| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Deep Track Capital LP | 8,831,007 | -28,641 | 54,928,863.54 | 1.0615 | 9.2046 | 06/30/2025 |
| 2 | RTW Investments LP | 8,221,929 | 2,683,761 | 51,140,398.38 | 0.5509 | 8.5698 | 06/30/2025 |
| 3 | Nantahala Capital Management LLC | 4,179,930 | 1,350,698 | 25,999,164.6 | 1.4012 | 4.3568 | 06/30/2025 |
| 4 | GMT Capital Corp. | 1,781,718 | 0 | 11,082,285.96 | 0.2995 | 1.8571 | 06/30/2025 |
| 5 | PFM Health Sciences LP | 1,779,259 | 1,327,992 | 11,066,990.98 | 0.9032 | 1.8545 | 06/30/2025 |
| 6 | Woodline Partners LP | 1,755,938 | 1,082 | 10,921,934.36 | 0.0534 | 1.8302 | 06/30/2025 |
| 7 | Millennium Management LLC | 1,741,782 | -1,031,739 | 10,833,884.04 | 0.0092 | 1.8155 | 06/30/2025 |
| 8 | ARK Investment Management LLC | 1,649,221 | -155,582 | 10,258,154.62 | 0.0614 | 1.719 | 06/30/2025 |
| 9 | UBS Securities LLC | 1,402,063 | 401,350 | 8,720,831.86 | 0.0037 | 1.4614 | 06/30/2025 |
| 10 | Tang Capital Management LLC | 1,300,000 | -100,000 | 8,086,000 | 0.3226 | 1.355 | 06/30/2025 |
| 11 | Aisling Capital Management LP | 1,198,418 | 0 | 7,454,159.96 | 1.5758 | 1.2491 | 06/30/2025 |
| 12 | HSBC Global Asset Management (France) SA | 1,075,485 | 1,075,485 | 6,689,516.7 | 0.0645 | 1.121 | 06/30/2025 |
| 13 | HSBC Global Asset Management (Switzerland) AG | 1,075,485 | 1,075,485 | 6,689,516.7 | 1.7038 | 1.121 | 08/31/2025 |
| 14 | 22NW LP | 882,844 | 236,285 | 5,491,289.68 | 2.5961 | 0.9202 | 06/30/2025 |
| 15 | Balyasny Asset Management LP | 854,840 | 235,345 | 5,317,104.8 | 0.0117 | 0.891 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | ARK Genomic Revolution ETF | 2,001,582 | 264,205 | 12,449,840.04 | 1.0518 | 2.0863 | 09/30/2025 |
| 2 | HSBC GIF - Global Equity Sustainable Healthcare | 1,075,485 | 1,075,485 | 6,689,516.7 | 1.6971 | 1.121 | 08/31/2025 |
| 3 | Columbia Small Cap Value Discovery Fund | 392,510 | 392,510 | 2,441,412.2 | 0.1396 | 0.4091 | 08/31/2025 |
| 4 | iShares Biotechnology ETF | 377,110 | -27,543 | 2,345,624.2 | 0.038 | 0.3931 | 09/30/2025 |
| 5 | Simplify Propel Opportunities ETF | 290,000 | 290,000 | 1,803,800 | 4.9762 | 0.3023 | 09/30/2025 |
| 6 | Nikko Asset Global All-Biogenome Equity Mother Fund | 255,832 | 0 | 1,591,275.04 | 0.7601 | 0.2667 | 12/09/2024 |
| 7 | BIT Biotech Opportunities | 242,967 | 0 | 1,511,254.74 | 4.2811 | 0.2532 | 02/28/2025 |
| 8 | AdvisorShares Psychedelics ETF | 232,345 | 91,804 | 1,445,185.9 | 8.2614 | 0.2422 | 09/30/2025 |
| 9 | 10XDNA - Disruptive Technologies | 213,709 | 80,851 | 1,329,269.98 | 1.8308 | 0.2227 | 08/29/2025 |
| 10 | SPDR S&P International Small Cap ETF | 80,036 | 55,541 | 497,823.92 | 0.0641 | 0.0834 | 09/30/2025 |
| 11 | Saba Capital Income & Opportunities Fund | 61,188 | 0 | 380,589.36 | 0.136 | 0.0638 | 07/31/2025 |
| 12 | ARK Genomic Revolution UCITS ETF | 57,597 | 43,324 | 358,253.34 | 1.1676 | 0.06 | 09/30/2025 |
| 13 | iShares IV Plc - NASDAQ US Biotechnology UCITS ETF | 54,061 | 23,331 | 336,259.42 | 0.0529 | 0.0563 | 09/30/2025 |
| 14 | ALPS Medical Breakthroughs ETF | 45,203 | -21,028 | 281,162.66 | 0.2892 | 0.0471 | 09/30/2025 |
| 15 | 10XDNA - Small & Mid Cap Technologies | 38,357 | 29,817 | 238,580.54 | 3.2307 | 0.04 | 08/29/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | RTW Investments LP | 8,221,929 | 2,683,761 | 51,140,398.38 | 0.5509 | 8.5698 | 06/30/2025 |
| 2 | Nantahala Capital Management LLC | 4,179,930 | 1,350,698 | 25,999,164.6 | 1.4012 | 4.3568 | 06/30/2025 |
| 3 | PFM Health Sciences LP | 1,779,259 | 1,327,992 | 11,066,990.98 | 0.9032 | 1.8545 | 06/30/2025 |
| 4 | HSBC Global Asset Management (France) SA | 1,075,485 | 1,075,485 | 6,689,516.7 | 0.0645 | 1.121 | 06/30/2025 |
| 5 | HSBC Global Asset Management (Switzerland) AG | 1,075,485 | 1,075,485 | 6,689,516.7 | 1.7038 | 1.121 | 08/31/2025 |
| 6 | Boothbay Fund Management LLC | 700,000 | 637,700 | 4,354,000 | 0.1228 | 0.7296 | 06/30/2025 |
| 7 | Schroder Investment Management North America, Inc. | 544,721 | 544,721 | 3,388,164.62 | 0.0036 | 0.5678 | 06/30/2025 |
| 8 | Cowen Financial Products LLC | 500,000 | 500,000 | 3,110,000 | 0.2818 | 0.5212 | 06/30/2025 |
| 9 | UBS Securities LLC | 1,402,063 | 401,350 | 8,720,831.86 | 0.0037 | 1.4614 | 06/30/2025 |
| 10 | Susquehanna Investment Group LLC | 471,840 | 398,613 | 2,934,844.8 | 0.0302 | 0.4918 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Logos Global Management LP | 0 | -2,000,000 | 0 | 0 | 0 | |
| 2 | Laurion Capital Management LP | 0 | -1,764,906 | 0 | 0 | 0 | |
| 3 | Millennium Management LLC | 1,741,782 | -1,031,739 | 10,833,884.04 | 0.0092 | 1.8155 | 06/30/2025 |
| 4 | Citadel Advisors LLC | 7,274 | -687,128 | 45,244.28 | 0.0001 | 0.0076 | 06/30/2025 |
| 5 | Driehaus Capital Management LLC | 236,686 | -465,068 | 1,472,186.92 | 0.0079 | 0.2467 | 06/30/2025 |
| 6 | Morgan Stanley & Co. LLC | 83,807 | -459,689 | 521,279.54 | 0.0002 | 0.0874 | 06/30/2025 |
| 7 | Rosalind Advisors, Inc. | 482,651 | -340,635 | 3,002,089.22 | 1.1121 | 0.5031 | 06/30/2025 |
| 8 | BIT Capital GmbH | 0 | -246,320 | 0 | 0 | 0 | |
| 9 | Acadian Asset Management LLC | 0 | -240,591 | 0 | 0 | 0 | |
| 10 | Polar Asset Management Partners, Inc. | 58,006 | -171,800 | 360,797.32 | 0.0092 | 0.0605 | 06/30/2025 |
Data provided by FactSet Research Systems Inc.