| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Deep Track Capital LP | 12,161,496 | 0 | 141,438,198.48 | 2.287 | 12.676 | 06/30/2026 |
| 2 | RTW Investments LP | 10,700,974 | 68,584 | 124,452,327.62 | 1.158 | 11.1537 | 06/30/2026 |
| 3 | BIT Capital GmbH | 6,348,797 | 2,857,563 | 73,836,509.11 | 2.9781 | 6.6174 | 06/30/2026 |
| 4 | Tang Capital Management LLC | 5,000,000 | 997,800 | 58,150,000 | 2.7935 | 5.2115 | 06/30/2026 |
| 5 | Two Sigma Investments LP | 4,470,485 | 1,886,986 | 51,991,740.55 | 0.0398 | 4.6596 | 06/30/2026 |
| 6 | Marshall Wace LLP | 4,328,682 | 290,347 | 50,342,571.66 | 0.0421 | 4.5118 | 06/30/2026 |
| 7 | ARK Investment Management LLC | 3,451,965 | 150,915 | 40,146,352.95 | 0.2573 | 3.598 | 06/30/2026 |
| 8 | Point72 Asset Management LP | 2,620,878 | 2,620,878 | 30,480,811.14 | 0.0493 | 2.7318 | 06/30/2026 |
| 9 | Logos Global Management LP | 2,250,000 | 2,250,000 | 26,167,500 | 1.378 | 2.3452 | 06/30/2026 |
| 10 | Eagle Health Investments LP | 2,060,427 | 0 | 23,962,766.01 | 4.1556 | 2.1476 | 06/30/2026 |
| 11 | DAFNA Capital Management LLC | 2,011,952 | -406,930 | 23,399,001.76 | 5.0518 | 2.0971 | 06/30/2026 |
| 12 | Bank of America, NA (Private Banking) | 2,002,805 | 1,986,580 | 23,292,622.15 | 0.0061 | 2.0875 | 06/30/2026 |
| 13 | NEXTBio Capital Management LP | 1,775,759 | -245,648 | 20,652,077.17 | 10.3937 | 1.8509 | 06/30/2026 |
| 14 | UBS Securities LLC | 1,478,372 | -360,353 | 17,193,466.36 | 0.0065 | 1.5409 | 06/30/2026 |
| 15 | Aisling Capital Management LP | 1,432,336 | 0 | 16,658,067.68 | 4.2531 | 1.4929 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | ARK Genomic Revolution ETF | 4,524,716 | 1,364,991 | 52,622,447.08 | 2.6822 | 4.7161 | 09/30/2026 |
| 2 | BIT Global Technology Leaders | 1,743,832 | 1,743,832 | 20,280,766.16 | 1.3321 | 1.8176 | 06/30/2026 |
| 3 | iShares Biotechnology ETF | 893,399 | 281,249 | 10,390,230.37 | 0.0932 | 0.9312 | 09/30/2026 |
| 4 | AdvisorShares Psychedelics ETF | 482,715 | 235,976 | 5,613,975.45 | 11.5285 | 0.5031 | 09/30/2026 |
| 5 | 10XDNA - Disruptive Technologies | 446,295 | -480,965 | 5,190,410.85 | 7.3381 | 0.4652 | 08/31/2026 |
| 6 | Legal & General UCITS ETF Plc - Healthcare Breakthrough | 281,735 | 281,735 | 3,276,578.05 | 0.9237 | 0.2937 | 09/30/2026 |
| 7 | ARK Genomic Revolution UCITS ETF | 281,187 | 133,597 | 3,270,204.81 | 2.9988 | 0.2931 | 09/30/2026 |
| 8 | T. Rowe Price Integrated U.S. Small-Cap Growth Equity Fund | 269,000 | 269,000 | 3,128,470 | 0.0359 | 0.2804 | 09/30/2026 |
| 9 | BIT Aggressive Growth | 258,097 | 258,097 | 3,001,668.11 | 3.5643 | 0.269 | 04/30/2026 |
| 10 | Nikko Asset Global All-Biogenome Equity Mother Fund | 254,048 | 0 | 2,954,578.24 | 1.1924 | 0.2648 | 12/08/2025 |
| 11 | SEB Nordamerikafond Smabolag | 222,445 | 222,445 | 2,587,035.35 | 1.1302 | 0.2319 | 09/30/2026 |
| 12 | Vermoegen - Global | 200,000 | 0 | 2,326,000 | 5.3259 | 0.2085 | 03/31/2026 |
| 13 | ALPS Medical Breakthroughs ETF | 183,458 | 183,458 | 2,133,616.54 | 1.0797 | 0.1912 | 09/30/2026 |
| 14 | Royce Small Cap Growth Fund | 178,000 | -71,000 | 2,070,140 | 0.9252 | 0.1855 | 06/30/2026 |
| 15 | Premier Diversified Growth | 155,350 | 155,350 | 1,806,720.5 | 0.5759 | 0.1619 | 08/28/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | BIT Capital GmbH | 6,348,797 | 2,857,563 | 73,836,509.11 | 2.9781 | 6.6174 | 06/30/2026 |
| 2 | Point72 Asset Management LP | 2,620,878 | 2,620,878 | 30,480,811.14 | 0.0493 | 2.7318 | 06/30/2026 |
| 3 | Logos Global Management LP | 2,250,000 | 2,250,000 | 26,167,500 | 1.378 | 2.3452 | 06/30/2026 |
| 4 | Bank of America, NA (Private Banking) | 2,002,805 | 1,986,580 | 23,292,622.15 | 0.0061 | 2.0875 | 06/30/2026 |
| 5 | Two Sigma Investments LP | 4,470,485 | 1,886,986 | 51,991,740.55 | 0.0398 | 4.6596 | 06/30/2026 |
| 6 | Candriam Belgium SA | 1,274,278 | 1,274,278 | 14,819,853.14 | 0.0357 | 1.3282 | 06/30/2026 |
| 7 | Tang Capital Management LLC | 5,000,000 | 997,800 | 58,150,000 | 2.7935 | 5.2115 | 06/30/2026 |
| 8 | Woodline Partners LP | 1,086,004 | 910,565 | 12,630,226.52 | 0.0394 | 1.1319 | 06/30/2026 |
| 9 | Axxion SA (Luxembourg) | 844,354 | 844,354 | 9,819,837.02 | 0.4093 | 0.8801 | 09/30/2026 |
| 10 | Occam Crest Management LP | 710,000 | 710,000 | 8,257,300 | 4.7772 | 0.74 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | GMT Capital Corp. | 0 | -3,078,536 | 0 | 0 | 0 | |
| 2 | Millennium Management LLC | 770,987 | -2,367,535 | 8,966,578.81 | 0.0062 | 0.8036 | 06/30/2026 |
| 3 | Baker Bros. Advisors LP | 0 | -2,344,720 | 0 | 0 | 0 | |
| 4 | HSBC Global Asset Management (Switzerland) AG | 0 | -1,628,334 | 0 | 0 | 0 | |
| 5 | Sio Capital Management LLC | 0 | -1,506,525 | 0 | 0 | 0 | |
| 6 | Heights Capital Management, Inc. | 205,932 | -1,286,483 | 2,394,989.16 | 0.0469 | 0.2146 | 06/30/2026 |
| 7 | PFM Health Sciences LP | 247,589 | -1,119,510 | 2,879,460.07 | 0.2538 | 0.2581 | 06/30/2026 |
| 8 | Susquehanna Financial Group LLLP | 66,562 | -1,056,026 | 774,116.06 | 0.0007 | 0.0694 | 06/30/2026 |
| 9 | Alyeska Investment Group LP | 0 | -1,000,000 | 0 | 0 | 0 | |
| 10 | Caption Management LLC | 756,116 | -854,014 | 8,793,629.08 | 0.3239 | 0.7881 | 06/30/2026 |
Data provided by FactSet Research Systems Inc.