| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Soleus Capital Management LP (Investment Management) | 7,309,254 | 0 | 21,050,651.52 | 0.7297 | 19.5476 | 09/30/2025 |
| 2 | Morgan Stanley & Co. International Plc | 3,361,780 | -1,700 | 9,681,926.4 | 0.0913 | 8.9906 | 09/30/2025 |
| 3 | Rock Springs Capital Management LP | 1,270,000 | 0 | 3,657,600 | 0.1774 | 3.3964 | 09/30/2025 |
| 4 | Bruce & Co., Inc. | 438,652 | -115,000 | 1,263,317.76 | 0.382 | 1.1731 | 09/30/2025 |
| 5 | UBS Securities LLC | 234,445 | 195,986 | 675,201.6 | 0.0003 | 0.627 | 09/30/2025 |
| 6 | Schonfeld Strategic Advisors LLC | 170,057 | 3,623 | 489,764.16 | 0.0033 | 0.4548 | 09/30/2025 |
| 7 | Parkman Healthcare Partners LLC | 154,832 | 0 | 445,916.16 | 0.043 | 0.4141 | 09/30/2025 |
| 8 | Cahill Financial Advisors, Inc. | 134,960 | 0 | 388,684.8 | 0.0432 | 0.3609 | 09/30/2025 |
| 9 | Summit Trail Advisors LLC | 102,339 | 102,339 | 294,736.32 | 0.004 | 0.2737 | 09/30/2025 |
| 10 | Sage Mountain Advisors LLC | 100,000 | 100,000 | 288,000 | 0.0162 | 0.2674 | 09/30/2025 |
| 11 | Cetera Investment Advisers LLC | 74,000 | -1,000 | 213,120 | 0.0002 | 0.1979 | 09/30/2025 |
| 12 | Commonwealth Equity Services LLC | 69,160 | 0 | 199,180.8 | 0.0003 | 0.185 | 09/30/2025 |
| 13 | Citadel Securities LLC | 48,251 | -37,868 | 138,962.88 | 0.0004 | 0.129 | 09/30/2025 |
| 14 | CW Advisors LLC | 42,500 | 42,500 | 122,400 | 0.0012 | 0.1137 | 09/30/2025 |
| 15 | BNP Paribas Financial Markets | 26,105 | -14,400 | 75,182.4 | 0.0001 | 0.0698 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Bruce Fund | 414,794 | -115,000 | 1,194,606.72 | 0.346 | 1.1093 | 09/30/2025 |
| 2 | Fidelity Nasdaq Composite Index Fund | 22,764 | 0 | 65,560.32 | 0.0003 | 0.0609 | 10/31/2025 |
| 3 | LUX IM - Global Medtech | 7,741 | 0 | 22,294.08 | 0.0125 | 0.0207 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | UBS Securities LLC | 234,445 | 195,986 | 675,201.6 | 0.0003 | 0.627 | 09/30/2025 |
| 2 | Summit Trail Advisors LLC | 102,339 | 102,339 | 294,736.32 | 0.004 | 0.2737 | 09/30/2025 |
| 3 | Sage Mountain Advisors LLC | 100,000 | 100,000 | 288,000 | 0.0162 | 0.2674 | 09/30/2025 |
| 4 | CW Advisors LLC | 42,500 | 42,500 | 122,400 | 0.0012 | 0.1137 | 09/30/2025 |
| 5 | Susquehanna Financial Group LLLP | 22,994 | 22,994 | 66,222.72 | 0.0001 | 0.0615 | 09/30/2025 |
| 6 | G1 Execution Services LLC | 20,698 | 20,698 | 59,610.24 | 0.0026 | 0.0554 | 09/30/2025 |
| 7 | Bernard Caroli Wealth Management, Inc. | 13,000 | 13,000 | 37,440 | 0.0131 | 0.0348 | 09/30/2025 |
| 8 | Simplicity Wealth LLC | 11,876 | 11,876 | 34,202.88 | 0.002 | 0.0318 | 09/30/2025 |
| 9 | UBS Switzerland AG (Investment Management) | 3,775 | 3,775 | 10,872 | 0 | 0.0101 | 09/30/2025 |
| 10 | Schonfeld Strategic Advisors LLC | 170,057 | 3,623 | 489,764.16 | 0.0033 | 0.4548 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Apis Capital Advisors LLC | 0 | -524,000 | 0 | 0 | 0 | |
| 2 | Scoggin Management LP | 0 | -350,000 | 0 | 0 | 0 | |
| 3 | Archon Capital Management LLC | 0 | -273,607 | 0 | 0 | 0 | |
| 4 | Bruce & Co., Inc. | 438,652 | -115,000 | 1,263,317.76 | 0.382 | 1.1731 | 09/30/2025 |
| 5 | PSM Vermogensverwaltung GmbH Langen v.d.Goltz, Dr. Prinz | 0 | -80,000 | 0 | 0 | 0 | |
| 6 | Citadel Securities LLC | 48,251 | -37,868 | 138,962.88 | 0.0004 | 0.129 | 09/30/2025 |
| 7 | Orion Capital Management LLC (CA) | 5,000 | -33,000 | 14,400 | 0.0049 | 0.0134 | 09/30/2025 |
| 8 | Illumine Investment Management LLC | 0 | -22,400 | 0 | 0 | 0 | |
| 9 | BNP Paribas Financial Markets | 26,105 | -14,400 | 75,182.4 | 0.0001 | 0.0698 | 09/30/2025 |
| 10 | Millennium Management LLC | 0 | -11,285 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.