| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | RTW Investments LP | 8,707,390 | 3,169,222 | 43,014,506.6 | 0.4481 | 9.0758 | 09/30/2025 |
| 2 | Deep Track Capital LP | 7,859,648 | -1,000,000 | 38,826,661.12 | 0.7659 | 8.1921 | 09/30/2025 |
| 3 | GMT Capital Corp. | 2,844,618 | 1,062,900 | 14,052,412.92 | 0.4044 | 2.965 | 09/30/2025 |
| 4 | Millennium Management LLC | 2,715,872 | -57,649 | 13,416,407.68 | 0.0106 | 2.8308 | 09/30/2025 |
| 5 | Tang Capital Management LLC | 2,200,000 | 800,000 | 10,868,000 | 0.3426 | 2.2931 | 09/30/2025 |
| 6 | ARK Investment Management LLC | 2,121,118 | 316,315 | 10,478,322.92 | 0.0661 | 2.2109 | 09/30/2025 |
| 7 | UBS Securities LLC | 1,836,849 | 836,136 | 9,074,034.06 | 0.0037 | 1.9146 | 09/30/2025 |
| 8 | Nantahala Capital Management LLC | 1,729,930 | -1,099,302 | 8,545,854.2 | 0.4903 | 1.8031 | 09/30/2025 |
| 9 | PFM Health Sciences LP | 1,662,836 | 1,211,569 | 8,214,409.84 | 0.6107 | 1.7332 | 09/30/2025 |
| 10 | Jefferies Investment Advisers LLC | 1,376,905 | 1,376,905 | 6,801,910.7 | 0.0812 | 1.4352 | 09/30/2025 |
| 11 | HSBC Global Asset Management (France) SA | 1,255,029 | 1,255,029 | 6,199,843.26 | 0.0621 | 1.3081 | 09/30/2025 |
| 12 | HSBC Global Asset Management (Switzerland) AG | 1,255,029 | 1,255,029 | 6,199,843.26 | 1.1974 | 1.3081 | 10/31/2025 |
| 13 | Columbia Management Investment Advisers LLC | 1,208,784 | 1,208,784 | 5,971,392.96 | 0.0014 | 1.2599 | 09/30/2025 |
| 14 | Aisling Capital Management LP | 1,198,418 | 0 | 5,920,184.92 | 1.1043 | 1.2491 | 09/30/2025 |
| 15 | Two Sigma Investments LP | 1,075,277 | 908,026 | 5,311,868.38 | 0.0083 | 1.1208 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | ARK Genomic Revolution ETF | 2,157,864 | 575,566 | 10,659,848.16 | 0.8508 | 2.2492 | 10/31/2025 |
| 2 | HSBC GIF - Global Equity Sustainable Healthcare | 1,255,029 | 1,255,029 | 6,199,843.26 | 1.1633 | 1.3081 | 10/31/2025 |
| 3 | Columbia Small Cap Value Discovery Fund | 394,410 | 394,410 | 1,948,385.4 | 0.104 | 0.4111 | 10/31/2025 |
| 4 | iShares Biotechnology ETF | 378,026 | 3,129 | 1,867,448.44 | 0.0268 | 0.394 | 10/31/2025 |
| 5 | 10XDNA - Disruptive Technologies | 352,995 | 205,137 | 1,743,795.3 | 2.5468 | 0.3679 | 10/31/2025 |
| 6 | Simplify Propel Opportunities ETF | 290,000 | 290,000 | 1,432,600 | 1.9415 | 0.3023 | 10/31/2025 |
| 7 | Nikko Asset Global All-Biogenome Equity Mother Fund | 255,832 | 0 | 1,263,810.08 | 0.5679 | 0.2667 | 12/09/2024 |
| 8 | BIT Biotech Opportunities | 242,967 | 0 | 1,200,256.98 | 3.3033 | 0.2532 | 02/28/2025 |
| 9 | AdvisorShares Psychedelics ETF | 228,025 | 59,484 | 1,126,443.5 | 6.2592 | 0.2377 | 10/31/2025 |
| 10 | Columbia Variable Portfolio - Small Cap Value Fund | 90,150 | 90,150 | 445,341 | 0.1052 | 0.094 | 09/30/2025 |
| 11 | ARK Genomic Revolution UCITS ETF | 84,559 | 68,509 | 417,721.46 | 0.9483 | 0.0881 | 11/28/2025 |
| 12 | SPDR S&P International Small Cap ETF | 78,794 | 54,299 | 389,242.36 | 0.0503 | 0.0821 | 11/28/2025 |
| 13 | 10XDNA - Small & Mid Cap Technologies | 69,400 | 47,393 | 342,836 | 3.4629 | 0.0723 | 10/31/2025 |
| 14 | iShares IV Plc - NASDAQ US Biotechnology UCITS ETF | 63,846 | 34,507 | 315,399.24 | 0.0378 | 0.0665 | 11/28/2025 |
| 15 | Fidelity Nasdaq Composite Index Fund | 62,962 | 20,793 | 311,032.28 | 0.0013 | 0.0656 | 10/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | RTW Investments LP | 8,707,390 | 3,169,222 | 43,014,506.6 | 0.4481 | 9.0758 | 09/30/2025 |
| 2 | Jefferies Investment Advisers LLC | 1,376,905 | 1,376,905 | 6,801,910.7 | 0.0812 | 1.4352 | 09/30/2025 |
| 3 | HSBC Global Asset Management (France) SA | 1,255,029 | 1,255,029 | 6,199,843.26 | 0.0621 | 1.3081 | 09/30/2025 |
| 4 | HSBC Global Asset Management (Switzerland) AG | 1,255,029 | 1,255,029 | 6,199,843.26 | 1.1974 | 1.3081 | 10/31/2025 |
| 5 | PFM Health Sciences LP | 1,662,836 | 1,211,569 | 8,214,409.84 | 0.6107 | 1.7332 | 09/30/2025 |
| 6 | Columbia Management Investment Advisers LLC | 1,208,784 | 1,208,784 | 5,971,392.96 | 0.0014 | 1.2599 | 09/30/2025 |
| 7 | GMT Capital Corp. | 2,844,618 | 1,062,900 | 14,052,412.92 | 0.4044 | 2.965 | 09/30/2025 |
| 8 | Cowen Financial Products LLC | 1,000,000 | 1,000,000 | 4,940,000 | 0.539 | 1.0423 | 09/30/2025 |
| 9 | Eagle Health Investments LP | 935,450 | 935,450 | 4,621,123 | 0.9725 | 0.975 | 09/30/2025 |
| 10 | Two Sigma Investments LP | 1,075,277 | 908,026 | 5,311,868.38 | 0.0083 | 1.1208 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Logos Global Management LP | 0 | -2,000,000 | 0 | 0 | 0 | |
| 2 | Laurion Capital Management LP | 0 | -1,764,906 | 0 | 0 | 0 | |
| 3 | Woodline Partners LP | 0 | -1,754,856 | 0 | 0 | 0 | |
| 4 | Nantahala Capital Management LLC | 1,729,930 | -1,099,302 | 8,545,854.2 | 0.4903 | 1.8031 | 09/30/2025 |
| 5 | Deep Track Capital LP | 7,859,648 | -1,000,000 | 38,826,661.12 | 0.7659 | 8.1921 | 09/30/2025 |
| 6 | Rosalind Advisors, Inc. | 0 | -823,286 | 0 | 0 | 0 | |
| 7 | Driehaus Capital Management LLC | 0 | -701,754 | 0 | 0 | 0 | |
| 8 | Citadel Advisors LLC | 0 | -694,402 | 0 | 0 | 0 | |
| 9 | 22NW LP | 0 | -646,559 | 0 | 0 | 0 | |
| 10 | Barclays Bank Plc (Private Banking) | 79,767 | -335,369 | 394,048.98 | 0.0001 | 0.0831 | 09/30/2025 |
Data provided by FactSet Research Systems Inc.