# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Sphera Funds Management Ltd. 179,425 -5,087 297,845.5 0.0395 3.4564 09/30/2025
2 Morgan Stanley & Co. LLC 90,065 -313,469 149,507.9 0 1.735 09/30/2025
3 Ikarian Capital LLC 53,262 -1 88,414.92 0.0139 1.026 09/30/2025
4 Stonepine Capital Management LLC 30,000 30,000 49,800 0.0208 0.5779 09/30/2025
5 Jane Street Capital LLC 21,511 16,369 35,708.26 0 0.4144 09/30/2025
6 RhumbLine Advisers LP 9,505 -464 15,778.3 0 0.1831 09/30/2025
7 BNP Paribas Financial Markets 5,750 2,275 9,545 0 0.1108 09/30/2025
8 GAMMA Investing LLC 2,514 -689 4,173.24 0.0002 0.0484 12/31/2025
9 UBS Securities LLC 99 0 164.34 0 0.0019 09/30/2025
10 SBI Securities Co., Ltd. 26 -2 43.16 0 0.0005 09/30/2025
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Stonepine Capital Management LLC 30,000 30,000 49,800 0.0208 0.5779 09/30/2025
2 Jane Street Capital LLC 21,511 16,369 35,708.26 0 0.4144 09/30/2025
3 BNP Paribas Financial Markets 5,750 2,275 9,545 0 0.1108 09/30/2025
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Morgan Stanley & Co. LLC 90,065 -313,469 149,507.9 0 1.735 09/30/2025
2 Yelin Lapidot Mutual Fund Management Ltd. 0 -144,573 0 0 0
3 Kestra Private Wealth Services LLC 0 -7,810 0 0 0
4 Boothbay Fund Management LLC 0 -6,547 0 0 0
5 Sphera Funds Management Ltd. 179,425 -5,087 297,845.5 0.0395 3.4564 09/30/2025
6 Ayalon Provident Funds Management Co. 0 -1,284 0 0 0
7 GAMMA Investing LLC 2,514 -689 4,173.24 0.0002 0.0484 12/31/2025
8 RhumbLine Advisers LP 9,505 -464 15,778.3 0 0.1831 09/30/2025
9 JPMorgan Securities LLC (Investment Management) 0 -295 0 0 0
10 SBI Securities Co., Ltd. 26 -2 43.16 0 0.0005 09/30/2025

Data provided by FactSet Research Systems Inc.