| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Citadel Advisors LLC | 9,158,677 | 0 | 185,646,382.79 | 0.198 | 23.5518 | 04/07/2025 |
| 2 | Baker Bros. Advisors LP | 1,461,425 | 0 | 29,623,084.75 | 0.1451 | 3.7581 | 09/30/2025 |
| 3 | Octagon Capital Advisors LP | 1,018,021 | 1,018,021 | 20,635,285.67 | 2.1817 | 2.6179 | 09/30/2025 |
| 4 | Yiheng Capital Management LP | 656,309 | 0 | 13,303,383.43 | 3.2392 | 1.6877 | 09/30/2025 |
| 5 | Great Point Partners LLC | 378,594 | 378,594 | 7,674,100.38 | 2.4434 | 0.9736 | 09/30/2025 |
| 6 | Adage Capital Management LP | 345,934 | 345,934 | 7,012,082.18 | 0.0106 | 0.8896 | 09/30/2025 |
| 7 | Millennium Management LLC | 337,863 | 337,863 | 6,848,483.01 | 0.0053 | 0.8688 | 09/30/2025 |
| 8 | Artisan Partners LP | 51,920 | 51,920 | 1,052,418.4 | 0.0008 | 0.1335 | 09/30/2025 |
| 9 | Nan Fung Trinity (HK) Ltd. | 37,095 | 37,095 | 751,915.65 | 0.0748 | 0.0954 | 09/30/2025 |
| 10 | Barclays Bank Plc (Private Banking) | 30,005 | 29,707 | 608,201.35 | 0.0003 | 0.0772 | 09/30/2025 |
| 11 | DLD Asset Management LP | 25,000 | 25,000 | 506,750 | 0.0888 | 0.0643 | 09/30/2025 |
| 12 | Citadel Securities LLC | 22,049 | -13,381 | 446,933.23 | 0.0012 | 0.0567 | 09/30/2025 |
| 13 | Two Sigma Investments LP | 16,682 | 16,682 | 338,144.14 | 0.0005 | 0.0429 | 09/30/2025 |
| 14 | Optiver US LLC | 8,347 | 0 | 169,193.69 | 0.0026 | 0.0215 | 09/30/2025 |
| 15 | Morgan Stanley & Co. International Plc | 8,098 | -29,120 | 164,146.46 | 0.0015 | 0.0208 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Artisan International Small-Mid Fund | 31,768 | 31,768 | 643,937.36 | 0.0206 | 0.0817 | 09/30/2025 |
| 2 | Fidelity Nasdaq Composite Index Fund | 3,877 | 0 | 78,586.79 | 0.0003 | 0.01 | 10/31/2025 |
| 3 | Artisan Multiple Invt. Tr. - International Small-Mid Tr. | 1,034 | 1,034 | 20,959.18 | 0.0202 | 0.0027 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Octagon Capital Advisors LP | 1,018,021 | 1,018,021 | 20,635,285.67 | 2.1817 | 2.6179 | 09/30/2025 |
| 2 | Great Point Partners LLC | 378,594 | 378,594 | 7,674,100.38 | 2.4434 | 0.9736 | 09/30/2025 |
| 3 | Adage Capital Management LP | 345,934 | 345,934 | 7,012,082.18 | 0.0106 | 0.8896 | 09/30/2025 |
| 4 | Millennium Management LLC | 337,863 | 337,863 | 6,848,483.01 | 0.0053 | 0.8688 | 09/30/2025 |
| 5 | Artisan Partners LP | 51,920 | 51,920 | 1,052,418.4 | 0.0008 | 0.1335 | 09/30/2025 |
| 6 | Nan Fung Trinity (HK) Ltd. | 37,095 | 37,095 | 751,915.65 | 0.0748 | 0.0954 | 09/30/2025 |
| 7 | Barclays Bank Plc (Private Banking) | 30,005 | 29,707 | 608,201.35 | 0.0003 | 0.0772 | 09/30/2025 |
| 8 | DLD Asset Management LP | 25,000 | 25,000 | 506,750 | 0.0888 | 0.0643 | 09/30/2025 |
| 9 | Two Sigma Investments LP | 16,682 | 16,682 | 338,144.14 | 0.0005 | 0.0429 | 09/30/2025 |
| 10 | New York State Common Retirement Fund | 3,420 | 3,420 | 69,323.4 | 0.0001 | 0.0088 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | UBS Securities LLC | 148 | -163,339 | 2,999.96 | 0 | 0.0004 | 09/30/2025 |
| 2 | Cantor Fitzgerald Europe | 0 | -95,460 | 0 | 0 | 0 | |
| 3 | Morgan Stanley & Co. International Plc | 8,098 | -29,120 | 164,146.46 | 0.0015 | 0.0208 | 09/30/2025 |
| 4 | Citadel Securities LLC | 22,049 | -13,381 | 446,933.23 | 0.0012 | 0.0567 | 09/30/2025 |
| 5 | Morgan Stanley Smith Barney LLC (Investment Management) | 366 | -2,687 | 7,418.82 | 0 | 0.0009 | 09/30/2025 |
| 6 | RhumbLine Advisers LP | 3,611 | -279 | 73,194.97 | 0.0001 | 0.0093 | 09/30/2025 |
| 7 | Desjardins Securities, Inc. | 150 | -275 | 3,040.5 | 0 | 0.0004 | 09/30/2025 |
| 8 | JPMorgan Securities LLC (Investment Management) | 20 | -100 | 405.4 | 0 | 0.0001 | 09/30/2025 |
Data provided by FactSet Research Systems Inc.