| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | RA Capital Management LP | 3,657,644 | 3,657,644 | 36,356,981.36 | 0.3411 | 5.8171 | 07/30/2026 |
| 2 | Perceptive Advisors LLC | 1,653,350 | 688,959 | 16,434,299 | 0.2872 | 2.6295 | 06/30/2026 |
| 3 | Baker Bros. Advisors LP | 1,461,425 | 0 | 14,526,564.5 | 0.0501 | 2.3242 | 06/30/2026 |
| 4 | Artisan Partners LP | 1,372,851 | -846,535 | 13,646,138.94 | 0.0108 | 2.1834 | 06/30/2026 |
| 5 | UBS Securities LLC | 1,307,194 | 1,232,663 | 12,993,508.36 | 0.0049 | 2.0789 | 06/30/2026 |
| 6 | Logos Global Management LP | 915,000 | 915,000 | 9,095,100 | 0.4641 | 1.4552 | 06/30/2026 |
| 7 | Morgan Stanley & Co. LLC | 895,380 | 895,380 | 8,900,077.2 | 0.0026 | 1.424 | 06/30/2026 |
| 8 | Octagon Capital Advisors LP | 574,200 | 0 | 5,707,548 | 0.7249 | 0.9132 | 06/30/2026 |
| 9 | Adar1 Capital Management LLC | 528,295 | -484,571 | 5,251,252.3 | 0.2809 | 0.8402 | 06/30/2026 |
| 10 | Ikarian Capital LLC | 525,000 | 0 | 5,218,500 | 0.9545 | 0.835 | 06/30/2026 |
| 11 | Redmile Group LLC | 410,440 | -80,900 | 4,079,773.6 | 0.2776 | 0.6528 | 06/30/2026 |
| 12 | Columbia Management Investment Advisers LLC | 378,068 | 147,080 | 3,757,995.92 | 0.0008 | 0.6013 | 06/30/2026 |
| 13 | Millennium Management LLC | 267,783 | -51,176 | 2,661,763.02 | 0.0018 | 0.4259 | 06/30/2026 |
| 14 | Elmind Capital LP | 265,000 | 0 | 2,634,100 | 0.7702 | 0.4215 | 06/30/2026 |
| 15 | Jane Street Capital LLC | 223,915 | 212,630 | 2,225,715.1 | 0.0014 | 0.3561 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Artisan International Small-Mid Fund | 1,117,811 | -245,378 | 11,111,041.34 | 0.4155 | 1.7778 | 09/30/2026 |
| 2 | Fidelity Advisor Series VII - Biotechnology Fund | 428,800 | 428,800 | 4,262,272 | 0.1715 | 0.682 | 09/30/2026 |
| 3 | DWS ESG Biotech | 59,240 | 0 | 588,845.6 | 0.1416 | 0.0942 | 08/31/2026 |
| 4 | Russell Investment Co. - US Small Cap Equity Fund | 22,707 | 0 | 225,707.58 | 0.0217 | 0.0361 | 09/30/2026 |
| 5 | Artisan Multiple Invt. Tr. - International Small-Mid Tr. | 13,306 | -3,458 | 132,261.64 | 0.4231 | 0.0212 | 09/30/2026 |
| 6 | ActivePassive International Equity ETF | 8,678 | 8,668 | 86,259.32 | 0.0076 | 0.0138 | 10/30/2026 |
| 7 | China Universal Global Healthcare Mixed Fund | 8,000 | 8,000 | 79,520 | 0.0913 | 0.0127 | 06/30/2026 |
| 8 | Russell Investment Funds - Investment US Small Cap Equity Fund | 5,834 | 0 | 57,989.96 | 0.025 | 0.0093 | 06/30/2026 |
| 9 | Steward Values Enhanced International Fund | 4,051 | 0 | 40,266.94 | 0.0117 | 0.0064 | 09/30/2026 |
| 10 | Lord Abbett Health Care Fund | 2,973 | 0 | 29,551.62 | 0.3208 | 0.0047 | 07/31/2026 |
| 11 | Fidelity Nasdaq Composite Index Fund | 1,509 | -7,388 | 14,999.46 | 0.0001 | 0.0024 | 09/30/2026 |
| 12 | Gabelli Healthcare & Wellness Trust | 400 | -400 | 3,976 | 0.0044 | 0.0006 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | RA Capital Management LP | 3,657,644 | 3,657,644 | 36,356,981.36 | 0.3411 | 5.8171 | 07/30/2026 |
| 2 | UBS Securities LLC | 1,307,194 | 1,232,663 | 12,993,508.36 | 0.0049 | 2.0789 | 06/30/2026 |
| 3 | Logos Global Management LP | 915,000 | 915,000 | 9,095,100 | 0.4641 | 1.4552 | 06/30/2026 |
| 4 | Morgan Stanley & Co. LLC | 895,380 | 895,380 | 8,900,077.2 | 0.0026 | 1.424 | 06/30/2026 |
| 5 | Perceptive Advisors LLC | 1,653,350 | 688,959 | 16,434,299 | 0.2872 | 2.6295 | 06/30/2026 |
| 6 | Jane Street Capital LLC | 223,915 | 212,630 | 2,225,715.1 | 0.0014 | 0.3561 | 06/30/2026 |
| 7 | Great Point Partners LLC | 156,906 | 156,906 | 1,559,645.64 | 0.4218 | 0.2495 | 06/30/2026 |
| 8 | Columbia Management Investment Advisers LLC | 378,068 | 147,080 | 3,757,995.92 | 0.0008 | 0.6013 | 06/30/2026 |
| 9 | HRT Financial LP | 151,197 | 127,112 | 1,502,898.18 | 0.004 | 0.2405 | 06/30/2026 |
| 10 | Ishara Investments LP | 184,500 | 82,000 | 1,833,930 | 1.6994 | 0.2934 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Citadel Advisors LLC | 0 | -9,158,677 | 0 | 0 | 0 | |
| 2 | Artisan Partners LP | 1,372,851 | -846,535 | 13,646,138.94 | 0.0108 | 2.1834 | 06/30/2026 |
| 3 | Adar1 Capital Management LLC | 528,295 | -484,571 | 5,251,252.3 | 0.2809 | 0.8402 | 06/30/2026 |
| 4 | Atika Capital Management LLC | 0 | -271,300 | 0 | 0 | 0 | |
| 5 | Balyasny Asset Management LP | 0 | -233,429 | 0 | 0 | 0 | |
| 6 | Morgan Stanley & Co. International Plc | 59,134 | -86,588 | 587,791.96 | 0.0042 | 0.094 | 06/30/2026 |
| 7 | Redmile Group LLC | 410,440 | -80,900 | 4,079,773.6 | 0.2776 | 0.6528 | 06/30/2026 |
| 8 | Diversify Wealth Management LLC | 0 | -63,672 | 0 | 0 | 0 | |
| 9 | Millennium Management LLC | 267,783 | -51,176 | 2,661,763.02 | 0.0018 | 0.4259 | 06/30/2026 |
| 10 | New York State Common Retirement Fund (Invt Mgmt) | 119,335 | -48,845 | 1,186,189.9 | 0.0014 | 0.1898 | 06/30/2026 |
Data provided by FactSet Research Systems Inc.