| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | RTW Investments LP | 8,757,390 | 50,000 | 83,895,796.2 | 0.8406 | 9.1279 | 12/31/2025 |
| 2 | Deep Track Capital LP | 7,334,323 | -525,325 | 70,262,814.34 | 1.4284 | 7.6446 | 12/31/2025 |
| 3 | GMT Capital Corp. | 2,844,618 | 0 | 27,251,440.44 | 0.7772 | 2.965 | 12/31/2025 |
| 4 | TD Asset Management, Inc. | 2,529,013 | 2,529,013 | 24,227,944.54 | 0.0115 | 2.636 | 12/31/2025 |
| 5 | ARK Investment Management LLC | 2,156,012 | 34,894 | 20,654,594.96 | 0.1326 | 2.2472 | 12/31/2025 |
| 6 | UBS Securities LLC | 1,676,546 | -160,303 | 16,061,310.68 | 0.0063 | 1.7475 | 12/31/2025 |
| 7 | Two Sigma Investments LP | 1,644,242 | 568,965 | 15,751,838.36 | 0.0225 | 1.7138 | 12/31/2025 |
| 8 | HSBC Global Asset Management (Switzerland) AG | 1,628,334 | 373,305 | 15,599,439.72 | 2.9418 | 1.6972 | 02/28/2026 |
| 9 | Jefferies Investment Advisers LLC | 1,576,905 | 200,000 | 15,106,749.9 | 0.1277 | 1.6436 | 12/31/2025 |
| 10 | Eagle Health Investments LP | 1,519,388 | 583,938 | 14,555,737.04 | 3.6033 | 1.5837 | 12/31/2025 |
| 11 | D. E. Shaw & Co. LP | 1,453,876 | 775,084 | 13,928,132.08 | 0.01 | 1.5154 | 12/31/2025 |
| 12 | Millennium Management LLC | 1,387,658 | -1,328,214 | 13,293,763.64 | 0.0092 | 1.4464 | 12/31/2025 |
| 13 | Aisling Capital Management LP | 1,198,418 | 0 | 11,480,844.44 | 2.4288 | 1.2491 | 12/31/2025 |
| 14 | Morgan Stanley & Co. LLC | 982,021 | 121,036 | 9,407,761.18 | 0.0032 | 1.0236 | 12/31/2025 |
| 15 | Renaissance Technologies LLC | 967,846 | 16,646 | 9,271,964.68 | 0.0135 | 1.0088 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | ARK Genomic Revolution ETF | 3,159,725 | 1,158,143 | 30,270,165.5 | 2.6196 | 3.2934 | 03/31/2026 |
| 2 | HSBC GIF - Global Equity Sustainable Healthcare | 1,628,334 | 373,305 | 15,599,439.72 | 2.8401 | 1.6972 | 02/28/2026 |
| 3 | 10XDNA - Disruptive Technologies | 822,442 | 605,201 | 7,878,994.36 | 11.6455 | 0.8572 | 02/27/2026 |
| 4 | iShares Biotechnology ETF | 612,150 | 235,040 | 5,864,397 | 0.0718 | 0.638 | 03/31/2026 |
| 5 | PGIM Jennison Health Sciences Fund | 610,510 | 610,510 | 5,848,685.8 | 0.427 | 0.6363 | 02/28/2026 |
| 6 | Columbia Small Cap Value Discovery Fund | 420,910 | 28,400 | 4,032,317.8 | 0.183 | 0.4387 | 03/31/2026 |
| 7 | Biotech Growth Trust Plc (The) | 393,400 | 393,400 | 3,768,772 | 0.9788 | 0.41 | 03/31/2026 |
| 8 | Nikko Asset Global All-Biogenome Equity Mother Fund | 254,048 | -1,784 | 2,433,779.84 | 1.5885 | 0.2648 | 12/08/2025 |
| 9 | Royce Smaller Companies Growth Fund | 249,000 | 249,000 | 2,385,420 | 1.2065 | 0.2595 | 03/31/2026 |
| 10 | AdvisorShares Psychedelics ETF | 246,739 | 14,394 | 2,363,759.62 | 10.049 | 0.2572 | 03/31/2026 |
| 11 | Simplify Propel Opportunities ETF | 159,052 | -130,948 | 1,523,718.16 | 22.4088 | 0.1658 | 03/31/2026 |
| 12 | ARK Genomic Revolution UCITS ETF | 147,590 | 89,993 | 1,413,912.2 | 2.7458 | 0.1538 | 03/31/2026 |
| 13 | CT Healthcare Trust plc | 142,049 | 142,049 | 1,360,829.42 | 0.8447 | 0.1481 | 11/30/2025 |
| 14 | 10XDNA - Small & Mid Cap Technologies | 139,134 | 87,086 | 1,332,903.72 | 11.9145 | 0.145 | 02/27/2026 |
| 15 | Royce Small Cap Trust | 133,000 | 133,000 | 1,274,140 | 0.0519 | 0.1386 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | TD Asset Management, Inc. | 2,529,013 | 2,529,013 | 24,227,944.54 | 0.0115 | 2.636 | 12/31/2025 |
| 2 | Point72 Asset Management LP | 844,816 | 844,816 | 8,093,337.28 | 0.0115 | 0.8806 | 12/31/2025 |
| 3 | D. E. Shaw & Co. LP | 1,453,876 | 775,084 | 13,928,132.08 | 0.01 | 1.5154 | 12/31/2025 |
| 4 | NEXTBio Capital Management LP | 752,631 | 752,631 | 7,210,204.98 | 3.5914 | 0.7845 | 12/31/2025 |
| 5 | Eagle Health Investments LP | 1,519,388 | 583,938 | 14,555,737.04 | 3.6033 | 1.5837 | 12/31/2025 |
| 6 | Two Sigma Investments LP | 1,644,242 | 568,965 | 15,751,838.36 | 0.0225 | 1.7138 | 12/31/2025 |
| 7 | HighVista Strategies LLC | 498,933 | 498,933 | 4,779,778.14 | 1.1352 | 0.52 | 12/31/2025 |
| 8 | Ikarian Capital LLC | 400,000 | 400,000 | 3,832,000 | 0.5105 | 0.4169 | 12/31/2025 |
| 9 | Squadron Capital Management LLC | 388,287 | 388,287 | 3,719,789.46 | 1.4943 | 0.4047 | 12/31/2025 |
| 10 | HSBC Global Asset Management (Switzerland) AG | 1,628,334 | 373,305 | 15,599,439.72 | 2.9418 | 1.6972 | 02/28/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Tang Capital Management LLC | 0 | -2,200,000 | 0 | 0 | 0 | |
| 2 | Millennium Management LLC | 1,387,658 | -1,328,214 | 13,293,763.64 | 0.0092 | 1.4464 | 12/31/2025 |
| 3 | Nantahala Capital Management LLC | 443,293 | -1,286,637 | 4,246,746.94 | 0.2488 | 0.462 | 12/31/2025 |
| 4 | HSBC Global Asset Management (France) SA | 0 | -1,255,029 | 0 | 0 | 0 | |
| 5 | Cowen Financial Products LLC | 0 | -1,000,000 | 0 | 0 | 0 | |
| 6 | PFM Health Sciences LP | 779,618 | -883,218 | 7,468,740.44 | 0.7748 | 0.8126 | 12/31/2025 |
| 7 | Columbia Management Investment Advisers LLC | 645,065 | -563,719 | 6,179,722.7 | 0.0014 | 0.6724 | 12/31/2025 |
| 8 | Deep Track Capital LP | 7,334,323 | -525,325 | 70,262,814.34 | 1.4284 | 7.6446 | 12/31/2025 |
| 9 | Balyasny Asset Management LP | 0 | -395,007 | 0 | 0 | 0 | |
| 10 | StemPoint Capital LP | 0 | -275,620 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.