| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Citadel Advisors LLC | 9,158,677 | 0 | 113,109,660.95 | 0.086 | 14.5665 | 04/07/2025 |
| 2 | RA Capital Management LP | 3,657,644 | 3,657,644 | 45,171,903.4 | 0.3896 | 5.8173 | 07/30/2026 |
| 3 | Perceptive Advisors LLC | 1,653,350 | 1,653,350 | 20,418,872.5 | 0.3256 | 2.6296 | 06/30/2026 |
| 4 | Baker Bros. Advisors LP | 1,461,425 | 0 | 18,048,598.75 | 0.0654 | 2.3243 | 06/30/2026 |
| 5 | Artisan Partners LP | 1,372,851 | -1,936,204 | 16,954,709.85 | 0.0138 | 2.1835 | 06/30/2026 |
| 6 | UBS Securities LLC | 1,307,194 | 1,062,332 | 16,143,845.9 | 0.0061 | 2.079 | 06/30/2026 |
| 7 | Logos Global Management LP | 915,000 | 890,000 | 11,300,250 | 0.5291 | 1.4553 | 06/30/2026 |
| 8 | Morgan Stanley & Co. LLC | 895,380 | 895,380 | 11,057,943 | 0.0032 | 1.4241 | 06/30/2026 |
| 9 | Octagon Capital Advisors LP | 574,200 | 0 | 7,091,370 | 0.7811 | 0.9132 | 06/30/2026 |
| 10 | Adar1 Capital Management LLC | 528,295 | 528,295 | 6,524,443.25 | 0.3046 | 0.8402 | 06/30/2026 |
| 11 | Ikarian Capital LLC | 525,000 | 0 | 6,483,750 | 1.2313 | 0.835 | 06/30/2026 |
| 12 | Redmile Group LLC | 410,440 | -139,400 | 5,068,934 | 0.3108 | 0.6528 | 06/30/2026 |
| 13 | Columbia Management Investment Advisers LLC | 378,068 | 378,068 | 4,669,139.8 | 0.001 | 0.6013 | 06/30/2026 |
| 14 | Millennium Management LLC | 267,783 | -373,102 | 3,307,120.05 | 0.0023 | 0.4259 | 06/30/2026 |
| 15 | Elmind Capital LP | 265,000 | 265,000 | 3,272,750 | 0.8799 | 0.4215 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Artisan International Small-Mid Fund | 840,251 | -1,184,274 | 10,377,099.85 | 0.4006 | 1.3364 | 06/30/2026 |
| 2 | Fidelity Advisor Series VII - Biotechnology Fund | 428,800 | 428,800 | 5,295,680 | 0.2285 | 0.682 | 07/31/2026 |
| 3 | DWS ESG Biotech | 59,240 | 59,240 | 731,614 | 0.1774 | 0.0942 | 07/31/2026 |
| 4 | Russell Investment Co. - US Small Cap Equity Fund | 22,707 | 12,584 | 280,431.45 | 0.0294 | 0.0361 | 07/31/2026 |
| 5 | Fidelity Nasdaq Composite Index Fund | 12,855 | 8,978 | 158,759.25 | 0.0006 | 0.0204 | 07/31/2026 |
| 6 | Artisan Multiple Invt. Tr. - International Small-Mid Tr. | 10,759 | -55,582 | 132,873.65 | 0.3994 | 0.0171 | 06/30/2026 |
| 7 | Russell Investment Funds - Investment US Small Cap Equity Fund | 5,834 | 5,834 | 72,049.9 | 0.0313 | 0.0093 | 06/30/2026 |
| 8 | ActivePassive International Equity ETF | 4,402 | 4,402 | 54,364.7 | 0.0048 | 0.007 | 08/31/2026 |
| 9 | Steward Values Enhanced International Fund | 4,051 | 0 | 50,029.85 | 0.0146 | 0.0064 | 07/31/2026 |
| 10 | Lord Abbett Health Care Fund | 2,973 | 2,973 | 36,716.55 | 0.3994 | 0.0047 | 04/30/2026 |
| 11 | Gabelli Healthcare & Wellness Trust | 400 | -100 | 4,940 | 0.0061 | 0.0006 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | RA Capital Management LP | 3,657,644 | 3,657,644 | 45,171,903.4 | 0.3896 | 5.8173 | 07/30/2026 |
| 2 | Perceptive Advisors LLC | 1,653,350 | 1,653,350 | 20,418,872.5 | 0.3256 | 2.6296 | 06/30/2026 |
| 3 | UBS Securities LLC | 1,307,194 | 1,062,332 | 16,143,845.9 | 0.0061 | 2.079 | 06/30/2026 |
| 4 | Morgan Stanley & Co. LLC | 895,380 | 895,380 | 11,057,943 | 0.0032 | 1.4241 | 06/30/2026 |
| 5 | Logos Global Management LP | 915,000 | 890,000 | 11,300,250 | 0.5291 | 1.4553 | 06/30/2026 |
| 6 | Adar1 Capital Management LLC | 528,295 | 528,295 | 6,524,443.25 | 0.3046 | 0.8402 | 06/30/2026 |
| 7 | Columbia Management Investment Advisers LLC | 378,068 | 378,068 | 4,669,139.8 | 0.001 | 0.6013 | 06/30/2026 |
| 8 | Elmind Capital LP | 265,000 | 265,000 | 3,272,750 | 0.8799 | 0.4215 | 06/30/2026 |
| 9 | Jane Street Capital LLC | 223,915 | 223,915 | 2,765,350.25 | 0.0016 | 0.3561 | 06/30/2026 |
| 10 | Ishara Investments LP | 184,500 | 184,500 | 2,278,575 | 1.7517 | 0.2934 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Artisan Partners LP | 1,372,851 | -1,936,204 | 16,954,709.85 | 0.0138 | 2.1835 | 06/30/2026 |
| 2 | Yiheng Capital Management LP | 170,142 | -469,627 | 2,101,253.7 | 0.7842 | 0.2706 | 06/30/2026 |
| 3 | Schonfeld Strategic Advisors LLC | 0 | -454,343 | 0 | 0 | 0 | |
| 4 | Millennium Management LLC | 267,783 | -373,102 | 3,307,120.05 | 0.0023 | 0.4259 | 06/30/2026 |
| 5 | Vestal Point Capital LP | 0 | -300,000 | 0 | 0 | 0 | |
| 6 | Squadron Capital Management LLC | 0 | -240,000 | 0 | 0 | 0 | |
| 7 | Balyasny Asset Management LP | 0 | -235,023 | 0 | 0 | 0 | |
| 8 | Atika Capital Management LLC | 0 | -206,881 | 0 | 0 | 0 | |
| 9 | Redmile Group LLC | 410,440 | -139,400 | 5,068,934 | 0.3108 | 0.6528 | 06/30/2026 |
| 10 | Citadel Securities LLC | 22,782 | -122,347 | 281,357.7 | 0.0007 | 0.0362 | 06/30/2026 |
Data provided by FactSet Research Systems Inc.