| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Citadel Advisors LLC | 9,158,677 | 0 | 97,539,910.05 | 0.0723 | 14.5658 | 04/07/2025 |
| 2 | RA Capital Management LP | 3,657,644 | 3,657,644 | 38,953,908.6 | 0.3771 | 5.8171 | 07/30/2026 |
| 3 | Perceptive Advisors LLC | 1,653,350 | 688,959 | 17,608,177.5 | 0.3068 | 2.6295 | 06/30/2026 |
| 4 | Baker Bros. Advisors LP | 1,461,425 | 0 | 15,564,176.25 | 0.0548 | 2.3242 | 06/30/2026 |
| 5 | Artisan Partners LP | 1,372,851 | -846,535 | 14,620,863.15 | 0.0119 | 2.1834 | 06/30/2026 |
| 6 | UBS Securities LLC | 1,307,194 | 1,232,663 | 13,921,616.1 | 0.0052 | 2.0789 | 06/30/2026 |
| 7 | Logos Global Management LP | 915,000 | 915,000 | 9,744,750 | 0.5021 | 1.4552 | 06/30/2026 |
| 8 | Morgan Stanley & Co. LLC | 895,380 | 895,380 | 9,535,797 | 0.0028 | 1.424 | 06/30/2026 |
| 9 | Octagon Capital Advisors LP | 574,200 | 0 | 6,115,230 | 0.7701 | 0.9132 | 06/30/2026 |
| 10 | Adar1 Capital Management LLC | 528,295 | -484,571 | 5,626,341.75 | 0.3007 | 0.8402 | 06/30/2026 |
| 11 | Ikarian Capital LLC | 525,000 | 0 | 5,591,250 | 1.0203 | 0.835 | 06/30/2026 |
| 12 | Redmile Group LLC | 410,440 | -80,900 | 4,371,186 | 0.2842 | 0.6528 | 06/30/2026 |
| 13 | Columbia Management Investment Advisers LLC | 378,068 | 147,080 | 4,026,424.2 | 0.0008 | 0.6013 | 06/30/2026 |
| 14 | Millennium Management LLC | 267,783 | -51,176 | 2,851,888.95 | 0.002 | 0.4259 | 06/30/2026 |
| 15 | Elmind Capital LP | 265,000 | 0 | 2,822,250 | 0.8034 | 0.4215 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Artisan International Small-Mid Fund | 1,117,811 | -245,378 | 11,904,687.15 | 0.447 | 1.7778 | 09/30/2026 |
| 2 | Fidelity Advisor Series VII - Biotechnology Fund | 428,800 | 428,800 | 4,566,720 | 0.1912 | 0.682 | 08/31/2026 |
| 3 | DWS ESG Biotech | 59,240 | 59,240 | 630,906 | 0.1568 | 0.0942 | 08/31/2026 |
| 4 | Russell Investment Co. - US Small Cap Equity Fund | 22,707 | 0 | 241,829.55 | 0.0256 | 0.0361 | 08/31/2026 |
| 5 | Artisan Multiple Invt. Tr. - International Small-Mid Tr. | 13,306 | -3,458 | 141,708.9 | 0.4554 | 0.0212 | 09/30/2026 |
| 6 | China Universal Global Healthcare Mixed Fund | 8,000 | 8,000 | 85,200 | 0.1003 | 0.0127 | 06/30/2026 |
| 7 | ActivePassive International Equity ETF | 6,265 | 6,265 | 66,722.25 | 0.0059 | 0.01 | 09/30/2026 |
| 8 | Russell Investment Funds - Investment US Small Cap Equity Fund | 5,834 | 0 | 62,132.1 | 0.027 | 0.0093 | 06/30/2026 |
| 9 | Steward Values Enhanced International Fund | 4,051 | 0 | 43,143.15 | 0.0125 | 0.0064 | 09/30/2026 |
| 10 | Lord Abbett Health Care Fund | 2,973 | 2,973 | 31,662.45 | 0.3518 | 0.0047 | 07/31/2026 |
| 11 | Fidelity Nasdaq Composite Index Fund | 1,509 | -7,388 | 16,070.85 | 0.0001 | 0.0024 | 08/31/2026 |
| 12 | Gabelli Healthcare & Wellness Trust | 400 | -400 | 4,260 | 0.0051 | 0.0006 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | RA Capital Management LP | 3,657,644 | 3,657,644 | 38,953,908.6 | 0.3771 | 5.8171 | 07/30/2026 |
| 2 | UBS Securities LLC | 1,307,194 | 1,232,663 | 13,921,616.1 | 0.0052 | 2.0789 | 06/30/2026 |
| 3 | Logos Global Management LP | 915,000 | 915,000 | 9,744,750 | 0.5021 | 1.4552 | 06/30/2026 |
| 4 | Morgan Stanley & Co. LLC | 895,380 | 895,380 | 9,535,797 | 0.0028 | 1.424 | 06/30/2026 |
| 5 | Perceptive Advisors LLC | 1,653,350 | 688,959 | 17,608,177.5 | 0.3068 | 2.6295 | 06/30/2026 |
| 6 | Jane Street Capital LLC | 223,915 | 212,630 | 2,384,694.75 | 0.0014 | 0.3561 | 06/30/2026 |
| 7 | Great Point Partners LLC | 156,906 | 156,906 | 1,671,048.9 | 0.44 | 0.2495 | 06/30/2026 |
| 8 | Columbia Management Investment Advisers LLC | 378,068 | 147,080 | 4,026,424.2 | 0.0008 | 0.6013 | 06/30/2026 |
| 9 | HRT Financial LP | 151,197 | 127,112 | 1,610,248.05 | 0.0042 | 0.2405 | 06/30/2026 |
| 10 | Ishara Investments LP | 184,500 | 82,000 | 1,964,925 | 1.801 | 0.2934 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Artisan Partners LP | 1,372,851 | -846,535 | 14,620,863.15 | 0.0119 | 2.1834 | 06/30/2026 |
| 2 | Adar1 Capital Management LLC | 528,295 | -484,571 | 5,626,341.75 | 0.3007 | 0.8402 | 06/30/2026 |
| 3 | Atika Capital Management LLC | 0 | -271,300 | 0 | 0 | 0 | |
| 4 | Balyasny Asset Management LP | 0 | -233,429 | 0 | 0 | 0 | |
| 5 | Morgan Stanley & Co. International Plc | 59,134 | -86,588 | 629,777.1 | 0.0045 | 0.094 | 06/30/2026 |
| 6 | Redmile Group LLC | 410,440 | -80,900 | 4,371,186 | 0.2842 | 0.6528 | 06/30/2026 |
| 7 | Diversify Wealth Management LLC | 0 | -63,672 | 0 | 0 | 0 | |
| 8 | Millennium Management LLC | 267,783 | -51,176 | 2,851,888.95 | 0.002 | 0.4259 | 06/30/2026 |
| 9 | New York State Common Retirement Fund (Invt Mgmt) | 119,335 | -48,845 | 1,270,917.75 | 0.0015 | 0.1898 | 06/30/2026 |
| 10 | Russell Investment Management LLC | 84,196 | -44,364 | 896,687.4 | 0.0007 | 0.1339 | 06/30/2026 |
Data provided by FactSet Research Systems Inc.