| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Avoro Capital Advisor LLC | 14,555,555 | 3,747,475 | 578,728,866.8 | 5.2627 | 10.8933 | 12/31/2025 |
| 2 | Adage Capital Management LP | 11,281,741 | 1,246,741 | 448,562,022.16 | 0.6659 | 8.4432 | 12/31/2025 |
| 3 | Fidelity Management & Research Co. LLC | 10,999,793 | 4,759,950 | 437,351,769.68 | 0.0239 | 8.2322 | 01/30/2026 |
| 4 | Farallon Capital Management LLC | 5,377,068 | 1,045,750 | 213,792,223.68 | 1.2563 | 4.0242 | 12/31/2025 |
| 5 | Janus Henderson Investors US LLC | 3,964,005 | -1,319,005 | 157,608,838.8 | 0.0762 | 2.9667 | 12/31/2025 |
| 6 | T. Rowe Price Associates, Inc. (IM) | 3,927,343 | -876,713 | 156,151,157.68 | 0.0187 | 2.9392 | 12/31/2025 |
| 7 | EcoR1 Capital, LLC | 3,115,000 | 2,565,000 | 123,852,400 | 4.8781 | 2.3313 | 12/31/2025 |
| 8 | Perceptive Advisors LLC | 2,917,634 | -183,268 | 116,005,127.84 | 1.959 | 2.1836 | 12/31/2025 |
| 9 | Franklin Advisers, Inc. | 2,368,381 | -190,033 | 94,166,828.56 | 0.0418 | 1.7725 | 12/31/2025 |
| 10 | Federated Global Investment Management Corp. | 2,342,139 | 592,489 | 93,123,446.64 | 0.8076 | 1.7529 | 12/31/2025 |
| 11 | First Light Asset Management LLC | 2,278,940 | -1,356,876 | 90,610,654.4 | 7.3365 | 1.7056 | 12/31/2025 |
| 12 | Braidwell LP | 2,188,320 | 2,188,320 | 87,007,603.2 | 2.6723 | 1.6377 | 12/31/2025 |
| 13 | Deep Track Capital LP | 2,000,000 | 2,000,000 | 79,520,000 | 1.6026 | 1.4968 | 12/31/2025 |
| 14 | Millennium Management LLC | 1,870,671 | 968,403 | 74,377,878.96 | 0.0531 | 1.4 | 12/31/2025 |
| 15 | RTW Investments LP | 1,790,837 | -500,910 | 71,203,679.12 | 0.71 | 1.3403 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | T Rowe Price Health Sciences Fund | 2,194,434 | -694,700 | 87,250,695.84 | 0.7672 | 1.6423 | 12/31/2025 |
| 2 | Fidelity Select Port. - Biotechnology Portfolio | 2,187,494 | -427,000 | 86,974,761.44 | 1.6399 | 1.6371 | 02/28/2026 |
| 3 | Fidelity Select Port. - Health Care Portfolio | 1,650,000 | 900,000 | 65,604,000 | 1.0984 | 1.2349 | 02/28/2026 |
| 4 | Federated Hermes Kaufmann Fund | 1,236,100 | 350,700 | 49,147,336 | 1.0626 | 0.9251 | 12/31/2025 |
| 5 | Fidelity Contrafund | 1,233,200 | 1,233,200 | 49,032,032 | 0.0292 | 0.9229 | 02/28/2026 |
| 6 | American Funds Small Cap World Fund | 1,136,910 | 452,105 | 45,203,541.6 | 0.0531 | 0.8509 | 12/31/2025 |
| 7 | Federated Hermes Kaufmann Small Cap Fund | 1,079,700 | 239,700 | 42,928,872 | 1.4344 | 0.808 | 12/31/2025 |
| 8 | FTIF SICAV - Biotechnology Discovery Fund | 1,062,994 | -113,820 | 42,264,641.44 | 2.2917 | 0.7955 | 02/28/2026 |
| 9 | Janus Henderson Triton Fund | 874,810 | -53,798 | 34,782,445.6 | 0.6038 | 0.6547 | 12/31/2025 |
| 10 | American Century Small Cap Growth Fund | 864,159 | 0 | 34,358,961.84 | 0.6838 | 0.6467 | 12/31/2025 |
| 11 | Fidelity Advisor Health Care Fund | 850,000 | 450,000 | 33,796,000 | 1.11 | 0.6361 | 02/28/2026 |
| 12 | Strategic Advisers Fidelity US Total Stock Fund | 800,000 | 800,000 | 31,808,000 | 0.0146 | 0.5987 | 02/28/2026 |
| 13 | Fidelity VIP - Mid Cap Portfolio | 702,200 | 0 | 27,919,472 | 0.3235 | 0.5255 | 02/28/2026 |
| 14 | Franklin Biotechnology Discovery Fund | 614,165 | -64,800 | 24,419,200.4 | 2.2945 | 0.4596 | 02/28/2026 |
| 15 | Franklin Small Cap Growth Fund | 590,822 | -22,581 | 23,491,082.72 | 0.9523 | 0.4422 | 02/28/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Fidelity Management & Research Co. LLC | 10,999,793 | 4,759,950 | 437,351,769.68 | 0.0239 | 8.2322 | 01/30/2026 |
| 2 | Avoro Capital Advisor LLC | 14,555,555 | 3,747,475 | 578,728,866.8 | 5.2627 | 10.8933 | 12/31/2025 |
| 3 | EcoR1 Capital, LLC | 3,115,000 | 2,565,000 | 123,852,400 | 4.8781 | 2.3313 | 12/31/2025 |
| 4 | Braidwell LP | 2,188,320 | 2,188,320 | 87,007,603.2 | 2.6723 | 1.6377 | 12/31/2025 |
| 5 | Deep Track Capital LP | 2,000,000 | 2,000,000 | 79,520,000 | 1.6026 | 1.4968 | 12/31/2025 |
| 6 | Maverick Capital Ltd. | 1,643,724 | 1,643,724 | 65,354,466.24 | 0.6965 | 1.2302 | 12/31/2025 |
| 7 | Adage Capital Management LP | 11,281,741 | 1,246,741 | 448,562,022.16 | 0.6659 | 8.4432 | 12/31/2025 |
| 8 | Farallon Capital Management LLC | 5,377,068 | 1,045,750 | 213,792,223.68 | 1.2563 | 4.0242 | 12/31/2025 |
| 9 | Millennium Management LLC | 1,870,671 | 968,403 | 74,377,878.96 | 0.0531 | 1.4 | 12/31/2025 |
| 10 | FIAM LLC | 902,446 | 865,046 | 35,881,252.96 | 0.0174 | 0.6754 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Commodore Capital LP | 1,000,000 | -1,850,000 | 39,760,000 | 1.8758 | 0.7484 | 12/31/2025 |
| 2 | First Light Asset Management LLC | 2,278,940 | -1,356,876 | 90,610,654.4 | 7.3365 | 1.7056 | 12/31/2025 |
| 3 | Janus Henderson Investors US LLC | 3,964,005 | -1,319,005 | 157,608,838.8 | 0.0762 | 2.9667 | 12/31/2025 |
| 4 | Point72 Asset Management LP | 0 | -1,079,355 | 0 | 0 | 0 | |
| 5 | T. Rowe Price Associates, Inc. (IM) | 3,927,343 | -876,713 | 156,151,157.68 | 0.0187 | 2.9392 | 12/31/2025 |
| 6 | Cormorant Asset Management LP | 1,325,000 | -600,000 | 52,682,000 | 2.8453 | 0.9916 | 12/31/2025 |
| 7 | Tanager Wealth Management LLP | 0 | -598,044 | 0 | 0 | 0 | |
| 8 | Ensign Peak Advisors, Inc. | 0 | -559,744 | 0 | 0 | 0 | |
| 9 | Driehaus Capital Management LLC | 0 | -515,979 | 0 | 0 | 0 | |
| 10 | Affinity Asset Advisors LLC | 600,552 | -506,610 | 23,877,947.52 | 1.4788 | 0.4495 | 12/31/2025 |
Data provided by FactSet Research Systems Inc.