| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Ikarian Capital LLC | 5,388,486 | 5,388,486 | 10,776,972 | 1.7096 | 9.6704 | 03/31/2026 |
| 2 | Boothbay Fund Management LLC | 1,234,582 | 1,234,582 | 2,469,164 | 0.0509 | 2.2156 | 03/31/2026 |
| 3 | 683 Capital Management LLC | 900,000 | 900,000 | 1,800,000 | 0.1464 | 1.6152 | 03/31/2026 |
| 4 | Perceptive Advisors LLC | 792,696 | 792,696 | 1,585,392 | 0.0279 | 1.4226 | 03/31/2026 |
| 5 | Adar1 Capital Management LLC | 742,400 | 742,400 | 1,484,800 | 0.0854 | 1.3323 | 03/31/2026 |
| 6 | Richmond Brothers, Inc. | 476,584 | 476,584 | 953,168 | 0.5642 | 0.8553 | 03/31/2026 |
| 7 | Millennium Management LLC | 474,601 | 474,601 | 949,202 | 0.0006 | 0.8517 | 03/31/2026 |
| 8 | BML Capital Management LLC | 408,887 | -858,613 | 817,774 | 0.4748 | 0.7338 | 03/31/2026 |
| 9 | David M. Knott Partnership | 387,835 | 387,835 | 775,670 | 0.4027 | 0.696 | 03/31/2026 |
| 10 | Stonepine Capital Management LLC | 310,000 | 310,000 | 620,000 | 0.2814 | 0.5563 | 03/31/2026 |
| 11 | Susquehanna Financial Group LLLP | 278,808 | 278,808 | 557,616 | 0.0006 | 0.5004 | 03/31/2026 |
| 12 | Propel Bio Management LLC | 209,493 | 209,493 | 418,986 | 0.232 | 0.376 | 03/31/2026 |
| 13 | Diadema Partners LP | 200,690 | 200,690 | 401,380 | 0.1802 | 0.3602 | 03/31/2026 |
| 14 | Burkehill Global Management LP | 150,000 | 150,000 | 300,000 | 0.0118 | 0.2692 | 03/31/2026 |
| 15 | Renaissance Technologies LLC | 120,700 | -37,500 | 241,400 | 0.0003 | 0.2166 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Fidelity Nasdaq Composite Index Fund | 35,806 | 12,486 | 71,612 | 0.0003 | 0.0643 | 04/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Ikarian Capital LLC | 5,388,486 | 5,388,486 | 10,776,972 | 1.7096 | 9.6704 | 03/31/2026 |
| 2 | Boothbay Fund Management LLC | 1,234,582 | 1,234,582 | 2,469,164 | 0.0509 | 2.2156 | 03/31/2026 |
| 3 | 683 Capital Management LLC | 900,000 | 900,000 | 1,800,000 | 0.1464 | 1.6152 | 03/31/2026 |
| 4 | Perceptive Advisors LLC | 792,696 | 792,696 | 1,585,392 | 0.0279 | 1.4226 | 03/31/2026 |
| 5 | Adar1 Capital Management LLC | 742,400 | 742,400 | 1,484,800 | 0.0854 | 1.3323 | 03/31/2026 |
| 6 | Richmond Brothers, Inc. | 476,584 | 476,584 | 953,168 | 0.5642 | 0.8553 | 03/31/2026 |
| 7 | Millennium Management LLC | 474,601 | 474,601 | 949,202 | 0.0006 | 0.8517 | 03/31/2026 |
| 8 | David M. Knott Partnership | 387,835 | 387,835 | 775,670 | 0.4027 | 0.696 | 03/31/2026 |
| 9 | Stonepine Capital Management LLC | 310,000 | 310,000 | 620,000 | 0.2814 | 0.5563 | 03/31/2026 |
| 10 | Susquehanna Financial Group LLLP | 278,808 | 278,808 | 557,616 | 0.0006 | 0.5004 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | BML Capital Management LLC | 408,887 | -858,613 | 817,774 | 0.4748 | 0.7338 | 03/31/2026 |
| 2 | Renaissance Technologies LLC | 120,700 | -37,500 | 241,400 | 0.0003 | 0.2166 | 03/31/2026 |
| 3 | G1 Execution Services LLC | 0 | -13,748 | 0 | 0 | 0 | |
| 4 | Citigroup Global Markets, Inc. (Investment Management) | 1 | -4,213 | 2 | 0 | 0 | 03/31/2026 |
| 5 | EverSource Wealth Advisors LLC | 1,247 | -335 | 2,494 | 0.0001 | 0.0022 | 03/31/2026 |
| 6 | UBS Securities LLC | 33 | -168 | 66 | 0 | 0.0001 | 03/31/2026 |
| 7 | SBI Securities Co., Ltd. | 6 | -1 | 12 | 0 | 0 | 03/31/2026 |
Data provided by FactSet Research Systems Inc.