| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Citadel Advisors LLC | 9,158,677 | 0 | 181,982,911.99 | 0.1733 | 16.4516 | 04/07/2025 |
| 2 | Artisan Partners LP | 3,309,055 | 332,155 | 65,750,922.85 | 0.0507 | 5.944 | 12/31/2025 |
| 3 | Baker Bros. Advisors LP | 1,461,425 | 0 | 29,038,514.75 | 0.1415 | 2.6251 | 01/12/2026 |
| 4 | Millennium Management LLC | 640,885 | 303,022 | 12,734,384.95 | 0.0088 | 1.1512 | 12/31/2025 |
| 5 | Yiheng Capital Management LP | 639,769 | -16,540 | 12,712,210.03 | 3.6588 | 1.1492 | 12/31/2025 |
| 6 | Octagon Capital Advisors LP | 574,200 | -443,821 | 11,409,354 | 1.1768 | 1.0314 | 12/31/2025 |
| 7 | Redmile Group LLC | 549,840 | 549,840 | 10,925,320.8 | 0.7017 | 0.9877 | 12/31/2025 |
| 8 | Ikarian Capital LLC | 525,000 | 525,000 | 10,431,750 | 1.416 | 0.9431 | 12/31/2025 |
| 9 | Schonfeld Strategic Advisors LLC | 454,343 | 454,343 | 9,027,795.41 | 0.0429 | 0.8161 | 12/31/2025 |
| 10 | Vestal Point Capital LP | 300,000 | 300,000 | 5,961,000 | 0.191 | 0.5389 | 12/31/2025 |
| 11 | UBS Securities LLC | 244,862 | 244,714 | 4,865,407.94 | 0.0019 | 0.4398 | 12/31/2025 |
| 12 | Squadron Capital Management LLC | 240,000 | 240,000 | 4,768,800 | 1.8273 | 0.4311 | 12/31/2025 |
| 13 | Balyasny Asset Management LP | 235,023 | 235,023 | 4,669,907.01 | 0.0088 | 0.4222 | 12/31/2025 |
| 14 | New York State Common Retirement Fund | 223,186 | 219,766 | 4,434,705.82 | 0.0055 | 0.4009 | 12/31/2025 |
| 15 | Atika Capital Management LLC | 206,881 | 206,881 | 4,110,725.47 | 0.4619 | 0.3716 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Artisan International Small-Mid Fund | 1,363,189 | 1,331,421 | 27,086,565.43 | 0.9663 | 2.4487 | 03/31/2026 |
| 2 | AdvisorShares Dorsey Wright ADR ETF | 46,255 | 46,255 | 919,086.85 | 2.0399 | 0.0831 | 04/30/2026 |
| 3 | Artisan Multiple Invt. Tr. - International Small-Mid Tr. | 16,764 | 15,730 | 333,100.68 | 0.9536 | 0.0301 | 03/31/2026 |
| 4 | Steward Values Enhanced International Fund | 4,051 | 4,051 | 80,493.37 | 0.0266 | 0.0073 | 03/31/2026 |
| 5 | Fidelity Nasdaq Composite Index Fund | 3,877 | 0 | 77,035.99 | 0.0003 | 0.007 | 02/28/2026 |
| 6 | Gabelli Healthcare & Wellness Trust | 500 | 500 | 9,935 | 0.019 | 0.0009 | 12/31/2025 |
| 7 | ActivePassive International Equity ETF | 10 | 10 | 198.7 | 0 | 0 | 04/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Redmile Group LLC | 549,840 | 549,840 | 10,925,320.8 | 0.7017 | 0.9877 | 12/31/2025 |
| 2 | Ikarian Capital LLC | 525,000 | 525,000 | 10,431,750 | 1.416 | 0.9431 | 12/31/2025 |
| 3 | Schonfeld Strategic Advisors LLC | 454,343 | 454,343 | 9,027,795.41 | 0.0429 | 0.8161 | 12/31/2025 |
| 4 | Artisan Partners LP | 3,309,055 | 332,155 | 65,750,922.85 | 0.0507 | 5.944 | 12/31/2025 |
| 5 | Millennium Management LLC | 640,885 | 303,022 | 12,734,384.95 | 0.0088 | 1.1512 | 12/31/2025 |
| 6 | Vestal Point Capital LP | 300,000 | 300,000 | 5,961,000 | 0.191 | 0.5389 | 12/31/2025 |
| 7 | UBS Securities LLC | 244,862 | 244,714 | 4,865,407.94 | 0.0019 | 0.4398 | 12/31/2025 |
| 8 | Squadron Capital Management LLC | 240,000 | 240,000 | 4,768,800 | 1.8273 | 0.4311 | 12/31/2025 |
| 9 | Balyasny Asset Management LP | 235,023 | 235,023 | 4,669,907.01 | 0.0088 | 0.4222 | 12/31/2025 |
| 10 | New York State Common Retirement Fund | 223,186 | 219,766 | 4,434,705.82 | 0.0055 | 0.4009 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Octagon Capital Advisors LP | 574,200 | -443,821 | 11,409,354 | 1.1768 | 1.0314 | 12/31/2025 |
| 2 | Great Point Partners LLC | 0 | -378,594 | 0 | 0 | 0 | |
| 3 | Adage Capital Management LP | 0 | -345,934 | 0 | 0 | 0 | |
| 4 | Barclays Bank Plc (Private Banking) | 0 | -30,005 | 0 | 0 | 0 | |
| 5 | DLD Asset Management LP | 0 | -25,000 | 0 | 0 | 0 | |
| 6 | Yiheng Capital Management LP | 639,769 | -16,540 | 12,712,210.03 | 3.6588 | 1.1492 | 12/31/2025 |
| 7 | TD Securities (USA) LLC | 0 | -320 | 0 | 0 | 0 | |
| 8 | Advisory Services Network LLC | 0 | -130 | 0 | 0 | 0 | |
| 9 | Principal Securities, Inc. | 0 | -8 | 0 | 0 | 0 | |
| 10 | Desjardins Securities, Inc. | 145 | -5 | 2,881.15 | 0 | 0.0003 | 12/31/2025 |
Data provided by FactSet Research Systems Inc.