# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Avoro Capital Advisor LLC 0 -14,555,555 0 0 0
2 Adage Capital Management LP 0 -11,281,741 0 0 0
3 Fidelity Management & Research Co. LLC 0 -10,999,793 0 0 0
4 Farallon Capital Management LLC 0 -5,377,068 0 0 0
5 Janus Henderson Investors US LLC 0 -3,964,005 0 0 0
6 T. Rowe Price Associates, Inc. (IM) 0 -3,927,343 0 0 0
7 EcoR1 Capital, LLC 0 -3,115,000 0 0 0
8 Perceptive Advisors LLC 0 -2,917,634 0 0 0
9 Franklin Advisers, Inc. 0 -2,368,381 0 0 0
10 Federated Global Investment Management Corp. 0 -2,342,139 0 0 0

Data provided by FactSet Research Systems Inc.