Port. - Biotechnology Portfolio | 2,234,094 | -671,900 | 56,947,056.06 | 1.05 | 1.672 | 12/31/2025 |
| 2 | T Rowe Price Health Sciences Fund | 2,194,434 | -1,012,994 | 55,936,122.66 | 0.4637 | 1.6423 | 12/31/2025 |
| 3 | Fidelity Select Port. - Health Care Portfolio | 1,600,000 | 1,600,000 | 40,784,000 | 0.6463 | 1.1974 | 12/31/2025 |
| 4 | Federated Hermes Kaufmann Fund | 1,236,100 | 1,236,100 | 31,508,189 | 0.661 | 0.9251 | 12/31/2025 |
| 5 | American Funds Small Cap World Fund | 1,136,910 | 720,087 | 28,979,835.9 | 0.0337 | 0.8509 | 12/31/2025 |
| 6 | Federated Hermes Kaufmann Small Cap Fund | 1,079,700 | 1,079,700 | 27,521,553 | 0.907 | 0.808 | 12/31/2025 |
| 7 | FTIF SICAV - Biotechnology Discovery Fund | 1,062,994 | -113,820 | 27,095,717.06 | 1.4696 | 0.7955 | 11/30/2025 |
| 8 | Janus Henderson Triton Fund | 874,810 | -79,131 | 22,298,906.9 | 0.3859 | 0.6547 | 12/31/2025 |
| 9 | American Century Small Cap Growth Fund | 864,159 | -23,852 | 22,027,412.91 | 0.4352 | 0.6467 | 12/31/2025 |
| 10 | Fidelity Advisor Health Care Fund | 850,000 | 850,000 | 21,666,500 | 0.6599 | 0.6361 | 12/31/2025 |
| 11 | Strategic Advisers Fidelity US Total Stock Fund | 725,000 | 725,000 | 18,480,250 | 0.0089 | 0.5426 | 12/31/2025 |
| 12 | Fidelity VIP - Mid Cap Portfolio | 702,200 | 0 | 17,899,078 | 0.2055 | 0.5255 | 12/31/2025 |
| 13 | Franklin Biotechnology Discovery Fund | 614,165 | -64,800 | 15,655,065.85 | 1.4563 | 0.4596 | 11/30/2025 |
| 14 | Franklin Small Cap Growth Fund | 590,822 | -22,581 | 15,060,052.78 | 0.6142 | 0.4422 | 01/31/2026 |
| 15 | Fidelity Small Cap Growth Fund | 525,560 | 525,560 | 13,396,524.4 | 0.1681 | 0.3933 | 11/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Avoro Capital Advisor LLC | 14,555,555 | 9,555,555 | 371,021,096.95 | 3.7009 | 10.8933 | 12/31/2025 |
| 2 | Fidelity Management & Research Co. LLC | 8,059,493 | 4,233,299 | 205,436,476.57 | 0.0112 | 6.0317 | 12/31/2025 |
| 3 | EcoR1 Capital, LLC | 3,115,000 | 3,115,000 | 79,401,350 | 3.1524 | 2.3313 | 12/31/2025 |
| 4 | Adage Capital Management LP | 11,281,741 | 2,878,741 | 287,571,578.09 | 0.4281 | 8.4432 | 12/31/2025 |
| 5 | Federated Global Investment Management Corp. | 2,342,139 | 2,342,139 | 59,701,123.11 | 0.5088 | 1.7529 | 12/31/2025 |
| 6 | Braidwell LP | 2,188,320 | 2,188,320 | 55,780,276.8 | 1.8307 | 1.6377 | 12/31/2025 |
| 7 | Perceptive Advisors LLC | 2,917,634 | 1,770,699 | 74,370,490.66 | 1.3445 | 2.1836 | 12/31/2025 |
| 8 | Maverick Capital Ltd. | 1,643,724 | 1,643,724 | 41,898,524.76 | 0.4406 | 1.2302 | 12/31/2025 |
| 9 | Deep Track Capital LP | 2,000,000 | 1,500,000 | 50,980,000 | 1.0502 | 1.4968 | 12/31/2025 |
| 10 | Jain Global LLC | 915,803 | 915,803 | 23,343,818.47 | 0.2241 | 0.6854 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Point72 Asset Management LP | 0 | -2,591,596 | 0 | 0 | 0 | |
| 2 | Janus Henderson Investors US LLC | 3,964,005 | -2,453,461 | 101,042,487.45 | 0.0485 | 2.9667 | 12/31/2025 |
| 3 | Commodore Capital LP | 1,000,000 | -2,298,289 | 25,490,000 | 1.4727 | 0.7484 | 12/31/2025 |
| 4 | First Light Asset Management LLC | 2,278,940 | -2,014,471 | 58,090,180.6 | 4.7084 | 1.7056 | 12/31/2025 |
| 5 | T. Rowe Price Associates, Inc. (IM) | 3,927,343 | -1,980,649 | 100,107,973.07 | 0.0119 | 2.9392 | 12/31/2025 |
| 6 | Polar Capital LLP | 0 | -1,000,000 | 0 | 0 | 0 | |
| 7 | Cormorant Asset Management LP | 1,325,000 | -761,600 | 33,774,250 | 1.7565 | 0.9916 | 12/31/2025 |
| 8 | Balyasny Asset Management LP | 468,815 | -752,795 | 11,950,094.35 | 0.0222 | 0.3509 | 12/31/2025 |
| 9 | Morgan Stanley & Co. LLC | 997,069 | -632,744 | 25,415,288.81 | 0.009 | 0.7462 | 12/31/2025 |
| 10 | Tanager Wealth Management LLP | 0 | -598,044 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.