| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Citadel Advisors LLC | 9,158,677 | 0 | 143,791,228.9 | 0.1303 | 15.4676 | 04/07/2025 |
| 2 | Artisan Partners LP | 2,219,386 | -757,514 | 34,844,360.2 | 0.0259 | 3.7482 | 03/31/2026 |
| 3 | Baker Bros. Advisors LP | 1,461,425 | 0 | 22,944,372.5 | 0.1092 | 2.4681 | 03/31/2026 |
| 4 | Adar1 Capital Management LLC | 1,012,866 | 1,012,866 | 15,901,996.2 | 0.8954 | 1.7106 | 03/31/2026 |
| 5 | Perceptive Advisors LLC | 964,391 | 964,391 | 15,140,938.7 | 0.2558 | 1.6287 | 03/31/2026 |
| 6 | Octagon Capital Advisors LP | 574,200 | -443,821 | 9,014,940 | 0.873 | 0.9697 | 03/31/2026 |
| 7 | Ikarian Capital LLC | 525,000 | 525,000 | 8,242,500 | 1.2698 | 0.8866 | 03/31/2026 |
| 8 | Redmile Group LLC | 491,340 | 491,340 | 7,714,038 | 0.4179 | 0.8298 | 03/31/2026 |
| 9 | Duquesne Family Office LLC | 383,363 | 383,363 | 6,018,799.1 | 0.1661 | 0.6474 | 03/31/2026 |
| 10 | Millennium Management LLC | 318,959 | -18,904 | 5,007,656.3 | 0.0034 | 0.5387 | 03/31/2026 |
| 11 | Atika Capital Management LLC | 271,300 | 271,300 | 4,259,410 | 0.5373 | 0.4582 | 03/31/2026 |
| 12 | Elmind Capital LP | 265,000 | 265,000 | 4,160,500 | 1.16 | 0.4475 | 03/31/2026 |
| 13 | Balyasny Asset Management LP | 233,429 | 233,429 | 3,664,835.3 | 0.0067 | 0.3942 | 03/31/2026 |
| 14 | Columbia Management Investment Advisers LLC | 230,988 | 230,988 | 3,626,511.6 | 0.0008 | 0.3901 | 03/31/2026 |
| 15 | Yiheng Capital Management LP | 170,142 | -486,167 | 2,671,229.4 | 0.998 | 0.2873 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Artisan International Small-Mid Fund | 1,363,189 | 1,331,421 | 21,402,067.3 | 0.754 | 2.3022 | 03/31/2026 |
| 2 | DWS ESG Biotech | 59,240 | 59,240 | 930,068 | 0.2244 | 0.1 | 04/30/2026 |
| 3 | AdvisorShares Dorsey Wright ADR ETF | 45,391 | 45,391 | 712,638.7 | 1.6548 | 0.0767 | 05/29/2026 |
| 4 | Artisan Multiple Invt. Tr. - International Small-Mid Tr. | 16,764 | 15,730 | 263,194.8 | 0.7446 | 0.0283 | 03/31/2026 |
| 5 | Fidelity Nasdaq Composite Index Fund | 8,897 | 5,020 | 139,682.9 | 0.0005 | 0.015 | 04/30/2026 |
| 6 | Russell Investment Funds - Investment US Small Cap Equity Fund | 5,834 | 5,834 | 91,593.8 | 0.0377 | 0.0099 | 03/31/2026 |
| 7 | Steward Values Enhanced International Fund | 4,051 | 4,051 | 63,600.7 | 0.0201 | 0.0068 | 05/31/2026 |
| 8 | ActivePassive International Equity ETF | 2,245 | 2,245 | 35,246.5 | 0.0033 | 0.0038 | 05/29/2026 |
| 9 | Gabelli Healthcare & Wellness Trust | 800 | 800 | 12,560 | 0.0217 | 0.0014 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Adar1 Capital Management LLC | 1,012,866 | 1,012,866 | 15,901,996.2 | 0.8954 | 1.7106 | 03/31/2026 |
| 2 | Perceptive Advisors LLC | 964,391 | 964,391 | 15,140,938.7 | 0.2558 | 1.6287 | 03/31/2026 |
| 3 | Ikarian Capital LLC | 525,000 | 525,000 | 8,242,500 | 1.2698 | 0.8866 | 03/31/2026 |
| 4 | Redmile Group LLC | 491,340 | 491,340 | 7,714,038 | 0.4179 | 0.8298 | 03/31/2026 |
| 5 | Duquesne Family Office LLC | 383,363 | 383,363 | 6,018,799.1 | 0.1661 | 0.6474 | 03/31/2026 |
| 6 | Atika Capital Management LLC | 271,300 | 271,300 | 4,259,410 | 0.5373 | 0.4582 | 03/31/2026 |
| 7 | Elmind Capital LP | 265,000 | 265,000 | 4,160,500 | 1.16 | 0.4475 | 03/31/2026 |
| 8 | Balyasny Asset Management LP | 233,429 | 233,429 | 3,664,835.3 | 0.0067 | 0.3942 | 03/31/2026 |
| 9 | Columbia Management Investment Advisers LLC | 230,988 | 230,988 | 3,626,511.6 | 0.0008 | 0.3901 | 03/31/2026 |
| 10 | New York State Common Retirement Fund | 168,180 | 164,760 | 2,640,426 | 0.0032 | 0.284 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Artisan Partners LP | 2,219,386 | -757,514 | 34,844,360.2 | 0.0259 | 3.7482 | 03/31/2026 |
| 2 | Yiheng Capital Management LP | 170,142 | -486,167 | 2,671,229.4 | 0.998 | 0.2873 | 03/31/2026 |
| 3 | Octagon Capital Advisors LP | 574,200 | -443,821 | 9,014,940 | 0.873 | 0.9697 | 03/31/2026 |
| 4 | Great Point Partners LLC | 0 | -378,594 | 0 | 0 | 0 | |
| 5 | Adage Capital Management LP | 0 | -345,934 | 0 | 0 | 0 | |
| 6 | DLD Asset Management LP | 0 | -25,000 | 0 | 0 | 0 | |
| 7 | Citadel Securities LLC | 0 | -22,049 | 0 | 0 | 0 | |
| 8 | Barclays Bank Plc (Private Banking) | 8,079 | -21,926 | 126,840.3 | 0.0001 | 0.0136 | 03/31/2026 |
| 9 | Millennium Management LLC | 318,959 | -18,904 | 5,007,656.3 | 0.0034 | 0.5387 | 03/31/2026 |
| 10 | Two Sigma Investments LP | 0 | -16,682 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.