| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Citadel Advisors LLC | 9,158,677 | 0 | 203,963,736.79 | 0.198 | 22.808 | 04/07/2025 |
| 2 | Artisan Partners LP | 3,309,055 | 3,309,055 | 73,692,654.85 | 0.0566 | 8.2406 | 12/31/2025 |
| 3 | Baker Bros. Advisors LP | 1,461,425 | 0 | 32,545,934.75 | 0.1618 | 3.6394 | 01/12/2026 |
| 4 | Millennium Management LLC | 640,885 | 372,871 | 14,272,508.95 | 0.01 | 1.596 | 12/31/2025 |
| 5 | Yiheng Capital Management LP | 639,769 | -16,540 | 14,247,655.63 | 3.7323 | 1.5932 | 12/31/2025 |
| 6 | Octagon Capital Advisors LP | 574,200 | -443,821 | 12,787,434 | 1.4489 | 1.4299 | 12/31/2025 |
| 7 | Redmile Group LLC | 549,840 | 549,840 | 12,244,936.8 | 0.7643 | 1.3693 | 12/31/2025 |
| 8 | Ikarian Capital LLC | 525,000 | 525,000 | 11,691,750 | 1.5289 | 1.3074 | 12/31/2025 |
| 9 | Schonfeld Strategic Advisors LLC | 454,343 | 454,343 | 10,118,218.61 | 0.0503 | 1.1315 | 12/31/2025 |
| 10 | Vestal Point Capital LP | 300,000 | 300,000 | 6,681,000 | 0.228 | 0.7471 | 12/31/2025 |
| 11 | UBS Securities LLC | 244,862 | 80,662 | 5,453,076.74 | 0.0022 | 0.6098 | 12/31/2025 |
| 12 | Squadron Capital Management LLC | 240,000 | 240,000 | 5,344,800 | 2.4176 | 0.5977 | 12/31/2025 |
| 13 | Balyasny Asset Management LP | 235,023 | 235,023 | 5,233,962.21 | 0.0096 | 0.5853 | 12/31/2025 |
| 14 | New York State Common Retirement Fund | 223,186 | 223,186 | 4,970,352.22 | 0.0064 | 0.5558 | 12/31/2025 |
| 15 | Atika Capital Management LLC | 206,881 | 206,881 | 4,607,239.87 | 0.5897 | 0.5152 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Artisan International Small-Mid Fund | 2,024,525 | 2,024,525 | 45,086,171.75 | 1.5185 | 5.0417 | 12/31/2025 |
| 2 | Artisan Multiple Invt. Tr. - International Small-Mid Tr. | 66,341 | 66,341 | 1,477,414.07 | 1.4129 | 0.1652 | 12/31/2025 |
| 3 | AdvisorShares Dorsey Wright ADR ETF | 48,500 | 48,500 | 1,080,095 | 2.1007 | 0.1208 | 01/30/2026 |
| 4 | Fidelity Nasdaq Composite Index Fund | 3,877 | 0 | 86,340.79 | 0.0004 | 0.0097 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Artisan Partners LP | 3,309,055 | 3,309,055 | 73,692,654.85 | 0.0566 | 8.2406 | 12/31/2025 |
| 2 | Redmile Group LLC | 549,840 | 549,840 | 12,244,936.8 | 0.7643 | 1.3693 | 12/31/2025 |
| 3 | Ikarian Capital LLC | 525,000 | 525,000 | 11,691,750 | 1.5289 | 1.3074 | 12/31/2025 |
| 4 | Schonfeld Strategic Advisors LLC | 454,343 | 454,343 | 10,118,218.61 | 0.0503 | 1.1315 | 12/31/2025 |
| 5 | Millennium Management LLC | 640,885 | 372,871 | 14,272,508.95 | 0.01 | 1.596 | 12/31/2025 |
| 6 | Vestal Point Capital LP | 300,000 | 300,000 | 6,681,000 | 0.228 | 0.7471 | 12/31/2025 |
| 7 | Squadron Capital Management LLC | 240,000 | 240,000 | 5,344,800 | 2.4176 | 0.5977 | 12/31/2025 |
| 8 | Balyasny Asset Management LP | 235,023 | 235,023 | 5,233,962.21 | 0.0096 | 0.5853 | 12/31/2025 |
| 9 | New York State Common Retirement Fund | 223,186 | 223,186 | 4,970,352.22 | 0.0064 | 0.5558 | 12/31/2025 |
| 10 | Atika Capital Management LLC | 206,881 | 206,881 | 4,607,239.87 | 0.5897 | 0.5152 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Adage Capital Management LP | 0 | -1,054,506 | 0 | 0 | 0 | |
| 2 | Octagon Capital Advisors LP | 574,200 | -443,821 | 12,787,434 | 1.4489 | 1.4299 | 12/31/2025 |
| 3 | Great Point Partners LLC | 0 | -374,679 | 0 | 0 | 0 | |
| 4 | MYDA Advisors LLC | 0 | -30,220 | 0 | 0 | 0 | |
| 5 | Point72 Asset Management LP | 0 | -17,000 | 0 | 0 | 0 | |
| 6 | Yiheng Capital Management LP | 639,769 | -16,540 | 14,247,655.63 | 3.7323 | 1.5932 | 12/31/2025 |
| 7 | Barclays Bank Plc (Private Banking) | 0 | -6,611 | 0 | 0 | 0 | |
| 8 | Steward Partners Investment Advisory LLC | 0 | -1,518 | 0 | 0 | 0 | |
| 9 | Raymond James Financial Services Advisors, Inc. | 0 | -666 | 0 | 0 | 0 | |
| 10 | Desjardins Securities, Inc. | 145 | -280 | 3,229.15 | 0 | 0.0004 | 12/31/2025 |
Data provided by FactSet Research Systems Inc.